Majalah Ilmu Kefarmasian Majalah Ilmu Kefarmasian
Volume 9 Number 3 Article 2
12-30-2012
Studi Disolusi Terbanding Tablet Komparator dan Generik Studi Disolusi Terbanding Tablet Komparator dan Generik
Glibenklamida 5 MG Menggunakan Parameter Difference Factor Glibenklamida 5 MG Menggunakan Parameter Difference Factor (f2) dan Similarity Factor (f1)
(f2) dan Similarity Factor (f1)
Sutriyo Sutriyo
Fakultas Farmasi Universitas Indonesia Kampus UI Depok, sutriyo@farmasi.ui.ac.id Siti Nur Aeni
Fakultas Farmasi Universitas Indonesia Kampus UI Depok Sundarsih Sundarsih
Fakultas Farmasi Universitas Indonesia Kampus UI Depok
Follow this and additional works at: https://scholarhub.ui.ac.id/mik Recommended Citation
Recommended Citation
Sutriyo, Sutriyo; Aeni, Siti Nur; and Sundarsih, Sundarsih (2012) "Studi Disolusi Terbanding Tablet Komparator dan Generik Glibenklamida 5 MG Menggunakan Parameter Difference Factor (f2) dan Similarity Factor (f1)," Majalah Ilmu Kefarmasian: Vol. 9 : No. 3 , Article 2.
DOI: 10.7454/psr.v9i3.3349
Available at: https://scholarhub.ui.ac.id/mik/vol9/iss3/2
)*+,- . ,- )/0+)- . *12345,- 56. *4301*.
7/89424*/2. ,45. 61512- 7. 60- 3157048- ,4. :.
86. 81566+54745. 942484*12. ,- ;;1215<1.
;4<*/2. = > ?@ . ,45. )- 8- 0- 24*A. ;4<*/2. = > B@
CDEFGHIJKLCGEGLMDFLNOPGQKLCDPRSFTGUQ
QVSWDXESTLVSFYSTGLZPG[OFTGESTL\PRIPOTGS
]^_`a]b`
cd de& % !fd& ghd!& % fdff%&(ijkjklmged#( d%d d%&'nho( f%! #p(&dqd% dh(d&r&hdh p(f ( %&(&&(d&s g &d't&d%dh(d&r&hdp!h (!
&h!&%(!!( 'ndp%&
utvwxwgyzg{|h}!! g&d#~||&d%d
&&&%xz|gr%zr&p!q(
%&rgx|g{rg|w|& '&h pdqd p(!f}(%( i%m&&d#%( i%wm& !f
( (( 'nd!p! dqd%( i(m!&dp!( if mp!}(%( i%mfdrgrx &&d#%( i%wm~~gw~ '
dhd&(&fd}(%( &&d#%(
'
uod&s# d&&hg d fsoffgd& 'od d! s&&hsqddhddhsd&r& ss&#h&s&d 't&d
hddhsd&r&#s&hd&h (!#&
&&s'vod&s& # d&
utvwxwgd&&&d%%yzg{|h~||&d!xz
|grs( szr&qsps #s
rgx|g{rg|w|&'vh qdd!&
s& }(%( i%m&&d#%( i%wmsh f sh s'ydd&ossh!pqdds ism&&ds&!sis&md}(
0211
¡ ¢ £¢¤¥¦§¨ ©¤ ª« ¬®¯¢°¯1±§ª§¤²§©³´0³µ0³00¶·
!"!#$%%&&'&((&&)*'+,+'--"*-$.
/01%&23&,+%0(&4&'1'&+,%&%54&6++%+%'&((&&). 789:;<=>=;9
? @ABAC?DAEF?CAGHAEAI?JABAG?FKALA?JAI?
KMGMNAEAAI?OHAE?KAJA?GADLANAPAE?AIEANA?
