PUBLIC
Hyperbaric Oxygen Teraphy in Aesthetic Plastic Surgery
Bambang Wicaksono, dr.,Sp.BP-RE
Sub Department of Plastic Reconstruction and Aesthetic Surgery Dr. Ramelan Naval Hospital, Surabaya, Indonesia
Email: [email protected]
Hyperbaric oxygen therapy (HBOT) is a therapy that have patients breath in pure oxygen in a pressurized chamber, has been long used as a treatment for conditions such as decompression sickness and carbon monoxide poisoning. HBOT has been shown to have detoxification effects and suppresses inflammation.
HBOT also stimulates angiogenesis, growing new blood vessels into tissue, and to cause stem cell release from our bone marrow into circulation.
HBO treatment was associated with vimentin immunoreactivity in fibroblasts, endothelial cells, and the bulbus pilorum of a subset of hair follicles. It also resulted in increased type IV collagen expression within the connective tissue in the hair follicles and sebaceous glands.
Recent study has shown that Hyperbaric Oxygen Teraphy have an important role in skin rejuvenation, treatment of photoaging skin, improvement in skin complexions , reduce visible wrinkles, and increase collagen deposition.
The interest in the use of HBOT for aesthetic purpose is continually growing and becoming more widespread.
Antiaging related to hyperbaric oxygen therapy
Marina Haroen
Department of Dermatology and Venereology, Dr. Ramelan Naval Hospital, Surabaya, Indonesia Email: [email protected]
Aging appears to be a genetically programmed event. Biologically, scientists have found that the chromosomes in our cells progressively shorten each time the cell divides. Eventually, the chromosomes can shorten no further and stop dividing. When this happens, the cells become senescent (sleepy) and die.
Hyperbaric oxygen therapy (HBOT), a therapy that have patients breath in pure oxygen in a pressurized chamber, has been long used as a treatment for conditions such as decompression sickness and carbon monoxide poisoning. Oxygen recently has been found to be an important component in skin rejuvenation, treatment of photoaging skin, and improvement in skin complexions. The interest in the use of HBOT for this purpose is continually growing and becoming more widespread. In addition to aging and genetic makeup, chronic UV radiation due to everyday exposure, especially UV-B, can greatly increase the rate of wrinkle formation through increasing skin angiogenesis and degradation of extracellular matrix molecules. The use of HBOT and hyperoxia conditions has been found to attenuate the formation of wrinkles from UV irradiation.
Oxygen use in skin care is justified by facilitation of collagen synthesis to combat wrinkle formation due to sun exposure and photo aging. Some studies listed below show that the use of oxygen therapy before the UV exposure decreases the wrinkle appearance.
The Effect of HBOT on the levels of ROS and clinical improvement of Autism
Sadya Wendra
Department of Mental Health, Dr. Ramelan Naval Hospital, Surabaya, Indonesia Email: [email protected]
Introduction
One of the benefits of Hyperbaric Oxygen Therapy (HBOT) provides enhancement of control capabilities with respect to the balance of Reactive Oxygen Species (ROS) and antioxidants.
Methodology
40 children of parents with autism, aged 2-9 years old, were divided into two groups of 20 children in the treatment group and 20 other children in the control. The treatment group was given HBOT as many as 10 times and standard therapy, while the control group was only given standard therapy. Before given HBOT, both groups review value ROS obtained from blood as well as the clinical symptoms assessed score by using ATEC and CARS. Then after being given HBOT both groups rated back ROS, ATEC and CARS.
Results
There are meaningful differences in appreciable changes in the group’s treatment compared to the control group the results of the test the samples t2 ROS shows the price p<0,05 that means there is meaningful difference the mean change in the value of the ROS between the treatment and control group. Mann-Whitney test results on the value of ATEC and CARS obtained value p<0,05 the means there is a meaningful difference the mean change ATEC and CARS between the treatment and control group. These results indicate there is lowering the levels of ROS at group treatment and there is clinical improvement.
Conclusion
HBOT improves the ability controlling the balance of ROS and antioxidants with declining ROS which improves oxidative stress as well as clinical improvement seen in child with Autism.
Hyperbaric Oxygen as an Adjuctive Treatment in Acute Ischemic Stroke
Ni Komang Sri Dewi Untari
Research and Development Unit, Drs. Med. R. Rijadi S., Phys.
Naval Health Institute, Indonesian Navy, Surabaya, Indonesia Email: [email protected]
Stroke, also known as cerebrovascular disease, is a common and serious neurological disease, which is also the fourth leading cause of death in United States so far. Related to the data from the World Health Organization, yearly 15 million people worldwide have stroke. The majority of patients with stroke have ischemic brain injury caused by thrombotic or embolic events. Ischemic stroke accounts for almost 85% of all cases. Brain ischemia, the most common cause of stroke, is defined as decreased blood flow to brain tissues that prevents adequate delivery of oxygen, glucose, and others nutrients leading to metabolic changes and possible cell death. Various molecular mechanisms of brain ischemia affect the degree of brain injury. Acute brain ischemia (ABI) is a neurological condition where neuronal cell death is caused by serial pathophysiological events, “ischemic cascade”, such as oxidative stress.
Oxidative stress presents one of the mechanisms contributing to neuronal damage, potentially induced through ABI. Therefore, antioxidant activity in the blood might be one of the important factors providing protection against the neurological damage caused by the oxidative stress related to brain ischemia. Now increasing evidence suggests that free radical such as superoxide anion, nitric oxide (NO), hydrogen peroxide, peroxynitrite, and highly reactive hydroxyl radical may play a key role in the pathogenesis of ABI.
Overproduced free radicals can induce functional and structural damage of neuronal cells due its capability of damaging lipids, proteins and nucleic acids. The existence of an abnormal balance between the oxidative and the antioxidative mechanisms in patients can be a causative factor for ABI
Hyperbaric medicine, as an emerging interdisciplinary subject, has been applied in the treatment of cerebral vascular disease since the 1960s. Now it is widely used to treat a variety of clinical disorders, especially hypoxia-induced disorders. However, owing to the complex mechanisms of hyperbaric oxygen (HBO) treatment, the therapeutic time window and the undefined dose as well as some common clinical side effects (such as middle ear barotrauma), the widespread promotion and application of HBO was hindered, slowing down the hyperbaric medicine development.
In August 2013, the US Food and Drug Administration declared artery occlusion as one of the 13 specific indications forHBO therapy. This provides opportunities, to some extent, for the further development of hyperbaric medicine. Currently, the mechanisms of HBO therapy for ischemic stroke are still not very clear.
This review focuses on the potential mechanisms of HBO therapy in acute ischemic stroke as well as the time window.