BAB V KESIMPULAN DAN SARAN
B. Saran
Berdasarkan hasil penelitian yang telah dilakukan, peneliti memberikan saran kepada penelitian selanjutnya yaitu.
1. Perlu dilakukan penelitian mengenai interaksi obat pada peresepan pasien dengan mempertimbangkan dosis pemberian obat karena akan mempengaruhi interaksi yang terjadi pada beberapa obat.
2. Perlu dilakukan penelitian mengenai interaksi obat pada pasien di Instalasi Rawat Inap RSUD Panembahan Senopati Bantul Yogyakarta untuk mengetahui akibat dari interaksi yang terjadi setelah pemberian obat.
Saran yang diberikan peneliti kepada pihak RSUD Panembahan Senopati yaitu. 1. Perlu meningkatkan kewaspadaan dengan cara memonitoring efek interaksi
Daftar Pustaka
Aschenbrenner, D.S., and Venable, S.J., 2009, Drug Therapy in Nursing, 3rd edition, Lippincott Williams and Wilkins, Philadelphia, pp.61-63. Baxter, K., 2010, Stokley’s Drug Interactions, Ninth edition, Pharmaceutical
Press, China, pp. 13, 15, 41.
Becker, D.E., 2011, Adverse Drug Interactions, Anesth Prog, Dayton, Oiho, 31-40.
Beevers, D.G., Gregory, Y.H., O’Brien, E., 2007, ABC of Hypertension, 5th edition, Blackwell Publishing, Massachuesetts, USA, pp. 7-12.
Berliani, P., 2010, Perbedaan Pola Peresepan Obat Hipertensi pada Pasien Gakin Antara Semester I dan Semester II di Puskesmas Induk Tegalrejo Yogyakarta Tahun 2009, Fakultas Farmasi Universitas Sanata Dharma, Yogyakarta.
Bibi, Z., 2008, Retracted: Role of Cytochrome P450 in Drug Interactions, Nutrition and Metabolism, 1-10.
Black, H.R., and Elliot, W.J., 2007, Hypertension: A Companion to Braunwald’s Heart Disease, Elsevier’s Health Sciences, Canada, pp. 39-53.
Chelmow, D., Geibel, J., Grimm, L., Harris, J.E., Maron, D.J., Meyers, A.D., et al., Drug Interaction Checker, Medscape, http://reference.medscape.com/drug-interactionchecker, diakses tanggal 28 mei 2014.
Chobanian,V.A., Bakris, G.L., Black, H.R., Cushman, W.C., Greem, L.A., Izzo, L.J., et al., 2003, The Seventh Report of the Joint National Comitee on Prevention, Detection, Evaluation, and Treatment of High Blood Pessure, JAMA, 2560-2563.
Dinas Kesehatan Kabupaten Bantul, 2010, Rencana Strategis Dinas Kesehatan Kabupaten Bantul Tahun 2011-2015, Dinas Kesehatan Kabupaten Bantul, Yogyakarta.
Dinas Kesehatan Daerah Istimewa Yogyakarta (DIY), 2012, Profil Kesehatan Daerah Istimewa Yogyakarta Tahun 2012, Dinas Kesehatan Daerah Istimewa Yogyakarta (DIY), Yogyakarta.
Dipiro, J.T., Talbert, R.L., Yee, G.C., Matzke, G.R., Wells, B.G., Posey, L.M., 2008, Pharmacotherapy: A Pathophysiologic Approach, 7th edition, Mc-GrawHil, USA, pp.160-168.
Fitriani, 2005, Profil Peresepan dan Evaluasi Interaksi Obat Hipertensi pada Pasien Geriatri Di Instalasi Rawat Inap Rumah Sakit Panti Rapih Yogyakarta Tahun 2005, Fakultas Farmasi Universitas Sanata Dharma, Yogyakarta.
Fulcher, E.M., Fulcher, R.M., Soto, C.D., 2012, Pharmacology: Principles and Applications, 3rd edition, Elsevier Sounder, USA, pp.357-360.
Guan, Y., Zhang, Y., Wu, J., Qi, Z., Yang, G., Dou, D., et al., 2007, Antihypertensive Effects of Selective Prostaglandin E2 Receptor Subtype 1 Targeting, The Journal of Clinical Investigation, Vol. 117, 2496-2504.
Ganong, F.W., 2005, Medical Physiology, 22nd edition, McGraw-Hill, USA, p. 641.
Hansten, P.D. and Horn, J.R., 2002, Managing Clinically Important Drug Interactions, Facts and Comparisons, USA, pp. 14, 65, 39-40, 99-100, 567.
