Effect of 12 Weeks of Resistance and Aerobic Training on Serum Levels of CTRP-12 and LCN-2 in Women With Type-2 Diabetes Morteza Fattahpour Marandi

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Effect of 12 Weeks of Resistance and Aerobic Training on Serum Levels of CTRP-12 and LCN-2 in Women With Type-2 Diabetes

Morteza Fattahpour Marandi¹ , Solmaz Babaei Bonab²^

1. Department of Sports Sciences, Faculty of Humanities, University of Maragheh, Maragheh, Iran.

E-mail: [email protected]

2. Corresponding Author, Department of Sports Sciences, Faculty of Humanities, University of Maragheh, Maragheh, Iran.

E-mail: [email protected]

Article Info ABSTRACT

Article type:

Research

Article history:

Received:

13 April 2023 Received in revised form:

23 May 2023 Accepted:

10 June 2023 Published online:

22 June 2023

Keywords:

Aerobic Training, CTRP-12, Lipocalin-2,

Tesistance Training, Type-2 Diabetes.

Introduction: Lipocalin-2 (LCN-2) and CTRP-12 are adipokines that are closely related to type-2 diabetes and are expressed in adipose tissue. Therefore, this research aimed to investigate the effect of 12 weeks of resistance and aerobic training on the serum levels of CTRP-12 and LCN-2 in women with type-2 diabetes.

Methods: The present research was conducted in a quasi-experimental manner.

The statistical population of the study included all women with type-2 diabetes in Urmia city, from which 30 women with type-2 diabetes in the age range of 40-45 years old were selected and randomly assigned into three Resistance Training (three sets with 10 repetitions at 30 to 75% of 1RM), Aerobic Training (15 to 45 minutes at 50 to 75% of RHR), and Control groups. The training groups practiced for 12 weeks and three sessions per week. Serum levels of CTRP-12 and LCN-2 were measured using an ELISA kit. To analyze the data, dependent t, and ANOVA tests were used at a significance level of less than 5%.

Results: In the resistance and aerobic training groups, the values of CTRP-12 increased significantly, while the values of LCN-2 in these two groups decreased significantly compared with the control group (p<0/05). In the between-group analysis, resistance and aerobic training produced significant changes in CTRP-12 and LCN-2 compared with the control group (p<0/05).

Conclusion: It seems that performing resistance and aerobic training induces up- regulation of anti-inflammatory adipokines (CTRP-12) and a down-regulation of the inflammatory adipokine lipocalin-2 (LCN-2).

Cite this article: Fattahpour Marandi M., Babaei Bonab S. Effect of 12 Weeks of Resistance and Aerobic Training on Serum Levels of CTRP-12 and LCN-2 in Women With Type-2 Diabetes. Journal of Sport Biosciences. 2023; 15 (2):45-57.

DOI: https://doi.org/10.22059/jsb.2023.357093.1581

Journal of Sport Biosciences by University of Tehran Press is licensed under CC BY-NC 4.0.

| Web site: https://jsb.ut.ac.ir/ | Email: [email protected].

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Introduction

Diabetes is a type of metabolic disease in which the blood sugar level is high. In diabetes, either insufficient insulin is secreted from the beta cells of the pancreas, or there is a decrease in insulin sensitivity in the body cells. Type-2 Diabetes Mellitus (T2DM) is a metabolic disorder caused by high blood glucose levels and a lack of response to the amount of insulin secreted by the pancreas. Lipocalin-2 is a new adipokine that is secreted from adipose tissue and is closely related to mild inflammation, obesity, insulin resistance, and metabolic syndrome. New studies show that there is a positive and significant relationship between LCN-2 levels and metabolic syndrome indicators. On the other hand, recently a set of C1q/TNF-Related Proteins (CTRP) have been identified, which contain a collagen-like domain followed by a C1q globular domain. CTRPs are expressed in a large amount in adipose tissue and potentially participate in the regulation of cardiovascular function and metabolism and are expressed in adipose tissue, especially in adipocytes and have the effects of increasing insulin sensitivity and anti-inflammatory, and the expression of CTRP-12 in conditions that obesity, diabetes, and inflammation are reduced.It seems that changes in lipocalin-2 and CTRP- 12 variables under the influence of exercise can neutralize the destructive effects of adipose tissue such as insulin resistance.

Methods

The current quasi-experimental research was implemented in the form of a pre-test and a post-test design with control and two experimental groups. The statistical population of the study included all women with type-2 diabetes referred to the medical center of Urmia City, who were assigned into three Resistance Training (n=10), Aerobic Training (n=10), and Control (n=10) groups. The resistance training (three sets with 10 repetitions at an intensity of 30 to 70% of 1RM), and the intermittent aerobic training were performed for 12 weeks, three sessions per week, with a gradual increase in duration (20 to 60 minutes), and training intensity (60 to 75% of RHR). In the first and the second weeks, intermittent aerobic training was performed for 20 minutes at an intensity of 60% of RHR, and in the 11th and 12th weeks, performed for 60 minutes at 75% of RHR. The training groups practiced for 12 weeks and three sessions per week. Serum levels of CTRP-12 and LCN-2 were measured using an ELISA kit. To analyze the data, dependent t, and ANOVA statistical tests were used at a significance level of less than 5%.

Results

In resistance and aerobic training groups, the values of CTRP-12 increased significantly, while the values of LCN-2 in these two groups decreased significantly compared with the control group (p<0/05). In the between-group analysis, resistance and aerobic training produced significant changes in CTRP-12 and LCN-2 compared with the control group (p<0/05).

Conclusion

One way to treat diabetes patients is to do physical exercises. Physical exercises improve fat metabolism, which minimizes complications related to diabetes.

Among the metabolic tissues, sports activity affects the fat tissue, which is effective in regulating the secretion of adipokines and adipocytokines in the bloodstream. It seems that performing resistance and aerobic training induces up-regulation of anti-inflammatory adipokines (CTRP-12) and a down-regulation of the inflammatory adipokine lipocalin-2 (LCN-2).

Ethical Considerations:

Compliance with ethical guidelines: The present study was conducted following ethical principles.

Funding: The research was done without using financial resources.

Authors’ contribution: all authors have contributed to the research equally.

Conflict of interest: No conflict of interest is declared

Acknowledgments: The authors thank all the participants who supported us in this research.

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ﺛﺄﺗ ﯿ ﺮ هدزاود ﺮﯾدﺎﻘﻣ ﺮﺑ يزاﻮﻫ و ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ

ﯽﻣﺮﺳ CTRP-12 و

LCN-2 ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز رد

عﻮﻧ ﺖﺑﺎﯾد 2

ﯽﻀﺗﺮﻣ حﺎﺘﻓ ﺪﻧﺮﻣ رﻮﭘ ي ، 1

ﺎﻨﺑ ﯽﺋﺎﺑﺎﺑ زﺎﻤﻟﻮﺳ ب

2



1 . هوﺮﮔ ﯽﺷزرو مﻮﻠﻋ ،

ﺪﮑﺸﻧاد ة ﯽﻧﺎﺴﻧا مﻮﻠﻋ هﺎﮕﺸﻧاد ، ﻪﻏاﺮﻣ ، ﻪﻏاﺮﻣ :ﻪﻣﺎﻧﺎﯾار .ناﺮﯾا ، [email protected]

2 . ﻮﻧ ﯾ ﺪﻨﺴ ة لﻮﺌﺴﻣ ، هوﺮﮔ ﯽﺷزرو مﻮﻠﻋ ،

ﺪﮑﺸﻧاد ة ﯽﻧﺎﺴﻧا مﻮﻠﻋ هﺎﮕﺸﻧاد ، ﻪﻏاﺮﻣ ، ﻪﻏاﺮﻣ :ﻪﻣﺎﻧﺎﯾار .ناﺮﯾا ،

@maragheh.ac.ir s.babaei

ﻪﻟﺎﻘﻣ تﺎﻋﻼﻃا هﺪﯿﮑﭼ

:ﻪﻟﺎﻘﻣ عﻮﻧ ﯽﺸﻫوﮋﭘ

رﺎﺗ ﯾ ﺦ رد ﯾ ﺖﻓﺎ : 24 / 01 / 1402

يﺮﮕﻧزﺎﺑ ﺦﯾرﺎﺗ :

02 / 03 / 1402

رﺎﺗ ﯾ ﺦ ﺬﭘ ﯾ شﺮ : 20 / 03 / 1402

رﺎﺗ ﯾ ﺦ رﺎﺸﺘﻧا : 01 / 04 / 1402

ﺪﯿﻠﮐ هژاو :ﺎﻫ

،ﯽﺘﻣوﺎﻘﻣ تﺎﻨﯾﺮﻤﺗ

،يزاﻮﻫ تﺎﻨﯾﺮﻤﺗ عﻮﻧ ﺖﺑﺎﯾد 2،

ﻦﯿﻟﺎﮐﻮﭙﯿﻟ - 2،

.CTRP-12 ﻣﺪﻘﻣ

:ﻪ ﭙﯿﻟ ﻦﯿﻟﺎﮐﻮ 2 و CTRP-12 ﺗرا ود عﻮﻧ ﺖﺑﺎﯾد ﺎﺑ ﻪﮐ ﺖﺳا ﯽﻨﯾﺎﮐﻮﭙﯾدآ

ﭼ ﺖﻓﺎﺑ رد و دراد ﯽﮑﯾدﺰﻧ طﺎﺒ نﺎﯿﺑ ﯽﺑﺮ

ﻣ ﯽ دﻮﺷ . ﻦﯾازا ور ﯽﺳرﺮﺑ ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ زا فﺪﻫ ﺛﺄﺗ

ﯿﺮ 12 ﻣ ﺮﺑ يزاﻮﻫ و ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ ﯽﻣﺮﺳ ﺮﯾدﺎﻘ

CTRP-12

و LCN-2 عﻮﻧ ﺖﺑﺎﯾد ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز رد

2 ﺖﺳا .