BAQI?EQIRRQILA?CANRA?OHAES?TIEFP?GMIRAU EADQ?CAB?QIQ?DABAC?DAEF?FKALA?KMGMNQIEAC?
AJABAC?GMGHFAE?OHAE?RMIMNQP?LAIR?CANU RAILA?NMBAEQV?BMHQC?GFNAC?JQHAIJQIRPAI?
OHAE?QIOWAEON?GAFKFI?OHAE?JMIRAI?GMNMP?
JARAIRX?PANMIA?JAKAE?GMIMPAI?HMHMNAKA?
POGKOIMI?CANRA?DMKMNEQ?HQALA?KNOGOU DQX?KNOJFPDQX?JAI?PMGADAI?LAIR?EMNBABF?
GMYACS?ZHAE?RMIMNQP?AJABAC?OHAE?LAIR?
JQKNOJFPDQ?JAI?JQKADANPAI?JMIRAI?IAGA?
LAIR?JQAGHQB?JANQ?[\\?][IEMNIAEQOIAB?\OI?
KNOKNQMEANL?\AGFD^?LAIR?JQEMEAKPAI?OBMC?
_`ZX?AEAF?HMNJADANPAI?aANGAPOKM?[IU JOIMDQA?AJABAC?IAGA?bAE?HMNPCADQAE?LAIR?
JQPAIJFIRILAS?
? cBQHMIPBAGQJA?GMNFKAPAI?OHAE?AIEQ? JQAHMEMD?ONAB?ROBOIRAI?DFBVOIQBFNMA?RMIU MNADQ?PMJFAX?LAIR?JQRFIAPAI?FIEFP?KMIU ROHAEAI?JQAHMEMD?GMBQEFD?EQKM?d?LAIR?EQJAP?
EMNRAIEFIR?JMIRAI?QIDFBQI?]\OI?[IDFU BQI?eMKMIJMIE?eQAHMEMD?fMBQEFD^S?cBQHU MIPBAGQJ?HMPMNgA?JMIRAI?GMNAIRDAIR?
DMPNMDQ?QIDFBQI?JANQ?DMB?HMEA?KAIhNMAD?JAI?
GMIQIRPAEPAI?DMIDQEQDADQ?gANQIRAI?KMNQU VMN?EMNCAJAK?QIDFBQI??]@YMMEGAIXdiid^S?? cBQHMIPBAGQJA?KNAPEQD?EQJAP?BANFE?JABAG?
AQN?]jSfAIQGANAI?ME?AB?di0i^?DMCQIRRA?
GMGQBQPQ?BAgF?JQDOBFDQ?LAIR?NMIJAC?JAI?
GMILMHAHPAI?KMIFNFIAI?AHDONKDQ??RADU ENOQIEMDEQIAB?]c[^S?kMHMNAKA?KMIMBQEQAI?
GMIRFIRPAKPAI?HACYA?AHDONKDQ?RBQHU MIPBAGQJA?JQHAEADQ?OBMC?BAgF?JQDOBFDQILAS? lMBANFEAI?OHAE?LAIR?NMIJAC?JABAG?AQN?
GMNFKAPAI?VAPEON?KMIEQIR?LAIR?GMGKMIU RANFCQ?HQOAWAQBAHQBQEAD?OHAE?PANMIA?PMBANFU
EAI?JANQ?OHAE?GMNFKAPAI?DABAC?DAEF?VAPU EON?LAIR?GMIMIEFPAI?PMhMKAEAI?AHDONKDQ? OHAE?EMNDMHFE?]jANDCODAb?m?diin^S?
? oHDONHDQ?OHAE?KMN?ONAB?JANQ?HMIEFP?
DMJQAAI?EAHBME?EMNRAIEFIR?KAJA?KNODMD?
KMBMKADAI?OHAE?JANQ?DMJQAAIX?JQDOBFDQ?OHAE? KAJA?DABFNAI?RADENOQIEMDEQIAB?JAI?KMNGMU AHQBQEAD?OHAE?GMBQIEADQ?GMGHNAI?DABFNAI?