Huang, J., Niu, C., Green, C.D., Yang, L., Mei, H., Han, D.H., 2013, Sistemic Prediction of Pharmacodynamic Drug-Drug Interactions through Protein-Protein-Interaction Network, Network-based Prediction of Drug-Drug Interaction, 1-5.
Huether, S.E., and McCance, K.L., 2008, Understanding Phatophysiology, 4th edition, Mosby Inc an affiliate of Elsevier Inc, China, pp. 588-598, 608-614.
Houston, M.C., 2009, Handbook of Hypertension, John Wiley and Sons, Garsington Road, UK, pp. 50-52, 97-106.
Izzo, J.L., Sica, D.A., Black, H.R., 2008, Hypertension Primer: The Essentials of High Blood Pressure: Basic Science, Population Science, and Clinical Management, 4th edition, Lippincott Williams and Wilkins, pp. 144-146, 163-165, 456-460.
James, P.A., Oparil, S., Carter, B.L., Cushman, W.C., Himmelfarb, C.D., Handler, J., et al., 2013, Evidence- Based Guidline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eight Joint National Comitee (JNC8), JAMA.
Jia, Z., Guo, X., Zhang, H., Wang, M.H., Dong, Z., Yang, T., 2008, Microsomal Prostaglandin Synthase-1-Derived Prostaglandin E2 Protects Against Angiotensin II-Induced Hypertension via Inhibition of Oxidative Stress, Journal of The American Heart Association, 952-958.
Kalliokosko, A., and Niemi, M., 2009, Impact of OATP transporters on pharmacokinetics, The British Pharmacological Society, 693-701. Katzung, B.G., Masters, S.B., Trevor, A.J., 2012, Farmakologi Dasar dan Klinik,
Vol.1, Edisi 12, Penerbit Kedokteran EGC, Jakarta, hal. 187-210. Kaplan, N.M., Victor, R.G., Flynn, J.T., 2010, Kaplan’s Clinical Hypertension,
10th edition, Lippincott Williams and Wilkins, pp. 169-180, 223-230. Kowalski, R.,E., 2007, The Blood Pessure Cure: 8 Weeks to Lower Blood
Pressure without Prescription Drugs,diterjemahkan oleh Ekawati,S.,R., hal. 42,43, Qanita, Bandung.
Lehne, R. A., 2013, Pharmacology for Nursing Care, 8th edition, Elsevier Health Science, St. Louis, Missouri, p. 547, 643-650.
Lilly, L.S., 2010, Pathophysiology of Heart Disease : A Collaborative Project of Medical Students and Faculty, 5th edition, Lippincott Williams and Wilkins, China, p. 309.
Lima, R., Wofford, M., and Reckelhoff, J.F., 2012, Hypertension in Postmenopausal Women, Curr Hypertens, 2-6.
Madhu, T., and Sreedevi, A., 2013, A Study of Socio Demographic Profile of Geriatric Pepulation in the Field Practice Area of Kurnool Medical College, Int J Res Dev Health, 69-71.
Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Bohm, J., et al., 2013, The Task Force for the Management of Arterial Hypertension of the Europan Society of Hypertension (ESH) and of the European Society of Cardiology (ESC), Journal of Hypertension, 1306-1316. Maron, B.A., and Leopold, J.A., 2010, Aldosterone Receptor Antagonists:
Effective but Often Forgotten, Journal of the American Heart Association, 934-938.
Martin, L.J., 2008, Hypertension Guidelines: Reversiting the JNC 7 Recommendation, The Journal of Lancaster General Hospital, vol.3, 91-97.
Miura, S., and Saku, K., 2012, Efficacy and Safety of Angiotensin II Type 1 Receptor Blocker/Calcium Channel Blocker Combination Therapy for Hypertension: Focus on a Single-Pill Fixed-Dose Combination of Valsartan and Amlodipine, Journal of International Medical Research, 1-5.
Munif, A., and Imron, M., 2010, Metodelogi Penelitian Bidang Kesehatan, Sagung Seto, Jakarta, hal: 107, 108, 158.
Nesbitt, S., 2007, Antihypertensive Combination Therapy: Optimizing Blood Pressure Control and Cardiovascular Risk Reduction, The Journal of Clinical Hypertension, 27-30.
Nishio, S., Watanabe, H., Kosuge, K., Uchida, S., Hayashi, H., and Ohashi, K., 2005, Interaction between Amlodipine and SImvastatin in Patients with Hypercholesterolemia and Hypertension, Hypertens Res, Vol. 28, Jepang, 223- 227.
