T- Helper Types and Their Associated Cytokines
6.5 CONCLUSION
94 Fish Vaccines facilitating antigen uptake (Zhao et al., 2014). Virus-like particles do not contain infective nucleic acid but still have the structure for inducing immunity (Vinay et al., 2016).
6.4.2 lImItatIons
Immunization is a revolution in aquaculture, but improper methods have caused mishaps. Careful immunization after knowing wholly about the fish species’ immune system is of primary impor- tance. Vaccines are available only for considerable species, so people must choose carefully. In non- encapsulated oral fish vaccines, the protection was for a short duration which started to decrease after 2–3 months after vaccination (Embregts and Forlenza, 2016). In cases of oral vaccination, gut nature presents more challenges. Carnivorous fishes have more protease usage, and non-carnivorous fishes have more amylase activity to digest plant matter. Nanoparticles have given more options to prepare vaccines but come with some limitations. As they can cross the blood-brain barrier (BBB), their application is challenging (Yildirimer et al., 2011). They also have proven to be toxic, and the estimation of toxicity is difficult. Its result ranges from cell necrosis to reactive oxygen spe- cies (ROS), causing apoptosis (Elsaesser and Howard, 2012). This effect also can reach humans and harm them. Vaccines give protection and adjuvants also have some side effects in fish, such as inflammation, pigmentation, intra-abdominal adhesion, etc. Injecting fish means causing stress, and spinal deformities have been noticed as side effects (Midtlyng et al., 1996).
Advancements in Vaccine Delivery and Methods of Vaccination 95
Aucouturier, J., Dupuis, L., and Ganne, V. 2001. Adjuvants designed for veterinary and human vaccines.
Vaccine, 19(17):2666–2672.
Bhardwaj, P., Bhatia, E., Sharma, S., Ahamad, N., and Banerjee, R. 2020. Advancements in prophylactic and therapeutic nanovaccines. Acta Biomaterialia, 108:1–21. https://doi.org/10.1016/j.actbio.2020.03.020 Brudeseth, B. E., Wiulsrød, R., Fredriksen, B. N., Lindmo, K., Løkling, K.-E., Bordevik, M., Steine, N., Klevan,
A., and Gravningen, K. 2013. Status and future perspectives of vaccines for industrialised fin-fish farm- ing. Fish & Shellfish Immunology, 35(6):1759–1768.
Corbeil, S., LaPatra, S. E., Anderson, E. D., and Kurath, G. 2000. Nanogram quantities of a DNA vaccine pro- tect rainbow trout fry against heterologous strains of infectious hematopoietic necrosis virus. Vaccine, 18(25):2817–2824.
Dadar, M., Alamian, S., Behrozikhah, A. M., Yazdani, F., Kalantari, A., Etemadi, A., and Whatmore, A. M.
2019. Molecular identification of Brucella species and biovars associated with animal and human infec- tion in Iran. Veterinary Research Forum, 10(4):315–321. https://doi.org/10.30466/vrf.2018.89680.2171 Dadar, M., Dhama, K., Vakharia, V. N., Hoseinifar, S. H., Karthik, K., Tiwari, R., Khandia, R., Munjal, A.,
Salgado-Miranda, C., and Joshi, S. K. 2017. Advances in aquaculture vaccines against fish pathogens:
Global status and current trends. Reviews in Fisheries Science & Aquaculture, 25(3):184–217. https://doi.
org/10.1080/23308249.2016.1261277
Dhar, A. K., Manna, S. K., and Thomas Allnutt, F. C. 2014. Viral vaccines for farmed finfish. Virusdisease, 25(1):1–17.
Dixon, P. and Stone, D. 2017. Spring viraemia of carp. In Woo, P. T. K. and Cipriano, R. C., editors, Fish Viruses and Bacteria: Pathobiology and Protection, pp. 79–90. CABI, 1 edition.
Dubey, S., Avadhani, K., Mutalik, S., Sivadasan, S. M., Maiti, B., Paul, J., Girisha, S. K., Venugopal, M.
N., Mutoloki, S., Evensen, Ø., Karunasagar, I., and Munangʼandu, H. M. 2016. Aeromonas hydrophila OmpW PLGA nanoparticle oral vaccine shows a dose-dependent protective immunity in rohu (Labeo rohita). Vaccine, 4(2):21.
Duff, D. C. B. 1942. The oral immunization of trout against Bacterium salmonicida. The Journal of Immunology, 44(1):87–94.
Edelman, R. 1980. Vaccine adjuvants. Reviews of Infectious Diseases, 2(3):370–383.
Ellis, A. 1988. Current aspects of fish vaccination. Diseases of Aquatic Organisms, 4:159–164.