RADENOQIEMDEQIABS??ZBMC?PANMIA?QEFX?JQDOBFDQ? QI?WQENO?DAIRAE?KMIEQIR?FIEFP?GMGKNMU JQPDQ?KMILMNAKAI?OHAE?DMhANA?QI?WQWOS?TgQ? JQDOBFDQ?QI?WQENO?GMNFKAPAI?DABAC?DAEF?
GMEOJM?LAIR?JAKAE?JQRFIAPAI?DMHARAQ?ABAE? KMIRMIJABQAI?GFEF?FIEFP?GMGADEQPAI?
NMKNOJFDQHQBQEAD?AIEAN?HAEhCS?@MBAQI?QEFX?FgQ? JQDOBFDQ?QI?WQENO?gFRA?JAKAE?JQRFIAPAI?DMU HARAQ?GMEOJM?DMIDQEQV?FIEFP?GMGHMJAPAI?
HMHMNAKA?VONGFBADQ?LAIR?GMIRAIJFIR?
OHAE?LAIR?DAGA?]fANEQI?o?X?@YANHNQhP??m?p?
qAGGANAEA?oX?0rr1^?
? @MDFAQ?JMIRAI?sMNAEFNAI?lMKABA?kAJAI?
sMIRAYAD?ZHAE?eAI?fAPAIAI?tMKFHBQP?
[IJOIMDQA?\OGON?`PSi1S0Sd1S0dS00S0id02?
uACFI?di00?EMIEAIR?ZHAE?_AgQH?TgQ? vPQWABMIDQX?DMGFA?OHAE?hOKL?YAgQH?JQBAPFU PAI?FgQ?MPQWABMIDQ?JMIRAI?KMGHAIJQIR?
OHAE?POGKANAEONS?TgQ?vPQWABMIDQ?AJABAC?FgQ? QI?WQWO?JAIwAEAF?QI?WQENO?FIEFP?GMIMIEFU PAI?MPQWABMIDQ?AIEANA?OHAE?FgQ?]OHAE?hOKL^? JMIRAI?OHAE?POGKANAEONS??ZHAE?POGKANAU EON?AJABAC?OHAE?LAIR?JQRFIAPAI?DMHAU RAQ?KMGHAIJQIR?JABAG?FgQ?MPQWABMIDQ?QI?
WQWO?JAIwAEAF?QI?WQENO?FIEFP?KMGHFPEQAI?
MPQWABMIDQ?DFAEF?OHAE?hOKLS?ZHAE?RMIMNQP?
AJABAC?OHAE?LAIR?JQKNOJFPDQ?JAI?JQMJANU PAI?JMIRAI?GMIRRFIAPAI?IAGA?RMIMNQP?
LAQEF?IAGA?HMNJADANPAI?[IEMNIAEQOIAB?
\OI?sNOKQMEANL?\AGMD?AEAF?aANGAPOKM?
!""!#$
""%&"'"
'#""%(!()
*+,%,,(+(,$
%"%+(,%%-$
#("#(#'- !"&!
#+(,%
(+.(&(' /"!((,(0 (#'()1"!+,%
,(+"(%"!"%
+"(%(#'- !"% #+#%'(2%
"(%(+"!(($
,(0(#'()3%%#"#$
'(%(#'('!%(
" !4+"%+(,$
%.5(#67800/)
*+"(%,($
"(%'"%'&''%
"'%"!##'$
"%'("("'%(6
#+#%'("("% '(" !#!%#'$
%"'#
'''"-(#%6'(
'#6#''#"'($
'!+#%&'("
.&%$'"'(''(,%01*95:/) 9"6+"(%%"%
"%##!,%1*95:)1%
' "%"!#'$
-('#.#% /'"
'(2%"(%",%4 !
