HUBUNGAN KADAR HDL DENGAN DERAJAT KEPARAHAN SEPSIS BERDASAR SKOR SEQUENTIAL ORGAN FAILURE ASSESSMENT (SOFA) Penelitian Observasional Analitik Cross-Sectional di Instalasi Gawat Darurat Departemen Ilmu Penyakit Dalam RSUD Dr. Soetomo Surabaya Divisi Tropik

IR-PERPUSTAKAAN UNIVERSITAS AIRLANGGA. DAFTAR PUSTAKA Abbas AK, 2018. Innate Immunity. In: Abbas AK, Lichtman AH & Pillai S, Eds. Cellular and Molecular Immunology, Ninth Edition. California: Elsevier Saunders 4: 57-86. Akira, S., Uematsu, S. and Takeuchi, O., 2006. Pathogen recognition and innate immunity. Cell, 124(4), pp.783-801. Akmal, M., Zely I., 2010. Ensiklopedi Kesehatan Umum. Yogyakarta: Ar-Ruzz Media. Al-Khafaji, A.H., Sharma, S. and Eschun, G., 2019. Multiple organ dysfunction syndrome in sepsis. Drugs & Diseases> Infectious Diseases. Updated: Feb 5. Almirall, J., Bolibar, I., Vidal, J., Sauca, G., Coll, P., Niklasson, B., Bartolome, M. and Balanzo, X., 2000. Epidemiology of community-acquired pneumonia in adults: a population-based study. European Respiratory Journal, 15(4), pp.757-763. Angele, M.K., Pratschke, S., Hubbard, W.J. and Chaudry, I.H., 2014. Gender differences in sepsis: cardiovascular and immunological aspects. Virulence, 5(1), pp.12-19. Angus, D.C. and Van der Poll, T., 2013. Severe sepsis and septic shock. New England Journal of Medicine, 369(9), pp.840-851. Baharoon, S., Telmesani, A., Tamim, H., Alsafi, E., Aljohani, S., Mahmoud, E. and AlJahdali, H., 2015. Community-versus nosocomial-acquired severe sepsis and septic shock in patients admitted to a tertiary intensive care in Saudi Arabia, etiology and outcome. Journal of infection and public health, 8(5), pp.418-424. Becker, K., Heilmann, C. and Peters, G., 2014. Coagulase-negative staphylococci. Clinical microbiology reviews, 27(4), pp.870-926. Bertsias, G., Cervera, R. and Boumpas, D.T., 2012. Systemic lupus erythematosus: pathogenesis and clinical features. EULAR textbook on rheumatic diseases, Geneva, Switzerland: European League Against Rheumatism, pp.476-505. Blasius, A.L. dan Beutler, B., 2010. Intracellular toll-like receptors. Immunity, 32(3), pp.305315. Bone, R.C., Balk, R.A., Cerra, F.B., Dellinger, R.P., Fein, A.M., Knaus, W.A., Schein, R.M. and Sibbald, W.J., 1992. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest, 101(6), pp.1644-1655. Botos, I., Segal, D.M. dan Davies, D.R., 2011. The structural biology of Toll-like receptors. Structure, 19(4), pp.447-459. Brandt, M., 2018. Introduction to Lipid Metabolism. [online] Rose-hulman.edu. Available at: https://www.rose-hulman.edu/~brandt/Chem330/Lipid_metab.pdf [Accessed 7 Aug. 2018]. Carbone, F., Nencioni, A., Mach, F., Vuilleumier, N. and Montecucco, F., 2013. Evidence on the pathogenic role of auto-antibodies in acute cardiovascular diseases. Thrombosis and haemostasis, 110(05), pp.854-868. Caroff, M., Karibian, D., Cavaillon, J.M. and Haeffner-Cavaillon, N., 2002. Structural and functional analyses of bacterial lipopolysaccharides. Microbes and infection, 4(9), pp.915-926. Ceccato, A. and Torres, A., 2018. Sepsis and community-acquired pneumonia. Annals of Research Hospitals, 2(7). 57 KARYA AKHIR. HUBUNGAN KADAR HDL... ZAKI NUGRAHA KUMARA PUTRA.

