The Effect of Ischemic Preconditioning With Different Frequency on the Simulated Judo Protocol and Its Induced Apoptosis
Parvin Farzanegi3
, Amin Farzaneh Hesari2 1 ,
mi Fatemeh Soghra Rahi
1. Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
E-mail: [email protected]
2. Corresponding Author, Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
E-mail: [email protected]
3. Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran. E-mail: [email protected]
Article Info ABSTRACT
Article type:
Research Article
Article history:
Received:
29 April 2022 Received in revised form:
16 October 2022 Accepted:
19 October 2022 Published online:
21 November 2022
Keywords:
apoptosis,
ischemic preconditioning, special judo test
Introduction: Ischemic preconditioning (IPC) leads to improvement in sports performance, but the effect of its different frequency on judo performance and its role in judo activity-induced muscle damage is still unclear. This study aimed to investigate the acute effect of different frequencies of IPC on the simulated judo competition and its resulting apoptosis in judo athletes.
Methods: In a crossover study, 12 male judokas participated in this study. Each participant was randomly assigned into four conditions: IPC in one session (low frequency), IPC in three consecutive sessions (high frequency), without IPC in one session, and non-ischemic repetitive actions. In each session, three simulated competitions were conducted at a 5-minutes interval and a Special Judo Fitness Test (SJFT) was performed five hours after the last competition. IPC was conducted with three 5-minutes cycles of occlusion, followed by five minutes of reperfusion. Pre- and post-judo competitions, blood samples were taken. For statistical analysis, one-way repeated measures ANOVA and Bonferroni’s post-hoc test were used.
Results: The results showed that a high frequency of IPC led to a significant increase in the number of techniques performed in SJFT (P≤0.05). The judo competition protocol increased serum Bax levels. Also, the serum Bcl-2 was significantly higher in both low and high frequencies of IPC than in other conditions (P≤0.05).
Conclusion: Based on the results of the present study, it seems that the high frequency of IPC has a greater effect on the specific performance of judokas.
frequency-independent IPC can improve apoptosis caused by judo competition.
Cite this article: Rahimi FS., Farzaneh Hesari A., & Farzanegi P. The Effect of Ischemic Preconditioning With Different Frequency on Simulated Judo Protocol and Its Induced Apoptosis. Journal of Sport Biosciences. 2022; 14 (3): 51-64.
DOI: http//doi.org/10.22059/jsb.2022.342373.1527
© The Author(s). Publisher: University of Tehran, Faculty of Sport Sciences and Health.
ExtendedAbstract
Introduction
Judo competition is considered one of the intense exercises that can lead to an increase in muscular damage and inflammatory indicators. Studies have shown that apoptosis during and after acute intense training causes muscle damage.
Various post-training recovery strategies are performed to reduce muscle fatigue and pain and improve recovery between training sessions or consecutive competitions. Recent studies have emphasized the effectiveness of ischemic preconditioning (IPC) in assisting post-training recovery, which can reduce the damage caused by ischemia-reperfusion injury, that is post-training-induced muscle damage. IPC involves a brief period of sublethal local tissue ischemia that confers protection against the subsequent lethal ischemia. On the other hand, IPC has been used to improve sports performance, but the effect of different frequencies on judo performance is still unclear. This study aimed to investigate the effect of different frequencies of IPC on simulated judo competition and match-induced apoptosis in judokas.
Methods
In a crossover study, 12 male judokas participated in this study. Each participant was randomly assigned into four conditions: IPC in one session (low frequency), IPC in three consecutive sessions (high frequency), without IPC in one session (placebo 1), and non-ischemic repetitive actions (placebo 2). IPC consisted of three 5-minutes cycles of ischemia, followed by five minutes of reperfusion. In each session, the judokas performed three 4-minute judo competitions followed by a 5-minute rest interval and a Special Judo Fitness Test (SJFT) conducted five hours after the last competition. During competitions, judokas competed against opponents in the same weight category and with a similar sport level relative to their rankings. For competition analysis, only actual (not feigned) attacks performed in the standing position were considered. Pre- and post-judo competitions, blood samples were taken. For statistical analysis, one-way repeated measures ANOVA and Bonferroni's post-hoc test were used.
Results
The results showed that there were no differences in the number of attacks in the three competitions among any frequency IPC and placebo. Also, the results showed that high-frequency IPC resulted in a significant increase in the number of techniques performed in SJFT(P=0.012). The judo competition increased serum Bax levels, however, no difference was observed after low- and high-frequency IPC compared to the pre-judo competition. The serum Bax levels were significantly decreased in low (P=0.021) and high (P=0.016) frequency IPC than placebo. The serum Bcl-2 levels were significantly higher in low (P=0.001) and high (P=0.001) frequency IPC than in placebo and pre-judo competition (P=0.011 and P=0.019, respectively).
Conclusion
Based on the results of the present study, a high frequency of IPC seems to have a greater effect on the specific judo fitness test following repetitive competitions. frequency-independent IPC can improve apoptosis following judo competitions. Our results suggest that the IPC may be used as a non-invasive, easy-to-use tool to accelerate the recovery in trained judokas during training or competitions.
Keywords
apoptosis, ischemic preconditioning, special judo test Ethical Considerations
Compliance with ethical guidelines:
This research was carried out with the approval of the Ethics Committee of Islamic Azad University, Sari branch with the ethical code of IR.IAU.SARI.REC.1400.061
Funding: Financial resources provided by the authors.
Authors’ contribution:
Conceptualization: Amin Farzaneh hesari, Parvin Farzanegi, Fatemeh Rahimi.
Methodology: Amin Farzaneh hesari, Fatemeh Rahimi.
Formal analysis: Amin Farzaneh hesari.
Investigation and Writing: Amin Farzaneh hesari, Parvin Farzanegi
Conflict of interest: The authors declared no conflict of interest.