Elsaesser, A. and Howard, C. V. 2012. Toxicology of nanoparticles. Advanced Drug Delivery Reviews, 64(2):129–137.
Embregts, C. W. E. and Forlenza, M. 2016. Oral vaccination of fish: Lessons from humans and veterinary spe- cies. Developmental & Comparative Immunology, 64:118–137. https://doi.org/10.1016/j.dci.2016.03.024 Estepa, A., Fernandez-Alonso, M., and Coll, J. M. 1999. Structure, binding and neutralization of VHSV with
synthetic peptides. Virus Research, 63(1):27–34.
Evensen, Ø. and Leong, J.-A. C. 2013. DNA vaccines against viral diseases of farmed fish. Fish & Shellfish Immunology, 35(6):1751–1758.
FAO. 2010. The state of world fisheries and aquaculture. Rome, FAO.
FAO. 2014. The state of world fisheries and aquaculture 2014, p. 223.
FAO. 2016. The state of world fisheries and aquaculture 2016. Number 2016 in the state of world fisheries and aquaculture, p. 190.
Gudding, R. and Van Muiswinkel, W. B. 2013. A history of fish vaccination: Science-based disease prevention in aquaculture. Fish & Shellfish Immunology, 35(6):1683–1688.
Hansen, E., Fernandes, K., Goldspink, G., Butterworth, P., Umeda, P. K., and Chang, K.C. 1991. Strong expres- sion of foreign genes following direct injection into fish muscle. FEBS Letters, 290(1):73–76.
Heppell, J., Lorenzen, N., Armstrong, N. K., Wu, T., Lorenzen, E., Einer-jensen, K., Schorr, J., and Davis, H. L. 1998. Development of DNA vaccines for fish: Vector design, intramuscular injection and antigen expression using viral haemorrhagic septicaemia virus genes as model. Fish & Shellfish Immunology, 8(4):271–286.
Hølvold, L. B., Myhr, A. I., and Dalmo, R. A. 2014. Strategies and hurdles using DNA vaccines to fish.
Veterinary Research, 45(1):21.
Hu, Y.-L., Xiang, L.-X., and Shao, J.-Z. 2010. Identification and characterization of a novel immunoglobu- lin Z isotype in zebrafish: Implications for a distinct B cell receptor in lower vertebrates. Molecular Immunology, 47(4):738–746.
Hwang, J. Y., Kwon, M. G., Seo, J. S., Hwang, S. D., Jeong, J. M., Lee, J. H., Jeong, A. R., and Jee, B. Y.
2020. Current use and management of commercial fish vaccines in Korea. Fish & Shellfish Immunology, 102:20–27.
96 Fish Vaccines
Irie, T., Watarai, S., Iwasaki, T., and Kodama, H. 2005. Protection against experimental Aeromonas salmoni- cida infection in carp by oral immunisation with bacterial antigen entrapped liposomes. Fish & Shellfish Immunology, 18(3):235–242.
Karunasagar, I., Pai, R., Malathi, G. R., and Karunasagar, I. 1994. Mass mortality of Penaeus monodon larvae due to antibiotic-resistant Vibrio harveyi infection. Aquaculture, 128(3):203–209.
Kavaliauskis, A., Arnemo, M., Speth, M., Lagos, L., Rishovd, A.-L., Estepa, A., Griffiths, G., and Gjøen, T. 2016. Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model. Developmental & Comparative Immunology, 61:248–257.
Kawai, K., Yamamoto, S., and Kusuda, R. 1989. Plankton-mediated oral delivery of Vibrio anguillarum vaccine to juvenile ayu. Nippon Suisan Gakkaishi, 55(1):35–40.
Kumar, S. R., Ahmed, V. P. I., Parameswaran, V., Sudhakaran, R., Babu, V. S., and Hameed, A. S. S. 2008.
Potential use of chitosan nanoparticles for oral delivery of DNA vaccine in Asian sea bass (Lates calcari- fer) to protect from Vibrio (Listonella) anguillarum. Fish & Shellfish Immunology, 25(1):47.
Langevin, C., Aleksejeva, E., Passoni, G., Palha, N., Levraud, J.-P., and Boudinot, P. 2013. The antiviral innate immune response in fish: Evolution and conservation of the IFN system. Journal of Molecular Biology, 425(24):4904–4920.
Lecocq-Xhonneux, F., Thiry, M., Dheur, I., Rossius, M., Vanderheijden, N., Martial, J., and de Kinkelin, P.
1994. A recombinant viral haemorrhagic septicaemia virus glycoprotein expressed in insect cells induces protective immunity in rainbow trout. Journal of General Virology, 75(Pt 7):1579–1587.
