مﺎﮕﻨﻫ ﻪﺑ ﻦﯿﻣﻮﮐرﻮﮐ ﻞﻤﮑﻣ فﺮﺼﻣ ﺮﺛا ﯽﺘﻧآ ﺖﯿﻓﺮﻇ ﺮﺑ ﺪﯾﺪﺷ ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ8
-
)ﯽﻧاﺪﯿﺴﮐا GPX
شﻮﻣ ﺐﻠﻗ ( رﺎﺘﺴﯾو ﺮﻧ ﯽﯾاﺮﺤﺻ يﺎﻫ
يزﺮُﮔ ﯽﻠﻋ يداﺮﮐا ﻪﻧﺎﻤﺳ ،1
ﯽﻧﺎﻤﺣر ﺪﻤﺣا ،2
3
-1 نﺎﺠﻧز هﺎﮕﺸﻧاد ﯽﺷزرو مﻮﻠﻋ و ﯽﻧﺪﺑ ﺖﯿﺑﺮﺗ هوﺮﮔ رﺎﯾدﺎﺘﺳا
-2 يﻮﺠﺸﻧاد نﺎﺠﻧز هﺎﮕﺸﻧاد يدﺮﺑرﺎﮐ ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ ﺪﺷرا ﯽﺳﺎﻨﺷرﺎﮐ
-3 نﺎﺠﻧز هﺎﮕﺸﻧاد ﯽﺷزرو مﻮﻠﻋ و ﯽﻧﺪﺑ ﺖﯿﺑﺮﺗ هوﺮﮔ رﺎﯾدﺎﺘﺳا
هﺪﯿﮑﭼ
ﻪﻣﺪﻘﻣ : ﯽﺘﻣﺎﻘﺘﺳا تﺎﻨﯾﺮﻤﺗ يﻻﺎﺑ ﻢﺠﺣ
، ﯽﻣ ﯽﺘﻧآ هﺎﮕﺘﺳد ﯽﯾارﺎﮐ ﺶﻫﺎﮐ ﺐﺟﻮﻣ ﺪﻧاﻮﺗ ﯽﻧاﺪﯿﺴﮐا
، ﺪﯿﻟﻮﺗ ﺶﯾاﺰﻓا
لﺎﮑﯾدار دﻮﺷ ﯽﺸﯾﺎﺴﮐا رﺎﺸﻓ ﺖﯾﺎﻬﻧ رد و دازآ يﺎﻫ ﺪﻫ .
ﻞﻤﮑﻣ فﺮﺼﻣ ﺮﺛا ﯽﺳرﺮﺑ ﺮﺿﺎﺣ ﺶﻫوﮋﭘ زا ف
ﯽﺘﻧآ ﻢﯾﺰﻧآ ﺖﯿﻟﺎﻌﻓ ناﺰﯿﻣ ﺮﺑ ﻦﯿﻣﻮﮐرﻮﮐ )ﯽﻧاﺪﯿﺴﮐا
GPX شﻮﻣ ﺐﻠﻗ ﺖﻓﺎﺑ رد ( ﯽﻃ رﺎﺘﺴﯾو ﺮﻧ ﯽﯾاﺮﺤﺻ يﺎﻫ
8
.دﻮﺑ ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ شور و داﻮﻣ
:ﺎﻫ نزو)رﺎﺘﺴﯾو ﺮﻧ ﯽﯾاﺮﺤﺻ شﻮﻣ ﺮﺳ30 17.06
255.79± ﻦﺳ و
8
رﻮﻃ ﻪﺑ يزﺎﺳﺎﻨﺷآ ﻪﺘﻔﻫ ﮏﯾ زا ﺲﭘ (ﻪﺘﻔﻫ ) لﺮﺘﻨﮐ هوﺮﮔ رﺎﻬﭼ ﻪﺑ ﯽﻓدﺎﺼﺗ
=6 )ﻦﯿﻣﻮﮐرﻮﮐ ،(n
=6 ﻦﯾﺮﻤﺗ ،(n
) ﯽﺘﻣﺎﻘﺘﺳا
=9 ) ﻦﯿﻣﻮﮐرﻮﮐ+ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ و (n