IR-PERPUSTAKAAN UNIVERSITAS AIRLANGGA. Centers for Disease Control and Prevention, 2018. Data and Reports. [online] Available at: https://www.cdc.gov/sepsis/datareports/index.html [Accessed 7 Aug. 2018]. Catapano, A.L., Pirillo, A., Bonacina, F. and Norata, G.D., 2014. HDL in innate and adaptive immunity. Cardiovascular research, 103(3), pp.372-383. Chapman, M.J., 2004. Are the effects of statins on HDL-cholesterol clinically relevant . European Heart Journal Supplements, 6(suppl_C), pp.C58-C63. Chong, D.L. and Sriskandan, S., 2011. Pro-inflammatory mechanisms in sepsis. In Sepsis-ProInflammatory and Anti-Inflammatory Responses (Vol. 17, pp. 86-107). Karger Publishers. Cirstea, M., Walley, K.R., Russell, J.A., Brunham, L.R., Genga, K.R. and Boyd, J.H., 2017. Decreased high-density lipoprotein cholesterol level is an early prognostic marker for organ dysfunction and death in patients with suspected sepsis. Journal of critical care, 38, pp.289-294. Dahlan MS. (2013). Langkah – langkah membuat proposal penelitian bidang kedokteran dan kesehatan. Seri Evidence Based Medicine, edisi ke-2, Jakarta. Salemba Medika: 158 – 159. De La Rica, A.S., Gilsanz, F. and Maseda, E., 2016. Epidemiologic trends of sepsis in western countries. Annals of translational medicine, 4(17). Dembic, Z., 2015. Cytokines of the immune system: interleukins. The cytokines of the immune system the role of cytokines in disease related to immune response. San Diego: Mica Haley, pp.143-175. Feingold, K.R. and Grunfeld, C., 2011. The role of HDL in innate immunity. Journal of lipid research, 52(1), pp.1-3 Gautier, T. and Lagrost, L., 2011. Plasma PLTP (phospholipid-transfer protein): an emerging role in ‘reverse lipopolysaccharide transport’and innate immunity. Grunfeld, C., Marshall, M., Shigenaga, J.K., Moser, A.H., Tobias, P. and Feingold, K.R., 1999. Lipoproteins inhibit macrophage activation by lipoteichoic acid. Journal of lipid research, 40(2), pp.245-252. Grunfeld, C. and Feingold, K.R., 2008. HDL and innate immunity: a tale of two apolipoproteins. Journal of lipid research, 49(8), pp.1605-1606. Hall, M.J., Williams, S.N., DeFrances, C.J. and Golosinskiy, A., 2011. Inpatient care for septicemia or sepsis: a challenge for patients and hospitals. Hannuksela, M., Marcel, Y.L., Kesäniemi, Y.A. and Savolainen, M.J., 1992. Reduction in the concentration and activity of plasma cholesteryl ester transfer protein by alcohol. Journal of lipid research, 33(5), pp.737-744. Heb, N., Waldow, F., Kohler, T.P., Rohde, M., Kreikemeyer, B., Gómez-Mejia, A., Hain, T., Schwudke, D., Vollmer, W., Hammerschmidt, S. and Gisch, N., 2017. Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae. Nature communications, 8(1), p.2093. Heidelbaugh, J.J. and Bruderly, M., 2006. Cirrhosis and chronic liver failure: part I. Diagnosis and evaluation. American family physician, 74(5).. 58 KARYA AKHIR. HUBUNGAN KADAR HDL... ZAKI NUGRAHA KUMARA PUTRA.