"!.5(#660;;</
=%#'"(#>=5"$
"%#+"(%'""$ '"(%%'&''+ (,%%"(,%
"(%6"!'"$
#("%"'"#!!
"?&-&(.-0/"#% -&$
(.-7/##"!'(2%"$
(%)=?&-&(.-0/"! #!!''"
"'(2%"(%'"'4
"#!%%-"$ '(2%"(%1#% -&(.-7/
"!#!'#
"%#'.@/"'(2%"(%, .5(#660;;A/)
B'+"(%"'"$
#'!'.2/)9"'0 .10/6#%"+"% "'
"#%#%##% "!"'"#((!2 .C/"#<@)D%10"'$
6#%#"+%! .17/)E% "'"#%% $"$07%%
#"!C6"""' !%&%"CF0<@)D%' "'607%#"+
%!)E% "'"#%%$ $$7G%%#
"!C6""%""% !%&%"CF0<@.5(#66 0;;</
1-2(#-6-(#%
"'('(""'#
"(%"(,%%""$ ("!- !# !
"'("(%' !") H%'%"%'!+$ "(%"!(!
"!((#'(#!$ %(!)I+
'%"%#!
'(2%'%'!%%#""% (#'("!6##$
"!'(2%#!!
'#"?&-&(.-0/"#$
%-&(.-7/)
!"#$%"&%'(#'%"!)*+","-.+/!0( 1"2324 56789"'*+:!0(;(!(<+!+0"=>4>%'"-?@%4
< &A#"=>40B5089"C+0 / " C %!%:"-D@ #'"
0B5589"*E"<+!+0"-.#!+/@8"& C"*+0 ! C"
F+ '"
GHI
" J%1+C: <%& "'! C& 0"-K &% "E+ !@4 / 0+"7%<%!+&8"& C"' <*+") CF"&%F#C : C"
1+0#* "! 1+!"F%1+C: <%& "L"<F") CF"
1+0+& 0"&%"* ' 0 C") %!#"' !#"*0(&#:"%C(4 M !(0N:(<* 0 !(0"-*0(&#:""C(<(0"1 !/@"
056O,L,8"'+0! "*0(&#:"F+C+0%:"-*0(&#:"P"
C(<(0"1 !/@"JJ0Q15R8""
STUVTW XYZ[Z\]X\Z
" =$%"&%'(#'%"! 1+!":(<* 0 !(0"& C"
F+C+0%:"<+CF C&#CF"F%1+C: <%&"L"<F"
&% :#: C"!+0@ & *"< '%CF4< '%CF"0,"
! 1+!9"<+CFF#C : C" !"&%'(#'%"!%*+","
-& )#CFN* &&+8^"_+&%#<"&%'(#'%") CF"
&%F#C : C" & @"255"<"& * 0";('; !"*E"
`9Q5"* & ""'#@#"1`"aK"b"59L"aK"& C":+/+4
* ! C"*#! 0 C"`L"0*<^"? <*+"'+1 C) :"
L"<"&% <1%"* & "c :!#"0L9"159"QL9"B5"
& C"0,5"<+C%!"#C!#:"&%!+C!#: C"$#< @"
F%1+C: <%& "!+0 0#!"'+/ 0 "'*+:!0(4
;(!(<+!0%^
ded]Z\Z\[\df]
" R#< @"(1 !") CF"!+0&%'(#'%"&%!+C4
!#: C"&+CF C"<+CF <1%"/ %0 C"' <*+"
& <"<+&%#<"&%'(#'%"* & "'+ CF"c :4
!#"!+0!+C!#"& C"&% C %' "<+CFF#C : C"
'*+:!0(;(!(<+!+0"=>4>%'"* & "* C$ CF"
F+(<1 CF"155"C<"& C"&%@%!#CF"&+CF C"
<+CFF#C : C"*+0' < C"%C%+0")"""" ! #""
:#0M ": %10 '%^"R#< @"(1 !") CF" 0#!"
