VIETHAM MEDICAL JOURHAL H'J - JANUARY - 2017
giffa dot bi€n gen BRAF vdi di can hach co va stf bdc Id mpt so dau an mien djch can dtfdc tiep tuc nghien CIJ'U them.
TAI L l | U T H A M KHAO
1. Le Thj Van Anh (2003). "Nghien ahr mo binh hge mgi so" ung thu" bii'u mo hjyen giap thuang gSp tai Benh viin K Ha ngl". Luan van tot nghiep bac sTy klioa khoa 1997-2003. Tru'dng Dai hoc y Ha ngi.
2. Vu Trung Chinh (2002). '7<ighien cuii ap dung^
phUdng phap dieu tii ung tiiWgiap bang the biit hoa bang cat bo tuyen giap toan bg kit iidp P^". Luan van thac sT y hoc. Oai hoc y Ha noi.
3. Al-Zarlier N., Al-Salam S., El Terafi H.
(2008). ^Thymid cardnoma In tiie United Arab Emirates:
perpectives and experience of a t&tiary care hopital".
Hematol Oncol Stem Cell Ther; 1(1), p. 14-21.
4. Bachmann K., Pawliska D., Kaifi J., et al.
(2007). '^P53 is an independent prognostic factor for suvival in thyroid cancer". Anticancer Res; 27(6B), p ^
3993-99. 'M 5. Cheema Y., Repplinger D., Elson D., C h e ^
H. (2006). "Is tumor size the best preidrtor o w t o w ^ fbr papillary thyroid cancer?"Pinn Surg Oncol. 1 3 ( l l ) j l
p. 1524-28. 2 6. Pao W, et al. Acquired resistance of lurig*
adenocarcinomas to gefitinib or erlot'nib is associated witti a second mutation in the EGFR kinase domain.
PLoS Med. 2005, 2: e73.
7. http://www.atdbio.com/content/19/Synttiesis ' and applications of chemically modified.
oligonucleotides'
TiraNG QUAN GIU'A MU'C DO BIEU HIEN RANG CfrA HINH XfiNG v A KICH THU-aC GAN XA RANG dy\ GIU'A, CiXA BEN ¥ A
COI LaN THU* NHAT H A M TREN
T O M TAT
Myc tieu: (1) X^c djnh kich-thtfdc gan xa rang cu^ gife, rSng cira ben va ring coi ldn thtf nhat ham tren; (2) Xac ffinh mdi tu'dng quan giiJa mu'c dp bleu hien rang CLICI hinh xeng va kich thu'dc gan xa rang o f t giiJa, rang cu^ bin va rang coi ldn thtf nhift ham tren. Phifdng phap: Nghien ciitf cSt n^ang mo ta va phin tich, mau nghien cijtf gom 100 mau h^m thach cao td 20 den 23 tudi (48 nam, 52 nii^. Danh gia va phan loai dac diem rang cda hinh xeng theo Hrdlicka, 1920. Kich thu'dc gan xa rang cCra giD^, rang cCte bin va ring coi Idn thtf nhat liam t r i n dudc do theo Moorrees, 1957. Ket qua: Cac kich thu'dc gan xa d nam gidi deu cao hdn gidi nu' gidi; SLT khac biet nay khong c6 y nghTa thong ke (p> 0,05). Co moi tu'dng quan thuan co y nghTa giij^ mtfc dp bieu hien RCHX CLia ring cira giii'a, ring cu'a ben ham tren va kich thu'dc gan xa ciia chlnh nd (r=0,42 va r=0,34). Co moi tutfng quan thuan co y nghTa giiJa mtfc do bieu hien RCHX cua cac rang cu'a ham t r i n va kfch thu'dc gan xa cua rang coi ldn thiJ nhat ham tren (r=0,38). Ket lu$n: lO'ch thtfdc gan xa rang cda giu^, rang cu^ ben va i^ng cm idn thtf nhat ham tren d nam cao hdn nti'.
Co mdi tudng quan thuan giffa mii'c dp bleu hien
'TrWdng Dai hoc Y Du'dc TP.HCM Chm trach nhiem chinh: Huynh Kim Khang Email: [email protected] Ngay nhan bai: 3/10/2016 Ngay phan bien khoa hoc: 3/11/2016 IMgay duyet bai: 20/11/2016
Huynh Kim Khang*, Qu^ch Hfru Thinh*
RCHX va kich thtfdc gan xa rang cu^ giffa, rgng cij^
ben va rang cdi Idn thtf nhat ham tren d ca hai gidi.
