links.lww.com/CCM/D72

Supplemental Digital Content (page 1 out 8):

A) Supplemental Table 1 provides the number of missing laboratory values:

Supplemental Table 1. Number of missing laboratory values

Variable Obese

(BMI >30) N = 1,258

Normal weight (BMI = 18.5 - 24.9)

N = 769 Variable Baseline

laboratory result

ICU laboratory

result

Baseline laboratory

result

ICU laboratory

result

WBC 55 27 34 9

Sodium 114 2 93 4

Potassium 104 1 86 4

BUN 88 5 62 5

BIC 136 26 104 9

Creatinine 78 4 59 5

Platelets 54 18 32 7

WBC: white blood cells; BUN: Blood Urea Nitrogen; BIC: Bicarbonate

B) Complete multivariable linear regression analysis:

White Blood Cell:

deviation_wbc

B CI p

(Intercept) 4.63 2.99 – 6.27 <.001

age -0.03 -0.05 – -0.01 .009

icu_type

CSRU 3.24 2.26 – 4.23 <.001

MICU -0.44 -1.48 – 0.60 .405

SICU 1.69 0.48 – 2.90 .006

TSICU 0.06 -1.55 – 1.67 .943

bmi_group (obese) 0.80 0.27 – 1.33 .003 avgwbc_baseline -0.25 -0.32 – -0.18 <.001

sapsii 0.08 0.06 – 0.10 <.001

Observations 1905

R² / adj. R² .121 / .117

Platelet:

deviation_platelets

B CI p

(Intercept) 76.44 51.28 – 101.59 <.001

age 0.27 0.02 – 0.52 .032

gender (M) 11.10 3.76 – 18.43 .003

icu_type

CSRU -53.75 -67.52 – -39.98 <.001

MICU 1.62 -12.91 – 16.16 .827

SICU 1.90 -14.98 – 18.78 .825

TSICU -3.41 -25.90 – 19.07 .766

bmi_group (obese) 4.94 -2.48 – 12.36 .192

avgplatelets_baseline -0.47 -0.51 – -0.44 <.001

sofa_score -6.62 -7.85 – -5.38 <.001

Observations 1918

R² / adj. R² .342 / .339

Sodium:

deviation_na

B CI p

(Intercept) 68.02 61.26 – 74.79 <.001

Comorbidity index -0.05 -0.08 – -0.02 .002

icu_type

CSRU -0.60 -1.23 – 0.02 .057

MICU 0.29 -0.37 – 0.95 .388

SICU -0.02 -0.80 – 0.75 .953

TSICU 0.30 -0.79 – 1.39 .594

bmi_group (obese) -0.06 -0.40 – 0.28 .712

avgsodium_baseline -0.50 -0.55 – -0.45 <.001

sapsii -0.02 -0.03 – -0.01 .002

Observations 1814

R² / adj. R² .210 / .206

Potassium:

deviation_k

B CI p

(Intercept) 2.61 2.20 – 3.02 <.001

age -0.00 -0.01 – -0.00 .034

icu_type

CSRU 0.81 0.66 – 0.95 <.001

MICU -0.15 -0.30 – 0.00 .051

SICU -0.12 -0.30 – 0.06 .177

TSICU -0.29 -0.54 – -0.04 .024

bmi_group (obese) 0.01 -0.07 – 0.09 .857

avgpotassium_baseline -0.58 -0.66 – -0.50 <.001

sapsii 0.02 0.01 – 0.02 <.001

Observations 1832

R² / adj. R² .312 / .309

Creatinine:

deviation_log_creatinine

B CI p

(Intercept) -0.04 -0.06 – -0.01 .007

gender (M) 0.02 0.01 – 0.04 <.001

Comorbidity index

0.00 0.00 – 0.00 <.001

icu_type

CSRU -0.12 -0.14 – -0.09 <.001

MICU -0.00 -0.03 – 0.02 .962

SICU -0.04 -0.07 – -0.01 .004

TSICU -0.09 -0.13 – -0.05 <.001 bmi_group

(obese)

0.03 0.02 – 0.05 <.001

log_cr_baseline -0.16 -0.20 – -0.13 <.001

sofa_score 0.02 0.02 – 0.02 <.001

Observations 1882

R² / adj. R² .277 / .273

BUN:

deviation_log_bun

B CI p

(Intercept) 0.29 0.22 – 0.35 <.001

age 0.00 0.00 – 0.00 <.001

gender (M) 0.04 0.03 – 0.06 <.001

elixhauser 0.00 0.00 – 0.00 <.001

icu_type

CSRU -0.17 -0.20 – -0.14 <.001

MICU -0.02 -0.05 – 0.01 .237

SICU -0.06 -0.09 – -0.02 .003

TSICU -0.10 -0.15 – -0.05 <.001 bmi_group

(obese) 0.01 0.00 – 0.02 .014

log_bun_baseline -0.30 -0.34 – -0.26 <.001

sofa_score 0.02 0.02 – 0.02 <.001

Observations 1868

R² / adj. R² .295 / .291

Bicarbonate:

deviation_bic

B CI p

(Intercept) 11.91 10.46 – 13.37 <.001

age 0.03 0.02 – 0.04 <.001

Comorbidity index

-0.04 -0.07 – -0.02 <.001

bmi_group (obese)

-0.19 -0.50 – 0.13 .254

avgbic_baseline -0.53 -0.58 – -0.48 <.001

sapsii -0.09 -0.11 – -0.08 <.001

Observations 1757

R² / adj. R² .277 / .275