COPYRIGHT © BY THE JOURNAL OF BONE AND JOINT SURGERY,INCORPORATED
WANG ET AL.
IN SITU-FORMING FIBRIN GEL ENCAPSULATION OF MSC-EXOSOMES FOR PARTIAL-THICKNESS ROTATOR CUFF TEARS IN A RABBIT MODEL.EFFECTIVENESS SHOWN IN PREVENTING TEAR PROGRESSION AND PROMOTING
HEALING
http://dx.doi.org/10.2106/JBJS.21.01157 Page 1
The following content was supplied by the authors as supporting material and has not been copy-edited or verified by JBJS.
Appendix Table 1. Histological Evaluation Scores of Tendon
Tendon repair assessment score
0 1 2 3
Fiber structure Continue, long fiber Slightly fragmented Moderately fragmented Severely fragmented Fiber arrangement Compacted and parallel Slightly loose and wavy Moderately loose, wavy
and cross to each other No identifiable pattern Rounding of the nuclei Long spindle shape cells Slightly rounding Moderately rounding Severely rounding Inflammation
(area infiltrated by Inflammation area)
＜10% 10%–20% 20%–30% > 30%
Increased vascularity
(area infiltrated by neo-vascular) ＜10% 10%–20% 20%–30% > 30%
Cell density Normal pattern Slightly increase Moderately increase Severely increase
COPYRIGHT © BY THE JOURNAL OF BONE AND JOINT SURGERY,INCORPORATED
WANG ET AL.
IN SITU-FORMING FIBRIN GEL ENCAPSULATION OF MSC-EXOSOMES FOR PARTIAL-THICKNESS ROTATOR CUFF TEARS IN A RABBIT MODEL.EFFECTIVENESS SHOWN IN PREVENTING TEAR PROGRESSION AND PROMOTING
HEALING
http://dx.doi.org/10.2106/JBJS.21.01157 Page 2
Appendix Table 2. Inter-rater reliability among three raters for histological scores
a Fleiss' kappa was used to measure of inter-rater agreement reliability among the three raters by SPSS (version 26.0).
b Values of Fleiss' kappa indicates different strength of agreement: ＜0.20, Poor; 0.21-0.40, Fair; 0.41-0.60, Moderate; 0.61-0.80, Good; 0.81-1.00, Very good.
Inter-rater reliability a,b
Time Fiber structure Fiber arrangement Rounding of the nuclei Inflammation Increased vascularity Cell density Total score
6 weeks 0.557 0.442 0.452 0.436 0.498 0.48 0.499
12 weeks 0.622 0.535 0.402 0.621 0.47 0.436 0.611