Tuf khoa: kfch thtfdc g3n xa, rang cii^ hinh xeng.
Ky hieu. rang ctfa hinh xeng: RCHX; rang cilS giOci: RCG; rang cuS ben: RCB; rang coi ldn thu" nhat:
RCLl, gan xa: GX .
S U M M A R Y
CORRELATION BETWEEN THE SHOVEL- SHAPED I N a S O R S A N D MESIODISTAL CROWN DIAMETERS OF THE MAXILLARY CENTRAL^ LATERAL I N a S O R S , FIRST M O U R
Objectives: The aim of this study was: ,[l),to determine the mesiodistal crown diameters of ' maxillary central, lateral incisors, first molar; (2) to '^
determine the correlation between shovel-shaped;'1 incisors and the mesiodistal crown diameters of maxiliary central, lateral incisors, first molar.
Materials and method: With the descriptive cross - 1 sectional and analytic study design, the sample,-i consisted 100 dental casts (at the age of 20-23). % Shovel-shaped incisors were evaluated and classified | by Hrdlicka (1920) method. The mesiodistal crown * diameters were measured by Moorrees (1957) method. Results: The mesiodistal crown diameters of male were higher than female, there were no significant differences (p>0.05). There' were positive • correlation between shovel-shaped incisora and the mesiodistal crown diameters of central, lateral ingsors (r=0.42, r=0.34). There were positive correlation' • between shovel-shaped incisors and the mesiodistal^
crown diameters of maxillary first molar (r=0.38);;,f Conclusions: The mesiodistal crown diameters of:§
maxillary central, lateral incisors and first molar of X
12
TAP CHi Y HOC VIET HAM TAP 450 - THAHG 1 - SO 1 - 2017
male w^e higher than female. There were positive
correlation between shovel-shaped incisors and tiie mea'odistal aown diameters of maxillary central, lateral incisors, first molar.
Key word: The mesiodistal crown diameters, shovel-shaped incisors.
I.DATVXNDE
Cac dac diem hinh thai rang van ludn la diem nong thu hut rat nhieu nha nghien CLTU, dac biet tu" gvda the ki 19 cho den nay. Viec md ta, phan loai va tim hieu bieu hien cac dac dieni nay tren nhu'ng dan sd khac nhau ddng vai trd rat quan trpng trong nghien ctfu nhan hpc. Oa sd cac nghien ctfu hien nay deu tap trung vao khfa canh nay nham chi ra mdi lien quan giu^ cac chung tpc, tinh trang di dan, hon churtg'^L. Md dau la cdng trinh cua Georg von Carabelli nam 1842 md ta num phu thtfdng gap d mat trong gan cua r^ng coi ham tren va chl ra mdi lien quan vdi dai chung Au. Nam 1905, De Terra tien hanh nghien cdu rang cua 60 nhdm thudc cac chung tdc khac nhau, chi'nh dng la ngtfdi dat cot moc klidi dau cho stf nghiep phat tJien sau nay cua nhan hpc rang. Hrdlictta ^1920) la ngtfdi dau tien nghien ctfu chi tiet ve dac diem rang ctfa hinh xeng.
Nam 1928, Hellman dtfa ra nhuHg nghien ctfu danh gia ve mau ranh va so mui cua rang coi Idn ham dtfdi... Cung vdi stf phat trien cua nganh nha khoa ndi chung va nganh nhan hpc rang ndi lieng, cac dac diem md ta hinh thai rang ngay cang dtfdc quan tam nghien ctfu de tim hieu nhthig anh htfdng cua nd den bp rang, kfch tiitfdc rang va cung rang.Gia trj cua nhffng dac diem hinh thai rang khdng chi tap trung d khia canh nhan hpc ma cdn lien quan den ITnh vtfc dieu trj lam sang nhtf chinh hinh, phuc hinh, nha chu... Xuat phat ttf thtfc te dd, chung tdi tien hanh nghien culj ve ttfdng quan giffa mu'c dp biSu hien rang cu^ hinh xeng va kich thtfdc gan xa rang vdi muc tieu nghien ctfu:
- A&" dinh kich tiiu'dc gSn xa rang cu^ giu^, r^ng cu^ ben va rang c6i idn thd" nhat ham trin.