Acknowledgments: The authors thank all the participants who supported us in this research
ﺮﺛا ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﻞﮑﺗوﺮﭘ ﺮﺑ ﻒﻠﺘﺨﻣ ﺮﺗاﻮﺗ ﺎﺑ ﯽﻤﮑﺴﯾا ﺒﺷ
ﯿ ﻪ زﺎﺳ ي ﺪﺷ ة ودﻮﺟ
زا ﯽﺷﺎﻧ زﻮﺘﭘﻮﭘآ و نآ
ﯽﻤﯿﺣر يﺮﻐﺻ ﻪﻤﻃﺎﻓ ، 1
يرﺎﺼﺣ ﻪﻧازﺮﻓ ﻦﯿﻣا
2
،
ﯽﮕﻧازﺮﻓ ﻦﯾوﺮﭘ
3
1 هوﺮﮔ . ﻮﻟﻮﯾﺰﯿﻓ ژ ي ﺷزرو ﯽ ، ﺪﮑﺸﻧاد ة ﯽﻧﺎﺴﻧا مﻮﻠﻋ هﺎﮕﺸﻧاد ، ﯽﻣﻼﺳا دازآ ، يرﺎﺳ ،يرﺎﺳ ﺪﺣاو :ﻪﻣﺎﻧﺎﯾار .ناﺮﯾا ،
@gmail.com 787
mahboobe.rahimi
2 . ﺪﻨﺴﯾﻮﻧ ة
،لوﺆﺴﻣ هوﺮﮔ ﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ ﯽ
، ﺪﮑﺸﻧاد ة ﯽﻧﺎﺴﻧا مﻮﻠﻋ هﺎﮕﺸﻧاد ، يرﺎﺳ ،يرﺎﺳ ﺪﺣاو ،ﯽﻣﻼﺳا دازآ .ناﺮﯾا ،
:ﻪﻣﺎﻧﺎﯾار [email protected]
3 . هوﺮﮔ ﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ ﯽ
، ﺪﮑﺸﻧاد ة ﯽﻧﺎﺴﻧا مﻮﻠﻋ هﺎﮕﺸﻧاد ، .ناﺮﯾا ،يرﺎﺳ ،يرﺎﺳ ﺪﺣاو ،ﯽﻣﻼﺳا دازآ :ﻪﻣﺎﻧﺎﯾار
[email protected] parvin.farz
ﻪﻟﺎﻘﻣ تﺎﻋﻼﻃا هﺪﯿﮑﭼ
:ﻪﻟﺎﻘﻣ عﻮﻧ ﯽﺸﻫوﮋﭘ
رﺎﺗ ﯾ ﺦ رد ﯾ ﺖﻓﺎ : 09 / 02 / 1401
:يﺮﮕﻧزﺎﺑ ﺦﯾرﺎﺗ 24
/ 07 / 1401
رﺎﺗ ﯾ ﺦ ﺬﭘ ﯾ شﺮ : 27 / 07 / 1401
رﺎﺗ ﯾ ﺦ رﺎﺸﺘﻧا : 30 / 08 / 1401
ﺪﯿﻠﮐ هژاو :ﺎﻫ ،زﻮﺘﭘﻮﭘآ
نﻮﻣزآ
،ودﻮﺟ هﮋﯾو ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا . :ﻪﻣﺪﻘﻣ
ﺶﯿﭘ هدﺎﻣآ ﺎﺳ ز ي ﯽﺷزرو دﺮﮑﻠﻤﻋ دﻮﺒﻬﺑ ﻪﺑ ﯽﻤﮑﺴﯾا ﺮﺠﻨﻣ
ﻣ ﯽ دﻮﺷ
، اﻮﺗ ﺮﺛا ﺎﻣا ﺘﺨﻣ يﺎﻫﺮﺗ ﺮﺑ نآ ﻒﻠ
زا فﺪﻫ .ﺖﺴﯿﻧ ﺺﺨﺸﻣ ودﻮﺟ ﺖﯿﻟﺎﻌﻓ زا ﯽﺷﺎﻧ ﯽﻧﻼﻀﻋ ﺐﯿﺳآ ﺮﺑ نآ ﺶﻘﻧ و ودﻮﺟ دﺮﮑﻠﻤﻋ ﺗ
ﻖﯿﻘﺤ ﺣ ﺮﺿﺎ
ﻒﻠﺘﺨﻣ يﺎﻫﺮﺗاﻮﺗ دﺎﺣ ﺮﺛا ﯽﺳرﺮﺑ ﭘﯿ
ﺶ هدﺎﻣآ زﺎﺳ ي ﺮﺑ ﯽﻤﮑﺴﯾا ﮥﻘﺑﺎﺴﻣ
ﺒﺷ ﯿﻪ زﺎﺳ ي ﺪﺷ ة ﺎﻧ زﻮﺘﭘﻮﭘآ و ودﻮﺟ زا ﯽﺷ
.دﻮﺑ نارﺎﮐودﻮﺟ رد نآ :ﺶﻫوﮋﭘ شور ﮏﯾ رد
ﮥﻌﻟﺎﻄﻣ ،ﻊﻃﺎﻘﺘﻣ 12 ﻦﯾا رد دﺮﻣ رﺎﮐودﻮﺟ ﺶﻫوﮋﭘ
ﺮﻫ .ﺪﻧدﺮﮐ ﺖﮐﺮﺷ آ
ﯽﻧدﻮﻣز
ﻪﺑ ترﻮﺻ لﺎﻤﻋا ﺖﯿﻌﺿو رﺎﻬﭼ رد ﯽﻓدﺎﺼﺗ ﭘﯿ
ﺶ هدﺎﻣآ زﺎﺳ ي رد ﯽﻤﮑﺴﯾا ﻋا ،(ﻢﮐ ﺮﺗاﻮﺗ) ﻪﺴﻠﺟ ﮏﯾ
لﺎﻤ
ﭘﯿ ﺶ هدﺎﻣآ زﺎﺳ ي ﻪﺳ رد ﯽﻤﮑﺴﯾا ﮥﺴﻠﺟ
ﻤﻋا نوﺪﺑ ،(دﺎﯾز ﺮﺗاﻮﺗ) ﯽﻟاﻮﺘﻣ لﺎ
ﻪﺴﻠﺟ ﮏﯾ رد ﯽﻤﮑﺴﯾا لﺎﻤﻋا و
ﻪﺳ ﻪﺴﻠﺟ ﺮﻫ رد .ﺖﻓﺮﮔ راﺮﻗ ﯽﻤﮑﺴﯾا نوﺪﺑ يراﺮﮑﺗ ﮥﻘﺑﺎﺴﻣ
ﺒﺷ ﯿﻪ زﺎﺳ ي هﺪﺷ ﺎﺑ ﮥﻠﺻﺎﻓ 5 ا ﻪﻘﯿﻗد ﮏﯾ و ﻢﻫ ز
نﻮﻣزآ ةﮋﯾو رد ودﻮﺟ 5
ﺖﻋﺎﺳ ﺲﭘ .ﺪﺷ اﺮﺟا ﻪﻘﺑﺎﺴﻣ ﻦﯾﺮﺧآ زا ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي رود ﻪﺳ رد ﯽﻤﮑﺴﯾا
ﺞﻨﭘ ﻗد ﯿ ﻪﻘ ا ي ﻪﻘﯿﻗد ﺞﻨﭘ ﺎﺑ داﺪﺴﻧا نﻮﺧ
ﻧﺎﺳر ﯽ ﻧا دﺪﺠﻣ مﺎﺠ ﺖﻓﺮﮔ . ﺶﯿﭘ و ﺲﭘ زا ودﻮﺟ ﻪﻘﺑﺎﺴﻣ ﻮﻤﻧ
ﮥﻧ ﯽﻧﻮﺧ
ياﺮﺑ .ﺪﺷ ﻪﺘﻓﺮﮔ ﺰﺠﺗ
ﯾﻪ ﻠﺤﺗو ﯿ ﻞ ﺎﺑ ﺲﻧﺎﯾراو ﺰﯿﻟﺎﻧآ شور زا يرﺎﻣآ هزاﺪﻧا
ﺎﻫ ي ﻣزآ و يراﺮﮑﺗ ﺒﯿﻘﻌﺗ نﻮ
ﯽ ﺑﻮ ﻧوﺮﻔﻧ ﯽ
.ﺪﺷ هدﺎﻔﺘﺳا ﯾ ﻪﺘﻓﺎ ﺎﻫ دﺎﯾز زود ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ : ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﺶﯾاﺰﻓا ﻪﺑ ﯽﻤﮑﺴﯾا ﻨﻌﻣ
ﺎ راد داﺪﻌﺗ ﻨﮑﺗ ﯿ ﮏ ﺎﻫ ي ﺮﺟا ﺪﺷا ة
ودﻮﺟ نﻮﻣزآ ﺮﺠﻨﻣ
) ﺪﺷ 05 /0 P≤ .(
ﮥﻘﺑﺎﺴﻣ ﯽﻣﺮﺳ ﺢﻄﺳ ودﻮﺟ داد ﺶﯾاﺰﻓا ار Bax
، ﻦﯿﻨﭽﻤﻫ Bcl-2 مﺮﺳ
دﺎﯾز و ﻢﮐ ﺮﺗاﻮﺗ ود ﺮﻫ رد ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﺮﯾﺎﺳ زا ﺮﺘﺸﯿﺑ ﯽﻤﮑﺴﯾا ﻌﺿو
ﯿ ﺖ ﺎﻫ دﻮﺑ ) 05 /0 P≤ .(
ﺘﻧ ﯿ ﻪﺠ ﮔﯿ ﺮ ي ،ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ ﺞﯾﺎﺘﻧ سﺎﺳاﺮﺑ : ﻪﺑ
ﺮﻈﻧ ﻣ ﯽ ﺪﺳر ﻪﮐ ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي راﺮﮑﺗ ﯽﻤﮑﺴﯾا ﯿﺑ ﺮﺛا ي
يﺮﺘﺸ
ﺶﯿﭘ و دراد نارﺎﮐودﻮﺟ ﯽﺻﺎﺼﺘﺧا دﺮﮑﻠﻤﻋ ﺮﺑ هدﺎﻣآ
زﺎﺳ ي ﺮﺗاﻮﺗ زا ﻞﻘﺘﺴﻣ ﯽﻤﮑﺴﯾا ﻣ
ﯽ ﺪﻧاﻮﺗ ﻧ زﻮﺘﭘﻮﭘآ زا ﯽﺷﺎ
ﮥﻘﺑﺎﺴﻣ .ﺪﺸﺨﺑ دﻮﺒﻬﺑ ار ودﻮﺟ
دﺎﻨﺘﺳا : ﺮﺛا .ﻦﯾوﺮﭘ ،ﯽﮕﻧازﺮﻓ و ﻦﯿﻣا ،يرﺎﺼﺣ ﻪﻧازﺮﻓ ؛يﺮﻐﺻ ﻪﻤﻃﺎﻓ ،ﯽﻤﯿﺣر ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﺮﺑ ﻒﻠﺘﺨﻣ ﺮﺗاﻮﺗ ﺎﺑ ﯽﻤﮑﺴﯾا ﻞﮑﺗوﺮﭘ
ﺒﺷ ﯿﻪ زﺎﺳ ي ﺪﺷ ة زا ﯽﺷﺎﻧ زﻮﺘﭘﻮﭘآ و ودﻮﺟ
ﺮﺸﻧ .نآ ﯽﺘﺴﯾز مﻮﻠﻋ ﯾﮥ ﺷزرو
ﯽ . 1401
؛ ) 3(
14 : 51-64 .
