Supplementary Appendix Table S1: Characteristics of Bleeding Observed on Initial Head CT by BIG Group
Characteristic BIG 1
N = 2011 BIG 1 on ASA 81
N = 921 BIG 2
N = 1031 BIG 3
N = 11241 p-value2 BIG 1 on ASA vs
SDH 92 (46%) 52 (57%) 49 (48%) 699 (62%)
BIG 1: 0.09 BIG 2: 0.2 BIG 3: 0.3
tSAH 94 (47%) 39 (42%) 49 (48%) 686 (61%)
BIG 1: 0.5 BIG 2: 0.5 BIG 3: < 0.001
IVH 0 (0%) 0 (0%) 0 (0%) 121 (11%) NA
IPH 22 (11%) 8 (8.7%) 26 (25%) 394 (35%) BIG 1: 0.6
BIG 2: 0.002 BIG 3: <0.001
EDH 2 (1.0%) 0 (0%) 3 (2.9%) 78 (6.9%)
BIG 1: > 0.9 BIG 2: 0.2 BIG 3: 0.01
1 Statistics presented: n (%)
Table S2: Predictors of the Primary Endpoint (In-hospital mortality or neurosurgery), Including TEG
Predictor Odds ratio p-value Odds ratio p-value In-hospital mortality or
neurosurgery, N = 977 Univariate analysis Multivariable analysis Age (by decade) 0.95 (0.89, 1.00) 0.06 1.01 (0.85, 1.20) 0.49
Male sex 1.33 (1.01, 1.76) 0.03 1.94 (1.15, 3.50) 0.02 ISS (per point) 1.18 (1.16, 1.21) <0.001 1.16 (1.11, 1.21) <0.001 Alcohol level (per mg/dL) 0.47 (0.11, 1.8) 0.29
R time (per minute) 1.01 (0.92, 1.12) 0.7
K time (per minute) 1.27 (1.1, 1.5) <0.001 1.05 (0.75, 1.45) 0.99 Alpha angle (per 10
degrees) 0.65 (0.52, 0.81) <0.001 0.94 (0.52, 1.68) 0.70 Maximum amplitude (per
mm)
0.96 (0.95, 0.98) <0.001 1.03 (0.98, 1.08) 0.68 LY30 (per percentage point) 1.01 (0.98, 1.03) 0.28
AA inhibition (per 10%) 0.95 (0.90, 1.01) 0.08 0.96 (0.88, 1.04) 0.23 ADP inhibition (per 10%) 1.11 (1.05, 1.19) <0.001 1.05 (0.97, 1.15) 0.35 INR 1.49 (1.24, 1.81) <0.001 1.52 (0.94, 2.57) 0.37 Fibrinogen (per 10 mg/dL) 0.96 (0.95, 0.98) <0.001 0.96 (0.93, 0.99) 0.02
Anticoagulant use 1.11 (0.74, 1.62) 0.59
Antiplatelet agent use 0.61 (0.45, 0.82) <0.001 0.53 (0.27, 1.04) 0.07 Blood product
administration 4.49 (3.42, 5.91) <0.001 2.14(1.16, 3.99) 0.02 Subdural hematoma (SDH) 2.56 (1.93, 3.42) <0.001 2.10 (1.02, 4.53) 0.05
Subarachnoid hemorrhage
(SAH) 1.16 (0.89, 1.50) 0.25 Intraventricular hemorrhage
(IVH)
2.59 (1.74, 3.83) <0.001 0.73 (0.26, 1.91) 0.54 Intraparenchymal
hemorrhage (IPH)
1.71 (1.31, 2.22) <0.001 1.10 (0.59, 2.04) 0.76 Epidural hemorrhage
(EDH) 2.53 (1.58, 3.99) <0.001 2.12 (0.61, 7.80) 0.24 ISS: injury severity scale; AIS head: Abbreviated injury scale head; INR: international
normalized ratio; aPTT: activated partial thromboplastin time; LY30: percentage of fibrinolysis within 30 minutes, AA: arachidonic acid; ADP: adenosine diphosphate; ICH: intracranial hemorrhage