• Xac dinh mm tifdng quan giij^ m&c do bieu hien rang cu^ hinh xeng va kfch thu'dc gan xa rang c&a giO^, rang cu^ tjen va rang cdi Idn thiy nhat ham tren.
II. DOI TU'QNG VA PHITONG PHAP NGHIEN CCfU 1. Doi tu'dng nghien cihi
- Chpn mau ngau nhien he thdng dap tfng vdi tieu chuan chpn miu.
- Tieu chuan chpn mau: bd rang vTnh vien cd du 24-28 rang tren cung ham (cd the cd hoac khdng cd rang khdn); rang khdng bj sau vd Idn hoac phuc hinh; khdng cd tinh trang mdn rang qua mtfc d mat nhai hoac mat bdn; chu^ trai qua dieu tn chinh hinh rang mat
- Loai khdi nghien ctfu mau ham bi bpt, bj khiem kiiuyet d nhffng vj tri la diem mdc do.
*Cd m i u : 100 mau ham thach cao d dp tuoi 20 den 23 tudi (48 nam, 52 nff).
*Thiet ke nghien cu'u: Nghien ctfu cat ngang md ta va phan tfch.
2. Phu'tfng phap nghien cu'u
• Phu'dng phap quan sat dac di^m rang cu'a hinh xeng:
Quan sat tren mau ham thach cao mat trong cac rang ctfa gida va cilfa ben ham tren bang mat thtfdng ket hdp vdi kinh lup cd dp phdng dai gap 4 lan, danh gia va phan Ioai (^c diem rang cda hinh xeng theo 4 mtfc dp the hien (Hrdlicka, 1920):
Op 0: Khdng cd hinh xeng: khdng cd dau vet nao cua gd men hay phan Idm
Op 1: Cd vet hinh xeng; dau vet cua gd men ro nhtfng chu^ du de xet vao mtfc dp ban xeng
Op 2: Hinh xeng trung binh: gd men rd nhtfng phan lom mat trong cdn can
Dp 3: Hinh xeng rd: gd men va phan Idm mat trong ro
• Do kfch thu'dc gan xa bSng thu'dc kep dien td:
Kfch thtfdc gan xa rang ctfa giu^, rang cu^
ben va rang coi idn thtf nhat ham tren: dtfdc do theo phtfdng phap cua Moorrees va cs (1957):
kich thtfdc gan xa la khoang each ldn nhat giffa hai mat ben, khi do thtfdc trtfdt giff song song vdi mat nhai va/hoac mat ngoai.
Xiy 1^ so lieu
- Stf dung Microsoft Excel de xu" ly so lieu.
- Stf dung phep kiem t de so sanh cac gia tn trung binh trong nghien ctfu.
- Stf dung ttfdng quan Spearman de xac djnh ttfdng quan giffa mtfc do bieu hien RCHX va kich thtfdc rang cite giffs, rang cCra ben va rang coi Idn thtf nhat ham tren.
til. KET QUA VA BAN LU^N
1. Kich thu'dc gan xa rang cufa giu^, rang cu'a ben va rang coi ldn thu' nhat ham tren
Nhin chung, cac kfch thtfdc ghi nhan d nam
gic^ deu cao hdn gidi nff gidi. Tuy nhien stf khac
biet nay khdng cd y nghTa thdng ke (p> 0,05)
(bang 1).
VIETNAM MEDICAL JOURNAL H'1 • JANUARY • 2017
Bang 1: Idch thWdc gin xa cac rang ham trin phin bSiheo gidl tmh Rang
Trai
Nam (n= 48) (mm) 8,78±0,52
8,79±0,47 7,16±0,43 10,59±0,59
Ng (n= 52) (mm) 8,63±0,46 7,01±0,39 10,30±0,43
8,64±0,45 7,07±0,40 10,41±0,51
Chunq fn=100) (mm) 8,70±0,49 7,08±0,41 10,39±0,50 8,71±0,46 7,11±0,42 10,50±0,56
>0,05
> 0,05.