IR-PERPUSTAKAAN UNIVERSITAS AIRLANGGA. Henriksen, D.P., Pottegård, A., Laursen, C.B., Jensen, T.G., Hallas, J. and Lassen, A.T., 2015. Risk factors for hospitalization due to community-acquired sepsis–a population-based case-control study. PLoS One, 10(4), p.e0124838. Hewing, B., Moore, K.J. and Fisher, E.A., 2012. HDL and cardiovascular risk: time to call the plumber. Circulation Research, 111(9), pp.1117-1120. Irawan, D., Hamidah, P., Triyono, E.A., Bramantono, A.V., Hadi, U., Nasronudin, S. and Soewandojo, E., 2012. Profil penderita sepsis akibat bakteri penghasil ESBL. J Peny Dalam, 13(1), p.63. Jiao, Y.L. and Wu, M.P., 2008. Apolipoprotein AI diminishes acute lung injury and sepsis in mice induced by lipoteichoic acid. Cytokine, 43(1), pp.83-87. Kaji, H., 2013. High-density lipoproteins and the immune system. Journal of lipids, 2013. Kardassis, D., Mosialou, I., Kanaki, M., Tiniakou, I. and Thymiakou, E., 2014. Metabolism of HDL and its regulation. Current medicinal chemistry, 21(25), pp.2864-2880. Kawai, T. dan Akira, S., 2011. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity, 34(5), pp.637-650. Keene, D., Price, C., Shun-Shin, M.J. and Francis, D.P., 2014. Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117 411 patients. Bmj, 349, p.g4379. King, M., 2018. Lipoproteins, Lipoprotein Metabolism and Disease [LDL, HDL, Lp(a)]. [online] Themedicalbiochemistrypage.org. Available at: https://themedicalbiochemistrypage.org/lipoproteins.php#hdl [Accessed 19 Aug. 2018]. Kitchens, R.L. and Thompson, P.A., 2003. Impact of sepsis-induced changes in plasma on LPS interactions with monocytes and plasma lipoproteins: roles of soluble CD14, LBP, and acute phase lipoproteins. Journal of endotoxin research, 9(2), pp.113-118. Lamar, C.D., Hurley, R.A. and Taber, K.H., 2011. Sepsis-associated encephalopathy: review of the neuropsychiatric manifestations and cognitive outcome. The Journal of neuropsychiatry and clinical neurosciences, 23(3), pp.237-241. Levy, M.M., Fink, M.P., Marshall, J.C., Abraham, E., Angus, D., Cook, D., Cohen, J., Opal, S.M., Vincent, J.L. and Ramsay, G., 2003. 2001 sccm/esicm/accp/ats/sis international sepsis definitions conference. Intensive care medicine, 29(4), pp.530-538. Lewis, D.H., Chan, D.L., Pinheiro, D., Armitage‐Chan, E. and Garden, O.A., 2012. The immunopathology of sepsis: pathogen recognition, systemic inflammation, the compensatory anti‐inflammatory response, and regulatory T cells. Journal of Veterinary Internal Medicine, 26(3), pp.457-482. Lie, K.C., Lau, C.Y., Chau, N.V.V., West, T.E. and Limmathurotsakul, D., 2018. Utility of SOFA score, management and outcomes of sepsis in Southeast Asia: a multinational multicenter prospective observational study. Journal of intensive care, 6(1), p.9. Liljestrand, J.M., Paju, S., Buhlin, K., Persson, G.R., Sarna, S., Nieminen, M.S., Sinisalo, J., Mäntylä, P. and Pussinen, P.J., 2017. Lipopolysaccharide, a possible molecular mediator between periodontitis and coronary artery disease. Journal of clinical periodontology, 44(8), pp.784-792.. 59 KARYA AKHIR. HUBUNGAN KADAR HDL... ZAKI NUGRAHA KUMARA PUTRA.

IR-PERPUSTAKAAN UNIVERSITAS AIRLANGGA. Maeda, K., Noguchi, Y. and Fukui, T., 2003. The effects of cessation from cigarette smoking on the lipid and lipoprotein profiles: a meta-analysis. Preventive medicine, 37(4), pp.283-290. Malanovic, N. and Lohner, K., 2016. Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides. Biochimica et Biophysica Acta (BBA)Biomembranes, 1858(5), pp.936-946. Marshall, J.C., 2001. Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome. Critical care medicine, 29(7), pp S99-S106. Marti, B., Knobloch, M.I.C.H.A.E.L., Riesen, W.F. and Howald, H., 1991. Fifteen-year changes in exercise, aerobic power, abdominal fat, and serum lipids in runners and controls. Medicine and science in sports and exercise, 23(1), pp.115-122. Martin GS, Brunkhorst FM, Janes JM, Reinhart K, Sundin DP, Garnett K, Beale R, 2009. The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes. Critical Care. 13(3):1-14. Masana, L., Cabré, A., Heras, M., Amigó, N., Correig, X., Martínez-Hervás, S., Real, J.T., Ascaso, J.F., Quesada, H., Julve, J. and Palomer, X., 2015. Remarkable quantitative and qualitative differences in HDL after niacin or fenofibrate therapy in type 2 diabetic patients. Atherosclerosis, 238(2), pp.213-219. Massy, Z.A. and De Zeeuw, D., 2013. LDL cholesterol in CKD—to treat or not to treat. Kidney international, 84(3), pp.451-456. Mattsson, E., Van Dijk, H., Verhoef, J., Norrby, R. and Rollof, J., 1996. Supernatants from Staphylococcus epidermidis grown in the presence of