Tatas Brotosudarmo <[email protected]>
European Journal of Medical Research: Decision on "Bile Pigments in Emergency and Critical Care Medicine"
1 message
European Journal of Medical Research <[email protected]> Thu, Sep 15, 2022 at 1:13 PM
To: [email protected] Dear Dr Brotosudarmo,
Thank you for your help with the manuscript, "Bile Pigments in Emergency and Critical Care Medicine", which you recently reviewed for European Journal of Medical Research.
For your records, the decision on this manuscript, based partly on your input, was: Revise. Any comments to authors have been appended below.
We greatly appreciate your assistance and participation in the review process for European Journal of Medical Research and hope that we can continue to benefit from your expertise on future submissions.
Kind regards, Editorial Assistant
European Journal of Medical Research Reviewer 1
The article has shown a summary of the current understanding of bile pigments and their proposed therapeutic potential. It has the potential to be a good critical review, a major revision should be done first to be accepted. Since 2001 the published articles about the topic have increased from about 200 articles to more than 500 articles per year. (1) The topic of therapeutic is already a broad one, and while the author uses 54 references, why are these references selected? (2) While reviewing their potential, it should be beneficial to be balanced with their critical uses of them, since it can result in neurotoxicity and oxidative stress. A more elaborate explanation should be described with critical references. (3) The summary in a table of the references that investigate the therapeutic potential and that critically examine the side/toxicity effect should give benefit the broad readership for critical comparison. This table should give clear data on the target and location of the target, doses, method used, type of effect, mechanism if any, and reference. These are necessary to be clearly shown in order to support the conclusion, written: “further research is required before their safe application…”.
Page 4: Please clearly elaborate on the meaning of simple elimination of ROS? What type of ROS? Which mechanism? Please be precise on the effectivity.
Page 5, Stocker et al.: The functions of bilirubin and biliverdin as antioxidants have not been well described elaborately with some recent cases and investigations. How do bilirubin and biliverdin penetrate mitochondria, please explain, and how are their bioavailability? The author already wrote it in the BV/BR Cycle, but this is hidden in the discussion on the pathway. It is better to split the structure of BV/BR and their properties, then about their metabolism, afterward on the detail of antioxidant mechanism. Any possible antioxidation mechanism of bilirubin and biliverdin at the molecular level needs to be elaborately explained, the addition of a reaction mechanism figure should be better to increase the impact of the article.
Figures 1 & 2: figure needs to be revised for clarity for the readership of other fields. The conversion of BR-BV should be made with clear chemical reaction indicating the chemical structure. All abbreviations should be explained in the figure caption. The figure caption used is not specific and not represents what is depicted in the image.
Reviewer 2
The manuscript by Seya et al. on 'Bile Pigments in Emergency and Critical Care Medicine' is an original thought and well written review. It is very extensive and detailed and I would recommend it for publication. There are some small typo's and grammatical errors that needs to be addressed. The reviewer would like to congratulate the authors with their work.
Tatas Brotosudarmo <[email protected]>
European Journal of Medical Research: Invitation from Dr Piacherski to review a manuscript
European Journal of Medical Research <[email protected]> Sun, Sep 4, 2022 at 12:52 PM
**The contents of this email are confidential.**
Ref: Submission ID db64fd21-b31d-4d95-97d9-97acf0e96866
Dear Dr Brotosudarmo,
I'd like to invite you to review a manuscript for European Journal of Medical Research. You'll find the details appended underneath this email.
Please accept or decline the manuscript using the link below.
Kind regards, Valery Piacherski Editor
European Journal of Medical Research
To accept or decline the manuscript, please use this link:
https://reviewer-feedback.nature.com/review-invitation/252aa1f9-acef-4622-aaaa-1c9fb47a2c50
If you wish to contact us about the manuscript, please email [email protected].
Submission details Authors:
Toshiyuki Aokage, Mizuki Seya, Tsuyoshi Nojima, Atsunori Nakao, Hiromichi Naito Title:
"Bile Pigments in Emergency and Critical Care Medicine"
Abstract:
Bile pigments such as bilirubin and biliverdin are end products of the heme degradation pathway in mammals and are widely known for their cytotoxic effects. However, recent studies have revealed that they exert cytoprotective effects through antioxidative, anti-inflammatory, and immunosuppressive properties. All these mechanisms are indispensable in the treatment of diseases in the field of emergency and critical care medicine such as coronary ischemia, stroke, encephalomyelitis, acute lung injury/acute respiratory distress syndrome, mesenteric ischemia, and sepsis. While further research is required before the safe application of bile pigments in the clinical setting, their underlying mechanisms shed light on their utilization as a therapeutic agent in the field of emergency and critical care medicine. This article aims to summarize the current understanding of bile pigments and re-evaluate their therapeutic potential in the diseases stated above.
