iii ABSTRAK
Pengujian ekstrak etanol daun ubi jalar (Ipomoea batatas (L.) Poir.) dan herba pegagan (Centella asiatica (L.) Urb.) terhadap jumlah trombosit, eritrosit, dan kadar hematokrit telah diteliti pada tikus putih jantan galur wistar (Rattus novergicus) dengan metode induksi heparin. Ekstrak diberikan secara oral selama 7 hari berturut-turut, dosis ekstrak etanol daun ubi jalar dan ekstrak etanol herba pegagan yang diberikan yaitu masing-masing 250 mg/kgBB dan 500 mg/kgBB. Pengamatan terhadap parameter-parameter tersebut dilakukan pada hari ketujuh dengan menggunakan alat Hematology analyzer sysmex XE-5000. Hasil penelitian terhadap jumlah trombosit menunjukkan bahwa ekstrak etanol herba pegagan pada dosis 500 mg/kgBB memiliki perbedaan nyata terhadap kontrol negatif pada taraf nyata α=0,05 dengan persentase peningkatan jumlah trombosit sebesar 36,02% terhadap kontrol negatif. Hasil penelitian terhadap jumlah eritrosit dan kadar hematokrit menunjukkan bahwa ekstrak etanol daun ubi jalar dosis 500 mg/kgBB dan ekstrak etanol herba pegagan dosis 500 mg/kgBB memiliki perbedaan nyata terhadap kontrol negatif pada taraf nyata α=0,05 dimana peningkatan jumlah eritrosit yang paling besar yaitu ekstrak etanol daun ubi jalar dosis 500 mg/kgBB dengan persentase peningkatan jumlah eritrosit sebesar 10,95% terhadap kontrol negatif, dan peningkatan kadar hematokrit yang paling besar yaitu ekstrak etanol daun ubi jalar dosis 500 mg/kgBB dengan persentase peningkatan kadar hematokrit sebesar 9,08% terhadap kontrol negatif.
Kata kunci: Trombosit, Eritrosit, Hematokrit, Daun ubi jalar (Ipomoea batatas (L.) Poir.), Herba pegagan (Centella asiatica (L.) Urb.)
FAKULTAS FARMASI
iv ABSTRACT
The aim of this research was to determine the effects of ethanol extracts of sweet potato leaves (Ipomoea batatas (L.) Poir.) and pegagan herb (Centella asiatica (L.) Urb.) against the number of thrombocytes, erythrocytes, and hematocrit levels on male white rats (Rattus novergicus ) by using Heparin Induction Method. Extracts was given orally for 7 continous days, the sweet potato leaves ethanol extract and the pegagan herb ethanol extract dosages used are 250 mg/kgBW and 500 mg/kgBW. Observation of the parameters was tested on the seventh day with using Hematology analyzer sysmex XE-5000. The results showed that the rats group which are given ethanol extract of pegagan herb 500 mg/kgBW dosage gave a significant differences in numbers of thrombocytes against negative control group (α=0.05) with a percentage value 36.02%. The rats group which are given ethanol extract of sweet potato leaves 500 mg/kgBW dosage and ethanol extract of pegagan herb 500 mg/kgBW dosage gave a significant differences in numbers of erythrocytes and hematocrit levels against negative control group (α=0.05). Sweet potato leaves extract at dosage 500 mg/kgBW gave the highest effect in increasing rats eyithrocytes number against negative control with a percentage value 10.95%. Sweet potato leaves extract at dosage 500 mg/kgBW gave the highest effect in increasing rats hematocrit levels against negative control with a percentage value 9,08%.
Keyword : Thrombocyte, Erythrocyte, Hematocrit, Sweet potato leaves (Ipomoea batatas (L.) Poir.), Pegagan herb (Centella asiatica (L.) Urb.)