2022.342373.1527
jsb.
/ 10.22059 http//doi.org/
DOI:
،ناﺮﻬﺗ هﺎﮕﺸﻧاد :ﺮﺷﺎﻧ ةﺪﮑﺸﻧاد
ﺷزرو مﻮﻠﻋ ﯽ ﺗ و ﯽﺘﺳرﺪﻨ . ﺴﯾﻮﻧ©
.نﺎﮔﺪﻨ
54 ﺰﯿﯾﺎﭘ ،مﻮﺳ ةرﺎﻤﺷ ،ﻢﻫدرﺎﻬﭼ ةرود ،ﯽﺷزرو ﯽﺘﺴﯾز مﻮﻠﻋ
1401
ﻪﻣﺪﻘﻣ ﺖﯿﻫﺎﻣ ﮥﻘﺑﺎﺴﻣ ودﻮﺟ ﻪﺑ ﻪﻧﻮﮔ ا ي تﺎﺿﺎﺒﻘﻧا ﺪﻨﻣزﺎﯿﻧ ﻪﮐ ﺖﺳا نورد
اﺮﮔ نوﺮﺑ و ﺘﻨﮐ ياﺮﺑ اﺮﮔ و ﮏﯿﻨﮑﺗ ياﺮﺟا ،ﻒﯾﺮﺣ لﺮ
لﺪﺑ رﺎﮐ ي زا .ﺖﺳا
ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﯽﻓﺮﻃ شﻼﺗ
ﺎﻫ ي ﺖﯿﻫﺎﻣ و ﻻﺎﺑ تﺪﺷ ﺎﺑ بوﺎﻨﺘﻣ ﺑ
ﯽ زاﻮﻫ ي ،نآ ندﻮﺑ ﻣ
ﯽ ناﻮﺗ ﮥﻘﺑﺎﺴﻣ ودﻮﺟ رد ار ةﺮﻣز ﺎﻌﻓ ﻟﯿ ﺖ ﺎﻫ ي ﺪﯾﺪﺷ ﻪﺑ رﺎﻤﺷ
دروآ )1 ( ﻪﮐ ﻣ ﯽ ﺪﻧاﻮﺗ ﺑ ﺶﯾاﺰﻓا ﻪ ﺺﺧﺎﺷ
ﺎﻫ ي ﯽﺑﺎﻬﺘﻟا )2 ( ﺖﯿﻟﺎﻌﻓ زا ﯽﺷﺎﻧ ﺐﯿﺳآ ﻪﺠﯿﺘﻧ رد و ﺮﺠﻨﻣ
ﺷ دﻮ ) 3(
. تﺎﻘﯿﻘﺤﺗ نﺎﺸﻧ
هداد ﺪﻧا ﻪﮐ
هوﻼﻋ ﺮﺑ ﺪﻨﯾاﺮﻓ ،ﯽﺑﺎﻬﺘﻟا يﺎﻫ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ زا ﺲﭘ و ﻦﯿﺣ رد زﻮﺘﭘﻮﭘآ
دﺎﺣ ﺪﯾﺪﺷ رد دﺎﺠﯾا ﺐﯿﺳآ ﻧﻼﻀﻋ دراد ﺶﻘﻧ ﯽ )
4(
ﺰﻓا . ﺶﯾا
لﺮﺘﻨﮐ ﺪﺸﻧ ة ﻦﺘﻓر ﺖﺳد زا ﺐﺟﻮﻣ ﺖﺳا ﻦﮑﻤﻣ زﻮﺘﭘﻮﭘآ ﺑﯿ
ﺶ ﺪﺣزا دﺮﮑﻠﻤﻋ ،دﻮﺷ لﻮﻠﺳ ﺖﻓﺎﺑ
ﺎﻫ ﺖﺤﺗ ار ﺛﺄﺗ ﯿﺮ راﺮﻗ ﺪﻫد و وﺎﮑﯾر ﺪﻧور ار ير
ﺪﻨﮐ لﻼﺘﺧا رﺎﭼد )5
( .