Lillehaug, A., Lunestad, B. T., and Grave, K. 2003. Epidemiology of bacterial diseases in Norwegian aquacul- ture a description based on antibiotic prescription data for the ten-year period 1991 to 2000. Diseases of Aquatic Organisms, 53(2):115–125.
Lorenzen, E., Einer-Jensen, K., Rasmussen, J. S., Kjær, T. E., Collet, B., Secombes, C. J., and Lorenzen, N.
2009. The protective mechanisms induced by a fish rhabdovirus DNA vaccine depend on temperature.
Vaccine, 27(29):3870–3880.
Ma, J., Bruce, T. J., Jones, E. M., and Cain, K. D. 2019a. A review of fish vaccine development strategies:
Conventional methods and modern biotechnological approaches. Microorganisms, 7(11):E569. https://
doi.org/10.3390/microorganisms7110569
Ma, J., Bruce, T. J., Sudheesh, P. S., Knupp, C., Loch, T. P., Faisal, M., and Cain, K. D. 2019b. Assessment of cross-protection to heterologous strains of Flavobacterium psychrophilum following vaccination with a live-attenuated coldwater disease immersion vaccine. Journal of Fish Diseases, 42(1):75–84. https://doi.
org/10.1111/jfd.12902
Midtlyng, P. J., Reitan, L. J., and Speilberg, L. 1996. Experimental studies on the efficacy and side-effects of intraperitoneal vaccination of Atlantic salmon (Salmo salarL.) against furunculosis. Fish & Shellfish Immunology, 6(5):335–350.
Miyazaki, T., Yasumoto, S., Kuzuya, Y., and Yoshimura, T. 2008. A primary study on oral vaccination with liposomes entrapping koi herpesvirus (KHV) antigens against KHV infection in carp. Diseases in Asian Aquaculture, 7:99–184.
Nagaraju, V. T. 2019. Nanovaccines in aquaculture. Archives of Nanomedicine: Open Access Journal, 2(1):153–159.
Nakanishi, T., Kiryu, I., and Ototake, M. 2002. Development of a new vaccine delivery method for fish:
Percutaneous administration by immersion with application of a multiple puncture instrument. Vaccine, 20(31–32):3764–3769.
Palm, R. C., Jr, Landolt, M. L., and Busch, R. A. 1998. Route of vaccine administration: Effects on the specific humoral response in rainbow trout Oncorhynchus mykiss. Diseases of Aquatic Organisms, 33(3):157–
166. https://doi.org/10.3354/dao033157
Petit, J. and Wiegertjes, G. F. 2016. Long-lived effects of administering beta-glucans: Indications for trained immunity in fish. Developmental & Comparative Immunology, 64:93–102.
Petrovsky, N. and Aguilar, J. C. 2004. Vaccine adjuvants: Current state and future trends. Immunology and Cell Biology, 82(5):488–496.
Phenix, K., McKenna, B., Fitzpatrick, R., Vaughan, L., Atkins, G., Liljestrom, P., and Todd, D. 2000. Cell culture evaluation of the Semliki Forest virus expression system as a novel approach for antigen delivery and expression in fish. Marine Biotechnology, 2(1):27–37.
Plant, K. P. and Lapatra, S. E. 2011. Advances in fish vaccine delivery. Developmental & Comparative Immunology, 35(12):1256–1262. https://doi.org/10.1016/j.dci.2011.03.007
Puricelli, C., Boggio, E., Gigliotti, C. L., Stoppa, I., Sutti, S., Rolla, R., and Dianzani, U. 2022. Cutting-edge delivery systems and adjuvants in tolerogenic vaccines: A review. Pharmaceutics, 14:1782. https://doi.
org/10.3390/pharmaceutics14091782
Advancements in Vaccine Delivery and Methods of Vaccination 97
Rather, M. A., Sharma, R., Aklakur, M., Ahmad, S., Kumar, N., Khan, M. and Ramya, V.L. 2011.
Nanotechnology: A novel tool for aquaculture and fisheries development. A prospective mini-review.
Fisheries and Aquaculture Journal, 16(1–5):3.
Secombes, C. and Ellis, A. 2012. The immunology of teleosts. In Fish Pathology, pp. 144–166. John Wiley
&Sons, Ltd. https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781118222942.ch4.
Shao, Z. J. 2001. Aquaculture pharmaceuticals and biologicals: Current perspectives and future possibilities.
Advanced Drug Delivery Reviews, 50(3):229–243.
Shoemaker, C. A., Klesius, P. H., Drennan, J. D., and Evans, J. J. 2011. Efficacy of a modified live Flavobacterium columnare vaccine in fish. Fish & Shellfish Immunology, 30(1):304–308.
