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Analysis of Bone Formation and Fracture Incidence in Distraction Osteogenesis

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% Patients with Insufficient Bone

Formation

Delta p-value

Gender Male Female

17 45 -28 0.44

Type of Distraction

Used

External Internal

43 25 28 1.0

Use of HBO

Yes No

29 30 -1.4 1.0

Table S1. Incidence of insufficient bone formation in the distractor gap stratified by categorical variables. *, p<0.05

(2)

Patients with Insufficient

Bone Formation

Patients without Insufficient Bone Formation

Age 52.4 46.6 5.9 1.0

Publication Year 2006.9 2008.3 -1.4 1.0

Dosage (Gy) 53.1 51.5 1.5 1.0

Defect Size

(mm) 45.5 48.3 -2.8 1.0

Latency Period

(days) 7.4 8.8 -1.5 0.15

Distraction Rate

(mm/day) 0.71 0.70 0.012 1.0

Total Amount of

DO (mm) 19.5 27.2 -7.7 1.0

Consolidation

Period (wks) 18.3 17.5 0.82 1.0

Table S2. Incidence of insufficient bone formation in the distractor gap stratified by numerical variables. *, p<0.05

(3)

% Patients with

Fractures Delta p-value

Gender Male Female

8.7 18 -9.4 1.0

Type of Distraction

Used

External Internal

0 20 -20 1.0

Use of HBO

Yes No

0 30 -30 0.92

Table S3. Incidence of fracture stratified by categorical variables. *, p<0.05

(4)

Publication Year 2007.0 2008.0 -1.0 1.0

Dosage (Gy) 61.3 50.4 10.9 0.38

Defect Size (mm) 38.3 50.2 -11.8 1.0

Latency Period

(days) 9.0 8.4 0.61 1.0

Distraction Rate

(mm/day) 0.63 0.72 -0.091 1.0

Total Amount of

DO (mm) 30.3 25.6 4.8 1.0

Consolidation

Period (wks) 16.0 17.6 -1.6 1.0

Table S4. Incidence of fracture stratified by numerical variables. *, p<0.05

(5)

% Patients with

Intraoral Exposure Delta p-value

Gender Male Female

8.7 18 -9.5 1.0

Type of Distraction

Used

External Internal

14 15 -0.7 1.0

Use of HBO

Yes No

14 30 -16 1.0

Table S5. Incidence of intraoral exposure stratified by categorical variables. *, p<0.05

(6)

Patients with Intraoral Exposure

Patients without Intraoral Exposure

Age 48.0 48.1 -0.1 1.0

Publication Year 2006.5 2008.1 -1.6 0.44

Dosage (Gy) 61.0 49.9 11.2 0.24

Defect Size (mm) 36.7 50.5 -13.9 0.56

Latency Period

(days) 10.0 8.3 1.7 0.76

Distraction Rate

(mm/day) 0.60 0.72 -0.12 1.0

Total Amount of

DO (mm) 30.3 25.6 4.8 1.0

Consolidation

Period (wks) 15.7 17.8 -2.1 1.0

Table S6. Incidence of intraoral exposure stratified by numerical variables. *, p<0.05

(7)

% Patients with

Cutaneous Exposure Delta p-value

Gender Male Female

4.3 27 -23 0.35

Type of Distraction

Used

External Internal

0 20 -20 1.0

Use of HBO

Yes No

0 20 -20 1.0

Table S7. Incidence of cutaneous exposure stratified by categorical variables. *, p<0.05

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Patients with Cutaneous

Exposure

Patients without Cutaneous

Exposure

Age 50.3 37.8 2.4 1.0

Publication Year 2009.0 2007.8 1.2 1.0

Dosage (Gy) 65.0 50.6 14.4 0.40

Defect Size (mm) 32.0 50.2 -18.2 0.12

Latency Period

(days) 9.0 8.4 0.61 1.0

Distraction Rate

(mm/day) 0.75 0.70 0.052 1.0

Total Amount of

DO (mm) 36.0 25.2 10.8 0.36

Consolidation

Period (wks) 16.0 17.6 -1.6 1.0

Table S8. Incidence of cutaneous exposure incidence stratified by numerical variables. *, p<0.05

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