ﺖﯿﻟﺎﻌﻓ زا ﯽﺷﺎﻧ ﺲﯾزﻮﺘﭘﻮﭘآ ﺪﻧاﻮﺘﺑ ﻪﮐ ﯽﻠﻣاﻮﻋ ﺖﺧﺎﻨﺷ
ًﺎﺘﺒﺴﻧ ﺗ ار ﯽﺷزرو ﺪﯾﺪﺷ ﺪﻨﮐ ﻞﯾﺪﻌ
، رد ﯽﻟﻮﻠﺳ تاﺮﯿﯿﻐﺗ دﺎﺠﯾا ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ .ﺖﺳا ﻢﻬﻣ
و ﯽﺘﻠﮑﺳا تﻼﻀﻋ لﻮﻠﺳ
ﺎﻫ ي زا ﯽﺷﺎﻧ ﯽﻟﻮﻠﺳ ياﺰﺟا رد لﻼﺘﺧا و ﯽﺿﺎﺒﻘﻧا هﺎﮕﺘﺳد ﯽﮕﭼرﺎﭙﮑﯾ ﻦﺘﻓر ﻦﯿﺑ زا ﻦﯿﻨﭽﻤﻫ و ﯽﻨﻤﯾا ﻟﺎﻌﻓ
ﯿ ﺖ ﺎﻫ ي
،ﺪﯾﺪﺷ دﺮﺒﻫار ﺎﻫ ي يروﺎﮑﯾر ﻒﻠﺘﺨﻣ ﺲﭘ
ﯾر دﻮﺒﻬﺑ و ﯽﻧﻼﻀﻋ درد و ﯽﮕﺘﺴﺧ ﺶﻫﺎﮐ فﺪﻫ ﺎﺑ ﺖﯿﻟﺎﻌﻓ زا ﺎﯾ ﯽﻨﯾﺮﻤﺗ تﺎﺴﻠﺟ ﻦﯿﺑ يروﺎﮑ
مﺎﺠﻧا بوﺎﻨﺘﻣ تﺎﻘﺑﺎﺴﻣ ﻣ
ﯽ ﺮﯿﮔ د )6 ( ،نﺎﯿﻣ ﻦﯾا رد . ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا رد و ﺖﯿﻟﺎﻌﻓ زا ﯽﺷﺎﻧ زﻮﺘﭘﻮﭘآ و بﺎﻬﺘﻟا ﺮﺑ ﺪﻧاﻮﺘﺑ ﺖﺳا ﻦﮑﻤﻣ1
ﻮﻠﺳ و ﮏﯿﻤﺘﺴﯿﺳ تاﺮﯿﯿﻐﺗ ﺪﻧداد نﺎﺸﻧ ﻪﮐ ﺪﺷ حﺮﻄﻣ يﺪﻫاﻮﺷ سﺎﺳاﺮﺑ ﻪﯿﺿﺮﻓ ﻦﯾا ﻊﻗاو رد .ﺪﺷﺎﺑ راﺬﮔﺮﺛا يروﺎﮑﯾر ﻪﺠﯿﺘﻧ ﺐﯿﺳآ زا ﯽﺷﺎﻧ ﯽﻟ
دراﻮﻣ ﻪﯿﺒﺷ ،ﺖﯿﻟﺎﻌﻓ زا ﯽﺷﺎﻧ ﯽﻧﻼﻀﻋ هﺪﻫﺎﺸﻣ
هﺪﺷ ﯽﻤﮑﺴﯾا ﺐﯿﺳآ رد -
ﻪﮐ ،ﺖﺳا نژﻮﯿﻓﺮﭘر ﺐﻠﻏا
ﺶﯾاﺰﻓا ﺎﺑ ﺖﻈﻠﻏ
ﺎﻫ ي ﻢﯿﺴﻠﮐ نورد ﻟﻮﻠﺳ ﯽ
رﻮﻬﻇ ﺶﯾاﺰﻓا و ﺌﺗوﺮﭘ
ﯿ ﻦ ﺎﻫ ي و نﻮﺧ نﺎﯾﺮﺟ رد ﻪﻠﻀﻋ ﺺﺧﺎﺷ
ﺎﻫ ي ﯽﻨﯾﺎﮐﻮﺘﯾﺎﺳ ﺪﻨﻧﺎﻣ
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا و زﺎﻧژورﺪﯿﻫد تﺎﺘﮐﻻ ،زﺎﻨﯿﮐ ﻦﯿﺗاﺮﮐ 6
ﻤﻫ ﺖﺳا هاﺮ )7 ( . ﺌﺗوﺮﭘ ﯿ ﻦ ﺎﻫ ي ﻪﮐ ﺪﻧﺮﯿﮔرد زﻮﺘﭘﻮﭘآ ﻢﯿﻈﻨﺗ رد ﯽﻔﻠﺘﺨﻣ ﻣ
ﯽ ناﻮﺗ ﻪﺑ داﻮﻧﺎﺧ ة
ﺌﺗوﺮﭘ ﯿﻨ ﯽ Bcl2
ﮐ ﻞﻣﺎﺷ ﻪ ﺌﺗوﺮﭘ ﯿ ﻦ ﺎﻫ ي هﺪﻨﻨﮐرﺎﻬﻣ و
ﺎﻘﻟا ﮐ ﺪﻨﻨ ة ﺪﻨﺘﺴﻫ زﻮﺘﭘﻮﭘآ
، .دﺮﮐ هرﺎﺷا وﺮﭘ
ﺌﺗﯿ ﻦ
Bcl2
ﺮﺳ،
ﮐ ﺮﻓ ﺮﮕﺑﻮ اﯾ بﻮﺴﺤﻣ زﻮﺘﭘﻮﭘآ ﺪﻨ ﻣ
ﯽ ﻮﺷ د ، ﻟﺎﺣرد ﯽ ﻪﮐ ﺌﺗوﺮﭘ ﯿ ﻦ ﺮﻓ ﺮﮔﺎﻘﻟا Bax
اﯾ ﺪﻨ
زﻮﺘﭘﻮﭘآ ﺖﺳا ) 8 .(
ﺌﺗوﺮﭘ ﯿ ﻦ Bcl2
ﺮﻃ زا ﯾ ﻪﺑ لﺎﺼﺗا ﻖ لﺎﻧﺎﮐ
ﺎﻫ ي ور دﻮﺟﻮﻣ ي
ﺎﺸﻏ ي ﺟرﺎﺧ ﯽ ﻣ ﯿ ﻮﺘ ﮐ رﺪﻨ ي ﻆﻔﺣ ﺐﺟﻮﻣ ﮑﯾ
ﮕﭼرﺎﭙ ﯽ ﺎﺸﻏ
ﻣ ﯽ ﻮﺷ د ، ﻟﺎﺣرد ﯽ ﻪﮐ اﺰﻓا ﯾ ﺑ ﺶ ﯿ نﺎ ﻪﺑ Bax
ﻐﺗ ﯿﯿ ﺬﭘذﻮﻔﻧ رد ﺮ ﯾﺮ
ي ﺎﺸﻏ ي ﻣ ﯿ ﻮﺘ ﮐ رﺪﻨ ي ﺳ نﺪﺷ دازآ ، ﯿ
ﻮﺘ ﮐ وﺮ م
، C ﺎﻓ نﺪﺷ دازآ ﮐ
ﺎﻫرﻮﺘ ي
ﺎﻘﻟا ﮐ ﺪﻨﻨ ة ﻣ زا زﻮﺘﭘﻮﭘآ ﯿ
ﻮﺘ ﮐ رﺪﻨ ي ﺎﻬﻧ رد و ﯾ ﺖ ﻪﻌﻄﻗ نﺪﺷ ﻪﻌﻄﻗ ﺮﺠﻨﻣ DNA
ﻣ ﯽ دﻮﺷ ) 8 .(
سﺎﺳاﺮﺑ ﺞﯾﺎﺘﻧ ﯽﭘ رد ﯽﺴﮐﻮﭙﯿﻫ ﺎﯾ ﯽﻤﮑﺴﯾا
يزﻮﺘﭘﻮﭘآ ﻦﯿﺌﺗوﺮﭘ نﺎﯿﺑ ،لﻮﻠﺳ ﺶﯾاﺰﻓاBax
ﻣ ﯽ ﯾ ﺪﺑﺎ ) 9 .(
ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا ﺪﭘ
ﯾ هﺪ ا ي ﺖﺳا ﻪﮐ ﺑ راﺮﻗﺮﺑ ﺎ ي هرود ﺎﻫ ي هﺎﺗﻮﮐ و بوﺎﻨﺘﻣ ﻢﮐ ﻧﻮﺧ ﯽ (ﯽﻤﮑﺴﯾا) و
نﺎﯾﺮﺟ (نژﻮﯿﻓﺮﭘر) دﺪﺠﻣ
ﻏﯿ هﺪﻨﺸﮐﺮ رد ﮏﯾ
،ﺖﻓﺎﺑ ﺪﻨﻤﺗرﺪﻗ ﺖﻇﺎﻔﺣ ي
ار رد ﺮﺑاﺮﺑ رﺎﺛآ زﯾ رﺎﺒﻧﺎ ﮏﯾ ﻢﮐ ﻧﻮﺧ ﯽ ةﺪﻨﺸﮐ ﻧﻻﻮﻃ ﯽ تﺪﻣ ﺲﭘ زا نآ رد نﺎﻤﻫ ﺖﻓﺎﺑ ﺎﻘﻟا
ﻣ ﯽ ﺪﻨﮐ ) 10 ( . هوﻼﻋ ﻪﮐ ﯽﺗﺎﻌﻟﺎﻄﻣ ﺮﺑ رد ﯽﺘﻈﻓﺎﺤﻣ ﺮﺛا
ﺖﻓﺎﺑ ﺎﻫ ﯽﯾ ﺪﻨﻧﺎﻣ
،ﺐﻠﻗ
،ﺰﻐﻣ ﻪﯿﻠﮐ و ﺪﺒﮐ ﮔ ار دﺮﮐ شراﺰ ها
،ﺪﻧ ﺖﺳا نآ زا ﯽﮐﺎﺣ ﺪﻫاﻮﺷ
ﻪﮐ ﺖﻓﺎﺑ ﮥﻠﻀﻋ ﺳا ﮑ ﯽﺘﻠ ﺰﯿﻧ ﺖﺳا ﻦﮑﻤﻣ زا
تاﺮﯿﺛﺄﺗ ﯽﺘﻇﺎﻔﺣ ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﻢﮐ ﻧﻮﺧ ﯽ رد ﯿﺳآ ﺮﺑاﺮﺑ ﺐ ﻢﮐ ﻧﻮﺧ ﯽ و نﺎﯾﺮﺟ دﺪﺠﻣ هﺮﻬﺑ ﺪﻨﻣ
دﻮﺷ ) 11 ( ، ﻦﯾاﺮﺑﺎﻨﺑ تﺎﻬﺟﻮﺗ ﻪﺑ ﺖﻤﺳ هدﺎﻔﺘﺳا زا ﻦﯾا شور رد دﻮﺒﻬﺑ ﻠﻤﻋ ﮑ دﺮ تﻼﻀﻋ ﺳا ﮑ ﯽﺘﻠ يﺎﻫاﺮﺟا و و
ﯽﺷرز فﻮﻄﻌﻣ ﺪﺷ ﻦﯾا رد .