>0,05
> 0,05
>0,05
> 0,05 _ Ket qua bang 3.2 cho thay co su' tang dan ve kich thu'Sc gan xa trung bmh cua rang aia giuS, rang cira ben va rang coi Ifin thiJ nhft theo mu'c do bieu hien RCHX (tang dan tif do 0 den do 3). ,.;
Bang 3.2: Kich thWdc gin xa cac rang d ham iren phin bd iheo cac mWc dp bieu hiin RCHX (Chung ca hai gidi)
Chung n=100 RCG (mm) RCB (mm) RCLl (mm)
Trai
DoO 8,34±0,52 6,98±0,32
8,48±0,34 7,01±0,27 10,15±0,42
8,53±0,54 7,C2±0,54 1C.33±0,51
8,83±0,47 7,08±0,43 10,49±0,49
8,40±0,55 6,96±0,35 10,16V0,80
8,51±0,31 .7,00±0,30 10,18±0,47
06 2 8,57±0,48 7,01±0,48 10,37±0,54
06 3 8,83+0,47 7,16±0,45 10,63±0,57
- ("lu'c do bieu hien RCHX cua rang cu'a giiJa, rSng ciTa ben ham tren va kich thu'dc gan xa cOa chi'nh no.
+ MLTC dp bieu hien RCHX cua cac rang CL(a ham tren va ki'ch thu'dc gan xa cua rang coi idn thiT nhat ham tren.
2. Tu'cfng quan giu'a mu'c do bieu hien RCHX va Icich thu'dc gan xa rang
Ket qua trong bang 3.3 cho thay nhin Chung d ca hai gidi, tim thay SLT tu'dng quan thuSn cd ^ nghla giu^:
Bang 3.3; He sdtWdng quan Spearman giii'a mWc do bleu hien RCHX va kich thWdc gan xa rang ham trin (chung ca hai gidi)
Chung n=100 Kich thu'dc GX
Trai RCG RCB RCLl Phai RCG RCB RCU
Mu'c do bieu hien RCHX Trai
RCG 0,42**
0,23*
0,29**
0,42**
0,32**
0,32**
RCB 0,34**
_0,34*
0,36**
0,31**
0,39**
0,38**
Phai RCG 0,35**
0,22*
0,24*
0,41**
0,32**
0,32**
RCB 0,27**
0,21*
0,23*
0,24**
0,32**
0,29**
• Ttieo nhieu nghien culi cho thay, kfch thtfdc rang d moi ca the khac nhau giffa cac cdng dong va ngay ca trong cung mot cdng ddng*^*'^\Tuy nhien, trong cung mpt ca the thi kich thtfdc rang cd xu htfdng ttfdng xtfng vdi nhau. Nhin chung, nhffng ngtfdi cd kfch thtfdc rang ctfa Idn thi thtfdng cung cd rang cdi va rang nanh ldn. Dtfa vao mdi ttfdng quan thuan cd y nghia giffa mtfc dp bieii hien rang ctfa hinh xeng va kfch thtfdc
(**):p < 0,01; (*):p < 0,05 gan xa cac rang ctfa va rang cdi Idn thtf nhat ham tren, cd the nhan xet rang bieu hien dac trtfng cua chung tpc Mongoloid (dac diem RCHX) se bieu hien cang rd tren nhffng ngtfdi cd kich thtfdc rang cang ldn*''. Ket qua nghien ctfu cua chung toi ciJng gan ttfdng ttf nhtf ket qua cCia Hasegawa (2009)''* tren ddi ttfdng la 33 phu nff Mdng Co (nghien cu'u cua Hasegawa thu dtfdc h?
sd ttfdng quan giffa mtfc dp bieu hien RCHX va
TAP CHi Y HOC VIET NAM TAP 450 • THAHG 1 - SO 1 - 2017
kich thtfdc gan xa rang cdi Idn thtf nhat ham tren cao hdn dat 6 mtfc trung binh).
• Trong nghien ctfu cua chung tdi khdng cd stf khac biet cd y nghTa ve kich thtfdc gan xa trung binh cua cac rang ctfa va rang coi Idn thtf nhat ham tren g i i j ^ nam va nff, dili cac gia trj trung binh d nam gidl o o hdn d nff. Nghien ctfu cua Huynh Kim Khang (2011)'*' tren tre ngtfdi Viet cung dtfa ra ket luan kfch thtfdc gan xa rang vTnh vien d nam Idn hdn nff nhtfng stf khac biet khdng cd y nghia thong ke. Mpt so nghien ctfu khac cua Asher (1986)'^' tren i s S tre chau Au, hay cua Bunger (2014)''*' tren cong ddng Punjab lai dtfa ra ket luan kfch thtfdc gan xa rang ciia nam gidi Idn hdn nd gidi mot each cd y nghla.
Nhin chung, kich thtfdc rang d nam gic^ thtfdng ldn hdn nff gidi, dieu nay gdp phan lam cd sd cho nhan xet: cac bleu hien dac trtfng cua chung tdc Mongoloid, cu the trong nghien ctfu nay la d a c diem RCHX se bieu hien r o h d n d nhffng bd ran^ cd kich thtfdc Idn hdn.
V. K i t L U A N
- Kich thtfdc gan xa rang ctfa giffa, rang cu^
ben va rang cdi ldn thtf nhat ham tren d nam cao hdn nff
- Cd moi ttfdng quan thuan g i i j ^ mtfc dp bleu hien RCHX va kfch thtfdc gan xa rang ctfa giij^.
rang cda ben va rang cdi idn thtf nhat ham tren d ca hai gidi.
T A I L i f u T H A M K H A O
1 . Huynh Kim Khang ( 2 0 1 1 ) , Nghiin ah/dgc mdi liin hi mgt so dac diem hinh thaigiu^ rang siia va rang vinh vien tre em ngu'di Wit, Luan an tien s7 khoa hpc Y Dtfdc, Dai hoc Y Duttc, TP.HCM. 121tr 2. Asher R.S. (1986>f, A longitudinal study of
mesiodistal crown diameters in human primary and permanent dentitions, Master's Theses, University of Nebraska-Uncoln.
3.. Bailit H. ( 1 9 7 5 ) , "Dental variation among populations", IPent Clin. North Am., vol. 19, pp. 125-139.
4. Bunger E., Jindal R., Pathania D., Bunger R.
(2014), "Mesiodistal crov/n dimensions of the permanent dentition among school going children in Punjab population: an aid in sex determination", Int J. of Dent and Healtii sd., vol 1(1), pp.13-23.
D. Carbonell V.M, ( 1 9 6 3 ) , "Variations in the frequency of shovel-shaped incisors in different populations". Dental Antiiropology, Brothwell DR ed. Symposia of the Society for the study of human biology, Pergamon Press, New York, vol. 5.
6. Hanihara T., Ishida H. ( 2 0 0 5 ) , "Metric dental variation of human populations". Am. J. Phy.
Athmpol., vol. 128, pp.287-298.
7. Hasegawa K., Terada K., Kageyama I . , Tsukada S., Uzuka S., Nakahara R., Nakahara S. (2009) "Influence of shovel-shaped indsors on the dental arch crow/ding in Mongolian females", Okajimas Folia Anat. Jpn., vol. 86(2), pp.67-72.
DANH GIA MOT SO YEU TO NGUY CO GAY SAU RANG O TRE Tir 6 DEN 10 T u d i TAI T R U ' N G TIEU HOC BE VAN DAN NAIVI 2 0 1 6
Trinh Thi Thai Ha*, Ph^m Thi Thu Hien*
T6M TAT
Muc tiiu: Nhin xet mot so yeu t d nguy cd sau rang 6 tre em ttf 6 den 10 tudi tai trtfdng tieu hpc Be Van Dan - quan Dong Oa - Ha Noi nam 2016. Boi tifdng va phu'dng phap nghien cuU: Nghien cCTu tren 350 hoc sinh tii' 6 den 10 tuoi dang hoc tai trtfdng tieu hpc Bg Van Dan - Quan Dong Oa - Thanh pho Ha Npi, td thang 1 den thang 5 nam 2016. Thiet ke
*Benh vien Rang Ham Mat TV" Ha Ngi CJiju trach nhiem chfnh: Pham Thi Thu Hien Email: [email protected] Ngay nhan bai: 7//10/2016 Ngay phan bien khoa hoc: 6/11/2016 Ngay duyet bai: 5/12/2016
nghien cilli: mo ta cat ngang. Kei qua: Cac yeu t d ve dp tudi, ity thuat chai rang ngang va thoi quen an vSt la nguy cd gay benh sau rang.
Tii'khoa: S§u rang ti^ em, yeu td nguy cd.
S U M M A R Y
STUDY ON THE RISK FACTORS OF DENTAL CARIES AMONG 6-10-YEAR-OLD CHILDREN
I N BE VAN DAN PRIMARY SCHOOL 2 0 1 6 Objective: The aim of this study isto assess the risk factors of dental caries among 6-10-year-old children in Be Van Dan primary school from January to March 2016. Subjects and methods:A cross- sectionai study was conducted in Be Van Dan primary school from January to March 2016. A total of 350 children aged 6-10 were randomly selected. Results:
