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REFERENCE:
1. Saxena RS, Gupta B, Saxena SK, Singh R, Prasad DN. Study of anti-inflammatory activity of the leaves of Nyctanthes arbor-tristis Linn.: An Indian Medicinal Plant. J Ethnopharmacol. 1987;11:319–30
.
2. Kumar, Abbas, Fausto, Mitchell. Robbins Basic Pathology, 8th Edition 2007. p:31
.
2 3. Katzung BG. Basic and clinical pharmacology, 2001, eight edition: 1088-1089.
34. Tranvsky K. et al. Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis….. J Rheumatol. 2004 Mar; 31(3): 565-72
.
5. Van Haselen RA, Fisher PA. A randomized Controlled trial Comparing topical piroxicam gel with a homeopathic gel in osteoarthritis of the knee. Rheumatology (oxford) 2000; 39(7): 714-9
.
6. Hatori M, Kokubun S. Clinical evaluation of indomethacin-containing patches for osteoarthritis andextremity trauma. curr Med Res opin 1997; 13(9): 511- 5
.
7. Ottillinger B. et al. Efficacy and safety of eltenac gel in the treatment of knee osteoarthritis. osteoarthritis cartilage.
2001 Apr; 9(3): 273-80
.
8. Biswal S, Medhi B, Pandhi P. Long term efficacy of topical nonsteroidal antinflammatory drugs in knee osteoarthritis metanalysis of randomized placebo controlled clinical trials. J Rheumatol 2006 Sep; 33(9): 1841-4
.
9. Banning M. The use of topical diclofenac for pain in osteoarthritis of the knee: a review. Br J community nurs: 2006 Nov; 11 (11): 487-92
.
10.Baer PA. et al. Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomized controlled 6 week trail. BMC Musculoskeletal Disord. 2005 Aug 8; 6:44
.
11.Machen J, White field M. Efficacy of a proprietary ibuprofen gel in soft tissue injuries: a randomized, double blind, placebo-controlled study. Int. J clin. Pract. 2002 Mar; 56(2): 102-6
.
12.Schnitzer, Thomas J. Non NSAID pharmacological treatment options for the management of chronic pain. The American journal of medicine 1998, jul 27, Vol. 105(1B). 458-523
.
13.Rosenstein, Elliot D. Topical agents in the treatment of the Rheumatic disorders/ Rheum. Dis. Clin. North Am.
1999, Nov; 25(4): 899-918
.
14.Hosseinzadeh h, Ramezani M, Salmani G. Antinociceptive, anti-inflammatory and acute toxicity effects of zataria multiflora Boiss extracts in mice and rats. J Ethnopharmacol, 2000; 73(3): 379-85
.
15.Murray MD, Brater DC. Renal toxicity of nonsteroidal anti-inflammatory drugs. Ann Rev pharmacol Toxicol, 1993;
32: 435-65
.
16.Naseri, Mohsen. Iranian traditional medicine and its development under WHO guidelines. Scientific Bimonthly - Medical Technology Research: Shahrivar 1383. Eleven years. No. 52. Pp. 53-68
.
17.Nasseri, Mohsen, “Nezam e Ahsan Va tahqiq“. Razi magazine. February edition. 1370. Pp. 47-50
.
1718.Patwardhan B, Vaidy ADB, Chorghade M. Ayurveda and natural products drug discovery. CURRENT SCIENCE.
2004; 86(6, 25):789-799
.
19.Naseri M. Shams Ardakani M.R.The School of Traditional Iranian Medicine The Definition, Origin and Advantages. Journal of ISHIM vol 3, No 6, 2004,pp:17-21
.
20.Naseri, Mohsen. “dehkade e Salamati”. Tehran: Publication of traditional and complementary medicine. The third print in 1388. Pp: 25-30
.
21.Naseri, Mohsen; Ghaffari, Farzane; Shirzad, Meysam. Avicenna's views on the use of drugs in traditional Iranian medicine. Proceedings of the seminar on traditional medicine and medicinal plants. Tehran. Shahrivar 1386, pp. 1- 17
.
22.Sardari, Soroush. Medicinal plants for pharmaceutical resources. Razi Pharmaceutical Journal: ninth year. 1377.
No. 6. Pp. 54-64
.
23.Patwardhan, B (2009, January 23). Drug Discovery and Development: Traditional Medicine and Ethnopharmacology Perspectives. SciTopics. Retrieved October 4, 2011, from http://www.scitopics.com/Drug_Discovery_and_Development_Traditional_Medicine_and_Ethnopharmacolgy_
Perspectives.html
.
24.Tobinick EL. The value of drug repositioning in the current pharmaceutical market. Drug News Perspect, 2009.
22:119-125
.
25.Graul AI, Revel L, Barrionuevo M, Cruces E,Rosa E, Verges C, Lupone B, Diaz N, Castaner R.The year's new drugs & biologics - 2008. DrugNews Perspect, 22:7-29, 2009
.
26.Miyata T, Kikuchi K, Kiyomoto H, van Ypersele de Strihou C.New era for drug discovery and development in renal disease. Nat Rev Nephrol. 2011 Jul 5;7(8):469-77. doi: 10.1038/nrneph.2011.84
.
27.Ansari Shirazi, Ali ibn Hussein. Rhetorical powers, edited and annotated (ekhtiarat e badiee, Tashih va tahshie”.