:ﺶﻫوﮋﭘ شور ﻖﯿﻘﺤﺗ

ﺮﺿﺎﺣ ﻪﺑ ترﻮﺻ ﻪﻤﯿﻧ ﯽﺑﺮﺠﺗ مﺎﺠﻧا ﺖﻓﺮﮔ . ﻌﻣﺎﺟ ﮥ ار ﺶﻫوﮋﭘ يرﺎﻣآ ﯽﻣﺎﻤﺗ

نﺎﻧز ﻪﺑ ﻼﺘﺒﻣ

عﻮﻧ ﺖﺑﺎﯾد 2 ﻪﯿﻣورا نﺎﺘﺳﺮﻬﺷ ﺎﻬﻧآ ﻦﯿﺑ زا ﻪﮐ ﺪﻧداد ﻞﯿﮑﺸﺗ

30 ﺖﺑﺎﯾد ﻪﺑ ﻼﺘﺒﻣ نز عﻮﻧ

2 رد ةدوﺪﺤﻣ ﯽﻨﺳ 40 - 45 لﺎﺳ

بﺎﺨﺘﻧا ﺪﺷ ﺪﻧ و ﻪﺑ رﻮﻃ ﻪﺳ) ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ هوﺮﮔ ﻪﺳ رد ﯽﻓدﺎﺼﺗ ﺖﺳ

ﺎﺑ 10 تﺪﺷ و راﺮﮑﺗ 30

ﺎﺗ 75 ﺪﺻرد ،(1RM

) يزاﻮﻫ ﻦﯾﺮﻤﺗ 15

ﺎﺗ 45 تﺪﺷ ﺎﺑ ﻪﻘﯿﻗد 50

ﺎﺗ 75 ﺪﺻرد .ﺪﻨﺘﻓﺮﮔ راﺮﻗ لﺮﺘﻨﮐ هوﺮﮔ و (RHR

هوﺮﮔ ﺎﻫ ي تﺪﻣ ﻪﺑ ﯽﻨﯾﺮﻤﺗ

12 ﻪﺘﻔﻫ ﺮﻫ و ﻪﺘﻔﻫ ﻪﺳ

ﯽﻣﺮﺳ ﺮﯾدﺎﻘﻣ .ﺪﻨﺘﺧادﺮﭘ ﻦﯾﺮﻤﺗ ﻪﺑ ﻪﺴﻠﺟ CTRP-12

و LCN-2 ﻪﺑ ﺖﯿﮐ زا هدﺎﻔﺘﺳا ﺎﺑ

شور ELISA هزاﺪﻧا

ﮔﯿ ﺮ ي ياﺮﺑ .ﺪﺷ ﺰﺠﺗ ﯾﻪ ﺗو ﻠﺤ ﯿ ﻞ هداد ﺎﻫ ﺢﻄﺳ رد اﻮﻧآ و ﻪﺘﺴﺒﻤﻫ ﯽﺗ يرﺎﻣآ نﻮﻣزآ زا رادﺎﻨﻌﻣ

ي ﮐ ﻤ ﺮﺘ

زا 5 .ﺪﺷ هدﺎﻔﺘﺳا ﺪﺻرد

ﯾ ﻪﺘﻓﺎ ﺎﻫ : ﺮﯾدﺎﻘﻣ CTRP-12 هوﺮﮔ

ﺎﻫ ي يزاﻮﻫ و ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ ﻪﺑ

رﻮﻃ رادﺎﻨﻌﻣ ي ﺖﻓﺎﯾ ﺶﯾاﺰﻓا

، ﻟﺎﺣرد ﯽ ﻪﮐ ﺮﯾدﺎﻘﻣ

LCN-2 ﺶﻫﺎﮐ لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ هوﺮﮔ ود ﻦﯾا رد

رادﺎﻨﻌﻣ ي داد نﺎﺸﻧ ) 05 /0 P<

(.

ﯽﺳرﺮﺑ رد ﻦﯿﺑ ﻦﯾﺮﻤﺗ ،ﯽﻫوﺮﮔ

تاﺮﯿﯿﻐﺗ يزاﻮﻫ و ﯽﺘﻣوﺎﻘﻣ رادﺎﻨﻌﻣ

ي رد ار CTRP-12

و LCN-2 ﻧ دﺮﮐ دﺎﺠﯾا لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴ )

05 /0 P<

( .

ﺘﻧ ﯿ ﻪﺠ ﮔﯿ ﺮ ي : ﻪﺑ ﺮﻈﻧ ﻣ ﯽ ﺪﺳر ﯽﺸﯾاﺰﻓا ﻢﯿﻈﻨﺗ ،يزاﻮﻫ و ﯽﺘﻣوﺎﻘﻣ تﺎﻨﯾﺮﻤﺗ مﺎﺠﻧا ﻪﮐ ﺎﮐﻮﭙﯾدآ

ﻦﯾ يﺎﻫ ﺑﺎﻬﺘﻟاﺪﺿ ﯽ

) CTRP-12 ﭙﯾدآ ﯽﺸﻫﺎﮐ ﻢﯿﻈﻨﺗ و (

ﻦﯿﻟﺎﮐﻮﭙﯿﻟ ﯽﺑﺎﻬﺘﻟا ﻦﯾﺎﮐﻮ -

2 ) LCN-2 .دراد (

دﺎﻨﺘﺳا : حﺎﺘﻓ يﺪﻧﺮﻣ رﻮﭘ ، ﯽﻀﺗﺮﻣ ؛ و بﺎﻨﺑ ﯽﺋﺎﺑﺎﺑ ، زﺎﻤﻟﻮﺳ ﺛﺄﺗ. ﯿﺮ هدزاود ﺮﯾدﺎﻘﻣ ﺮﺑ يزاﻮﻫ و ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ ﯽﻣﺮﺳ

CTRP-12 و

LCN-2 ﻼﺘﺒﻣ نﺎﻧز رد ﺖﺑﺎﯾد ﻪﺑ

عﻮﻧ 2 ﺮﺸﻧ . ﯾﮥ ﯽﺘﺴﯾز مﻮﻠﻋ ﺷزرو

ﯽ . 1402

؛ )2 ( 15 : 45-57 .

2023.357093.1581 jsb.

/ 10.22059 https://doi.org/

DOI:

ﺰﻨﻣﺎﮐ ﻮﯿﺘﯾﺮﮐ ﺲﻨﺴﯾﻻ سﺎﺳا ﺮﺑ ار دﻮﺧ يﺮﮑﻓ ﺖﯿﮑﻟﺎﻣ ﻖﺣ و ﺖﺳا نﺎﮕﯾار ،ﯽﻤﻠﻋ ﮥﯾﺮﺸﻧ ﻦﯾا ﻪﺑ ﯽﺳﺮﺘﺳد )

CC BY-NC 4.0 (

.ﺖﺳا هدﺮﮐ راﺬﮔاو نﺎﮔﺪﻨﺴﯾﻮﻧ ﻪﺑ :ﻪﯾﺮﺸﻧ سردآ|

/ https://jsb.ut.ac.ir :ﻞﯿﻤﯾا|

[email protected]

.ناﺮﻬﺗ هﺎﮕﺸﻧاد تارﺎﺸﺘﻧا :ﺮﺷﺎﻧ .نﺎﮔﺪﻨﺴﯾﻮﻧ©

(4)

ﻪﻣﺪﻘﻣ ،ﺖﺑﺎﯾد يرﺎﻤﯿﺑ ﮏﯿﻟﻮﺑﺎﺘﻣ يرﺎﻤﯿﺑ ﯽﻋﻮﻧ

ﺖﺳا ﻪﮐ ﺖﺳﻻﺎﺑ نﻮﺧ ﺪﻨﻗ ناﺰﯿﻣ نآ رد )1

.(

ﻪﺑ ﺎﯾ ،ﺖﺑﺎﯾد يرﺎﻤﯿﺑ رد ةزاﺪﻧا

زا ﯽﻓﺎﮐ ﻠﺳ لﻮ ﺎﻫ ي يﺎﺘﺑ

ﺢﺷﺮﺗ ﻦﯿﻟﻮﺴﻧا ساﺮﮑﻧﺎﭘ ﻤﻧ

ﯽ دﻮﺷ رد ﯽﻨﯿﻟﻮﺴﻧا ﺖﯿﺳﺎﺴﺣ ﺶﻫﺎﮐ ﺎﯾ لﻮﻠﺳ

ﺎﻫ ي نﺪﺑ ﻪﺑ دﻮﺟو ﻣ ﯽ آﯾ ﺪ ) 2 .(

ﺖﺑﺎﯾد عﻮﻧ 2

) T2DM

ﯽﻋﻮﻧ (

رد لﻼﺘﺧا ﺖﺧﻮﺳ

زﺎﺳو ﺖﺳا نﺪﺑ ﻦﯿﻟﻮﺴﻧا ناﺰﯿﻣ ﻪﺑ ﺦﺳﺎﭘ مﺪﻋ و نﻮﺧ ﺰﮐﻮﻠﮔ ﺢﻄﺳ ندﻮﺑ ﻻﺎﺑ ﻪﺑ ﻪﮐ

ﺢﺷﺮﺗ هﺪﺷ دﺎﺠﯾا ،هﺪﻌﻤﻟازﻮﻟ زا ﻣ

ﯽ دﻮﺷ

)3 .(

ضراﻮﻋ ﻻﺎﺑ نﻮﺧ ﺰﮐﻮﻠﮔ زا ﯽﺷﺎﻧ ﻣ

ﯽ ﺪﻧاﻮﺗ ﻞﻣﺎﺷ ﺑﯿ رﺎﻤ ي ،ﯽﻗوﺮﻋ ـ ﯽﺒﻠﻗ ﻪﺘﮑﺳ

ﺎﻫ

،ﯽﺘﺑﺎﯾد ﯽﺗﺎﭘﻮﻨﯿﺘﯾر ، ﯽﯾﺎﺳرﺎﻧ

ﻠﮐ ﯿﻮ ي و ...

ﺪﺷﺎﺑ ، ﻪﮐ

ﻞﻣاﻮﻋ ﻦﯾا ﺮﺘﺸﯿﺑ ﻪﺑ

ﺐﯾﺮﺨﺗ و ﯽﺑﺎﻬﺘﻟا ﻂﯾاﺮﺷ تاﺮﯿﯿﻐﺗ ﻞﯿﻟد ﺳ

ﯿ ﻟﺎﻨﮕ ﯿ ﮓﻨ ﺎﻫ ي ﻖﯾﺮﻃ زا ﯽﻟﻮﮑﻟﻮﻣ ﺎﻫرﻮﺘﮐﺎﻓ

ي دﺎﺠﯾا ﯽﺑﺎﻬﺘﻟا ﻣ

ﯽ دﻮﺷ ﯽﻗﺎﭼ .