ﻪﻨﯿﻣز ﯽﻀﻌﺑ ، تﺎﻘﯿﻘﺤﺗ ﯽﺷزرو دﺮﮑﻠﻤﻋ دﻮﺒﻬﺑ
) 12-14 ( مﺪﻋ ﺮﮕﯾد ﯽﻀﻌﺑ و ﺛﺄﺗ
ﯿﺮ ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﺮﺑ ار ﯽﻤﮑﺴﯾا زرو دﺮﮑﻠﻤﻋ
شراﺰﮔ ﯽﺷ
دﺮﮐ ها ﺪﻧ ) 15
، 16 (.
ﻪﮐ ﺖﺳا هﺪﺷ هداد نﺎﺸﻧ ًاﺮﯿﺧا هدﺎﻣآ
زﺎﺳ ي ﯽﻤﮑﺴﯾا ﺪﻨﯾاﺮﻓ ﻪﯿﻟوا ﺖﻟﺎﺣ ﻪﺑ ﺖﺸﮔزﺎﺑ ﺲﭘ
ﻊﯾﺮﺴﺗ ار ﺪﯾﺪﺷ ﺖﯿﻟﺎﻌﻓ زا ﻣ
ﯽ ﺪﻨﮐ ) 17
، 18 ( .
رﺎﮐوزﺎﺳ ﺎﻫ ي ﻦﯾا ياﺮﺑ ﯽﻟﺎﻤﺘﺣا تاﺮﯿﺛﺄﺗ
ا ﻞﻣﺎﺷ ﺖﺳا ﻦﮑﻤﻣ ﮏﯿﻧژﻮﮔرا ﻦﯾزﻮﻧدآ ﺢﻄﺳ ﺶﯾاﺰﻓا ،ناﺪﯿﺴﮐا ﺪﯿﻟﻮﺗ ﺶﻫﺎﮐ ،نﻮﺧ نﺎﯾﺮﺟ ﺶﯾاﺰﻓ
ﺪﺷﺎﺑ ﯽﺑﺎﻬﺘﻟا ﺦﺳﺎﭘ ﺶﻫﺎﮐ ﺎﯾ و )
18 ( ﻞﯾرآ . ) نارﺎﮑﻤﻫ و2
2018 لﺎﻤﻋا ﻪﮐ ﺪﻧداد نﺎﺸﻧ ( ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا ﺲﭘ زا ﻟﺎﻌﻓ ﯿ ﺖ ةﺪﻨﯾاﺰﻓ
ﻪﺧﺮﭼود راﻮﺳ ي ﻬﺑ ﻪﺑ ﺒ دﺮﮑﻠﻤﻋ ﺶﯾاﺰﻓا ﻪﺠﯿﺘﻧ رد و يروﺎﮑﯾر دﻮ بﺎﮐر
ﻧز ﯽ رد 24 ﺪﻌﺑ ﺖﻋﺎﺳ ﺮﺠﻨﻣ
) ﺪﺷ 17 ﺰﻧاﺮﻓ .(
) نارﺎﮑﻤﻫ و3
2018 (
لﺎﻤﻋا ﻪﮐ ﺪﻧدﺮﮐ شراﺰﮔ ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا ﺶﯿﭘ ﻓ زا ﯽﻧﻼﻀﻋ ﯽﮕﺘﻓﻮﮐ ،ﺖﯿﻟﺎﻌ ﺧﺄﺗ
ﯿﺮ ي داد ﺶﻫﺎﮐ ار ﯽﻣﺮﺳ زﺎﻨﯿﮐ ﻦﯿﺗاﺮﮐ ﺢﻄﺳ و
1. Ischemic preconditioning
2. Arriel
3. Franz
ﺶﯿﭘ ﺮﺛا هدﺎﻣآ زﺎﺳ ﻞﮑﺗوﺮﭘ ﺮﺑ ﻒﻠﺘﺨﻣ ﺮﺗاﻮﺗ ﺎﺑ ﯽﻤﮑﺴﯾا ي ﺒﺷ
ﯿ ﻪ زﺎﺳ ي ﺪﺷ ودﻮﺟ ة ...