=9 ) ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ .ﺪﻧﺪﺷ ﻢﯿﺴﻘﺗ (n
،ﻪﺘﻔﻫ 8 رد ﻪﺴﻠﺟ 5
ﺐﯿﺗﺮﺗ ﻪﺑ ﺶﻫوﮋﭘ لوا ﮥﺘﻔﻫ رد نﺪﯾود تﺪﻣ و ﺖﻋﺮﺳ .ﺪﺷ مﺎﺠﻧا نﺎﮔﺪﻧﻮﺟ صﻮﺼﺨﻣ نادﺮﮔراﻮﻧ يور ﺮﺑ (ﻪﺘﻔﻫ و ﻪﻘﯿﻗد رد ﺮﺘﻣ10 ﺖﻋﺮﺳ ﻪﺑ ﺮﺧآ ﮥﺘﻔﻫ رد و دﻮﺑ ﻪﻘﯿﻗد30
نﺎﻣز و ﻪﻘﯿﻗد رد ﺮﺘﻣ35 شﻮﻣ .ﺪﯿﺳر ﻪﻘﯿﻗد70
يﺎﻫ
) ﺪﻧدﺮﮐ ﺖﻓﺎﯾرد ﯽﻗﺎﻔﺻ ﻞﺧاد ﻖﯾرﺰﺗ ﻪﻠﯿﺳو ﻪﺑ ار ﻦﯿﻣﻮﮐرﻮﮐ ﻞﻤﮑﻣ ﯽﯾاﺮﺤﺻ ،ﻪﺘﻔﻫ8
،ﻪﺘﻔﻫ رد ﻪﺴﻠﺟ3 30
ﯽﻠﯿﻣ ﻢﯾﺰﻧآ ﺖﯿﻟﺎﻌﻓ .(نﺪﺑ نزو زا مﺮﮔﻮﻠﯿﮐ ﺮﻫ يازا ﻪﺑ مﺮﮔ GPX
شور هدﺎﻔﺘﺳا ﺎﺑ ﺐﻠﻗ ﺖﻓﺎﺑ رد يﺮﺘﻣﻮﺗﻮﻓﻮﺘﮑﭙﺳا
هداد .ﺪﺷ هﺪﯿﺠﻨﺳ ﻪﺑ ﺎﻫ
.ﺖﻓﺮﮔ راﺮﻗ ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ درﻮﻣ ﺲﻧﺎﯾراو ﻞﯿﻠﺤﺗ ﮥﻠﯿﺳو ﻪﺘﻓﺎﯾ
ﺎﻫ : ﻦﯾا زا ﻞﺻﺎﺣ ﺞﯾﺎﺘﻧ
ﻪﮐ داد نﺎﺸﻧ ﺶﻫوﮋﭘ ﻦﯿﻣﻮﮐرﻮﮐ فﺮﺼﻣ
هاﺮﻤﻫ ﻪﺑ ﺪﯾﺪﺷ ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ
لﺮﺘﻨﮐ هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد
) (p=0.00
و
ﺪﯾﺪﺷ ﯽﺘﻣﺎﻘﺘﺳا تﺎﻨﯾﺮﻤﺗ هوﺮﮔ
) p=0.025
ﺒﻬﺑ ﺐﺟﻮﻣ (
ﯽﺘﻧآ ﺖﯿﻓﺮﻇ دﻮ ﯽﻣ ﯽﻧاﺪﯿﺴﮐا
ﺢﻄﺳ ﻦﯾا ﺮﺑ هوﻼﻋ.دﻮﺷ
ﯽﺘﻧآ ﻢﯾﺰﻧآ ﯽﻧاﺪﯿﺴﮐا
GPX ﯽﻨﻌﻣ ﺶﯾاﺰﻓا ﺪﯾﺪﺷ ﯽﺘﻣﺎﻘﺘﺳا هوﺮﮔ رد ﺖﺳا ﻪﺘﺷاد يراد
) p=0.03
و ﺚﺤﺑ (.
