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Supplemental Digital Content 8

Seroprotection rate for HI antibodies 7 days after first vaccination in the revaccination study, overall and by age strata (per-protocol cohort)

Primed Unprimed

N n SPR, % (95% CI) N n SPR, % (95% CI) All ages

A/H1N1 224 217 96.9 (93.7-98.7) 209 72 34.4 (28.0-41.3)

A/H3N2 224 193 86.2 (80.9-90.4) 209 81 38.8 (32.1-45.7)

B/Victoria 224 217 96.9 (93.7-98.7) 209 84 40.2 (33.5-47.2) B/Yamagata 224 216 96.4 (93.1-98.4) 209 83 39.7 (33.0-46.7) 17-29 months

A/H1N1 91 86 94.5 (87.6-98.2) 92 20 21.7 (13.8-31.6)

A/H3N2 91 75 82.4 (73.0-89.6) 92 27 29.3 (20.3-39.8)

B/Victoria 91 85 93.4 (86.2-97.5) 92 30 32.6 (23.2-43.2)

B/Yamagata 91 85 93.4 (86.2-97.5) 92 26 28.3 (19.4-38.6)

30-48 months

A/H1N1 133 131 98.5 (94.7-99.8) 117 52 44.4 (35.3-53.9)

A/H3N2 133 118 88.7 (82.1-93.5) 117 54 46.2 (36.9-55.6)

B/Victoria 133 132 99.2 (95.9-100) 117 54 46.2 (36.9-55.6) B/Yamagata 133 131 98.5 (94.7-99.8) 117 57 48.7 (39.4-58.1)

CI: confidence interval; HI: hemagglutination inhibition; SPR: seroprotection rate

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