Table S3: Predictors of Mortality
Predictor Odds ratio p-value Odds ratio p-value
Mortality Univariate analysis Multivariate analysis Age (by decade) 1.14 (1.05, 1.24) <0.001 1.42 (1.26, 1.61) <0.001
Male sex 0.88 (0.63, 1.26) 0.50
ISS (per point) 1.15 (1.13, 1.18) <0.001 1.14 (1.11, 1.17) <0.001 Alcohol level (per mg/dL) 0.19 (0.02, 1.28) 0.10 0.53 (0.03, 7.25) 0.60
INR 1.65 (1.36, 2.03) <0.001 1.41 (1.08, 1.86) 0.01 Fibrinogen (per 10 mg/dL) 0.95 (0.93, 0.97) <0.001 0.96 (0.95, 0.99) 0.01
Anticoagulant use 1.23 (0.73, 1.99) 0.40 Antiplatelet agent use 0.85 (0.57, 1.22) 0.40
Blood product administration 6.59 (4.66, 9.38) <0.001 2.31 (1.44, 3.69) <0.001 Subdural hematoma (SDH) 2.74 (1.87, 4.13) <0.001 1.81 (1.06, 3.15) 0.03 Subarachnoid hemorrhage (SAH) 1.45 (1.03, 2.07) 0.03 2.02 (1.24, 3.35) 0.006
Intraventricular hemorrhage (IVH)
3.07 (1.92, 4.79) <0.001 1.90 (0.97, 3.63) 0.056 Intraparenchymal hemorrhage
(IPH) 1.53 (1.07, 2.15) 0.01 1.41 (0.86, 2.32) 0.20 Epidural hemorrhage (EDH) 1.07 (0.49, 2.08) 0.84
ISS: injury severity scale; AIS head: Abbreviated injury scale head; INR: international
Table S4: Predictors of Neurosurgery
Predictor Odds ratio p-value Odds ratio p-value
Neurosurgery Univariate analysis Multivariate analysis Age (by decade) 0.85 (0.79, 0.91) <0.001 0.89 (0.81, 0.98) 0.03
Male sex 1.51 (1.09, 2.10) 0.01 1.46 (0.98, 2.19) 0.065 ISS (per point) 1.14 (1.11, 1.16) <0.001 1.12 (1.09, 1.14) <0.001 Alcohol level (per mg/dL) 0.73 (0.15, 3.17) 0.69
INR 1.04 (0.83, 1.27) 0.65
Fibrinogen (per 10 mg/dL) 0.97 (0.96, 0.99) <0.001 1.01 (0.99, 1.03) 0.20 Anticoagulant use 0.92 (0.56, 1.45) 0.74
Antiplatelet agent use 0.51 (0.45, 0.72) <0.001 0.65 (0.39, 1.03) 0.067 Blood product administration 3.62 (2.66, 4.90) <0.001 1.91 (1.26, 2.87) 0.002 Subdural hematoma (SDH) 2.58 (1.86, 3.65) <0.001 2.42 (1.58, 3.79) <0.001 Subarachnoid hemorrhage (SAH) 0.96 (0.72, 1.29) 0.81
Intraventricular hemorrhage (IVH)
1.87 (1.17, 2.91) 0.006 1.10 (0.60, 1.96) 0.80 Intraparenchymal hemorrhage
(IPH) 1.71 (1.27, 2.31) <0.001 1.39 (0.94, 2.04) 0.10 Epidural hemorrhage (EDH) 3.05 (1.84, 4.92) <0.001 1.87 (1.00, 3.48) 0.048 ISS: injury severity scale; AIS head: Abbreviated injury scale head; INR: international
normalized ratio; aPTT: activated partial thromboplastin time; LY30: percentage of fibrinolysis within 30 minutes, AA: arachidonic acid; ADP: adenosine diphosphate; ICH: intracranial hemorrhage
