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SUPPLEMENT TABLE 1. CLINICAL AND HEMATOLOGICAL CHARACTERISTICS OF PATIENTS WITH THROMBOSIS OF LOWER LIMB ARTERIES DURING COVID19 INFECTION.

Successfull Thrombectomy Re-Thrombosis Successfull Thrombectomy

Patient 1 2 3 4 5 6 7 8 9

Age 81 82 83 49 67 62 75 57 64

Sex Female Male Female Male Male Male Male Female Female

Comorbidities ^Hypertens

ion, diabetes

Hypertensi on, diabetes

Hypertensio

n, obesity Chronic C- Hepatitis,

cocaine abuse

Coronary arteries disease, diabetes, chronic renal

failure

None COPD,

hypertension, previous

EVAR

Hypertension,

dyslipidemia COPD, hypertension, active smoker

Co-existing Peripheral Arterial Disease (PAD)

Yes Yes No No Yes No Yes No No

Site of thrombosis ^{Femoral Popliteal} and tibial

Femoral, popliteal and

tibial

Femoral and popliteal

Popliteal and tibial

Iliac and femoral

Femoro- femoral

bypass

Femoral Iliac and femoral Type of intervention Embolecto

my Embolecto

my Embolectom

y Embolectom

y Embolectom

y Embolecto

my Embolectomy Embolectomy Embolectomy Additional procedures Femoral

Endarterec tomy

Angioplast

y Angioplasty Superficial

femoral artery stenting Days from COVID19 diagnosis

to thrombotic event

0 0 0 0 0 0 108 41 149

COVID19 severity^6,7 Mild Mild Mild Severe Severe Severe Moderate Moderate Moderate

Laboratory findings

White-cell count (per mm³) 8620 8470 12300 33200 6200 14040 8600 6200 18700

Total lymphocytes (per mm³) 1100 900 1200 1000 400 590 2100 1820 2100

Platelet count (per mm³) ^{352000 273000 459000 571000 383000 89000 271000 192000 265000}

Lactate dehydrogenase (mU/ml)

402 326 456 1825 256 2903 167.0 245.0 256.0

Creatinine (mg/dl) 0.90 1.49 0.90 1.42 1.96 1.13 0.86 0.61 1.47

Creatinine kinase (mU/ml) 892 560 418 1203 41 53985 314.0 69.0 137.0

High-sensitivity C-reactive protein (mg/dl)

1.26 2.56 1.53 20.19 11.69 7.80 0.34 0.10 2.56

Ptothrombin time (%) 88 86 82 36 61 59 95.00 118.00 88.00

Activate partial-

thromboplastin time (sec)

24.20 22.56 23.90 28.10 27.70 23.00 24.90 24.30 18.20

Fibrinogen (mg/dl) ^{146 258 265 561}

D-dimer (µg/l) ^{2650 3659 5690 7516 2630 35000 1155 308 2476}

Thrombophilia test

Anti-Cardiolipin IgM antibodies (MPL U/ml)

1.2 1.8 2.9 2.4 0.9 11.0

Anti-Cardiolipin IgG antibodies (GPL U/ml)

1.8 2.1 2.8 1.9 1.7 0.3

Anti-Beta2glycoprotein antibodies IgM (U/ml)

0.4 0.7 0.3 0.9 0.1 4.6

Anti-Beta2 glycoprotein antibodies IgG (U/ml)

1.2 1.1 1.5 1.1 1.4 0.5

Lupus-like Anticoagulant ^{Absent Absent Absent Absent Absent Absent}

Factor V (R506Q gene) mutation

Absent Absent Absent Absent Absent Heterozygosis

Antiplatelet antibody (PF4-IgG)

Negative Negative Negative Negative Negative Negative

PATIENT OUTCOME

^{Recovered Recovered Recovered Recovered Recovered Deceased Recovered Recovered Recovered}

LIMB OUTCOME

^{Viable Viable Minor}

amputation Viable Major

amputation Viable Viable Viable Viable