55
) 18 ﺞﯿﭘ .(
) نارﺎﮑﻤﻫ و1
2017 ﻪﮐ ﺪﻧدﺮﮐ شراﺰﮔ ( ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا ﯽﻧﻼﻀﻋ ﯽﮕﺘﻓﻮﮐ ﺶﻫﺎﮐ ﻪﺑ ﺧﺄﺗ
ﯿﺮ ي زﺎﻨﯿﮐ ﻦﯿﺗاﺮﮐ ﺢﻄﺳ و
يروﺎﮑﯾر دﻮﺒﻬﺑ ﻪﺠﯿﺘﻧ رد و ﯽﻣﺮﺳ ﺲﭘ
ﺪﯾﺪﺷ ﺖﯿﻟﺎﻌﻓ زا ﺪﯿﻣﺎﺠﻧا
) 19 ( ﯽﻟﺎﻫ ،ﻞﺑﺎﻘﻣ رد . ) نارﺎﮑﻤﻫ و2
2019 ﻪﮐ ﺪﻨﺘﻓﺮﮔ ﻪﺠﯿﺘﻧ (
ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﺲﭘ يدارا ﮏﯾﺮﺘﻣوﺰﯾا ضﺎﺒﻘﻧا زا ﮥﻨﯿﺸﯿﺑ
تﻼﻀﻋ ةﺪﻨﻨﮐزﺎﺑ ﺮﺑ ﻮﻧاز ﺺﺧﺎﺷ ﺎﻫ ي ﺖﺷاﺪﻧ يﺮﺛا ﯽﮕﺘﺴﺧ ﯽﺒﺼﻋ و ﯽﻄﯿﺤﻣ
) 20 ( ﯽﺳرﻮﻧ . ) نارﺎﮑﻤﻫ و3
2018 مﺪﻋ ( ﺛﺄﺗ ﯿﺮ هرود ﺎﻫ ي ﯽﻤﮑﺴﯾا بوﺎﻨﺘﻣ ﺖﯿﻟﺎﻌﻓ زا ﺪﻌﺑ
ﻪﺘﺴﺧ ﺪﻨﻨﮐ ة ﯽﺘﻣوﺎﻘﻣ ) ﺲﭘ هدﺎﻣآ زﺎﺳ ي ﺮﺑ ار (ﯽﻤﮑﺴﯾا
ﺪﻧدﺮﮐ شراﺰﮔ ﺖﯿﻟﺎﻌﻓ ﺐﻗﺎﻌﺘﻣ يروﺎﮑﯾر )
21 ( ﺮﺛا ،ﯽﻨﯿﻟﺎﺑ تﺎﻌﻟﺎﻄﻣ رد . ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا ﮏﯿﻤﮑﺴﯾا ﺐﯿﺳآ زا يﺮﯿﮔﻮﻠﺟ رد دﺎﺣ
ﺖﻓﺎﯾ ﺶﻫﺎﮐ
، ﻟﺎﺣرد ﯽ ﻪﮐ راﺮﮑﺗ نآ نآ ﯽﺘﻈﻓﺎﺤﻣ ﺮﺛا ﺖﯾﻮﻘﺗ ﻪﺑ زور ﺪﻨﭼ ﯽﻃ ﺮﺠﻨﻣ
ﺪﺷ ) 22 ( . تﺎﻘﯿﻘﺤﺗ رﺮﮑﻣ لﺎﻤﻋا ﻪﮐ ﺪﻧدﺮﮐ شراﺰﮔ
ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا زا ﻞﻘﺘﺴﻣ ار (ﮏﭼﻮﮐ قوﺮﻋ نﻮﺧ نﺎﯾﺮﺟ ﺶﯾاﺰﻓا و ﻮﯿﺗاﺪﯿﺴﮐا ﺖﯿﻓﺮﻇ) ﯽﺘﻠﮑﺳا تﻼﻀﻋ يرﺎﮔزﺎﺳ ،زور ﺪﻨﭼ رد
ﺶﯾاﺰﻓا ﺖﯿﻟﺎﻌﻓ ﻣ
ﯽ ﺪﻫد ) 23 ( ﻪﮐ ﻣ ﯽ ﺪﻧاﻮﺗ دﺮﮑﻠﻤﻋ دﻮﺒﻬﺑ هﺪﻫﺎﺸﻣ
هﺪﺷ ﺪﻫد ﺢﯿﺿﻮﺗ ار )
24 ( ﮑﻨﯾا ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ،ﯽﻓﺮﻃ زا . ﻪ
تاﺮﯿﺛﺄﺗ
ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ) ﻪﯿﻟوا زﺎﻓ ود رد ﯽﻤﮑﺴﯾا 3
ﺎﺗ 4 ﺖﻋﺎﺳ ﺲﭘ و (نژﻮﯿﻓﺮﭘر زا ﺧﺄﺗ
ﯿﺮ ي ) 12 ﺎﺗ 24 ﺖﻋﺎﺳ ﺲﭘ عوﺮﺷ (ﻪﻠﺧاﺪﻣ زا ﻣ
ﯽ دﻮﺷ ،
ﮥﻬﺟاﻮﻣ ﺎﺑ يراﺮﮑﺗ ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا ﺶﯿﭘ زﺎﻓ ﺮﺛا زا ﺧﺄﺗ
ﯿﺮ ي ﻣ ﯽ ﺪﻧاﻮﺗ ﺮﺛا ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا نﺎﺴﻧا رد ار قوﺮﻋ دﺮﮑﻠﻤﻋ ﺮﺑ
ﺖﯾﻮﻘﺗ ) ﺪﻨﮐ 23 ﺞﯾﺎﺘﻧ سﺎﺳاﺮﺑ .(
تﺎﻘﯿﻘﺤﺗ هﺪﺷﺮﮐذ ﺮﺗاﻮﺗ ﺶﯾاﺰﻓا ﺖﺳا ﻦﮑﻤﻣ ، ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي
،ﯽﻤﮑﺴﯾا تاﺮﯿﺛﺄﺗ
لﺎﻤﻋا ﻪﺑ ﺖﺒﺴﻧ يﺮﺘﺸﯿﺑ
ﻪﺴﻠﺟ ﮏﯾ ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا .ﺪﺷﺎﺑ ﻪﺘﺷاد
نﺎﺸﻧ ﺪﻫاﻮﺷ ﻪﮐ ﺎﺠﻧآ زا هداد
ﺪﻧا تاﺮﯿﺛﺄﺗ ﮏﯿﻧژﻮﮔرا ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا ﺖﺳا ﻦﮑﻤﻣ ﺖﻋﺎﺳ
ﺎﻫ ﺎﺑ ،ﺪﺸﮑﺑ لﻮﻃ و ﺮﺗاﻮﺗ لﺎﺣ ﻦﯾا
نﺎﻣز ﺪﻨﺑ ي ﺮﺛﺆﻣ ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا رد ﮥﻨﯿﻣز دﺮﮑﻠﻤﻋ دﻮﺒﻬﺑ ﻪﺑ
ﻨﺷور ﯽ ﺮﺑ ،ﺖﺴﯿﻧ ﺺﺨﺸﻣ رد نﺎﻘﻘﺤﻣ ،سﺎﺳا ﻦﯾا
ﻖﯿﻘﺤﺗ ﺮﺿﺎﺣ
ﺮﮔا ﻪﮐ ﺪﻧدﺮﮐ ضﺮﻓ ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي دﻮﺷ لﺎﻤﻋا ﺖﯿﻟﺎﻌﻓ زا ﻞﺒﻗ ﯽﻟاﻮﺘﻣ زور ﺪﻨﭼ رد ﯽﻤﮑﺴﯾا
، ﺳا ﻦﮑﻤﻣ ﺖ تاﺮﯿﺛﺄﺗ ﻫ ﻢ اﺰﻓا ﯽﯾ و دﺎﺣ زﺎﻓ
ﺧﺄﺗ ﯿﺮ ي .ﺪﺘﻔﯿﺑ قﺎﻔﺗا ﻪﺑ
ﺮﺛا ﺎﯾآ ،ﺮﮕﯾد ترﺎﺒﻋ ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﺑ ﻪﺘﺴﺑاو ﯽﺷزرو دﺮﮑﻠﻤﻋ ﺮﺑ ﯽﻤﮑﺴﯾا
؟ﺖﺳا ﺮﺗاﻮﺗ ﻪ زا
،ﯽﻓﺮﻃ ﺑ ﻪﮑﻨﯾا ﻪﺑ ﻪﺟﻮﺗ ﺎ
رﺎﻬﭼ زور ﮏﯾ ﯽﻃ ﺪﯾﺎﺑ لاﺪﻣ ﺐﺴﮐ ياﺮﺑ نارﺎﮑﺷزرو ،ودﻮﺟ ﯽﻤﺳر تﺎﻘﺑﺎﺴﻣ رد ﺎﺗ
ﺪﻨﻫد مﺎﺠﻧا ﻪﻘﺑﺎﺴﻣ ﺞﻨﭘ روﺎﮑﯾر ،
ﻦﯿﺑ بﻮﺧ ي و تﺎﻘﺑﺎﺴﻣ
زا هدﺎﻔﺘﺳا رﺎﮑﻫار
ﺎﻫ ﯽﯾ ﺪﺸﺨﺑ دﻮﺒﻬﺑ ار يروﺎﮑﯾر ﻢﮐ نﺎﻣز رد ﺪﻧاﻮﺘﺑ ﻪﮐ
، .دراد تروﺮﺿ ﻦﯾازا
ور رد ﺶﻫوﮋﭘ ﺿﺎﺣ ا هﺪﺷ ﯽﻌﺳ ﺮ ﮏﯾ ﻪﮐ ﺖﺳ
ﺮﻈﻧ زا ودﻮﺟ ﯽﻤﺳر داﺪﯾور نﺎﻣز
ﺪﻨﺑ ي تﺎﻘﺑﺎﺴﻣ داﺪﻌﺗ و ﺒﺷ
ﯿﻪ زﺎﺳ ي ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ .دﻮﺷ تاﺮﯿﺛﺄﺗ
ﻣ ﯽﺘﻈﻓﺎﺤ ﭘﯿ ﺶ هدﺎﻣآ زﺎﺳ ي ﺐﯿﺳآ رد ﯽﻤﮑﺴﯾا
ﯽﻤﮑﺴﯾا - رد نژﻮﯿﻓﺮﭘر ﺖﻓﺎﺑ
ﺎﻫ ي ﻠﺘﺨﻣ ،ﻒ ﺮﮔا ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا ﻪﺑ
ناﻮﻨﻋ و ﯽﻠﻤﻋ نﺎﺳآ شور ﮏﯾ ﻏ
ﯽﻤﺟﺎﻬﺗﺮﯿ ﻧ ﻪﮐ
ﻪﺑ زﺎﯿ
ﺪﻧاﻮﺘﺑ ،دراﺪﻧ ﯽﺻﺎﺧ تﺎﻧﺎﮑﻣا و تاﺰﯿﻬﺠﺗ ﺪﻨﯾاﺮﻓ
زا ﯽﺷﺎﻧ يزﻮﺘﭘﻮﭘآ و ﯽﺑﺎﻬﺘﻟا يﺎﻫ ﮥﻘﺑﺎﺴﻣ
ﺎﮐ ار ودﻮﺟ ﺪﻫد ﺶﻫ
، ﻣ ﺑ ﺖﺳا ﻦﮑﻤ ﻊﯾﺮﺴﺗ ﻪ
ﺪﻨﮐ ﮏﻤﮐ يروﺎﮑﯾر .