& <"'# !#"c :!#"!+0!+C!#9"g"&%C) ! : C"
'+1 F %"'# !#"*+0'+C! '+"& 0%": C&#CF C"
) CF"!+0!+0 "& <" 1+^"E '%"#$%"&%'(#'%"
& 0%"! 1+!":(<* 0 !(0"& C"! 1+!"F+C+0%:9"
< '%CF4< '%CF"&%1# !"F0 h:"*0(h"&%'(4 #'%"&+CF C"<+CF@#1#CF: C"$#< @"(1 !"
) CF"!+0&%'(#'%"!+0@ & *"c :!#^"
ded]Z\Z\[dd
" 3 ! "*0('+C! '+"F%1+C: <%& ") CF"
!+0&%'(#'%"* & "'+!% *"c :!#"& 0%"< '4
%CF4< '%CF"! 1+!"&%1 C&%CF: C"&+CF C"
*+C&+: ! C"<(&+"%C&+*+C&+C!"<+C#0#!"
i39"<+CFF#C : C"; :!(0"*+01+& C"
-;08"& C"; :!(0":+' < C"-;,8^"i :!(0"*+04 1+& C"-;08"<+CF@%!#CF"*+01+& C" C! 4 0 "&# ":#0M "* & "'+!% *"!%!%:"c :!#^
i :!(0":+' < C"<+CF#:#0"*+0' < C"
*+0'+C"&%'(#'%" C! 0 "&# ":#0M ^
C" & @"$#< @"!%!%:"*+CF <1% C"
' <*+9"j!"*+0'+C"&%'(#'%"! 1+!":(<* 04 !(0"* & "c :!#"!9"& C"2!"*+0'+C"&%'(#'%"
! 1+!"#$%"* & "c :!#"!^"k0(h" ! #":#0M "
&%'(#'%"<+<%%:%"*+0' < C"$%: "C% %";0"
<+C&+: !%"5"-540L8"& C";,"<+C&+: !%"055"
-L540558^
E?l7"3O"k._PE?O
" 3%'(#'%" & @"*0('+'"<+ 0#!C) "A !"
* & !"& <"'# !#"*+ 0#!^"?+& CF: C"
$#"&%'(#'%"&%&+hC%'%: C"'+1 F %"$#< @"
'+C) c "A !" :!%;") CF"<+ 0#!":+"& <"
0#! C"*+0"' !# C"c :!#"* & ":(C&%'%"
*+0<#: C"* & !4/ %09"'#@#"& C":(<4
*('%'%"*+ 0#!") CF"&%1 :#: C"-_ 0!%C"
"9"?c 010%/:""R"m"K << 0 ! "9"02218^"
k0('+'"&%'(#'%"<+%1 !: C"&# "! @ *"
!"
#!#$##%&$# $'(
)&*#&+&$"
#,#!+#$-!#$ 0.2'!02,/120&#$!#
!+#$1'!022/000203( 4++5#&$67
*#&+&$#"
$##&+&#!%+&%
!)8/12!#&698:;/#&+&!
<<2+##3#$'!8,
!#+$0.2 6&#$$#=20
;.9).>;?9@,A2$#3 !#$(A#$#"
!*#&+&#B"
$+!<#+&<C/#$67*
#&+&6!&6!0
2A03*$*6 $%#&+&
#&!#$$#
+&#++52D3#"
6,0()&*$$67
$#!+#$&6!"
&*#&+&6#!$
#++5()*$"
$67+$"
$#+'6EE0192F&#
$+!+#++'6
02>?.,.#&$6&*#&+&( )&&&$+#
!#$#!#*$$
67#G'%'+2%03#&"
%'+2%.3!+5#&+&
!+#$12$3#!+#$
-2$+!+3&"&
&&,/,90#==/.=02.3( H$23 I"$##&+&203
J+#$- J+#$1 0, 8=/=0 >1/..