ﻪﺠﯿﺘﻧ -
ﻪﺘﻓﺎﯾ سﺎﺳا ﺮﺑ :يﺮﯿﮔ ﯽﻣ ﺮﺿﺎﺣ ﺶﻫوﮋﭘ يﺎﻫ
ﻞﻤﮑﻣ ﻪﮐ ﺖﻔﮔ ناﻮﺗ ﯽﺘﻧآ ﺖﯿﻓﺮﻇ دﻮﺒﻬﺑ ﺐﺟﻮﻣ ﻦﯿﻣﻮﮐرﻮﮐ
ﮥﺒﺨﻧ نارﺎﮑﺷزرو ﯽﻧاﺪﯿﺴﮐا ﯽﻣ ﯽﺘﻣﺎﻘﺘﺳا
ﻦﯾا ﺮﺑ هوﻼﻋ.دﻮﺷ ﺖﯿﻟﺎﻌﻓ ﻪﮐ
دﺮﮑﻠﻤﻋ دﻮﺒﻬﺑ و يرﺎﮔزﺎﺳ ﻪﺑ ﺮﺠﻨﻣ ﻢﻈﻨﻣ
.ﺖﺳا هﺪﺷ ﯽﺸﯾﺎﺴﮐا ﺪﺿ هﺎﮕﺘﺳد ﯽﺘﻈﻓﺎﺤﻣ
هژاو يﺪﯿﻠﮐ يﺎﻫ :
ﯽﺘﻧآ ﺖﯿﻓﺮﻇ ،ﻦﯿﻣﻮﮐرﻮﮐ ﻞﻤﮑﻣ ،ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ .ﺐﻠﻗ ﺖﻓﺎﺑ،ﯽﻧاﺪﯿﺴﮐا
The effect of curcumin supplementation during 8- weeks of endurance training on heart’s antioxidant capacity on male Wistar rat
Gorzi.Ali1, Ekradi.Samaneh2, Rahmani.Ahmad3 1- Assistant Professor, University of zanjan
2- MSc in Exercise Physiology, University of zanjan
ﯽﺷزرو ﻪﯾﺬﻐﺗ و يژﻮﻟﻮﯾﺰﯿﻓ
3- Assistant Professor, University of zanjan Abstract
Introduction: High volume endurance training can reduce antioxidant capacity and increased production of free radicals and oxidative stress. The purpose of this study was to investigate the effects of curcumin supplementation on heart’s antioxidant capacity during 8 weeks of endurance training in male wistar rats. Materials and Methods: 30 Male wistar rats (weight=
255.79±17.06 g, aged= 8 weeks) after one week familiarization period, were randomly divided in to 4 groups; Control (n=6), curcumin (n=6), Endurance (n=9) and Endurance+curcumin (n=9). Endurance training (8 weeks, 5 sessions a week) carried out on animal treadmill. The speed and duration of running were 10 m/min and 30 min at first week, respectively and reached to the 35 m/min and 70 min at last week. The animals in supplement groups received curcumin supplement by subperitonealinjection (8 weeks, 3 sessions a week, 30 mg/kg.Bw). Analysis of variance was used to analysis of the data. Results: the result of this study showed that strenuous endurance training in combination with curcumin improves the activity of antioxidant enzyme of heart tissue in compare with control (p=0/00) and endurance (p=0/025) groups. Moreover, the level of antioxidant enzymes GPX strenuous endurance training had a significant increase compared to the control (p=0.03). Conclusion:
Based on the findings of this study, curcumin supplementation can improves the antioxidant capacity of heart tissue. Regular activities will lead to compatibility and improved performance on antioxidant system.
Keywords: Endurance training, Curcumin supplementation, Anti-oxidant capacity, heart.