different antibiotics induce differential release of tumor necrosis factor alpha from human monocytes. Infection and immunity, 64(10), pp.4351-4355. Mayr, F.B., Yende, S. and Angus, D.C., 2014. Epidemiology of severe sepsis. Virulence, 5(1), pp.4-11. McPherson, D., Griffiths, C., Williams, M., Baker, A., Klodawski, E., Jacobson, B. and Donaldson, L., 2013. Sepsis-associated mortality in England: an analysis of multiple cause of death data from 2001 to 2010. BMJ open, 3(8), p.e002586. Mizock, B.A., 2009. The multiple organ dysfunction syndrome. Disease-a-Month, 55(8), pp.476-526. Morgantini, C., Meriwether, D., Baldi, S., Venturi, E., Pinnola, S., Wagner, A.C., Fogelman, A.M., Ferrannini, E., Natali, A. and Reddy, S.T., 2014. HDL lipid composition is profoundly altered in patients with type 2 diabetes and atherosclerotic vascular disease. Nutrition, Metabolism and Cardiovascular Diseases, 24(6), pp.594-599. Morin, E.E., Guo, L., Schwendeman, A. and Li, X.A., 2015. HDL in sepsis–risk factor and therapeutic approach. Frontiers in pharmacology, 6, p.244. Morton, J., Ng, M.K., Chalmers, J., Woodward, M., Mancia, G., Poulter, N.R., Marre, M., Cooper, M.E., Zoungas, S. and ADVANCE collaborative group, 2013. The association of high-density lipoprotein cholesterol with cancer incidence in type ii diabetes: a case of reverse causality. Cancer Epidemiology and Prevention Biomarkers. Muennig, P., Sohler, N. and Mahato, B., 2007. Socioeconomic status as an independent predictor of physiological biomarkers of cardiovascular disease: evidence from NHANES. Preventive medicine, 45(1), pp.35-40. 60 KARYA AKHIR. HUBUNGAN KADAR HDL... ZAKI NUGRAHA KUMARA PUTRA.

IR-PERPUSTAKAAN UNIVERSITAS AIRLANGGA. Munker R, 2007. Lymphocytosis, Lymphocytopenia, Lymphadenopathy, and Splenomegaly. In: Munker R, Hiller E, Glass J, Paquette R, Eds. Modern Hematology: Biology and Clinical Management, Second Edition. New Jersey: Humana Press. 217-224. Murch, O., Collin, M., Hinds, C.J. and Thiemermann, C., 2007. Lipoproteins in inflammation and sepsis. I. Basic science. Intensive care medicine, 33(1), pp.13-24. Murch, O., Collin, M., Hinds, C.J. and Thiemermann, C., 2007. Lipoproteins in inflammation and sepsis. I. Basic science. Intensive care medicine, 33(1), pp.13-24. Naresh, M., Vidyasagar, S. and Elagandula, J., 2015. Study of serum HDL levels in severe sepsis patients in medical intensive care unit. International Journal of Scientific and Research Publication, 5. Navab, M., Reddy, S.T., Van Lenten, B.J. and Fogelman, A.M., 2011. HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms. Nature Reviews Cardiology, 8(4), p.222. Neviere, R., 2013. Pathophysiology of sepsis. In UpToDate. UpToDate, Waltham (MA). Newton, K. and Dixit, V.M., 2012. Signaling in innate immunity and inflammation. Cold Spring Harbor perspectives in biology, p.a 006049. Osterbur, K., Mann, F.A., Kuroki, K. and DeClue, A., 2014. Multiple organ dysfunction syndrome in humans and animals. Journal of veterinary internal medicine, 28(4), pp.1141-1151. Patel, P.N., Shah, R.Y., Ferguson, J.F. and Reilly, M.P., 2015. Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases. Arteriosclerosis, thrombosis, and vascular biology, 35(3), pp.525-534. Pawar, A., Raut, A., Kalrao, V., Jacob, J., Godha, I. and Thomas, R., 2016. Etiology and clinical outcomes of neonatal and pediatric sepsis. Archives of Pediatric Infectious Diseases, 4(2). PERKENI, 2015. Konsensus Pegelolaan dan Pencegahan Diabetes Mellitus Tipe 2 di Indonesia 2015. Pengurus Besar Perkumpulan Endokrinologi Indonesia, hal 11. Pirillo, A., Catapano, A.L. and Norata, G.D., 2015. HDL in infectious diseases and sepsis. In High Density Lipoproteins (pp. 483-508). Springer, Cham. Pirillo, A., Tibolla, G., Norata, G.D. and Catapano, A.L., 2014. HDL: to treat or not to treat. Current atherosclerosis reports, 16(8), p.429. Rader, D.J., 2006. Molecular regulation of HDL metabolism and function: implications for novel therapies. The Journal of clinical investigation, 116(12), pp.3090-3100. Ramirez, M., 2013. Multiple organ dysfunction syndrome. Current problems in pediatric and adolescent health care, 43(10), pp.273-277. Ranzani, O.T., Shankar-Hari, M., Harrison, D.A., Rabello, L.S., Salluh, J.I., Rowan, K.M. and Soares, M., 2019. A Comparison of Mortality from Sepsis in Brazil and England: The Impact of Heterogeneity in General and Sepsis-Specific Patient Characteristics. Critical care medicine, 47(1), pp.76-84. Remick, D.G., 2007. Pathophysiology of sepsis. The American journal of pathology, 170(5), pp.1435-1444.. 61 KARYA AKHIR. HUBUNGAN KADAR HDL... ZAKI NUGRAHA KUMARA PUTRA.