92 >9/2K >8/,K 1, >=/,K >>/80 K2 =9/>9 ==/02 0.2 02,/12 022/00
LMNOPQRQ)&*#&+&$#,###!%+&%!)8/12
LMNOPQSQJ6#G'%'+#&%'+J+#$-#J+#$1
###!%+&%!)8/12$0.( H$ I T 2I"T3 2I"T3. %0 %.
0, 1/.2 9/== 2/.0 2/2, ,/,9 ==/.=
92 1/9K 1/0, 2/.0 2/2, 1, 1/1= 1/>0 2/9. 2/02 K2 1/>> 1/K> 2/.0 2/21 0.2 1/=, ,/.8 2/9. 2/02
../=0 0/.8 2/91
!"##$
%!%#&'# #%'!(')*##
#+&,-,&.-0/'&&$ 0$012##(#(,&!
(#0% (##%###&3 -,&.-4/'&& 1050002
##(#(,&! (# 000267###+&,-,&.-0/%'%&
18192%###&3-,&.-4/%'%&
::84:2!"!((')*(!&;
#%!%#&%'!#('&'. '&
0/6
<%###'!(#(')*&;
#%!%#' #'(# &#( ',)==0190>##(#(%$
&;#%!%#'(&&$
&',)00?74146@&;#%!%#
'&!(%)%!&&
!!%#6#%!%#&!(%)
%!-,&3 !('%&%#
'&&%#&'##%$
'&8%)# "#(%!!%#' &#%!%#%,&, "!) 3 !)#&%3& &;8 (A(#-%#&%'!
(%(#,#'%&%#(
%#&(!%#%#%#(6
BCDEFGHIJK
<%###!"##%!%#' #'$
(#1 &!(#L&M (&&' &',) 00?74148 &!( &#(&!(
N#%#!(')*O
@&!( &#(N.&',)==0190
>/##(#(%&;#%!%#$ &!(#L&M(&&.$
&',)00?7414/67###+&,-,$
&.-0/%##-,&.-4/&!(
N&)&!(%# $%# 1819 2.%3&0$012/::84:2.%3&10$
0002/
PJQRJSTJUHJK
#6&(V%##%#VW6
>(&O&X%)Y$
!'#(V%#60::1
#8Z6[6&-<)
<![&L#,%&!
##%&#\&-&&! ]L!$
#Y%&,)6^_`abcdefghif`cj a_klimf`nnea`blefieoebkefkho`afhibofahkj bpefghinkfkdboej_qfbcaffqhklbqqihrbof dsbcpektfdsen`klimufnbc_gbdl_i`cpufbcaf dhclihokuf`cfr`lihfa`kkho_l`hcflekl`cpufbcaf
`cfr`rhfv`hew_`rboecdefahd_neclbl`hcxf Y,(L#60::1
#6Z6[6&-<)
<![&L#,%&! $
##%&#\&-&&! ]L!$
#Y%&,)6=!#,-&Y,($
L#60::y
#8@&!&XN@ $
*%z'{(Y!'#(V$
%#7&<(6096064960460060040y
|)!4000
{[*&'&#,(>}\&6
~binbk`fk`fabkbijabkbif`n`bfk`f abobnf`on_fgbinbkel`fea`k`fel`pbxfeixf abi`fsmk`dbofqsbinbdmufqsmk`dbofdsen`j dbofqi`cd`qoekf`cflsefqsbinbde_l`dbofkd`j ecdek)%)#6>(&O@&'#
Z#L&%#%V%#60::9O?1 [*8[6\68./{&#O
,&! &-&,8@)&,!#$ ,@&%%8840046
W&%)%A>8|&#Y8{%-L#87($
),)#6.400?6/6
W6{#&876)&8{6{)$
#8X6Y"(!&8Y!'3{,)
\),(8]),-#%%!#
&-#',#'3%##%&$
%#,) 38V&6>6-\!&&
@)&6Y%&,)640004.9/