Doctor Mohammad Taqi Mir. Tehran: published by Pakhshe razi pharmaceutical company. 1371. Page 246
.
28.Aghili Khorasani Shirazi, Mohammad Hussain, ”Makhzan Aladviyeh”. Correction by Reza Shams Ardakani, Roja Rahimi, Fateme Farjadmand. Tehran University of Medical Sciences. 1387, pp. 490-491
.
29.Ibn Sina, Hussein. “Alqanoun fi Alteb“. Correction by Ibrahim Shams al-Din. Beirut. , 2005, Volume II, page 148
.
30.Razi Mohammad ibn Zakaria, Alhavy. Translation and adjustment by Dr. Soleyman Afsharypour. Iran’s academy of medical sciences. 1384. Vol 21, p 56
.
31.31.Tonekaboni, Mir Mohammed Momen (11 AH). “Tohfat al momenin”. correction and Research Roja Rahimi;
Muhammad Reza Shams Ardakani; Fateme Frjadmnd. Shahid Beheshti University of Medical Sciences. 1386. Page 269
.
32.Hajhashemi V, Abbasi N. Hypolipidemic activity of Anethum graveolens in rats, Phytother.
Res, 2008 Mar; 22 (3): 372 - 5
.
33.Yazdanparast-R, Alavi-M, Antihyperlipidaemic and antihypercholesterolaemic effects of Anethum graveolens leaves after the removal of furocoumarins, Cytobios 2001; 105: 185 - 91
.
34.Delaquis-PJ, Stanich-K, Girard-B, Mazza-G, Antimicrobial activity of individual and mixed fractions of dill, cilantro, coriander and eucalyptus essential oils, Int J Food Microb, 2002, 74: 101 - 9
.
35.Chaurasia SC and Jain PC. Antibacterial activity of essential oils of four medicinal plants Indian-J-Hosp-Pharm.
1978; 15: 166-8 In: Duke JA. Handbooke of Medical herbs. CRC press, London: 2001, p:42
.
36.Hosseinzadeh H, Karimi GR, Ameri M. Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice., BMC Pharmacol. 2002 Dec; 19: 2, 21
.
37.Panda-S, The effect of Anethum graveolens L. (dill) on corticosteroid induced diabetes mellitus:involvement of thyroid hormones, Phytother Res. 2008 Dec; 22 (12): 1695 - 7
.
38.Gharib Naseri M.K., Heidari A., Antispasmodic effect of Anethum graveolens fruit extract on rat ileum.
International journal of pharmacology, 2007; 3(3): 260-264
.
39.Valady, Ali; Nasri, Sima; Abbasi; Naser; Amin, GholamReza. Anti-inflammatory and analgesic effects of ethanolic seed extract of the plant Anethum graveolens L., Journal of herbs, year nine, Volume II, No. 34, 1389 pp. 124-130
.
40.(NRC) Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, 1985.
Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC
.
41.Draize, J.H. The Appraisal of Chemicals in Foods, Drugs and Cosmetics. The Association of Food and Drug Officials of the United States, 1959, p. 46
.
42.Ostad, Seyednaser. Food chemistry and toxicology’s excellence. Tehran’s university of medical sciences. First print, 1386. Chapter 7, acute toxicity studies, pp. 146-157
.
43.Gad, S.C. The mouse ear-swelling test (MEST) in the 1990s. Toxicology1994; 93: 33–46
.
4344.Gad, S.C. The mouse ear swelling test. In: Burleson, R.G., Dean, H.J., Monson, E.A. (Eds.), Method in Immunotoxicology.Wiley–Liss, NewYork, pp. 1995; 357–372
.
45.Gad, S.C., Dunn, J.B., Dobbs, W.D., Reilly, C., Walsh, R.D. Development and validation of an alternative dermal sensitization test: the mouse ear swelling test (MEST). Journal of Toxicology and Applied Pharmacology. 1986; 84:
93–114
.
46.Deal CL, Schnitzer TJ, Lipstein E, Seibold JR, Stevens RM, Levy MD, et al. Treatment of arthritis with topical capsaicin: a double-blind trial. Clin Ther 1991;13: 383-95
.
47.Shackel NA. et al / Copper – Salicylate gel for pain relief in osteoarthritis : a randomized controlled trial/ Med J Aust. 1997 Aug 4; 167(3): 134-6
.
48.Barzi Daryoush, Mehdi; Nasseri, Mohsen; Faghih Zadeh, Socrates; Kamali Nejad, Muhammad; Bahrami, Mohsen.
Double-blind, placebo-controlled clinical trial of topical ointment in patients with osteoarthritis of the knee joint.
Daneshvar, Aban 1387, 16 (77): pp. 49-56
.
49.Rostami A. Chemical Constituents of Oily Extract from Chamomile, Dill and Fenugreek. [Dissertation] Shahid Beheshty University of Medical Sciences, Tehran (2011
.(
50.Laska, M.; Liesen, A.; Teubner, P. American Journal of Physiology- Regulatory Integrative and Comparative Physiology, 1999, 277, R1098-R1103
51.Moghimi, HamidReza; Shafizadeh, Aida, with the assistance and advice of Muhammad Kmalynezhad. The structure of the traditional pharmaceutical drug delivery systems from basis to bio-pharmacy and comparison with current systems, Mohaya publication, in collaboration with the Research Center for Traditional Medicine and Materia of the medical university of shahid Beheshti. 2010, pp. 96