IR-PERPUSTAKAAN UNIVERSITAS AIRLANGGA. Rhee, C., Dantes, R., Epstein, L., Murphy, D.J., Seymour, C.W., Iwashyna, T.J., Kadri, S.S., Angus, D.C., Danner, R.L., Fiore, A.E. and Jernigan, J.A., 2017. Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014. Jama, 318(13), pp.1241-1249. Riemens, S.C., Van Tol, A., Sluiter, W.J. and Dullaart, R.P.F., 1999. Acute and chronic effects of a 24-hour intravenous triglyceride emulsion challenge on plasma lecithin: cholesterol acyltransferase, phospholipid transfer protein, and cholesteryl ester transfer protein activities. Journal of lipid research, 40(8), pp.1459-1466. Schuetz, P., Castro, P. and Shapiro, N.I., 2011. Diabetes and sepsis: preclinical findings and clinical relevance. Diabetes care, 34(3), pp.771-778. Seidell, J.C., Cigolini, M., Charzewska, J., Ellsinger, B.M., Björntorp, P., Hautvast, J.G. and Szostak, W., 1991. Fat distribution and gender differences in serum lipids in men and women from four European communities. Atherosclerosis, 87(2-3), pp.203-210. Simon, V., Ho, D.D. and Karim, Q.A., 2006. HIV/AIDS epidemiology, pathogenesis, prevention, and treatment. The Lancet, 368(9534), pp.489-504. Singer, M., Deutschman, C.S., Seymour, C.W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G.R., Chiche, J.D., Coopersmith, C.M. and Hotchkiss, R.S., 2016. The third international consensus definitions for sepsis and septic shock (Sepsis3). Jama, 315(8), pp.801-810. Starr, M.E. and Saito, H., 2014. Sepsis in old age: review of human and animal studies. Aging and disease, 5(2), p.126. Stoller, J., Halpin, L., Weis, M., Aplin, B., Qu, W., Georgescu, C. and Nazzal, M., 2016. Epidemiology of severe sepsis: 2008-2012. Journal of critical care, 31(1), pp.58-62. Szabo, G., Romics, J.L. and Frendl, G., 2002. Liver in sepsis and systemic inflammatory response syndrome. Clinics in liver disease, 6(4), pp.1045-66. Taeb, A.M., Hooper, M.H. and Marik, P.E., 2017. Sepsis: current definition, pathophysiology, diagnosis, and management. Nutrition in Clinical Practice, 32(3), pp.296-308. Takeuchi, O. dan Akira, S., 2010. Pattern recognition receptors and inflammation. Cell, 140(6), pp.805-820. Tambajong, R.N., Lalenoh, D.C. and Kumaat, L., 2016. Profil penderita sepsis di ICU RSUP Prof. Dr. RD Kandou Manadoperiode Desember 2014–November 2015. e-CliniC, 4(1). Tanaka, S., Labreuche, J., Drumez, E., Harrois, A., Hamada, S., Vigué, B., Couret, D., Duranteau, J. and Meilhac, O., 2017. Low HDL levels in sepsis versus trauma patients in intensive care unit. Annals of intensive care, 7(1), p.60. Tanaka, S., Diallo, D., Delbosc, S., Genève, C., Zappella, N., Yong-Sang, J., Patche, J., Harrois, A., Hamada, S., Denamur, E. and Montravers, P., 2019. High-density lipoprotein (HDL) particle size and concentration changes in septic shock patients. Annals of intensive care, 9(1), p.68. Tang, B.M., Herwanto, V., McLean, A.S., 2018. Immune paralysis in Sepsis: Recent Insights and Future Development. Annual Update in Intensive Care and Emergency Medicine 2018, pp 13-23. Triantafilou, M., Mouratis, M.A., Lepper, P.M., Haston, R.M., Baldwin, F., Lowes, S., Ahmed, M.A.E., Schumann, C., Boyd, O. and Triantafilou, K., 2012. Serum proteins 62 KARYA AKHIR. HUBUNGAN KADAR HDL... ZAKI NUGRAHA KUMARA PUTRA.