ﻞﻣﺎﻋ ازﺮﻄﺧ ي رد ﯽﻠﺻا عﻮﻧ ﺖﺑﺎﯾد و ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ ﺪﻨﻧﺎﻣ ﯽﮑﯿﻟﻮﺑﺎﺘﻣ تﻻﻼﺘﺧا عاﻮﻧا شﺮﺘﺴﮔ 2

بﻮﺴﺤﻣ ﻣ ﯽ دﻮﺷ ) 4 .(

ﺖﺳا هﺪﺷ نﺎﯿﺑ

زا يژﻮﻟﻮﺗﺎﭘ ﻂﯾاﺮﺷ زا يداﺪﻌﺗ ﺎﺑ ﯽﻗﺎﭼ ﻪﮐ ﻪﺑ ﺖﻣوﺎﻘﻣ ﻪﻠﻤﺟ

رﺪﻨﺳ ،ﻦﯿﻟﻮﺴﻧا و

ﮏﯿﻟﻮﺑﺎﺘﻣ م ،ﺑ

ﯿ رﺎﻤ ي ﺎﻫ ي ﯽﺒﻠﻗ - هاﺮﻤﻫ ود عﻮﻧ ﺖﺑﺎﯾد و ﯽﻗوﺮﻋ

ﺖﺳا ) 5 ( ﻪﮐ رﺎﮐوزﺎﺳ دﺎﺠﯾا اﯾ ﻦ ﻪﻧﻮﮔ ﺳآ ﯿ ﺐ ﺎﻫ ﻪﺑ دآ ﯾ ﺎﮐﻮﭙ ﯾ ﻦ ﺎﻫ ي هداد ﺖﺒﺴﻧ ﺪﯿﻔﺳ ﯽﺑﺮﭼ ﺖﻓﺎﺑ زا ﻪﺤﺷﺮﺘﻣ ﻣ

ﯽ دﻮﺷ ﺖﻓﺎﺑ ﺮﮕﯾد نﺎﯿﺑ ﻪﺑ ؛

ﻦﯾاﺮﮐوﺪﻧا و ﮏﯿﻟﻮﺑﺎﺘﻣ گرﺰﺑ ﺖﻓﺎﺑ نﺪﺑ ﯽﺑﺮﭼ ﺖﺳا

) 6 ( ﻪﮐ ﻪﺑ ﻞﯿﻟد ﻊﯾزﻮﺗ ﻊﯿﺳو نﻮﻣرﻮﻫ ﺎﻫ ي نﺪﺑ ﺮﺳاﺮﺳ رد نآ زا ﻪﺤﺷﺮﺘﻣ ﻣ

ﯽ ﺪﻧاﻮﺗ ﺮﺑ

زا يرﺎﯿﺴﺑ دﺮﮑﻠﻤﻋ ﺳ

ﯿ ﻢﺘﺴ ﺎﻫ دراﺬﮕﺑ ﺖﺒﺜﻣ ﺎﯾ ﯽﻔﻨﻣ ﺮﯿﺛﺄﺗ زا ﺶﯿﺑ ﺢﺷﺮﺗ و ﺪﯿﻟﻮﺗ ﻂﺳﻮﺗ ﺮﯿﺛﺄﺗ ﻦﯾا .

600 رﻮﺘﮐﺎﻓ ﯾﺎﮐﻮﺘﯾﺎﺳﻮﭙﯾدآ مﺎﻧ ﻪﺑ ﯽﺘﺴﯾز ﻦ

دﺎﺠﯾا (ﻦﯾﺎﮐﻮﭙﯾدآ) ﻣ

ﯽ دﻮﺷ ) 7 .(

ﻪﺑ ﮔزﺎﺗ ﯽ ، ﻪﻋﻮﻤﺠﻣ ا ي زا ﺌﺗوﺮﭘ ﯿ ﻦ ﺎﻫ ي ﺎﺑ ﻂﺒﺗﺮﻣ

CTRP۱

ﺪﺷ ﯽﯾﺎﺳﺎﻨﺷ ها

ﻪﮐ ﺪﻧ زا لﻮﻠﺳ ﺎﻫ ي ﯽﺑﺮﭼ ) دآ ﯾ ﺳﻮﭙ ﯿ ﺖ ﺎﻫ ( ﻖﯾﺮﻃ زا و ﺰﺘﻨﺳ

لﻮﻠﺳ ﺎﻫ ي ﯽﺑﺮﭼ ﺖﻓﺎﺑ ﮏﯾﺮﺘﻧﺰﻣ ﺪﯿﻟﻮﺗ

ﻣ ﯽ ﺪﻧﻮﺷ )8 .(

،ﺎﻬﻧآ ﻦﯿﺑ زا ) CTRP-12

ﻦﯿﻟﻮﭙﯾدآ ﻦﯾﺎﮐﻮﭙﯾدآ ﻪﮐ (

ﺑﺎﻬﺘﻟاﺪﺿ ﯽ ﻂﯾاﺮﺷ رد و ﺖﺳا

ﺶﻫﺎﮐ ﺖﺑﺎﯾد و ﯽﻗﺎﭼ ﻣ

ﯽ ﯾ ﺪﺑﺎ نﻮﺧ نﺎﯾﺮﺟ ﺮﯾدﺎﻘﻣ .ﺖﺳا ﻪﺘﻓﺮﮔ راﺮﻗ ﻪﺟﻮﺗ درﻮﻣ ﺮﺘﺸﯿﺑ ،

CTRP-12

رد ﻪﻧﻮﻤﻧ ﺎﻫ ي ﯽﯾاﺬﻏ ﻢﯾژر ﺎﺑ ﯽﻧاﻮﯿﺣ

بﺮﭼﺮﭘ اﺪﯿﭘ ﺶﻫﺎﮐ 2

ﻣ ﯽ ﺪﻨﮐ ) 9 .(

ةرﺎﺑرد

12 - ﮫﺑCTRP ناﻮﻨﻋ ﯾدآ ،ﺪﯾﺪﺟ ﻦﯾﺎﮐﻮﭙ نﺎﯿﺑ

ﯽﺑﺮﭼ ﺖﻓﺎﺑ رد ﻦﯾﺎﮐﻮﭙﯾدآ ﻦﯾا ﻪﮐ ﺖﺳا هﺪﺷ ﻪﺑ

وﯾ هﮋ رد

دآ ﯾ ﺳﻮﭙ ﯿ ﺖ ﺎﻫ نﺎﯿﺑ ﻣ ﯽ دﻮﺷ ياراد و تاﺮﯿﺛﺄﺗ ﺶﯾاﺰﻓا نﺎﯿﺑ و ﺖﺳا ﯽﺑﺎﻬﺘﻟاﺪﺿ و ﻦﯿﻟﻮﺴﻧا ﻪﺑ ﺖﯿﺳﺎﺴﺣ

CTRP-12

و ﺖﺑﺎﯾد ،ﯽﻗﺎﭼ ﻂﯾاﺮﺷ رد

ﺶﻫﺎﮐ بﺎﻬﺘﻟا ﻣ

ﯽ ﯾ ﺪﺑﺎ ) 10 ( يﺎﻘﻟا ﺐﺒﺳ ﯽﻗﺎﭼ ﻂﯾاﺮﺷ و ﺦﺳﺎﭘ

ﺎﻫ ي ﺘﺳا ،ﯽﺑﺎﻬﺘﻟا رد ﯽﺸﯾﺎﺴﮐا سﺮﺘﺳا و ﮏﯿﻤﺳﻼﭘوﺪﻧا ﻪﮑﺒﺷ سﺮ

دآ ﯾ ﺳﻮﭙ ﯿ ﺖ ﺎﻫ ﻣ ﯽ دﻮﺷ ﺶﻫﺎﮐ رد ﻞﻣاﻮﻋ ﻦﯾا مﺎﻤﺗ ﻪﮐ ،

CTRP-12

ﺛﺄﺗ ﯿ ﺪﻧراﺬﮔﺮ )9 ( . زا ﯽﮑﯾ رد ﻘﯿﻘﺤﺗ

تﺎ شراﺰﮔ ﺎﺑ نارﺎﻤﯿﺑ ﻪﮐ ﺖﺳا هﺪﺷ

ﯽﻠﭘ ناﺪﻤﺨﺗ مورﺪﻨﺳ عﻮﻧ ﺖﺑﺎﯾد و ﯽﻗﺎﭼ رﺎﭼد ﻪﮐ ﮏﯿﺘﺴﯿﮐ

2 ﯽﺘﻓﺎﺑ و ﯽﯾﺎﻤﺳﻼﭘ حﻮﻄﺳ ،ﺪﻧدﻮﺑ )

ﯽﺑﺮﭼ ( ﺎﭘ ﯿﯾ ﻦ ﺮﺗ ﭙﯾدآ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ار ﻦﯿﻟﻮ

ﺪﻨﺘﺷاد لﺮﺘﻨﮐ )

11 .(

ﯽﻣﺮﺳ ﺖﻈﻠﻏ -12

ﯽﻧﺪﺑ ةدﻮﺗ ﺺﺧﺎﺷ ﺎﺑ ﯽﻔﻨﻣ ﯽﮕﺘﺴﺒﻤﻫCTRP

ﻦﮕﻟ ﻪﺑ ﺮﻤﮐ رود ﺖﺒﺴﻧ3

) (WHR

ﺰﮐﻮﻠﮔ حﻮﻄﺳ و

دراد ) 11 .(

نﺎﻤﮔ ﻪﺠﯿﺘﻧ رد ﻣ

ﯽ ور د دراد طﺎﺒﺗرا ﺖﺑﺎﯾد ﺎﯾ ﯽﻗﺎﭼ ﺎﺑ ﻦﯿﻟﻮﭙﯾدآ نﻮﺧ نﺎﯾﺮﺟ ﺮﯾدﺎﻘﻣ ﻪﮐ ﮏﯿﺗﺎﻤﺘﺴﯿﺳ ﻊﯾزﻮﺗ ﻪﮐ ﺖﺳا هﺪﺷ نﺎﯿﺑ .

