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Table S1: Costs, length of stay and cost‐categories

A) Costs and length of stay for the first 100 days after the first and second HCT

^Auto¹⁽ⁿ⁼⁴³⁾ Allo (n=110)

Median total costs, $1000’s (range)

76 (42‐123) 117 (26‐490)

Median Inpatient costs,

$1000’s (range)

49 (8‐118) 35 (0‐431)

Median Outpatient costs,

$1000’s (range)

27 (3‐51) 73 (7‐199)

Median hospital stay, days (range)

16 (5‐34) 12 (0‐76)

1For first 30 days after the autologous HCT

Abbreviations: Auto, autologous transplant; allo, allogeneic transplant

B) Categories of costs (percent of total costs) in auto‐allo group

Auto‐allo

Outpatient 18%

Inpatient 22%

Pharmacy 20%

Laboratory/ pathology 19%

Radiology/ diagnostics 6%

Transfusion 7%

Miscellaneous 8%

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Table S2: Linear regression for costs for second alloegeneic HCT following a prior autologous transplant

Variable

Baseline model Full model

^Cost

multiplier

95% CI P

value

Cost multiplier

95% CI

P value

Pre‐transplant factors

Age

<50

≥50

1.0

1.13

0.93‐1.37

0.23

1.0

1.02

0.85‐1.21

0.87

Disease

Lymphoma

Acute leukemia/MDS

Myeloma

1.0

1.14

0.93

0.84‐1.55

0.70‐1.23

0.41

0.61

1.0

1.12

1.11

0.86‐1.47

0.85‐1.45

0.41

0.45

Disease status

Remission

Relapse

1.0

1.11

0.88‐1.39

0.38

1.0

1.11

0.91‐1.35

0.33

Graft source

PBSC

BM/Cord

1.0

0.91

0.64‐1.31

0.62

1.0

0.93

0.68‐1.27

0.64

Conditioning

NMA

1.0

^1.0

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MA

1.26

0.98‐1.61 0.07 1.16 0.93‐1.45

0.19

Reason for transplant

Relapse

Secondary malignancy

1.0

0.73

0.48‐1.12

0.15

1.0

0.85

0.58‐1.23

0.38

Year of transplant

Per year

1.04

0.98‐1.10

0.24

1.04

0.99‐1.10

0.15

Donor type

Matched related

Matched unrelated

Mismatched (related and unrelated)

1.0

1.21

1.38

0.96‐1.53

1.05‐1.81

0.11

0.02

1.0

1.16

1.21

0.94‐1.42

0.94‐1.55

0.17

0.14

Patient CMV serostatus

Negative

Positive

1.0

1.06

0.87‐1.28

0.56

1.0

0.94

0.79‐1.13

0.53

Post‐transplant complications

Death

Relapse

GVHD (II‐IV)

SOS

Pulmonary

Renal

1.37 1.12

1.13

0.85

1.20

1.00

0.99‐1.90

0.91‐1.38

0.94‐1.35

0.58‐1.23

0.90‐1.58

0.84‐1.19

0.06 0.29

0.18

0.38

0.21

0.99

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Infection

1.49 1.22‐1.81

0.0001

Abbreviations: MDS, myelodysplastic syndrome; PBSC, peripheral blood stem cells; BM, bone marrow; NMA, non‐myeloablative; MA, myeloablative; CMV, cytomegalovirus; GVHD, graft vs.

host disease; SOS, sinusoidal obstruction syndrome