زا فﺪﻫ ﻦﯾاﺮﺑﺎﻨﺑ ﻖﯿﻘﺤﺗ
ﺮﺛا ﯽﺳرﺮﺑ ،ﺮﺿﺎﺣ ﺶﯿﭘ
ﻣآ هدﺎ زﺎﺳ ي ﯽﻤﮑﺴﯾا ﻧ زﻮﺘﭘﻮﭘآ ﺮﺑ زا ﯽﺷﺎ
ﮥﻘﺑﺎﺴﻣ ﻦﯿﻨﭽﻤﻫ .دﻮﺑ ودﻮﺟ
يراﺮﮑﺗ لﺎﻤﻋا ﺮﺛا ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا ﯽﻟاﻮﺘﻣ زور ﺪﻨﭼ رد ﺶﯿﭘ
رﺎﮐودﻮﺟ دﺮﮑﻠﻤﻋ ﺮﺑ ﻪﻘﺑﺎﺴﻣ زا .ﺪﺷ ﯽﺳرﺮﺑ نا
شور ﺳﺎﻨﺷ ﯽ ﺶﻫوﮋﭘ
حﺮﻃ ﺶﻫوﮋﭘ و ﺖﮐﺮﺷ نﺎﮔﺪﻨﻨﮐ
12 نارﺎﮐودﻮﺟ زا ﺮﻔﻧ دﺮﻣ
ﯽﻨﺳ ﻦﯿﮕﻧﺎﯿﻣ ﺎﺑ) 4/
±5 14 / 22 لﺎﺳ نزو ، 4/
±8 13 / 78 ﺪﻗ و مﺮﮔﻮﻠﯿﮐ 2/
±7 14 / 176 ﯽﺘﻧﺎﺳ ﻞﻗاﺪﺣ ﻪﮐ (ﺮﺘﻣ ﺞﻨﭘ
و ودﻮﺟ ﻦﯾﺮﻤﺗ ﮥﻘﺑﺎﺳ لﺎﺳ ﯾ
ﮏ رﺎﺑ رﻮﺸﮐ تﺎﻘﺑﺎﺴﻣ رد ﺖﮐﺮﺷ و نﺎﺘﺳا رد ﯽﻧﺎﻣﺮﻬﻗ ﮥﺑﺮﺠﺗ ي
ﺪﻨﺘﺷاد ار
، ﺑ ﻪ ترﻮﺻ رد ﻪﻧﺎﺒﻠﻃواد ﺶﻫوﮋﭘ ﻦﯾا
ﺖﮐﺮﺷ ﺮﮐ ﺪﻧد . ﺶﯿﭘ ياﺮﺟا زا ﻖﯿﻘﺤﺗ ﯽﻣﺎﻤﺗ ، ﻧدﻮﻣزآ ﯽ ﺎﻫ ﮥﮔﺮﺑ ﺎﺿر ﯾ ﺖ ﻣﺎﻧ ﮥ رد ﺖﮐﺮﺷ ﻞﯿﻤﮑﺗ ار ﺶﻫوﮋﭘ
ﺎﺳ ،ﺪﻧدﺮﮐ ﯽﮑﺷﺰﭘ ﮥﻘﺑ
ﺎﻬﻧآ رﺮﺑ ﯽﺳ
و ﺪﺷ ﻧدﻮﻣزآ ﯽ ﺎﻫ رﺎﻤﯿﺑ ي ﯽﺻﺎﺧ هدﺎﻔﺘﺳا ﯽﯾوراد ﭻﯿﻫ و ﺪﻨﺘﺷاﺪﻧ ﻤﻧ
ﯽ ﺪﻧدﺮﮐ . نﺎﯾﺎﺷ داﺮﻓا ﺖﺳا ﺮﮐذ ي
ﻪﮐ اراد ي رﺎﺸﻓ زا ﺮﺘﺸﯿﺑ نﻮﺧ
100 / 140 رﺎﻤﯿﺑ ﻪﺑ ﻼﺘﺒﻣ داﺮﻓا ﺰﯿﻧ و ﺪﻧدﻮﺑ ي
ﯽﻗوﺮﻋ ـ ﯽﺒﻠﻗ
، زا ﻖﯿﻘﺤﺗ ﺪﺷ فﺬﺣ .ﺪﻧ
Page
1.
2. Halley orthey N
3.
56 ﺰﯿﯾﺎﭘ ،مﻮﺳ ةرﺎﻤﺷ ،ﻢﻫدرﺎﻬﭼ ةرود ،ﯽﺷزرو ﯽﺘﺴﯾز مﻮﻠﻋ
1401
اﺮﺟا ﺪﻧور ي
ﻘﺤﺗ ﯿ ﻖ
ياﺮﺑ مﺎﻤﺗ زا ،ﺶﻫوﮋﭘ مﺎﺠﻧا ﻧدﻮﻣزآ
ﯽ ﺎﻫ ،ﺪﯾﺪﺷ ﺖﯿﻟﺎﻌﻓ و ﻦﯿﺌﻓﺎﮐ فﺮﺼﻣ زا ﻪﮐ ﺪﺷ ﻪﺘﺳاﻮﺧ 24
ﺖﻋﺎﺳ ﺶﯿﭘ راددﻮﺧ نﻮﻣزآ زا ي
.ﺪﻨﻨﮐ
ﻧدﻮﻣزآ ﯽ ﺎﻫ ﯽﻃ ﺞﻨﭘ اﺰﺠﻣ ﮥﺴﻠﺟ ي
اﺮﺟا ﻞﺤﻣ ﻪﺑ بوﺎﻨﺘﻣ ي
حﺮﻃ ،لوا ﮥﺴﻠﺟ رد .ﺪﻧﺪﻣآ ﺶﻫوﮋﭘ فﺪﻫ و
اﺮﺟا شور و ﺶﻫوﮋﭘ ي
نﻮﻣزآ ﺎﻫ
ﺪﺷ هداد ﺢﯿﺿﻮﺗ و نزو ،ﺪﻗ ،ﻦﺳ و
ﺖﺣاﺮﺘﺳا نﻮﺧرﺎﺸﻓ هزاﺪﻧا
ﮔﯿ ﺮ ي ﺪﺷ ﺲﭙﺳ . ﻧدﻮﻣزآ ﯽ ﺎﻫ ﻪﺑ ترﻮﺻ ﺖﯿﻌﺿو رﺎﻬﭼ رد ﯽﻓدﺎﺼﺗ 1
. لﺎﻤﻋا
ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ،(ﻪﺴﻠﺟ ﮏﯾ) ﻢﮐ ﺮﺗاﻮﺗ ﺎﺑ ﯽﻤﮑﺴﯾا 2.