CTRP-12

رد ﯽﻨﯿﻟﻮﺴﻧا ﺖﯿﺳﺎﺴﺣ و ﺰﮐﻮﻠﮔ ﻞﻤﺤﺗ دﻮﺒﻬﺑ ﺐﺒﺳ شﻮﻣ

ﺎﻫ ي بﺮﭼﺮﭘ ﯽﯾاﺬﻏ ﻢﯾژر ﺎﺑ قﺎﭼ ﻣ

ﯽ دﻮﺷ ﻊﯾزﻮﺗ ﻦﯿﻨﭽﻤﻫ ،

CTRP-

ﺐﺟﻮﻣ12

نژ نﺎﯿﺑ و ﺎﻫژﺎﻓوﺮﮐﺎﻣ ذﻮﻔﻧ ﻞﯿﻠﻘﺗ ﺶﯿﭘ

ﯽﺑﺮﭼ ﺖﻓﺎﺑ رد ﯽﺑﺎﻬﺘﻟا شﻮﻣ

ﺎﻫ ي قﺎﭼ ﻣ ﯽ دﻮﺷ ) 12 ( ﻦﯾا ﺎﺑ ﻮﺴﻤﻫ . ﯾ

ﻪﺘﻓﺎ ﺎﻫ هﺪﺷ شراﺰﮔ

ﻪﮐ ﺖﺳا

CTRP-12

ﺖﯿﺳﺎﺴﺣ دﻮﺒﻬﺑ ﺐﺒﺳ رد ﯽﺑﺮﭼ ﺖﻓﺎﺑ و ﺪﺒﮐ ﯽﻨﯿﻟﻮﺴﻧا ﮓﻨﯿﻟﺎﻨﮕﯿﺳ ﻖﯾﺮﻃ زا ﯽﻨﯿﻟﻮﺴﻧا

شﻮﻣ ﺎﻫ ي قﺎﭼ ﻣ ﯽ دﻮﺷ ) 13 .(

) ﺖﯿﺳﻮﺗﺎﭙﻫ نﺎﻣرد لﻮﻠﺳ

ﺎﻫ ي و (يﺪﺒﮐ دآ ﯾ ﺳﻮﭙ ﯿ ﺖ ﺎﻫ ي ﺖﺸﮐ ﺎﺑ هﺪﺷ

CTRP-12

ﺮﯿﺴﻣ زﺎﻨﯿﮐ ﻦﯿﺌﺗوﺮﭘ ﮓﻨﯿﻟﺎﻨﮕﯿﺳ ) B

لﺎﻌﻓ ار (Akt

ﻣ ﯽ ﺪﻨﮐ

ﺮﺠﻨﻣ ﺰﮐﻮﻠﮔ فﺮﺼﻣ ﺶﯾاﺰﻓا و ﺰﻧژﻮﺌﻧﻮﮐﻮﻠﮔ رﺎﻬﻣ ﻪﺑ و ﻣ

ﯽ دﻮﺷ ) 13 ( . ﮏﯿﻤﺘﺴﯿﺳ ﻖﯾرﺰﺗ ﻪﮐ ﺖﺳا هﺪﺷ نﺎﯿﺑ ،ﻪﺠﯿﺘﻧ رد CTRP-12

ﺐﺟﻮﻣ

رد ﻦﯿﻟﻮﺴﻧا ﻪﺑ ﺖﻣوﺎﻘﻣ ﺶﻫﺎﮐ و ﺰﮐﻮﻠﮔ ﻞﻤﺤﺗ ﺶﻫﺎﮐ شﻮﻣ

ﺎﻫ ي قﺎﭼ بﺮﭼﺮﭘ ﯽﯾاﺬﻏ ﻢﯾژر ﺎﺑ هﺪﺷ ﻣ

ﯽ دﻮﺷ ) 14 .(

هوﻼﻋ ﺮﺑ

،ﻦﯾا

CTRP-12

ﺎﻫژﺎﻓوﺮﮐﺎﻣ ﻊﻤﺠﺗ ﺶﻫﺎﮐ ﺐﺒﺳ

رد دآ ﯾ ﺳﻮﭙ ﯿ ﺖ ﺎﻫ نژ نﺎﯿﺑ ﺶﻫﺎﮐ و ﺎﺳ

ﯾ ﺎﮐﻮﺘ ﯾ ﻦ ﺎﻫ ي ﭘﯿ ﺶ ﺑﺎﻬﺘﻟا ﯽ رد ﺖﻓﺎﺑ

ﯽﺑﺮﭼ شﻮﻣ ﺎﻫ ي قﺎﭼ ﻣ ﯽ دﻮﺷ ) 15 ( و ﻣ ﯽ ﺪﻧاﻮﺗ ﺮﯾﺎﺳ ﺎﺑ دآ ﯾ ﺎﮐﻮﭙ ﯾ ﻦ ﺎﻫ زا ﻪﮐ ﺪﺷﺎﺑ ﻪﺘﺷاد طﺎﺒﺗرا ﻠﻤﺟ

ﮥ ﻦﯾا دآ ﯾ ﺎﮐﻮﭙ ﯾ ﻦ ﺎﻫ ﻣ ﯽ ناﻮﺗ ﻦﯿﻟﺎﮐﻮﭙﯿﻟ ﻪﺑ 2

4) -2

( LCN

دﺮﮐ هرﺎﺷا .

شراﺰﮔ ﺎﻫ ي ﺧا ﯿ ﺮـ ﺑﯿ ﺮﮕﻧﺎـ نآ ﺖﺳا ﻪﮐ اﯾ ﻦ دآ ﯾ ﮐﻮﭙ ﯿ ﻦ ﻮـﻧ ﯾ ﻪـﺘﻓﺎ ﻪﺑ ناﻮﻨﻋ ﯾ ﮏـ ﺺﺧﺎـﺷ ﺑﺎﻬﺘﻟا

ﯽ ﺎﺑ ، ﻗﺎﭼ ﯽ بﺎﻬﺘﻟا و

1. C1q/TNF-Related Protein (CTRP)

2. High Fat Diet (HFD)

3. Body Mass Index (BMI)

4. Lipocalin-2

(5)

ﺛﺄﺗ ﯿ ﺮ 12 ﯽﻣﺮﺳ ﺮﯾدﺎﻘﻣ ﺮﺑ يزاﻮﻫ و ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ CTRP-12

و LCN-2 عﻮﻧ ﺖﺑﺎﯾد ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز رد

2 49

ﺷﺎﻧ ﯽ ﺖﺳا ﻂﺒﺗﺮﻣ نآ زا )

16 .(

اﯾ ﻦـ ﺌﺗوﺮﭘ ﯿ ﻦ ﻪﮐ زا ﺎﻀﻋا ي داﻮﻧﺎﺧ ة ﻟﯿ ﻟﺎـﮐﻮﭙ ﯿ ﻦ ﺎـﻫ ،ﺖـﺳ ﻪﺑ ناﻮﻨﻋ ﻟﯿ ﻟﺎﮐﻮﭙ ﯿ ﻦ ﻪﺑ ﻞﺼﺘﻣ ﺗﻻژ

ﯿ زﺎﻨ

ﻓوﺮﺗﻮﻧ ﯿ ﻞـ

1) NGAL

و ( 3

24 P

و

2

ﺖـﺳا هﺪﺷ ﻪﺘﺧﺎﻨﺷ lcn

) 17 .(

اﯾ ﻦ ﺌﺗوﺮﭘ ﯿ ﻦ ﻪﺑ ناﻮﻨﻋ ﯾ ﮏـ ﺌﺗوﺮـﭘ ﯿ ﻦ ﻞـﻣﺎﺣ اﺮﺑ ي لﻮﮑﻟﻮﻣ ﺎﻫ ي

ﻫﯿ بﻮﻓورﺪ ﮏﭼﻮﮐ ﺶﻘﻧ ﻦﻫآ ﻪﻠﻤﺟ زا اﯾ

ﺎﻔ ﻣ ﯽ ﺪﻨﮐ . ﻨﭽﻤﻫ ﯿ ﻦ ﻪﺑ ناﻮﻨﻋ ﺸﺨﺑ ﯽ هﺎﮕﺘﺳد زا اﯾ

ﻨﻤ ﯽ ـﺗاذ ﯽ

، ﺶﻘﻧ ﻠﮐ ﯿﺪ ي ﻪـﺑ دﺎـﺣ زﺎـﻓ ﺦﺳﺎﭘ رد

ﺎـﻘﻟا و ﺖـﻧﻮﻔﻋ ي

زﻮـﺘﭘﻮﭘآ دراد ) 17 .(

نﺎﺸﻧ هزوﺮﻣا تﺎﻘﯿﻘﺤﺗ ﻣ

ﯽ ﺪﻨﻫد ﻦﯿﺑ ﺺﺧﺎﺷ ﺎﻫ ي ﺢﻄﺳ و ﯽﮑﯿﻟﻮﺑﺎﺘﻣ

LCN-2 طﺎﺒﺗرا

رادﺎﻨﻌﻣ دﻮﺟو ﯽﺘﺒﺜﻣ دراد

) 18 .(

زا ﯽﮑﯾ شور ﺎﻫ ي

اﺮﺑ ﺪﯿﻔﻣ رﺎﯿﺴﺑ ﻪﮐ ﺖﺳا ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ مﺎﺠﻧا ﯽﮔﺪﻧز ﺪﻧور دﻮﺒﻬﺑ ي

ﺐﺒﺳ زا يﺮﯿﮔﻮﻠﺟ ﺑﯿ

رﺎﻤ ي ﺎﻫ ي ﻠﻗ و ﯽﮑﯿﻟﻮﺑﺎﺘﻣ ﯽﺒ

- ﯽﻗوﺮﻋ ﻣ ﯽ دﻮﺷ و

ﻣ ﯽ ﺪﻧاﻮﺗ ﺐﺒﺳ دﻮﺷ نﻮﺧ ﺰﮐﻮﻠﮔ ﺶﻫﺎﮐ و ﯽﻨﯿﻟﻮﺴﻧا ﺖﻣوﺎﻘﻣ دﻮﺒﻬﺑ )

19 .(

ﻦﯿﻨﭽﻤﻫ ﻟﺎﻌﻓ

ﯿ ﺖ ﺎﻫ ي رد ﯽﻧﺪﺑ ﮐ

هﺎﺗﻮ تﺪﻣ و تﺪﻣﺪﻨﻠﺑ رد و

تﺪﺷ ﺎﻫ ي ﻣ ،ﯽﻨﯾﺮﻤﺗ ﻒﻠﺘﺨ ﻣ

ﯽ ﺪﻧاﻮﺗ ناﺰﯿﻣ ﺮﺑ دآ ﯾ ﮐﻮﭙ ﯿ ﻦ ﺎﻫ ﺛﺄﺗ ﯿ راﺬﮔﺮ ﺪﺷﺎﺑ ) 19 .(

ﻪﺑ ﺮﻈﻧ ﻣ ﯽ ﺪﺳر دﺮﮑﻠﻤﻋ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ

CTRP-12

ر ﺖﺤﺗ ا

نارﺎﮑﻤﻫ و نﺎﯿﺋﺎﺿر ﻪﻨﯿﻣز ﻦﯾا رد .ﺪﻫد راﺮﻗ ﺮﯿﺛﺄﺗ )

1399 ( ﻪﺑ ﻦﯾﺮﻤﺗ دﺎﺣ ﺮﯿﺛﺄﺗ ﯽﺳرﺮﺑ زاﻮﻫ

ي ﺎﻘﻣ ﺮﺑ ﻣاﻮﻋ ﯽﺧﺮﺑ و ﻦﯿﻟﻮﭙﯾدآ ﯽﻣﺮﺳ ﺮﯾد ﻞ

آ ﯽﺸﻫﺎﮐ تاﺮﯿﯿﻐﺗ و ﺪﻨﺘﺧادﺮﭘ ﻪﺴﺋﺎﯾ قﺎﭼ نﺎﻧز رد ﯽﺑﺎﻬﺘﻟا ﺪﻧداد نﺎﺸﻧ ار ﻦﯾﺮﻤﺗ ﻪﺴﻠﺟ ﮏﯾ ﺎﺑ ﻦﯿﻟﻮﭙﯾد

) 20 .(

ﻦﯾا ﯽﻟﺎﺣ رد ﺑ ﻪﮐ دﻮ ﺖﻤﺣر ﻬﻠﻟا ﯽ

نارﺎﮑﻤﻫ و )