IR-PERPUSTAKAAN UNIVERSITAS AIRLANGGA. modulate lipopolysaccharide and lipoteichoic acid-induced activation and contribute to the clinical outcome of sepsis. Virulence, 3(2), pp.136-145. Tran‐Dinh, A., Diallo, D., Delbosc, S., Varela‐Perez, L.M., Dang, Q.B., Lapergue, B., Burillo, E., Michel, J.B., Levoye, A., Martin‐Ventura, J.L. and Meilhac, O., 2013. HDL and endothelial protection. British journal of pharmacology, 169(3), pp.493-511. Trieb, M., Horvath, A., Birner-Gruenberger, R., Spindelboeck, W., Stadlbauer, V., Taschler, U., Curcic, S., Stauber, R.E., Holzer, M., Pasterk, L. and Heinemann, A., 2016. Liver disease alters high-density lipoprotein composition, metabolism and function. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1861(7), pp.630-638. Tsunoda, F., Asztalos, I.B., Horvath, K.V., Steiner, G., Schaefer, E.J. and Asztalos, B.F., 2016. Fenofibrate, HDL, and cardiovascular disease in Type-2 diabetes: The DAIS trial. Atherosclerosis, 247, pp.35-39. Van Amersfoort, E.S., Van Berkel, T.J. and Kuiper, J., 2003. Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. Clinical microbiology reviews, 16(3), pp.379-414. Van Leeuwen, H.J., Heezius, E.C., Dallinga, G.M., van Strijp, J.A., Verhoef, J. and van Kessel, K.P., 2003. Lipoprotein metabolism in patients with severe sepsis. Critical care medicine, 31(5), pp.1359-1366. Vickers, K.C. and Remaley, A.T., 2014. HDL and cholesterol: life after the divorce. Journal of lipid research, 55(1), pp.4-12. Vincent JL, Moreno R, Takala J, Willatts S, De Mendon A, Bruining H, Reinhart CK, Suter PM, Thijs LG, 1996. Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Medicine. 22(7): 707-710. Vitali, C., Khetarpal, S.A. and Rader, D.J., 2017. HDL cholesterol metabolism and the risk of CHD: new insights from human genetics. Current cardiology reports, 19(12), p.132. Walter,. M., 2009. Interrelationships among HDL metabolism, aging, and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, 29(9), pp.12441250.. Wang, H. and Ma, S., 2008. The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome. The American journal of emergency medicine, 26(6), pp.711-715. Ward, N.S., Casserly, B. and Ayala, A., 2008. The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients. Clinics in chest medicine, 29(4), pp.617625. Ware, L.B. and Matthay, M.A., 2000. The acute respiratory distress syndrome. New England Journal of Medicine, 342(18), pp.1334-1349. Weissglas-Volkov, D. and Pajukanta, P., 2010. Genetic causes of high and low serum HDLcholesterol. Journal of lipid research, 51(8), pp.2032-2057. Wendel, M., Paul, R. and Heller, A.R., 2007. Lipoproteins in inflammation and sepsis. II. Clinical aspects. Intensive care medicine, 33(1), pp.25-35.. 63 KARYA AKHIR. HUBUNGAN KADAR HDL... ZAKI NUGRAHA KUMARA PUTRA.

IR-PERPUSTAKAAN UNIVERSITAS AIRLANGGA. World Health Organization, 1998. Obesity: preventing and managing the global epidemic: report of a WHO consultation on obesity, Geneva, 3-5 June 1997 (No. WHO/NUT/NCD/98.1). Geneva: World Health Organization. Wood, P.J., 2012. Immunological response to infection: inflammatory and adaptive immune responses. Anaesthesia & Intensive Care Medicine, 13(6), pp.269-272. Zhu, X. and Parks, J.S., 2012. New roles of HDL in inflammation and hematopoiesis. Annual review of nutrition, 32, pp.161-182.. 64 KARYA AKHIR. HUBUNGAN KADAR HDL... ZAKI NUGRAHA KUMARA PUTRA.