To accept or decline the manuscript, please use this link:
https://reviewer-feedback.nature.com/review-invitation/252aa1f9-acef-4622-aaaa-1c9fb47a2c50
Reviewing for European Journal of Medical Research
European Journal of Medical Research is committed to providing a rapid and fair review process. So, if you decide to accept the manuscript, we would hope to receive your report at your earliest convenience.
The editorial board and publishing team of European Journal of Medical Research are not able to anticipate all potential competing interests, so we ask you to draw our attention to anything that might affect your review, and to decline submissions where it may be hard to remain objective.
If you would prefer us not to contact you in the future, please let us know by emailing [email protected].
European Journal of Medical Research
Your review report
Manuscript
Bile Pigments in Emergency and Critical Care Medicine
Feedback for the author(s)
Review file(s) No files added.
Comments to the author(s)
The article has shown a summary of the current understanding of bile pigments and their proposed therapeutic potential. It has the potential to be a good critical review, a major revision should be done first to be accepted. Since 2001 the published articles about the topic have increased from about 200 articles to more than 500 articles per year. (1) The topic of therapeutic is already a broad one, and while the author uses 54 references, why are these references selected? (2) While reviewing their potential, it should be beneficial to be balanced with their critical uses of them, since it can result in neurotoxicity and oxidative stress. A more elaborate explanation should be described with critical references. (3) The summary in a table of the
references that investigate the therapeutic potential and that critically examine the side/toxicity e ect should give benefit the broad readership for critical comparison. This table should give clear data on the target and location of the target, doses, method used, type of e ect, mechanism if any, and reference. These are necessary to be clearly shown in order to support the conclusion, written: “further research is required before their safe
application…”.
Page 4: Please clearly elaborate on the meaning of simple elimination of ROS? What type of ROS? Which mechanism? Please be precise on the e ectivity.
Page 5, Stocker et al.: The functions of bilirubin and biliverdin as antioxidants have not been well described elaborately with some recent cases and investigations. How do bilirubin and biliverdin penetrate mitochondria, please explain, and how are their bioavailability? The author already wrote it in the BV/BR Cycle, but this is hidden in the discussion on the pathway. It is better to split the structure of BV/BR and their properties, then about their metabolism, afterward on the detail of antioxidant mechanism. Any possible antioxidation mechanism of bilirubin and biliverdin at the molecular level needs to be elaborately explained, the addition of a reaction mechanism figure should be better to increase the impact of the article.
Figures 1 & 2: figure needs to be revised for clarity for the readership of other fields. The conversion of BR-BV should be made with clear chemical
reaction indicating the chemical structure. All abbreviations should be explained in the figure caption. The figure caption used is not specific and not represents what is depicted in the image.
Confidential feedback for the Editor
Your recommendation Revise
Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?
No, but these points can be addressed with revisions
Comments It is already addressed in the
comments, more balance discussion is needed to support conclusion.
Please rate the novelty of the research on a scale of 1-5 (1=not at all novel and 5=extremely novel)?
Not relevant for this manuscript
Comments Not relevant since it is more review
Is the presentation of the work clear, with regards to language and grammar? Needs some language corrections before being published
Does the title of this paper clearly reflect its content? No
Comments The title is too broad however what
expressed inside need to be elaborated to support the title.
Does the abstract su ciently reflect the content? No
Comments general points are already addressed,
but need to be more elaborate
Are the keywords representative of the research? Yes
Does the introduction present the purpose of the investigation and is the purpose supported by the pertinent literature?
Yes
Are the methods described su ciently to allow the study to be repeated by other parties? No
Comments There is no methods described. In the
comment is already addressed on the method of how this review done
Are <a href='https://www.rrids.org/' target='_blank'> Research Resource Identifiers </a>
(RRID) included where applicable?
Not applicable
Is the use of statistics and treatment of uncertainties appropriate? Not relevant to this manuscript
Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?
Yes
Are the table and figures well designed and necessary? No
Comments this has been address in the comment
Are the references provided appropriate and up to date? No
Comments need more references to support the
discussion
Confidential comments to the Editor
none
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