1396 ﺶﯾاﺰﻓا ( ﯽﭘ رد ار ﻦﯿﻟﻮﺴﻧا ﻪﺑ ﺖﻣوﺎﻘﻣ ﺶﻫﺎﮐ و ﯽﯾﺎﻤﺳﻼﭘ ﻦﯿﻟﻮﭙﯾدآ رادﺎﻨﻌﻣ

ﺖﺸﻫ ﺘﻔﻫ ﻦﯾﺮﻤﺗ ﻪ زاﻮﻫ

ي ﯽﻣواﺪﺗ )ﭘ ﺞﻨ

ﯾاﺰﻓ تﺪﺷ ﺎﺑ ﻪﺘﻔﻫ رد ﻪﺴﻠﺟ زا هﺪﻨ

5 ﺎﺗ 10 ﻪﺑ ﻪﻘﯿﻗد ﺮﺑ ﺮﺘﻣ 22

ﺮﺘﻣ ﺮﺑ ﻪﻘﯿﻗد رد(

تر يﺎﻫ قﺎﭼ ﺎﺑ هﺪﺷ ) ﺪﻧداد نﺎﺸﻧHFD

21 .(

) نارﺎﮑﻤﻫ و هﮋﯿﺑ 1391

و يزاﻮﻫ ﻦﯾﺮﻤﺗ ﺮﺛا ( هزور

راد ي ﻦﯿﻟﺎﮐﻮﭙﯿﻟ ﺢﻄﺳ ﺮﺑ ار -

2 ﻞﯾﺎﻓوﺮﭘ و ﻟ

نزو ﻪﻓﺎﺿا ياراد داﺮﻓا رد يﺪﯿﭙﯿ ﯽﺳرﺮﺑ

ﺪﻧدﺮﮐ ﻪﮐ ﺪﻧﺪﯿﺳر ﻪﺠﯿﺘﻧ ﻦﯾا ﻪﺑ و هزور

راد ي يزاﻮﻫ تﺎﻨﯾﺮﻤﺗ مﺎﺠﻧا و ﺐﺒﺳ

ﺶﻫﺎﮐ رادﺎﻨﻌﻣ ﺎﮐﻮﭙﯿﻟ ﯿﻟ ﻦ 2 دﻮﺒﻬﺑ و ﺳ رد يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ ﺢﻄ

ﯽﻗﺎﭼ ﻪﺑ ﻼﺘﺒﻣ داﺮﻓا ﻣ

ﯽ دﻮﺷ ) 22 مﺎﺠﻧا يﺮﮕﯾد ﻖﯿﻘﺤﺗ ،نارﺎﮑﻤﻫ و هﮋﯿﺑ تﺎﻘﯿﻘﺤﺗ ﺞﯾﺎﺘﻧ ﺎﺑ ﻮﺴﻤﻫﺎﻧ .(

ﺖﻓﺮﮔ ﺎﮑﻤﻫ و يﻮﭼ و نار

) 2009 ﺑ ( ﻪ

ﻦﯿﻟﺎﮐﻮﭙﯿﻟ ﯽﻣﺮﺳ ﺢﻄﺳ ناﺰﯿﻣ ﺮﺑ ﯽﺘﻣﺎﻘﺘﺳا و ﯽﺗرﺪﻗ تﺎﻨﯾﺮﻤﺗ مﺎﺠﻧا ﻪﮐ ﺪﻧﺪﯿﺳر ﻪﺠﯿﺘﻧ ﻦﯾا ﺛﺄﺗ

ﯿﺮ ادﺎﻨﻌﻣ ر ي راﺪﻧ ) د 23 .(

و دوﺪﺤﻣ ﺞﯾﺎﺘﻧ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﻨﺘﻣ

ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ و ،درﻮﻣ ﻦﯾا رد ﺾﻗﺎ رﺎﮐوزﺎﺳ

تﺎﻨﯾﺮﻤﺗ مﺎﺠﻧا يراﺬﮔﺮﺛا ﺮﺑ ﯽﻧﺪﺑ

نزو ﺶﻫﺎﮐ ﻪﮐ

ﻪﺑ ﺳو ﯿﻠ ﮥ ﺮﯿﯿﻐﺗ

رد ﺌﺗوﺮﭘ ﯿ ﻦ ﺎﻫ ي هوﺮﮔ

CTRP-12 , ﻦﯿﻟﺎﮐﻮﭙﯿﻟ و

- 2 دﺎﺠﯾا ﻣ ﯽ دﻮﺷ

، دراد تروﺮﺿ .دﻮﺷ ﻪﺘﺧادﺮﭘ عﻮﺿﻮﻣ ﻦﯾا ﻪﺑ ﻪﮐ

ﻪﺑ رﻮﻈﻨﻣ ﮥﻌﺳﻮﺗ ﻦﯿﺑ ﺖﻣﻼﺳ يزاﻮﻫ تﺎﻨﯾﺮﻤﺗ مﺎﺠﻧا ،ﻪﻌﻣﺎﺟ داﺮﻓا

ﻣ ﯽ ﺪﻧاﻮﺗ ﺎﭼد ﻪﮐ يداﺮﻓا ﻪﺑ ﺘﺴﻫ نزو ﻪﻓﺎﺿا ر

ﺪﻨ

، ﻨﮐ ﮏﻤﮐ ﺪ ) 24 .(

ﺎﻨﻋ ﺎﺑ ﯾ ﺖ ﺐﻟﺎﻄﻣ ﻪﺑ ﻪﺋارا

هﺪﺷ ﺶﺳﺮﭘ ﺎﯾآ ﻪﮐ ﺖﺳا ﻦﯾا ﺶﻫوﮋﭘ 12

ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ زاﻮﻫ و

ي ﺮﺑ ﺎﻘﻣ دﯾ ﺮ ﻣﺮﺳ ﯽ CTRP-12

و LCN-2 د ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز رد

ﯾ ﺖﺑﺎ عﻮﻧ 2 ﺛﺄﺗ ﯿﺮ

؟ﺮﯿﺧ ﺎﯾ دراد

شور ﺳﺎﻨﺷ ﯽ ﺶﻫوﮋﭘ

ﺮﺿﺎﺣ ﺶﻫوﮋﭘ شور ﻪﻤﯿﻧ

حﺮﻃ ﺐﻟﺎﻗ رد و دﻮﺑ ﯽﺑﺮﺠﺗ ﭘﯿ

ﺶ نﻮﻣزآ - ﺲﭘ نﻮﻣزآ ﺠﺗ و لﺮﺘﻨﮐ هوﺮﮔ ﺎﺑ ﺪﺷ اﺮﺟا ﯽﺑﺮ

. ﮥﻌﻣﺎﺟ آ ﺶﻫوﮋﭘ يرﺎﻣ

عﻮﻧ ﺖﺑﺎﯾد ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز مﺎﻤﺗ ﻞﻣﺎﺷ 2

ﻪﻌﺟاﺮﻣ هﺪﻨﻨﮐ ﻪﮐ دﻮﺑ ﻪﯿﻣورا نﺎﺘﺳﺮﻬﺷ ﯽﻧﺎﻣرد ﺰﮐﺮﻣ ﻪﺑ ﻦﯿﺑ زا

55 نز ﺎﯾد ﻪﺑ ﻼﺘﺒﻣ عﻮﻧ ﺖﺑ

2 زا ﻪﮐ

ﺷ ﻦﺳ رد يوﺎﺴﻣ ﻂﯾاﺮ )

40-45 (لﺎﺳ لﻮﻃ ،يرﺎﻤﯿﺑ ، رود

ة ﺮﺑ نﺎﻣرد شور و نﺎﻣرد ﺪﻧدﻮﺑ رادرﻮﺧ

، 30 يرﺎﻤﯿﺑ ﻪﺑ ﻼﺘﺒﻣ نز د

عﻮﻧ ﺖﺑﺎﯾ 2

ﻪﺑ ترﻮﺻ و بﺎﺨﺘﻧا ﻪﻧﺎﺒﻠﻃواد ﻪﺑ

ترﻮﺻ هدﺎﺳ ﯽﻓدﺎﺼﺗ ﻪﺑ

ﻪﺳ ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ هوﺮﮔ )

10 ﺗ ،(ﺮﻔﻧ ) يزاﻮﻫ ﻦﯾﺮﻤ 10

) لﺮﺘﻨﮐ هوﺮﮔ و (ﺮﻔﻧ 10

.ﺪﻧﺪﺷ ﻢﯿﺴﻘﺗ (ﺮﻔﻧ ﻮﻣزآ ﻧد ﯽ ﺎﻫ ﻣﺎﻨﺸﺳﺮﭘ ﮥ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ رد ﺖﮐﺮﺷ ﯽﮔدﺎﻣآ و ﯽﮑﺷﺰﭘ

PAR-Q )

Physical Activity Readiness Questionnaire (

.ﺪﻧدﺮﮐ ﺮﭘ ار دورو يﺎﻫرﺎﯿﻌﻣ

ﺖﮐﺮﺷ نﺎﮔﺪﻨﻨﮐ ﻞﻣﺎﺷ عﻮﻧ ﺖﺑﺎﯾد ﻪﺑ ﻼﺘﺑا 2

يﻻﺎﺑ يﺎﺘﺷﺎﻧ ﺰﮐﻮﻠﮔ ، 126

ﻣ ﯿﻠ ﯽ مﺮﮔ ﺮﺘﯿﻟ ﯽﺳد ﺮﺑ و

ﻦﺘﺷاﺪﻧ

ﻓ تﺪﻣ ﻪﺑ ﻢﻈﻨﻣ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌ ﺶﺷ

دﻮﺑ هﺎﻣ ) 25 .(

جوﺮﺧ يﺎﻫرﺎﯿﻌﻣ ﻦﯿﻨﭽﻤﻫ ﺖﮐﺮﺷ

نﺎﮔﺪﻨﻨﮐ زا

ﻖﯿﻘﺤﺗ ترﺎﺒﻋ ﻞﯾﺎﻤﺗ زا دﻮﺑ ﻦﺘﺷاﺪﻧ

ﻧدﻮﻣزآ ﯽ ﺎﻫ ﻪﺑ ﻪﻣادا نداد ﻣﺎﻧﺮﺑ ﮥ ،ﯽﻨﯾﺮﻤﺗ ﺳآ ﯿ ﺐ دﯾ ﮔﺪ ﯽ رد ﺖﮐﺮﺷ مﺪﻋ و ﻪﻣﺎﻧﺮﺑ

ﺎﻫ ي زا ﺶﯿﺑ ﯽﻨﯾﺮﻤﺗ ود

ﮥﺴﻠﺟ و ﯽﻟاﻮﺘﻣ ﻪﺳ

ﮥﺴﻠﺟ

1. neutrophil gelatinase-associated lipocalin

(6)

.ﯽﻟاﻮﺘﻣﺮﯿﻏ ﻧدﻮﻣزآ

ﯽ ﺎﻫ ي هوﺮﮔ ﯽﺑﺮﺠﺗ تﺪﻣ ﻪﺑ 12 ﺘﻔﻫ رد ﻪﺴﻠﺟ ﻪﺳ و ﻪﺘﻔﻫ لﺮﺘﻨﮐ هوﺮﮔ .ﺪﻨﺘﺧادﺮﭘ ﯽﺷزرو تﺎﻨﯾﺮﻤﺗ ﻪﺑ ﻪ

نﺎﻣز تﺪﻣ ﻦﯾا رد

ﺪﻨﺘﺷاﺪﻧ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ﺮﮐذ نﺎﯾﺎﺷ .