ﻢﮐ ﺮﺗاﻮﺗ لﺎﻤﻋا هرود
ﺎﻫ ي ، رﺎﺸﻓ نوﺪﺑ 3
. ﺶﯿﭘ لﺎﻤﻋا هدﺎﻣآ
زﺎﺳ ي ﺮﺗاﻮﺗ ﺎﺑ ﯽﻤﮑﺴﯾا
،(ﻪﺴﻠﺟ ﻪﺳ) دﺎﯾز 4
. دﺎﯾز ﺮﺗاﻮﺗ لﺎﻤﻋا هرود
ﺎﻫ ي ﺑ تﺎﻋﺎﺳ ﻦﯿﺑ و ﻪﺴﻠﺟ ﺮﻫ رد .ﺪﻨﺘﻓﺮﮔ راﺮﻗ ،رﺎﺸﻓ نوﺪ 10
ﺎﺗ 12 زا ﺪﻌﺑ ، 15 ،ندﺮﮐ مﺮﮔ ﻪﻘﯿﻗد
ﻪﻘﺑﺎﺴﻣ ﻪﺳ ﺒﺷ
ﯿﻪ زﺎﺳ ي ﺪﺷ ة ﺎﺑ (يروﺪﻧر) ودﻮﺟ ﮥﻠﺻﺎﻓ
30 ﻢﻫ زا ﻪﻘﯿﻗد ﺪﺷ اﺮﺟا
دﻮﺑ ﻪﻘﯿﻗد رﺎﻬﭼ ﻪﻘﺑﺎﺴﻣ ﺮﻫ نﺎﻣز . )
25 ( ﺖﻋﺎﺳ ﺞﻨﭘ ﻦﯿﻨﭽﻤﻫ .
ﺖﻋﺎﺳ ﻦﯿﺑ) ﺪﻌﺑ 16
ﺎﺗ 17 نﻮﻣزآ ،(
ةﮋﯾو مﺎﺠﻧا ودﻮﺟ ﺖﻓﺮﮔ
و ﻪﺴﻠﺟ ﮏﯾ رد ﯽﻤﮑﺴﯾا ﻢﮐ ﺮﺗاﻮﺗ . 15
مﺎﺠﻧا مﻮﺳ ﻪﻘﺑﺎﺴﻣ زا ﺪﻌﺑ ﻪﻘﯿﻗد
،ﺖﻓﺮﮔ
ﻟﺎﺣرد ﯽ ﻪﮐ ،رﻮﻈﻨﻣ ﻦﯾا ياﺮﺑ .ﺪﺷ لﺎﻤﻋا ﻪﺴﻠﺟ ﻪﺳ رد ﯽﻤﮑﺴﯾا دﺎﯾز ﺮﺗاﻮﺗ ﮥﺴﻠﺟ
لوا 48 ﺖﻋﺎﺳ ﺶﯿﭘ زا ﮥﻘﺑﺎﺴﻣ آ رد ﻪﮐ ﺪﺷ لﺎﻤﻋا ودﻮﺟ ن
ﺪﻫد مﺎﺠﻧا ﯽﺘﯿﻟﺎﻌﻓ ﻪﮑﻨﯾا نوﺪﺑ و دﺮﮐ ﻪﻌﺟاﺮﻣ ﻖﯿﻘﺤﺗ ياﺮﺟا ﻞﺤﻣ ﻪﺑ ﯽﻧدﻮﻣزآ
، ﺖﯿﻌﺿو رد قﺎﻃ
زﺎﺑ و ﺪﯿﺑاﻮﺧ هرود ﺎﻫ ي وا يور ﯽﻤﮑﺴﯾا
.ﺪﺷ لﺎﻤﻋا ﮥﺴﻠﺟ
مود 24 ﺖﻋﺎﺳ ﺶﯿﭘ ﺎﺑ ﻪﺑﺎﺸﻣ و ودﻮﺟ ﻞﮑﺗوﺮﭘ زا ﮥﺴﻠﺟ
.ﺪﺷ لﺎﻤﻋا لوا ﮥﺴﻠﺟ
و ودﻮﺟ ﻞﮑﺗوﺮﭘ ياﺮﺟا زور رد مﻮﺳ 15
ﻪﻘﯿﻗد ﺲﭘ زا ﮥﻘﺑﺎﺴﻣ ﺳ ) ﺖﻓﺮﮔ ترﻮﺻ مﻮ 26
ﻞﮑﺷ) ( 1 .(
ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﺖﯿﻌﺿو رد ﯽﻤﮑﺴﯾا قﺎﻃ
زﺎﺑ و ﺎﭘ ود ﺮﻫ ﯽﻧﺎﯾﺮﺷ داﺪﺴﻧا ﺎﺑ و رود ﻪﺳ رد
ﺞﻨﭘ ﻗد ﯿ ﻪﻘ ا ي نژﻮﯿﻓﺮﭘر ﻪﻘﯿﻗد ﺞﻨﭘ ﺎﺑ داﺪﺴﻧا
مﺎﺠﻧا ﺖﻓﺮﮔ ،رﻮﻈﻨﻣ ﻦﯾا ياﺮﺑ. ﯽﺘﻧزﺮﺑ فﺎﮐ ﺎﺑ نار ود ﺮﻫ لﺎﻤﯾﺰﮔوﺮﭘ ﺖﻤﺴﻗ
) 85 ﯽﺘﻧﺎﺳ و لﻮﻃ ﺮﺘﻣ ﺶﺷ
ﯽﺘﻧﺎﺳ ضﺮﻋ ﺮﺘﻣ (
ﻪﮐ نآ نورد
ﻮﯿﺗ ب ﻻ دﻮﺑ ﺮﺘﻣورﺎﺑ ﺐﺼﻧ ياﺮﺑ يﺮﮕﯾد و اﻮﻫ دورو ياﺮﺑ ﯽﮑﯾ ،اﺮﺠﻣ ود ياراد و ﺖﺷاد راﺮﻗ ﯽﮑﯿﺘﺳ )
و ﯽﺣاﺮﻃ ﺖﺒﺛ
هﺪﺷ ﯽﻨﯿﺴﺣ ﻂﺳﻮﺗ
يراوﺰﺒﺳ ﻢﯿﮑﺣ هﺎﮕﺸﻧاد رد نارﺎﮑﻤﻫ و ﮏﺧﺎﮐ (،
راﺪﻘﻣ ﻪﺑ و ﻪﺘﺴﺑ ﻻ
ﺪﺷ دﺎﺑ مز .
ﻪﺑ رﻮﻈﻨﻣ ندﺮﮐ دوﺪﺤﻣ ﺖﻬﺟ فﺎﮐ ﺐﺳﺎﻨﻣ رﺎﺸﻓ ﻦﯿﯿﻌﺗ
ﺮﻫ ياﺮﺑ نﻮﺧ نﺎﯾﺮﺟ ﻪﺒﺳﺎﺤﻣ توﺎﻔﺘﻣ نار ﻢﺠﺣ ﺎﺑ ﯽﻧدﻮﻣزآ ﺪﻨﭼ ياