ATOM INDONESIA JOURNAL
Editor’s Report
Article No. : #378
Title of Paper : Association between Expressions of p70s6k with Radiotherapy Response in Cervical Cancer
Referee Name :
Comment on Descriptions 1. Title
[ ] Appropriate [ ] Should be changed
2. Abstract
Yes[X] No[ ] Is the length reasonable?
Yes[X] No[ ] Is it an appropriate summary of the content?
3. Main Text
Yes[ ] No[ ] Is there anything new in this work?
Yes[ ] No[ ] Is the relation to previous studies adequately stated?
Yes[ ] No[ ] Are the assumption(s) and/or method(s) described comprehensively?
Yes[ ] No[ ] Are the new results adequately emphasized?
Line # Referee’s Comments
14
In the present study, we determined the association between the expressions of …in cervical cancer was determined.
Immunohistochemical staining of p70s6k, MIB-1 and p53…
The result showed that p70s6k…
23 This treatment, and sometimes, could be combined…
28 …with chemoradiotherapy are such as clinical…
44-45 The activation target of p70s6k and its downstream target are ribosomal…
50 …of apoptosis as one kind of death in cancer cell…
63 …synthesis (S), and gap2 (G2) and mitosis (M)…
75-79
If it doesn’t change the actual meaning, the sentence should be revised into: “In our previous publication there were negative correlation between apoptosis cascape-3 with radiotherapy response, that is high level of Act expression related with poor or bad radiotherapy response, and there were…”
82 The aim of the study is to investigate the association…
98-99 …external radiation and internal radiation.
100 …with C-60 of total doses…
117 Do you mean ‘written informed concern’?
146 …as low expression while moderate…
152 …used to analyze the comparison…
166-
167 …high expression (61.9%... and low expression … 187-
188 9 Gy irradiation 190 ....Whenre where ...
204 …in mutant than in wild type.
205 …for this current data that explaining higher 212-
213 …as one of the way of cancer cell death…
230 …process of death cell and should…
237-
238 …radiotherapy response was early response, we think that major of cancer cell death was … 258 Expressions of p70s6k have important role…
260 radioresistance
Fig 2. Please state clearly which expressed of high and low expressions of p70s6k in x-axis (in the figure just written as 1 and 2)?
Fig 3. Same with figure 2, which expressed of high or low expressions of p70s6k? And the picture is not clear enough. Please provide with another picture that more clearly.
Some corrections is also needed as referee’s report.
Final comments and recommendations:
Accepted with some corrections above.
This paper is recommended to be [ ] Accepted without further revision [ ] Accepted with minor revision [ X ] Major Revision is required [ ] Rejected
ATOM INDONESIA JOURNAL 2nd Editor’s Report
Article No. : #378 Title of Paper : Referee Name :
Comment on Descriptions 1. Title
[ ] Appropriate [ ] Should be changed 2. Abstract
Yes[ ] No[ ] Is the length reasonable?
Yes[ ] No[ ] Is it an appropriate summary of the content?
3. Main Text
Yes[ ] No[ ] Is there anything new in this work?
Yes[ ] No[ ] Is the relation to previous studies adequately stated?
Yes[ ] No[ ] Are the assumption(s) and/or method(s) described comprehensively?
Yes[ ] No[ ] Are the new results adequately emphasized?
Line # Referee’s Comments
Final comments and recommendations:
For Reference :
1. The primary references ( journals ) must be greater or equal to 80 % 2. Publish year reference must be greater or equal to 2010 (80 %)
This paper is recommended to be [ ] Accepted without further revision [ ] Accepted with minor revision [ ] Major Revision is required [ ] Rejected