ﻪﻣﺪﻘﻣ
ةﺪﻤﻋ ﺴﮐا ﯿ نﮋ
،نﺪﺑ رد هﺪﺷ فﺮﺼﻣ فﺮﺻ
ﺖﺧﻮﺳ ﻟﻮﺗ و نﺪﺑ زﺎﺳو ﺪﯿ
ردATP
ﻣﯿ رﺪﻨﮐﻮﺘ ﯽﻣ ي )دﻮﺷ (1 ﺖﺧﻮﺳ . -
زﺎﺳو ﺖﻓﺎﺑ يروﺮﺿ ﺪﻨﯾاﺮﻓ هﺪﻧز يﺎﻫ
اﺮﺑ ي ﻟﻮﺗ ﯿﺪ ژﺮﻧا ي ا ﺎﺑ .ﺖﺳا ﯾ
ﻦ ﺖﺧﻮـﺳ ،لﺎـﺣ زﺎـﺳو
ﯽـﻌﯿﺒﻃ ﻪـﻧﻮﮔ نﺪـﺑ ﺎـﻫ
ي
ﺴﮐا ﯿ نﮋ ﺶﻨﮐاو ﺮﯾﺬﭘ ) ( ROS
دار ﺪﻨﻧﺎﻣ ﻒﻠﺘﺨﻣ ﯾ
لﺎـﮑ ﻮﺳ ﺮﭘ ـﺴﮐا ﯿﺪ )
O2•−
(،
ﻫ ـﯿ نژورﺪ ﯿـﺴﮐاﺮﭘ ﺪ )
H2O2
( دار و ﯾ لﺎـﮑ
ﻫﯿ ﺴﮐورﺪ ﯿ ﻞ
HO•)
( ﯽﻣ ﺪﯿﻟﻮﺗ ار )ﺪﻨﮐ
.(2 ﺎﺴﮐا رﺎﺸﻓ ﯾﺸ
ﯾ ﯽ ﮏ ﺑ لدﺎﻌﺗ مﺪﻋ ﯿ
ﻦ ﻟﻮﺗ ـﯿ ﺪ ﻓﺮﻇ وROS
ـﯿ ﺖ ـﺘﻧآ عﺎـﻓد ﯽ
-
ﯿﺴﮐا ﻧاﺪ ﯽ هﺪﻤﻋ ﺶﻘﻧ و ﺖﺳا نﺪﺑ يا
رد ﺐﯿﺳآ ﯽﯾاز ﺎﻬﻟﻮﮑﻟﻮﻣوﺮﮐﺎﻣ ﻪﺑ ي
ز ﯾ ﺘﺴ ﯽ ﺳا ﻪﻠﻤﺟ زا ﯿ
ﺎﻫﺪ ي ﻪﺘﺴﻫ يا ـﺳا) ﯿﺪ
ﺌﻠﮐﻮﻧ ﯿ ﮏ ﺌﺗوﺮﭘ ،(
ﯿ ﻦ ﻟ و ﯿﭙﯿ ﺎﻫﺪ ﯽﻣ ﺎﻔﯾا ﺪﻨﮐ ) .( 3 لﻮﻠﺳ هﺪﺷ ﺪﯿﻟﻮﺗ ﯽﺸﯾﺎﺴﮐا رﺎﺸﻓ ﺎﺑ ﻪﻠﺑﺎﻘﻣ ﺖﻬﺟ ﯽـﺘﻧآ ﻢﺘـﺴﯿﺳ ﻪـﺑ ﺎـﻫ
ﻪﻠﻤﺟ زا ﯽﻤﯾﺰﻧآ ﯽﻧاﺪﯿﺴﮐا ﺰﻧآ
ﯾ ﻢ ﺴﮐاﺮﭘﻮﺳ ﯿﺪ
د ﯾ زﺎﺗﻮﻤـﺴ )
،(SOD
زﻻﺎـﺗﺎﮐ
) (CAT
ﺗﺎـﺗﻮﻠﮔ ، ﯿ نﻮ ـﺴﮐاﺮﭘ ﯿ زاﺪ
) GPX
(
هﺪﺷ ﺰﯿﻬﺠﺗ ﺪـﻧا
يرﺎﯿﺴﺑ راﺪﻘﻣ ﺪﯾﺪﺷ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ . ﻪﻧﻮﮔ
ﺎﻫ ي ﺴﮐا ﯿ نﮋ ﺶﻨﮐاو ﯽﻣ ﺪﯿﻟﻮﺗ ﺮﯾﺬﭘ ﺪﻨﮐ
ـﺘﺣ ﻪـﮐ ﯽ ﻦـﮑﻤﻣ
ﺖﺳا ﺎﻬﻧآ ﺪﯿﻟﻮﺗ ناﺰﯿﻣ زا