ﻪﮐ ﺖﺳا ﺶﯿﭘ

عوﺮﺷ زا ﺶﻫوﮋﭘ رد ﺴﻠﺟ ﮥ ﯽﻬﯿﺟﻮﺗ ﻣﺎﻤﺗ ﯽ ﻪﻣﺎﻧﺮﺑ ﺎﻫ ، ﻮﯿﺷ ة و تﺎﻨﯾﺮﻤﺗ ياﺮﺟا ﺢﯿﺤﺻ

ﺮﻄﺧ يﺎﻫ ياﺮﺑ ﯽﻟﺎﻤﺘﺣا ﺖﮐﺮﺷ

نﺎﮔﺪﻨﻨﮐ و ﺪﺷ هداد ﺢﯿﺿﻮﺗ ﮥﻤﻫ

ﺖﮐﺮﺷ نﺎﮔﺪﻨﻨﮐ مﺮﻓ ﺎﺿر ﯾ ﺖ ﻪﻣﺎﻧ ﺮﭘ ار مﺮﻓ ﻦﯾا رد .ﺪﻧدﺮﮐ ﮐﺄﺗ

ﯿﺪ دﻮﺑ هﺪﺷ

ﺖﮐﺮﺷ ﻪﮐ زا جوﺮﺧ و

ﻖﯿﻘﺤﺗ ﻂﺳﻮﺗ نﺎﺒﻠﻃواد

ًﻼﻣﺎﮐ و ﺖﺳا يرﺎﯿﺘﺧا و دازآ ﮥﻤﻫ

ﺐﻠﻃواد تﺎﻋﻼﻃا

ًﻼﻣﺎﮐ ﺞﯾﺎﺘﻧ و ﺖﺳا ﻪﻧﺎﻣﺮﺤﻣ ﺶﻫوﮋﭘ

ﺎﻫ

زا ﯽﮑﯾ ﻪﮑﻨﯾا ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﻦﯿﻨﭽﻤﻫ .ﺪﺷ ﺪﻫاﻮﺧ ﺮﺸﺘﻨﻣ ﯽﻫوﺮﮔ و ﯽﻠﮐ تﺎﻋﻼﻃا ﺐﻟﺎﻗ رد دوﺪﺤﻣ

ﯾ ﺖ ﺎﻫ ي ﻦﯾا ﺶﻫوﮋﭘ ﮐ مﺪﻋ ﻢﯾژر ﻖﯿﻗد لﺮﺘﻨ

ﯽﯾاﺬﻏ ﻧدﻮﻣزآ ﯽ ﺎﻫ دﻮﺑ

، و لﻮﻤﻌﻣ ﻢﯾژر ﻪﮐ ﺪﺷ ﻪﺘﺳاﻮﺧ ﺎﻬﻧآ زا ﻦﯾاﺮﺑﺎﻨﺑ ﮥﻧازور

فﺮﺼﻣ زا و ﺪﻨﻫﺪﻧ ﺮﯿﯿﻐﺗ ار دﻮﺧ ﻪﻧﻮﮔﺮﻫ

ﻞﻤﮑﻣ و ﯽﻓﺎﺿا ياﺬﻏ

.ﺪﻨﻨﮐ ﺰﯿﻫﺮﭘ ﯽﯾاﺬﻏ

هزاﺪﻧا ﮔﯿ ﺮ ي ﮏﯾﺮﺘﻣﻮﭘوﺮﺘﻧآ ﺺﺧﺎﺷ

ﺺﺧﺎﺷ ﺎﻫ ي ) ﺪﻗ ﺪﻨﻧﺎﻣ ﯽﮑﯾﺮﺘﻣﻮﭘوﺮﺘﻧآ ﺘﻧﺎﺳ

ﯽ ﺮﺘﻣ زا هدﺎﻔﺘﺳا ﺎﺑ ( ﺘﻧﺎﺳ

ﯽ ﺘﻣ ﺮ (مﺮﮔﻮﻠﯿﮐ) نزو ،يراﻮﻧ هدﺎﻔﺘﺳا ﺎﺑ

ا يوزاﺮﺗ ز د

ﺺﺧﺎﺷ ،ﯽﻟﺎﺘﯿﺠﯾ

ةدﻮﺗ ﻦﮕﻟ ﻪﺑ ﺮﻤﮐ رود ﺖﺒﺴﻧ ،(ﺮﺘﻣ) ﺪﻗ روﺬﺠﻣ ﻪﺑ (مﺮﮔﻮﻠﯿﮐ) نزو ﻢﯿﺴﻘﺗ زا هدﺎﻔﺘﺳا ﺎﺑ ﯽﻧﺪﺑ )

(WHR

ﺎﺑ ا ترﺪﻗ ،يراﻮﻧ ﺮﺘﻣ زا هدﺎﻔﺘﺳ

) ﻪﻨﯿﺸﯿﺑ راﺮﮑﺗ ﮏﯾ راﺪﻘﻣ و ﯽﻧﻼﻀﻋ شور زا هدﺎﻔﺘﺳا ﺎﺑ (1RM

) Brzycki

ﺑ ﺐﻠﻗ نﺎﺑﺮﺿ و(

زا هدﺎﻔﺘﺳا ﺎ ﺮﺿ

نﺎﺑ رﻼﭘ ﺞﻨﺳ هزاﺪﻧا

ﮔﯿ ﺮ ي .ﺪﺷ

ﮥﻣﺎﻧﺮﺑ ﯽﻨﯾﺮﻤﺗ

يزاﻮﻫ تﺎﻨﯾﺮﻤﺗ ﯽﺑوﺎﻨﺗ

تﺪﻣ ﻪﺑ 12 ) تﺪﻣ ﯽﺠﯾرﺪﺗ ﺶﯾاﺰﻓا ﺎﺑ و ﻪﺘﻔﻫ رد ﻪﺴﻠﺟ ﻪﺳ ،ﻪﺘﻔﻫ 20

ﺎﺗ 60 ) ﻦﯾﺮﻤﺗ تﺪﺷ و (ﻪﻘﯿﻗد 60

ﺎﺗ 75

ﺐﻠﻗ نﺎﺑﺮﺿ ﺪﺻرد هﺮﯿﺧذ

) يزاﻮﻫ تﺎﻨﯾﺮﻤﺗ .ﺪﺷ اﺮﺟا ((RHR

ﯽﺑوﺎﻨﺗ رد ﺘﻔﻫ ﻪ يﺎﻫ ﻪﺑ مود و لوا تﺪﻣ

20 تﺪﺷ ﺎﺑ ﻪﻘﯿﻗد 60

نﺎﺑﺮﺿ ﺪﺻرد

ﺐﻠﻗ هﺮﯿﺧذ رد و ﺘﻔﻫ ﻪ يﺎﻫ 11 و 12 تﺪﻣ ﻪﺑ 60 ﺎﺑ ﻪﻘﯿﻗد 75 ﺐﻠﻗ نﺎﺑﺮﺿ ﺪﺻرد هﺮﯿﺧذ

ﺮﻫ .ﺪﺷ اﺮﺟا1

ﮥﺴﻠﺟ ﻞﻣﺎﺷ ﯽﻨﯾﺮﻤﺗ 10

مﺮﮔ ﻪﻘﯿﻗد

،(ﯽﺸﺸﮐ تﺎﮐﺮﺣ و ﻊﯾﺮﺳ ﻦﺘﻓر هار) ندﺮﮐ .دﻮﺑ (ﯽﺸﺸﮐ تﺎﮐﺮﺣ و ﻪﺘﺴﻫآ يود) ندﺮﮐ دﺮﺳ ﻪﻘﯿﻗد ﺞﻨﭘ و

ﺑ ﯽﺘﻣوﺎﻘﻣ تﺎﻨﯾﺮﻤﺗ تﺪﻣ ﻪ

12

ﺟ ﻪﺳ ،ﻪﺘﻔﻫ ﯽﺠﯾرﺪﺗ ﺶﯾاﺰﻓا ﺎﺑ و ﻪﺘﻔﻫ رد ﻪﺴﻠ

) ﻦﯾﺮﻤﺗ 30-75 رد .ﺪﺷ اﺮﺟا (ﻪﻨﯿﺸﯿﺑ راﺮﮑﺗ ﮏﯾ ﺪﺻرد ﮥﺘﻔﻫ

ﺖﺳ ود ﺎﺑ لوا 10

و يراﺮﮑﺗ

تﺪﺷ 30 رد و ﻪﻨﯿﺸﯿﺑ راﺮﮑﺗ ﮏﯾ ﺪﺻرد ﮥﺘﻔﻫ

تﺪﺷ و يراﺮﮑﺗ ﺖﺸﻫ ﺖﺳ ﻪﺳ ﺎﺑ ﻢﻫدزاود 70

ﺮﻫ .ﺪﺷ اﺮﺟا ﻪﻨﯿﺸﯿﺑ راﺮﮑﺗ ﮏﯾ ﺪﺻرد ﮥﺴﻠﺟ

ﻞﻣﺎﺷ ﯽﻨﯾﺮﻤﺗ 10

د تﺪﺷ ﺎﺑ ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ ،(ﯽﺸﺸﮐ تﺎﮐﺮﺣ و ﻪﺘﺴﻫآ يود) ندﺮﮐ مﺮﮔ ﻪﻘﯿﻗ 30

- 70 ياﺮﺑ ﻪﻨﯿﺸﯿﺑ راﺮﮑﺗ ﮏﯾ ﺪﺻرد

وزﺎﺑ يﻮﻠﺟ ،هﺪﯿﺑاﻮﺧ نار ﺖﺸﭘ ،نار يﻮﻠﺟ هﺎﮕﺘﺳد ﻪﻧﺎﺷﺮﺳ سﺮﭘ ،هﺎﮕﺘﺳد ﻪﻨﯿﺳ سﺮﭘ) تﺎﮐﺮﺣ ﺳ

ﯿ ﻢ ﺶﮐ ﻦﺸﻨﺘﺴﮐا و ﭻﻧﻻ ،ﺖﺴﺸﻧ و زارد ،

ﮐ تﺎﮐﺮﺣ و ﻪﺘﺴﻫآ يود) ندﺮﮐ دﺮﺳ ﻪﻘﯿﻗد ﺞﻨﭘ و (ﻪﻨﺗ دﻮﺑ ﻪﻘﯿﻗد ﻪﺳ تﺎﮐﺮﺣ ﻦﯿﺑ و ﻪﻘﯿﻗد ﮏﯾ ﺖﺳ ﺮﻫ ﻦﯿﺑ ﺖﺣاﺮﺘﺳا .دﻮﺑ (ﯽﺸﺸ

) 26،27 (.