Singh, M. and O’Hagan, D. T. 2003. Recent advances in veterinary vaccine adjuvants. International Journal for Parasitology, 33(5–6):469–478. https://doi.org/10.1016/s0020-7519(03)00053-5
Sinyakov, M. S., Dror, M., Lublin-Tennenbaum, T., Salzberg, S., Margel, S., and Avtalion, R. R. 2006. Nano- and microparticles as adjuvants in vaccine design: Success and failure is related to host natural antibod- ies. Vaccine, 24(42–43):6534–6541. https://doi.org/10.1016/j.vaccine.2006.06.021
Sneeringer, S., Bowman, M., and Clancy, M. 2019. The U.S. and EU animal pharmaceutical industries in the age of antibiotic resistance (No. 1477-2019-2172).
Tafalla, C., Bøgwald, J., and Dalmo, R. A. 2013. Adjuvants and immunostimulants in fish vaccines: Current knowledge and future perspectives. Fish & Shellfish Immunology, 35(6):1740–1750.
Vijayan, V., Mohapatra, A., Uthaman, S., Park, I.-K. 2019. Recent advances in nanovaccines using biomimetic immunomodulatory materials. Pharmaceutics, 11, 534. https://doi.org/10.3390/pharmaceutics11100534 Vimal, S., Abdul Majeed, S., Nambi, K. S. N., Madan, N., Farook, M. A., Venkatesan, C., Taju, G., Venu, S.,
Subburaj, R., Thirunavukkarasu, A. R., and Sahul Hameed, A. S. 2014. Delivery of DNA vaccine using chitosan-tripolyphosphate (CS/TPP) nanoparticles in Asian sea bass, Lates calcarifer (Bloch, 1790) for protection against nodavirus infection. Aquaculture, 420–421:240–246.
Vinay, T. N., Bhat, S., Gon Choudhury, T., Paria, A., Jung, M.-H., Shivani Kallappa, G., and Jung, S.-J. 2018.
Recent advances in application of nanoparticles in fish vaccine delivery. Reviews in Fisheries Science &
Aquaculture, 26(1):29–41. https://doi.org/10.1080/23308249.2017.1334625
Vinay, T. N., Gon Choudhury, T., Paria, A., Gupta, S., and Sarkar, B. 2016. Nanovaccines: A possible solution for mass vaccination in aquaculture. World Aquaculture, 47(3):30–33.
Vinitnantharat, S., Gravningen, K., and Greger, E. 1999. Fish vaccines. Advances in Veterinary Medicine, 41:539–550.
Wang, Y., Liu, G.-L., Li, D.-L., Ling, F., Zhu, B., and Wang, G.-X. 2015. The protective immunity against grass carp reovirus in grass carp induced by a DNA vaccination using single-walled carbon nanotubes as delivery vehicles. Fish & Shellfish Immunology, 47(2):732–742.
Yasumoto, S., Kuzuya, Y., Yasuda, M., Yoshimura, T., and Miyazaki, T. 2006. Oral immunization of common carp with a liposome vaccine fusing koi herpesvirus antigen. Fish Pathology, 41(4):141–145.
Yildirimer, L., Thanh, N. T. K., Loizidou, M., and Seifalian, A. M. 2011. Toxicology and clinical potential of nanoparticles. Nano Today, 6(6):585–607.
Zaman, M., Good, M. F., and Toth, I. 2013. Nanovaccines and their mode of action. Methods, 60(3):226–231.
Zhao, L., Seth, A., Wibowo, N., Zhao, C.-X., Mitter, N., Yu, C., and Middelberg, A. P. J. 2014. Nanoparticle vaccines. Vaccine, 32(3):327–337.
Zhu, B., Liu, G.-L., Gong, Y.-X., Ling, F., Song, L.-S., and Wang, G.-X. 2014. Single-walled carbon nanotubes as candidate recombinant subunit vaccine carrier for immunization of grass carp against grass carp reo- virus. Fish & Shellfish Immunology, 41(2):279–293.
Zhu, B., Liu, G.-L., Gong, Y.-X., Ling, F., and Wang, G.-X. 2015. Protective immunity of grass carp immunized with DNA vaccine encoding the vp7 gene of grass carp reovirus using carbon nanotubes as a carrier molecule. Fish & Shellfish Immunology, 42(2):325–334.
Section III
Adjuvants in Vaccination
An Underpinning
101
Role of Adjuvants in Vaccination Studies
Md Yasin Ina-Salwany, Tilusha Manchanayake, and Aslah Mohamad
Universiti Putra Malaysia
Md. Shirajum Monir
Bangladesh Fisheries Research Institute Freshwater Station
Mohammad Noor Amal Azmai, Salleh Annas, and Mohd Zamri-Saad
Universiti Putra Malaysia