Hubungan Kadar Low-Density Lipoprotein Cholesterol dengan Kejadian dan Keparahan Stroke Akut

ABSTRAK

Latar Belakang : Peranan kolesterol serum sebagai penyebab stroke masih belum pasti.

Penelitian mengenai hubungan kadar

low-density lipoprotein cholesterol (LDL-C) dengan

stroke akut masih sangat sedikit, dengan hasil yang tidak konsisten. Penelitian ini bertujuan

untuk mengetahui hubungan kadar LDL-C dengan kejadian dan korelasinya dengan

keparahan stroke akut.

Metode :

Penelitian ini merupakan penelitian potong lintang terhadap 51 orang pasien

stroke akut yang dirawat di RSUP H. Adam Malik Medan. Subyek dikategorikan berdasarkan

tipe strokenya, yaitu: stroke iskemik dan hemoragik. Semua pasien menjalani penilaian skor

NIHSS saat masuk, skor SKG, penilaian volume lesi, pemeriksaan kadar lipid darah dan

penilaian keluaran dilakukan setelah 30 hari onset stroke.

Hasil : Subyek terdiri dari 26 (51%) laki-laki dan 25 (49%) perempuan dengan rerata umur

59.4+10.3 tahun. Dijumpai korelasi positif sangat lemah antara kadar LDL-C dengan

kejadian stroke iskemik dan hemoragik akut (r=0.178, p=0.472).

Dijumpai korelasi negatif

antara kadar LDL-C dengan skor NIHSS (r=-0.279, p=0.048), juga dengan skor mRS dalam

30 hari (r=-0.343, p=0.014). Subyek dengan kadar LDL-C <130 mg/dl memiliki peningkatan

rasio odds 6 kali lipat (RO=6.0; IK 95%, 0.941-42.8) untuk kematian dalam 30 hari

dibandingkan dengan subyek dengan kadar LDL-C>130 mg/dl (p=0.037).

Kesimpulan : Dijumpai korelasi positif sangat lemah yang tidak signifikan antara kadar

LDL-C dengan kejadian stroke iskemik dan hemoragik akut. Dijumpai pula korelasi negatif lemah

yang signifikan antara kadar LDL-C dengan keparahan dan keluaran stroke akut dalam 30

hari.

Kata Kunci :

low-density lipoprotein cholesterol- stroke akut- kejadian stroke-keparahan

stroke.

ABSTRACT

Introduction

: The role of serum cholesterol as the stroke etiology is still uncertain.

Studies that focused on the association between low-density lipoprotein cholesterol

(LDL-C) and acute stroke was still rare, with inconsistent results. The aim of this study is to

evaluate the correlation between LDL-C level and the acute stroke occurance and

severity.

Methods

: We conducted a cross-sectional study of 51-acute stroke patients in Adam

Malik General Hospital, Medan. Subjects was categorized according to their stroke type:

ischemic and hemorrhagic stroke. All subjects underwent evaluation of NIHSS score on

admission, Glasgow Coma Scale score, lesion volume and measurement of blood lipid

level. The outcome was assessed in 30

-

_{days after stroke onset.}

Results

: Subjects consists of 26 (51%) male and 25 (49%) female, with mean age of

59.4+10.3 years. There was a positive correlation between LDL-C level and the

occurance of acute ischemic and hemorrhagic stroke (r=0.178,p=0.472). There were

negative correlations between LDL-C level and NIHSS score on admission (r=-0.279,

p=0.048), and mRS score in 30 days (r=-0.343, p=0.014). There was an increase in odds

ratio for mortality in 30 days (OR=6.0;95%CI,0.941-42.8) in subjects with LDL-C level

<130 mg/dl compared to subjects with LDL-C level >130 mg/dl (p=0.037).

Conclusions

: There was an insignificant very weak positive correlation between LDL-C

level and the occurance of acute ischemic and hemorrhagic stroke. There were also a

significant weak negative correlation between LDL-C level and stroke severity and

outcome in 30-days.

Keywords

: acute stroke- low-density lipoprotein cholesterol- stroke occurance- stroke

severity.