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1 Supplemental Digital Content

Supplemental Digital Content 1. Post-intervention survey periods for African sites in HPTN 043.

Supplemental Digital Content 1 legend:

Blood samples used for antiretroviral drug testing were collected in HPTN 043 during the post- intervention assessment. The time period for the post-intervention survey in each African community is shown (horizontal lines). Dashed lines indicate survey periods for control communities; solid lines indicate survey periods for intervention communities. Calendar dates are shown on the X axis (month/year).

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2

Supplemental Digital Content 2. Antiretroviral drug detection in demographic sub-groups*.

Population N

tested

Zimbabwe N (%)

Tanzania N (%)

KwaZulu-Natal N (%)

Soweto N (%)

All sites N (%)

Men 1,899 81 (17.6) 30 (22.2) 223 (24.8) 75 (18.6) 409 (21.5)

Women 5,440 245 (22.9) 84 (21.2) 928 (34.0) 342 (27.5) 1,599 (29.4) Pregnant women 362 23 (19.0) 8 (25.8) 80 (58.4) 32 (43.8) 143 (39.5) Age 18-24 2,246 47 (13.7) 20 (21.5) 325 (23.6) 80 (18.5) 472 (21.0) Age 25-32 5,074 278 (23.5) 94 (21.5) 821 (36.7) 337 (27.8) 1,530 (30.2) Men age 18-24a 452 13 (16.2) 0 (0.0) 54 (18.2) 12 (18.2) 79 (17.5) Men age 25-32 1,435 67 (17.7) 30 (24.0) 168 (28.1) 63 (18.8) 328 (22.9) Women age 18-24 1,792 34 (13.0) 20 (24.1) 271 (25.1) 68 (18.6) 393 (21.9) Women age 25-32 3,634 211 (26.1) 64 (20.4) 650 (39.7) 274 (31.2) 1,199 (33.0) Single 5,258 31 (18.8) 29 (22.0) 1095 (31.2) 366 (25.1) 1521 (28.9) Married 1,553 203 (20.9) 66 (20.4) 42 (43.8) 42 (26.1) 353 (22.7) Separated/divorced 331 43 (17.8) 16 (25.4) 5 (38.5) 4 (30.8) 68 (20.5) Widowed 167 48 (32.2) 3 (25.0) 1 (50.0) 2 (50.0) 54 (32.3) Employed 3,954 208 (21.0) 76 (21.8) 505 (30.2) 222 (23.6) 1011 (25.6) Unemployed 3,374 118 (21.9) 38 (20.9) 646 (33.1) 194 (27.6) 996 (29.5)

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3 Supplemental Digital Content 2 footnotes.

*Stored plasma samples collected from HIV-infected participants during the post-intervention survey in HPTN 043 were tested for the presence of 20 antiretroviral (ARV) drugs. The table shows the number and percentage of individuals in different demographic sub-groups who had at least one ARV drug detected. Some participants did not have data for sex or age. N:

number.

a In Tanzania, there were only 10 men in this age-group compared to 66-296 men per site at the other study sites.

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