ﺪﺟ لو 1 . ﻣﺎﻧﺮﺑ ﮥ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﯽﺑوﺎﻨﺗ

) ﯽﺘﻣوﺎﻘﻣ و 12

(ﻪﺴﻠﺟ ﻪﺳ ﻪﺘﻔﻫ ﺮﻫ ،ﻪﺘﻔﻫ

ﻪﺘﻔﻫ يزاﻮﻫ ﻦﯾﺮﻤﺗ

ﯽﺑوﺎﻨﺗ ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ

ندﺮﮐ دﺮﺳ (ﻪﻘﯿﻗد)

مود و لوا 10

20 ﻪﻘﯿﻗد

:ﻦﯾﺮﻤﺗ 60 ﺎﺑ ﻪﯿﻧﺎﺛ 30 ﺪﺻرد RHR

ا :ﺖﺣاﺮﺘﺳ 60 ﺎﺑ ﻪﯿﻧﺎﺛ 50 ﺪﺻرد RHR لوا ﺖﺳ

30 ﺪﺻرد ﺎﺗ1RM 10 راﺮﮑﺗ

مود ﺖﺳ 30 ﺪﺻرد ﺎﺗ1RM 10 راﺮﮑﺗ 5

مرﺎﻬﭼ و مﻮﺳ 10

30 ﻪﻘﯿﻗد

:ﺖﺣاﺮﺘﺳا 60 ﺎﺑ ﻪﯿﻧﺎﺛ 50 ﺪﺻرد RHR لوا ﺖﺳ

40 ﺪﺻرد 1RM ﺎﺗ 10 راﺮﮑﺗ

مود ﺖﺳ 40 ﺪﺻرد 1RM ﺎﺗ 10 راﺮﮑﺗ 5

ﻢﺠﻨﭘ ﻢﺸﺷ و 40 10

ﻪﻘﯿﻗد

:ﻦﯾﺮﻤﺗ 60 ﺎﺑ ﻪﯿﻧﺎﺛ 50 ﺪﺻرد RHR ﺖﺳ

لوا 50 ﺪﺻرد 1RM ﺎﺗ 10 راﺮﮑﺗ

مود ﺖﺳ 50 ﺪﺻرد 1RM ﺎﺗ 10 راﺮﮑﺗ 5

1. Heart Rate Reserve

(7)

ﺛﺄﺗ ﯿ ﺮ 12 ﯽﻣﺮﺳ ﺮﯾدﺎﻘﻣ ﺮﺑ يزاﻮﻫ و ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ CTRP-12

و LCN-2 ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز رد

د عﻮﻧ ﺖﺑﺎﯾ 2

51

:ﺖﺣاﺮﺘﺳا 60 ﺎﺑ ﻪﯿﻧﺎﺛ 50 ﺪﺻرد مﻮﺳ ﺖﺳ RHR

ﻢﺘﺸﻫ و ﻢﺘﻔﻫ 10

50 ﻪﻘﯿﻗد

:ﺖﺣاﺮﺘﺳا 60 ﻪﯿﻧﺎﺛ ﺎﺑ 50 ﺪﺻرد RHR لوا ﺖﺳ

60 ﺪﺻرد 1RM ﺎﺗ 10 راﺮﮑﺗ

مود ﺖﺳ 60 ﺪﺻرد 1RM ﺎﺗ 10 راﺮﮑﺗ

مﻮﺳ ﺖﺳ 60 ﺪﺻرد 1RM ﺎﺗ 10 راﺮﮑﺗ 5

ﻢﻫد و ﻢﻬﻧ 10

50 ﻪﻘﯿﻗد

:ﺖﺣاﺮﺘﺳا 60 ﺎﺑ ﻪﯿﻧﺎﺛ 5 0 ﺪﺻرد RHR لوا ﺖﺳ

مود ﺖﺳ 70 ﺪﺻرد ﺎﺗ1RM 8 ﮑﺗ راﺮ

مﻮﺳ ﺖﺳ 70 ﺪﺻرد 1RM ﺎﺗ 8 راﺮﮑﺗ 5

ﻢﻫدزاود و ﻢﻫدزﺎﯾ 10

60 ﻪﻘﯿﻗد

:ﺖﺣاﺮﺘﺳا 60 ﺎﺑ ﻪﯿﻧﺎﺛ 50 ﺪﺻرد RHR ﺖﺳ

لوا 75 ﺪﺻرد ﺎﺗ1RM 8 راﺮﮑﺗ

ﺖﺳ مود 75 ﺪﺻرد ﺎﺗ1RM 8 راﺮﮑﺗ

مﻮﺳ ﺖﺳ 75 ﺪﺻرد ﺎﺗ1RM 8 راﺮﮑﺗ 5

هزاﺪﻧا ﮔﯿ ﺮ ي ﯽﯾﺎﯿﻤﯿﺷﻮﯿﺑ

ﺮﺑ يا هزاﺪﻧا ﮔﯿ ﺮ ي ﻐﺘﻣ ﯿ ﺎﻫﺮ ي ،ﯽﯾﺎﯿﻤﯿﺷﻮﯿﺑ ﻪﻧﻮﻤﻧ

ﮔﯿ ﺮ ي ﯽﻧﻮﺧ ﺲﭘ زا 12 راﺪﻘﻣ ﻪﺑ ،ﻪﻠﺣﺮﻣ ود رد و ﯽﯾﺎﺘﺷﺎﻧ ﺖﻋﺎﺳ 5

ﺳ ﯽ ﺳ ﯽ ﯽﯾوزﺎﺑ ﺪﯾرو زا

مﺎﺠﻧا ﺖﻓﺮﮔ ﻠﺣﺮﻣ رد . ﮥ

ﻞﻤﻌﻟارﻮﺘﺳد ﻖﺒﻃ لوا ﻪﺋارا

ﻂﯾاﺮﺷ صﻮﺼﺨﻣ هﺪﺷ نﻮﺧ

ﮔﯿ ﺮ ي زا ، ﻧدﻮﻣزآ ﯽ ﺎﻫ ﻪﺘﻔﻫ ﮏﯾ ﺪﺷ ﻪﺘﺳاﻮﺧ ﺶﯿﭘ

زا

ﻪﻧﻮﻤﻧ ﮔﯿ ﺮ ي مﺎﺠﻧا زا ﯽﻧﻮﺧ ﻪﻧﻮﮔﺮﻫ

ﻂﯾاﺮﺷ ،ﻦﯿﮕﻨﺳ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ سﺮﺘﺳا

روآ .ﺪﻨﻨﮐ يراددﻮﺧ ﻞﻤﮑﻣ فﺮﺼﻣ و نﻮﺧ

ﮔﯿ ﺮ ي ﻠﺣﺮﻣ ﮥ مود 48

ﺖﻋﺎﺳ ﺲﭘ مﺎﺠﻧا زا ﺴﻠﺟ ﻦﯾﺮﺧآ نداد ﮥ

،ﯽﻨﯾﺮﻤﺗ ﻪﺑ ﻦﯾﺮﺧآ يﺎﻫﺮﺛا ﻦﺘﻓر ﻦﯿﺑ زا رﻮﻈﻨﻣ ﺴﻠﺟ

ﮥ ترﻮﺻ لﺮﺘﻨﮐ و ﯽﺑﺮﺠﺗ هوﺮﮔ زا ﯽﻨﯾﺮﻤﺗ

ﯽﻣﺮﺳ ﺮﯾدﺎﻘﻣ .ﺖﻓﺮﮔ

CTRP-12

ﮕﺸﯾﺎﻣزآ شور زا هدﺎﻔﺘﺳا ﺎﺑ ﯽﻫﺎ

ELISA ) ﺖﯿﮐ و

LaboratoryBioassayTechnology

ﺖﺧﺎﺳ (

ﺖﯿﺳﺎﺴﺣ و ﻦﯿﭼ ﺐﯾﺮﺿ

) ng/mL 025

/ 0 ﺮﯾدﺎﻘﻣ و ( ﻦﯿﻟﺎﮐﻮﭙﯿﻟ ﯽﻣﺮﺳ -

ﺖﯿﮐ زا هدﺎﻔﺘﺳا ﺎﺑ 2 )

R& Dsystems, USA

شور ﻪﺑ (

ELISA

هزاﺪﻧا ﮔﯿ ﺮ ي تاﺮﯿﯿﻐﺗ ﺐﯾﺮﺿ .ﺪﺷ نورد

نﻮﻣزآ 6/

4 تاﺮﯿﯿﻐﺗ ﺐﯾﺮﺿ و ﺪﺻرد نوﺮﺑ

نآ نﻮﻣزآ 9/

5 دﻮﺑ ﺪﺻرد .

شور رﺎﻣآ ي

،ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ رد ﻪﺑ

رﻮﻈﻨﻣ لﺎﻣﺮﻧ زﺎﺳ ي هداد ﺎﻫ ﺪﺷ هدﺎﻔﺘﺳا ﮏﻠﯾووﺮﯿﭘﺎﺷ نﻮﻣزآ زا .

نﻮﻟ نﻮﻣزآ زا ﻦﯿﻨﭽﻤﻫ ﻪﺑ

رﻮﻈﻨﻣ ﻦﮕﻤﻫ يزﺎﺳ راو ﯾ ﺲﻧﺎ ﺎﻫ ،

ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ و ﺲﻧﺎﯾراوﻮﮐ ﻞﯿﻠﺤﺗ نﻮﻣزآ زا ياﺮﺑLSD

ﻦﯿﯿﻌﺗ توﺎﻔﺗ ﺎﻫ ي ﻦﯿﺑ .ﺪﺷ هدﺎﻔﺘﺳا ﯽﻫوﺮﮔ ﺰﺠﺗ

ﯾﻪ ﻠﺤﺗو ﯿ ﻞ هداد ﺎﻫ ي ﺎﺑ ﺶﻫوﮋﭘ

زا هدﺎﻔﺘﺳا مﺮﻧ

راﺰﻓا يرﺎﻣآ ﮥﺨﺴﻧSPSS

22 مﺎﺠﻧا ﺖﻓﺮﮔ ) 05 / 0 P<

.(

ﯾ ﻪﺘﻓﺎ ﺎﻫ ي ﺶﻫوﮋﭘ

دراﺪﻧﺎﺘﺳا فاﺮﺤﻧا و ﻦﯿﮕﻧﺎﯿﻣ ﻐﺘﻣ

ﯿ ﺎﻫﺮ ي عﻮﻧ ﺖﺑﺎﯾد ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز ﮏﯾژﻮﻟﻮﯾﺰﯿﻓ و ﮏﯾﺮﺘﻣﻮﭘوﺮﺘﻧآ 2

لوﺪﺟ رد 2

ﺖﺳا هﺪﺷ هداد نﺎﺸﻧ .