هﺎﮕﺘﺳد ﯽﺘﻧآ ﯽﺸﯾﺎﺴﮐا تاﺮﻄﺧ ﺐﺟﻮﻣ و دﺮﯿﮕﺑ ﯽﺸﯿﭘ ﯽﻧاﺪﯿﺴﮐا ﺬﭘﺎﻧ ناﺮﺒﺟ
ﯾﺮ ﻟﻮﻠـﺳ ﯽ ﻪـﮐ
ﻪﺑ دﺮﮑﻠﻤﻋ و ﺖﻣﻼﺳ دﺮﻓ ﯽﻧﺎﻤﺴﺟ
ﺳآ ﯿ ﺐ ﯽﻣ ﺪﻧﺎﺳر ﯾ ﻪﺠﯿﺘﻧ رد . ﮏ
ﯽﺘﻧآ لﻮﻣﺮﻓ ﯽﻧاﺪﯿﺴﮐا
ﻣ بﻮﺧ ﯽ دﺮـﮑﻠﻤﻋ ﺪﻧاﻮﺗ
ﺷزرو ﯽ ﺪﺸﺨﺑ دﻮﺒﻬﺑ ار ﻪﺑ و
زﺎﺑ ﯾﺑﺎ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ ﯽ ﺪـﺷ
ﯾﺪ هدﻮـﻤﻧ ﮏـﻤﮐ ا هﺎﮕﺘـﺳد دﺮـﮑﻠﻤﻋ زا و
ﯾ ـﻨﻤ ﯽ بﻮـﻠﻄﻣ
ﺪﻨﮐ ﺖﯾﺎﻤﺣ )
.( 4 ﻢﻬﻣ ﯽﺘﺴﯾز ةدﺎﻣ ﻦﯾﺮﺗ دﻮﺟﻮﻣ
دوﺪـﺣ ﻪـﮐ ﺖـﺳا ﻦﯿﻣﻮـﮐرﻮﮐ ﻪـﺑﻮﭼدرز رد ﺎـﺗ2
نزو ﺪـﺻرد8
ﯽﻣ ﻞﯿﮑﺸﺗ ار ﻪﺑﻮﭼدرز ﻢﻬﻣ .ﺪﻫد
تاﺮﺛا ﻦﯾﺮﺗ نآ ﯽﺘﺧﺎﻨﺷ ﺖﺴﯾز
ﯽﺘﻧآ ﺖﯿﺻﺎﺧ ، يرﺎـﻤﯿﺑ نﺎـﻣرد و ﯽﻧاﺪﯿـﺴﮐا
يﺎـﻫ
ﺖﯿﺳﺎﺴﺣ ،ﯽﺷراﻮﮔ ﺮﻤﯾاﺰﻟآ ،ﯽﯾاز
و ﺖﺳا نﺎﻃﺮﺳ )
.( 5 اﯾ ﻦ دراد ﺮﻈﻧ رد ﻪﻌﻟﺎﻄﻣ ـﻫد ﺦـﺳﺎﭘ لاﻮـﺳ ﻦﯾا ﻪﺑ
ﺪ آ ﻪـﮐ ـﯾﺎ
فﺮﺼﻣ ﻞﻤﮑﻣ ﻣﻮﮐرﻮﮐ ﯿ ﻦ لﻮﻃ رد ﺖﯿﻟﺎﻌﻓ ﻪﺘﻔﻫ8
ﺘﻣﺎﻘﺘﺳا ﯽ ﺪﺷ ﯾﺪ ﻣ ﯽ ﺪـﻧاﻮﺗ ﺖـﯿﻟﺎﻌﻓ ﯽـﺘﻧآ ﯽﻧاﺪﯿـﺴﮐا ﺐـﻠﻗGPx
يﺎﻬﺷﻮﻣ اﺮﺤﺻ
ﯽﯾ داﮋﻧ ﺮﻧ ار رﺎﺘﺴﯾو دﻮﺒﻬﺑ
؟ﺮﯿﺧ ﺎﯾ ﺪﻫد
شور ﻖﯿﻘﺤﺗ ﯽﺳﺎﻨﺷ
نزو) رﺎﺘﺴﯾو ﺮﻧ ﯽﯾاﺮﺤﺻ شﻮﻣ ﺮﺳ 30 17.06
± 255.79 ﻦﺳ و
يزﺎﺳﺎﻨﺷآ ﻪﺘﻔﻫ ﮏﯾ زا ﺲﭘ (ﻪﺘﻔﻫ 8 ﺎﺑ
ﯽﯾﺎﻨﺷور ﻪﺑ ﯽﮑﯾرﺎﺗ ﻪﺧﺮﭼ) رﻮﻧ ةﺪﺷ لﺮﺘﻨﮐ ﻂﯾاﺮﺷ رد تﺎﻨﯾﺮﻤﺗ 12:12
) ﺎﻣد ،(
/4 1
± ﺖﺑﻮﻃر و (داﺮﮔ ﯽﺘﻧﺎﺳ22
) 5
± ﻪﺑ ﯽﻓدﺎﺼﺗ رﻮﻃ ﻪﺑ ،تﺎﻧاﻮﯿﺣ هﺎﮕﺸﯾﺎﻣزآ (ﺪﺻرد45 )لﺮﺘﻨﮐ هوﺮﮔ 4
=6 )ﻦﯿﻣﻮﮐرﻮﮐ،(n
=6 ﻦﯾﺮﻤﺗ ،(n
)ﯽﺘﻣﺎﻘﺘﺳا
=9 ) ﻦﯿﻣﻮﮐرﻮﮐ +ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ و (n
=9 ﯽﺘﻣﺎﻘﺘﺳا ﻦﯾﺮﻤﺗ .ﺪﻧﺪﺷ ﻢﯿﺴﻘﺗ(n
) ،ﻪﺘﻔﻫ8 (ﻪﺘﻔﻫ رد ﻪﺴﻠﺟ5
ﺐﯿﺗﺮﺗ ﻪﺑ ﺶﻫوﮋﭘ لوا ﮥﺘﻔﻫ رد نﺪﯾود تﺪﻣ و ﺖﻋﺮﺳ .ﺪﺷ مﺎﺠﻧا نﺎﮔﺪﻧﻮﺟ صﻮﺼﺨﻣ نادﺮﮔراﻮﻧ يور ﺮﺑ ﺮﺘﻣ10
تﺪﻣ ﻪﺑ ﻪﻘﯿﻗد رد ﺖﻋﺮﺳ ﻪﺑ ﺮﺧآ ﮥﺘﻔﻫ رد و دﻮﺑ ﻪﻘﯿﻗد30
لدﺎﻌﻣ) ﻪﻘﯿﻗد رد ﺮﺘﻣ 35 ﺎﺗ80
نﮋﯿﺴﮐا ﺪﺻرد85
نﺎﻣز و (ﻪﻨﯿﺸﯿﺑ ﯽﻓﺮﺼﻣ شﻮﻣ .ﺪﯿﺳر ﻪﻘﯿﻗد70
يﺎﻫ ﺖﮐﺮﺷ زا هﺪﺷ ﻪﯿﻬﺗ) ﻦﯿﻣﻮﮐرﻮﮐ ﻞﻤﮑﻣ ﯽﯾاﺮﺤﺻ
Merck
) ﺪﻧدﺮﮐ ﺖﻓﺎﯾرد ﯽﻗﺎﻔﺻ ﻞﺧاد ﻖﯾرﺰﺗ ﻪﻠﯿﺳو ﻪﺑ ار (نﺎﻤﻟآ ،ﻪﺘﻔﻫ8
،ﻪﺘﻔﻫ رد ﻪﺴﻠﺟ 3 ﯽﻠﯿﻣ 30
ﺮﻫ يازا ﻪﺑ مﺮﮔ
.(نﺪﺑ نزو زا مﺮﮔﻮﻠﯿﮐ هوﺮﮔ مﺎﻤﺗ ﻦﯾﺮﻤﺗ ﻪﺴﻠﺟ ﻦﯾﺮﺧآ زا ﺲﭘ ﺖﻋﺎﺳ 48
و ﻦﯿﻣﺎﺘﮐ ﯽﺷﻮﻬﯿﺑ يوراد ﺎﺑ ﺎﻫ
ﺢﯾﺮﺸﺗ و شﻮﻬﯿﺑ ﻦﯾزﻼﯾاز ﺲﭙﺳ .ﺪﺷ ﺖﺷادﺮﺑ ﺎﻬﻧآ ﺐﻠﻗ ﺖﻓﺎﺑ و ﺪﻧﺪﺷ
ﻢﯾﺰﻧآ ﺖﯿﻟﺎﻌﻓ
GPX
ﺎﺑ ﺐﻠﻗ ﺖﻓﺎﺑ رد
جﻮﻣ لﻮﻃ رد يرﻮﻧ بﺬﺟ) يﺮﺘﻣﻮﺗﻮﻓﻮﺘﮑﭙﺳا شور هدﺎﻔﺘﺳا شور،ﺮﺘﻣﻮﻧﺎﻧ532
TBARS
راﺮﻗ ﺶﺠﻨﺳ درﻮﻣ (
)ﺖﻓﺮﮔ هداد .(6
ﻪﺑ ﺎﻫ ﺪﺷ ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ ﻪﻓﺮﻃ ﮏﯾ ﺲﻧﺎﯾراو ﻞﯿﻠﺤﺗ ﮥﻠﯿﺳو )
0.05
<
.(p
ﻪﺘﻓﺎﯾ ﺎﻫ
.(p<0.05) ﯽﺘﻣﺎﻘﺘﺳا و لﺮﺘﻨﮐ هوﺮﮔ ﺎﺑ رادﯽﻨﻌﻣ توﺎﻔﺗ =*(.U/mg.pro)ﺐﻠﻗGPX ﺖﯿﻟﺎﻌﻓ ﻦﯿﮕﻧﺎﯿﻣ يﺮﯿﮔ ﻪﺠﯿﺘﻧ و ﺚﺤﺑ
ﺢﻄﺳ ﻢﯾﺰﻧآ
GPX
ﯽﻨﻌﻣ ﺶﯾاﺰﻓا لﺮﺘﻨﮐ و ﯽﺘﻣﺎﻘﺘﺳا هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﻦﯿﻣﻮﮐرﻮﮐ+ﯽﺘﻣﺎﻘﺘﺳا هوﺮﮔ ﻪﺑ .دﺮﮐ اﺪﯿﭘ يراد
ﯽﻣ ﯽﺗرﺎﺒﻋ ﺖﯿﻟﺎﻌﻓ دﻮﺒﻬﺑ ﺐﺟﻮﻣ ﺪﯾﺪﺷ ﯽﺘﻣﺎﻘﺘﺳا تﺎﻨﯾﺮﻤﺗ ياﺮﺟا مﺎﮕﻨﻫ ﻪﺑ ﻦﯿﻣﻮﮐرﻮﮐ ﻞﻤﮑﻣ فﺮﺼﻣ ﺖﻔﮔ ناﻮﺗ
ﯽﻣ ﯽﻧاﺪﯿﺴﮐا ﯽﺘﻧآ ﻢﯾﺰﻧآ .دﻮﺷ
ﺢﻄﺳ ﻢﯾﺰﻧآ
GPX
ﯽﺘﻣﺎﻘﺘﺳا هوﺮﮔ لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﺪﯾﺪﺷ
ﯽﻨﻌﻣ ﺶﯾاﺰﻓا يراد
ﺪﺿ هﺎﮕﺘﺳد ﯽﺘﻈﻓﺎﺤﻣ دﺮﮑﻠﻤﻋ دﻮﺒﻬﺑ و يرﺎﮔزﺎﺳ ﻪﺑ ﺮﺠﻨﻣ ﻢﻈﻨﻣ ﺖﯿﻟﺎﻌﻓ ﻪﮐ ﺖﺳا ﻦﯾا ةﺪﻨﻫد نﺎﺸﻧ ﻪﮐ.ﺖﺳا ﻪﺘﺷاد .ﺖﺳا هﺪﺷ ﯽﺸﯾﺎﺴﮐا
ﯽﯾاﺮﺟا مﺎﯿﭘ -
ﺶﻫوﮋﭘ ﯽﻤﻠﻋ
1.52
1.79 1.66 1.8
0 0.5 1 1.5 2 2.5 ﻦﯿﮕﻧﺎﯿﻣ ﺖﯿﻟﺎﻌﻓGPXﺐﻠﻗ رد(U/mg.pro)
*
لرﺗﻧﮐ نﯾﻣوﮐروﮐ ﯽﺗﻣﺎﻘﺗﺳا نﯾﻣوﮐروﮐ+ﯽﺗﻣﺎﻘﺗﺳا
رﺎﺸﻓ و ﺪﺷ دازآ يﺎﻫ لﺎﮑﯾدار ﺶﯾاﺰﻓا زوﺮﺑ زا يﺮﯿﮕﺸﯿﭘ ﺚﻋﺎﺑ ﻦﯿﻣﻮﮐرﻮﮐ ﻞﻤﮑﻣ فﺮﺼﻣ ﺶﻫوﮋﭘ ﻦﯾا رد ﯽﺷﺎﻧ ﯽﺸﯾﺎﺴﮐا ﻪﻓﺮﺣ نارﺎﮑﺷزرو ﻪﺑ ﻦﯾاﺮﺑﺎﻨﺑ .داد ﺶﻫﺎﮐ ار تﺎﻨﯾﺮﻤﺗ زا
ﯽﺘﻣﺎﻘﺘﺳا تﺎﻨﯾﺮﻤﺗ مﺎﺠﻧا ﻪﺑ رﻮﺒﺠﻣ ﻪﮐ يا
ﯽﻣ ﻪﯿﺻﻮﺗ ﺪﻨﺘﺴﻫ ﺪﯾﺪﺷ .ﺪﻨﻨﮐ هدﺎﻔﺘﺳا (ﻦﯿﻣﻮﮐرﻮﮐ يوﺎﺣ) ﻪﺑﻮﭼدرﺰﯿﯾاﺬﻏ ﮥﯾودا زا دﻮﺧ ﯽﯾاﺬﻏ ﮥﻣﺎﻧﺮﺑ رد دﻮﺷ
ﻊﺑﺎﻨﻣ 1. Chance B، Sies H، Boveris A: Hydroperoxide metabolism in mammalian organs. Physiol Rev. 1979;
59: 527-605.
2. Khan RA: Protective effect of Launaea procumbens (L.) on lungs against CCl4-induced pulmonary damages in rat. BMC complementary and alternative medicine. 2012; 12(1):133-40.
3. Sun, Y: Free radicals, antioxidant enzymes, and carcinogenesis. Free Radical Biol. Med.1990;8:583–
599.
4. Lamina S، Ezema CI، Theresa AI، Anthonia EU. Effects of free radicals and antioxidants on exercise performance. Oxidants and Antioxidants in Medical Science. 2013; 2(2):83-91.
5. Prasad S، Tyagi AK، Aggarwal BB. Recent Developments in Delivery، Bioavailability، Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice. Cancer Research and Treatment.
2014;46(1):2-18.
6. Kaya H, Sezik M, Ozkaya O, et al: Lipid peroxidation at various estradiol concentrations in human circulation during ovarian stimulation with exogenous gonadotropins. HormMetabRes , 2004 :36:693.