Nugrahaeni, K.D., 2010, Konsep Dasar Epidemiologi, Penerbit Buku Kedokteran EGC, Jakarta, hal : 129-133.
Porth, M.C., and Matfin, G., 2009, Pathophysiology: Concepts of Altered Health States, 8th edition, Wolters Kluwer Health, Lipincott Williams and Wilkins, Philadelphia, pp. 505-528.
Porth, C., 2011, Essentials of Pathophysiology:Concepts of Altered Health States, 3rd edition, Lippincott Williams and Wilkins,pp. 431-438.
Rodriguez, J.C.H., and Calvert, J.F., 2006, Hyperkalemia, Journal of American Family Physician, Vol. 73, 283-288.
Rowan, C., Brinker, A.D., Nourjah, P., Chang, J., Mosholder, A., Barrett, J.S., et al., 2009, Rhabdomyolysis Report Show Interaction between Simvastatin and CYP3A4 Inhibitors, Pharmacoepidemiol Drug Saf, 1-4.
Stokes, G.S., 2009, Management of Hypertension in the Elderly Patient, Clinical Interventions in Aging, 378.
Swarjana, I.K., 2012, Metodologi Penelitian Kesehatan Tuntunan Praktis Pembuatan Proposal Penelitian, Penerbit ANDI, Yogyakarta, hal: 53-55.
Syamsudin, 2011, Interaksi Obat Konsep Dasar dan Klinis, Penerbit Universitas Indonesia (UI-Pres), Jakarta, hal : 39-88.
Tatro, D.S., 2007, Drug Interaction Facts, Wolters Kluwer Health, United States of America, pp. ix-xxix, 36, 277, 278, 286, 549, 942, 1195, 1424. Theodorine, G., 2002, Studi Literatur Tentang Interaksi Obat Hipertensi Tanpa
Komplikasi Penderita Lanjut Usia pada Instalasi Rawat Inap Rumah Sakit Panti Rapih Yogyakarta Periode Januari-Desember 2001, Fakultas Farmasi Universitas Sanata Dharma, Yogyakarta.
Triplittt, C., 2006, Drug Interactions of Medications Commonly Used in Diabetes, Diabetes Spectrum Journals, 202-208.
William, K., Thompson, D., Seto, I., Curtis,S., Constantin, E., Batmanabane, G., Hartling, L., et al., 2012, Standard 6 : Age Groups For Paediatric Trial, Paediatric Official Journal Of the American Academy Of Paediatric, 6. Zillich, A.J., Garg, J., Basu, S., Bakris, G.L., Carter, B.L., 2006, Tiazid Diuretics,
Potassium, and the Development of Diabetes: A Quantitative Review, Journal of the American Heart Association, 219-221.
Lampiran 3: Alat atau instrumen pengambilan data penelitian peresepan obat pada pasien hipertensi di Instalasi Rawat Jalan RSUD Panembahan Senopati Bantul Yogyakarta periode Desember 2013
No Tanggal No. RM
Pasien
Diagnosis Tekanan
Darah
Terapi yang diberikan
Jumlah Obat
Keterangan
Obat Hipertensi Obat Lain
Umur Jenis
Kelamin Jenis Obat
Regimen
Dosis Jenis Obat
Regimen Dosis Obat HT Obat Lain
I Putu Yuda Pratama merupakan anak pertama dari pasangan I Nyoman Widana dan Ni Kadek Ayu Mahayuni, lahir di Nongan tanggal 12 Mei 1993. Pendidikan dimulai di Taman Kanak Kanak Dipa Kumara Kuwum tahun 1998 hingga tahun 1999.
Kemudian melanjutkan pendidikan di Sekolah Dasar Negeri 1 Kuwum mulai tahun 1999 hingga tahun 2005. Kemudian ke jenjang pendidikan Sekolah Menengah Pertama Negeri 1 Marga tahun 2005 hingga tahun 2008. Setelah itu naik ke jenjang pendidikan Sekolah Menengah Atas Negeri 1 Tabanan mulai tahun 2008 hingga tahun 2011.
Kemudian naik ke jenjang berikutnya pada tahun 2011 di Perguruan Tinggi Fakultas Farmasi Universitas Sanata Dharma Yogyakarta dan menyelesaikan masa studi pada tahun 2014. Selama menjadi mahasiswa penulis aktif dalam kegiatan kemahasiswaan antara lain Pharmacy day tahun 2012 dan Desa Mitra 1 dan 2 pada tahun 2013.