لوﺪﺟ 2 . ﯽﮔﮋﯾو ﺑ ﻼﺘﺒﻣ نﺎﻧز ﮏﯾژﻮﻟﻮﯾﺰﯿﻓ و ﮏﯾﺮﺘﻣﻮﭘوﺮﺘﻧآ يﺎﻫ عﻮﻧ ﺖﺑﺎﯾد ﻪ

2

ﺮﯿﻐﺘﻣ هوﺮﮔ

لﺮﺘﻨﮐ ﯽﺘﻣوﺎﻘﻣ

يزاﻮﻫ

(لﺎﺳ) ﻦﺳ 36

/0 12± / 43 37

/1 98± / 42 76

/1 61± / 43

) ﺪﻗ ﺘﻧﺎﺳ ﯽ ﺮﺘﻣ ( 32

/2 68± / 160 54

/4 17± / 161 12

/1 23± / 160

(مﺮﮔﻮﻠﯿﮐ) نزو ﭘﯿ

ﺶ نﻮﻣزآ 67

/2 87± / 73 98

/4 78± / 72 21

/1 45± / 73

ﺲﭘ نﻮﻣزآ 84

/6 89± / 73

* 54 /1 35± / 69

* 13 /1 98± / 68

(8)

BMI ﯿﮐ) ﺮﺑ مﺮﮔﻮﻠ ﻊﺑﺮﻣﺮﺘﻣ ﭘﯿ (

ﺶ نﻮﻣزآ 23

/5 27± / 29 76

/5 54± / 29 15

/2 43± / 29

/1 51± / 29 57*

/2 72± / 28 15*

/1 29± / 28

WHR ) ﺘﻧﺎﺳ ﯽ ﺮﺘﻣ ﭘﯿ (

ﺶ نﻮﻣزآ 04

/0 96± / 0 08

/0 96± / 0 832

95± / 0

/1 96± / 0 43*

/1 90± / 0 02*

/0 89± / 0

CTRP-12 ﺮﺑ مﺮﮔﻮﻧﺎﻧ) ﻣﯿ

ﻠ ﯽ ﻟﯿ ﺮﺘ ﭘﯿ (

ﺶ نﻮﻣزآ 58

/2 37± / 4 28

/2 44± / 4 1/

3 29± / 4

/1 79± / 3 15*

/2 89± / 7 14*

/2 87± / 7

LCN-2 ﺮﺑ مﺮﮔوﺮﮑﯿﻣ) ﻣﯿ

ﻠ ﯽ ﻟﯿ ﺮﺘ ﭘﯿ (

ﺶ نﻮﻣزآ 67

/1 23± / 21 12

/3 76± / 20 17

/1 54± / 21

/3 89± / 20 19*

/1 35± / 18 19*

/2 97± / 18

ﺢﻄﺳ • رادﺎﻨﻌﻣ ي زا ﺮﺘﻤﮐ 5 مﺪﺻ

ﻞﯿﻠﺤﺗ نﻮﻣزآ ﺞﯾﺎﺘﻧ ﺲﻧﺎﯾراوﻮﮐ

ﯽﺳرﺮﺑ رد (اﻮﻧآ) لوﺪﺟ رد ﺶﻫوﮋﭘ يﺎﻫﺮﯿﻐﺘﻣ ﺮﯾدﺎﻘﻣ

3 رد ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ .ﺖﺳا هﺪﺷ هداد نﺎﺸﻧ

ﻐﺘﻣ ﯿﺮ ،نزو ﺛﺄﺗ ﯿﺮ ﺮﯿﻐﺘﻣ ﭘﯿ ﺶ نﻮﻣزآ ﺖﺳا رادﺎﻨﻌﻣ

287) 156/

،F=

001 /0

،(P =

ﺮﺛا لﺮﺘﻨﮐ زا ﺲﭘ ﭘﯿ

ﺶ نﻮﻣزآ ﻦﯿﺑ ، هوﺮﮔ ﺎﻫ ي زا ﺲﭘ ﺶﻫوﮋﭘ 12

ﻠﺧاﺪﻣ ﻪﺘﻔﻫ ﮥ

توﺎﻔﺗ ﯽﻨﯾﺮﻤﺗ رادﺎﻨﻌﻣ

ي داد نﺎﺸﻧ )

29 /

7 F=

، 005 /

۰ P =

ﻪﺑ ﺖﺒﺴﻧ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﮐ داد نﺎﺸﻧ ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ ﺞﯾﺎﺘﻧ و (

) لﺮﺘﻨﮐ هوﺮﮔ 001

/

۰ P = لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ و (

۰۰٥) ۰/ P=

ﺶﻫﺎﮐ ﺐﺟﻮﻣ(

رادﺎﻨﻌﻣ .ﺪﺷ نزو

رد ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ ﻦﯿﻨﭽﻤﻫ ﻐﺘﻣ

ﯿﺮ ﺺﺧﺎﺷ ةدﻮﺗ ) ﯽﻧﺪﺑ ،(BMI

ﺛﺄﺗ ﯿﺮ ﺮﯿﻐﺘﻣ ﭘﯿ ﺶ نﻮﻣزآ ) ﺖﺳا رادﺎﻨﻌﻣ 292

/

٥۲۹ F=

، 001 /0

P =

،(

ي ) داد نﺎﺸﻧ 154

/

۱۲ F=

، 005 /0

P= ) لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﮐ داد نﺎﺸﻧ ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ ﺞﯾﺎﺘﻧ و ( 001

/

0 P = لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ و (

) 005 /

۰ P= ﺶﻫﺎﮐ ﺐﺟﻮﻣ ( رادﺎﻨﻌﻣ

ﺺﺧﺎﺷ دﻮﺗ ة ) ﯽﻧﺪﺑ .ﺪﺷ (BMI

رد ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ ﻐﺘﻣ

ﯿﺮ ) ﻦﮕﻟ ﻪﺑ ﺮﻤﮐ رود ﺖﺒﺴﻧ ،(WHR

ﺛﺄﺗ ﯿﺮ ﺮﯿﻐﺘﻣ ﭘﯿ ﺶ نﻮﻣزآ ) ﺖﺳا رادﺎﻨﻌﻣ 015

/0

، F=

001 /0

،( P = زا ﺲﭘ

ﺮﺛا لﺮﺘﻨﮐ ﭘﯿ

ﺶ نﻮﻣزآ ﻦﯿﺑ ، هوﺮﮔ يﺎﻫ زا ﺲﭘ ﺶﻫوﮋﭘ 12

/0

، F=

004 /0 = .(P

ﺞﯾﺎﺘﻧ

) لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﮐ داد نﺎﺸﻧ ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ 001

/0

P= ) لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ و ( 004

/

۰ P= (

ﺶﻫﺎﮐ ﺐﺟﻮﻣ رادﺎﻨﻌﻣ

) ﻦﮕﻟ ﻪﺑ ﺮﻤﮐ رود ﺖﺒﺴﻧ .ﺪﺷ (WHR

رد ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ ،يرﺎﻣآ نﻮﻣزآ ﺞﯾﺎﺘﻧ ﻦﯿﻨﭽﻤﻫ ﻐﺘﻣ

ﯿﺮ

CTRP-12

، ﺛﺄﺗ ﯿﺮ ﺮﯿﻐﺘﻣ ﭘﯿ ﺶ ﻮﻣزآ ن ) ﺖﺳا رادﺎﻨﻌﻣ 598

/0

، F=

001 /0

P=

،(

ﻪﺘﻔﻫ ﻠﺧاﺪﻣ ﮥ ﯽﻨﯾﺮﻤﺗ توﺎﻔﺗ رادﺎﻨﻌﻣ ي ) داد نﺎﺸﻧ 398

/ 5

،F=

005 /0

P= ) لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﮐ داد نﺎﺸﻧ ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ ﺞﯾﺎﺘﻧ و .(

001 / 0 ﻪﺑ ﺖﺒﺴﻧ ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ و (P=

هوﺮﮔ ) لﺮﺘﻨﮐ 005 /0

P= ( ﺶﯾاﺰﻓا ﺐﺟﻮﻣ رادﺎﻨﻌﻣ

CTRP-12

.ﺪﺷ

ﺮﯿﻐﺘﻣ رد ﻦﯿﻨﭽﻤﻫ

LCN-2

، ﺛﺄﺗ ﯿﺮ ﻐﺘﻣ ﯿﺮ ﭘﯿ ﺶ نﻮﻣزآ ) ﺖﺳا رادﺎﻨﻌﻣ 703

/0

F=

، 001 /0

P =

،(

ﺶ نﻮﻣزآ ﻦﯿﺑ ،

هوﺮﮔ ﺎﻫ ي زا ﺲﭘ ﺶﻫوﮋﭘ 12

/4

F=

، 005 /0

P= زآ ﺞﯾﺎﺘﻧ .(

ﻪﮐ داد نﺎﺸﻧ ﯽﺒﯿﻘﻌﺗ نﻮﻣ

) لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ يزاﻮﻫ ﻦﯾﺮﻤﺗ 001

/0

P=

) لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﯽﺘﻣوﺎﻘﻣ ﻦﯾﺮﻤﺗ و(

005 /0

P= ﺶﻫﺎﮐ ﺐﺟﻮﻣ ( رادﺎﻨﻌﻣ

LCN-2

.ﺪﺷ

لوﺪﺟ 3 . ﺶﻫوﮋﭘ يﺎﻫﺮﯿﻐﺘﻣ ﺮﯾدﺎﻘﻣ ﯽﺳرﺮﺑ رد ﺲﻧﺎﯾراوﻮﮐ ﻞﯿﻠﺤﺗ نﻮﻣزآ ﺞﯾﺎﺘﻧ

ﺮﯿﻐﺘﻣ عﻮﻤﺠﻣ ﻞﻣﺎﻋ

تﺎﻌﺑﺮﻣ ﮥﺟرد

يدازآ ﻦﯿﮕﻧﺎﯿﻣ

تﺎﻌﺑﺮﻣ رادﺎﻨﻌﻣ F

ي ﺎﺗا روﺬﺠﻣ

نزو (مﺮﮔﻮﻠﯿﮐ) ﭘﯿ

ﺶ نﻮﻣزآ 423

/ 2874 1

423 / 2874 287

/ 156 001

/ 0 79

/ 0

هوﺮﮔ 534

/ 2473 2

163 / 132 29

/ 7 005

/ 0 36

/ 0

BMI (ﻊﺑﺮﻣ ﺮﺘﻣ ﺮﺑ مﺮﮔﻮﻠﯿﮐ) ﭘﯿ

ﺶ نﻮﻣزآ 292

/ 529 1

292 / 529 56

/ 275 001

/ 0 83

/ 0

هوﺮﮔ 89

/ 35 2

154 / 12 76

/ 4 005

/ 0 28

/ 0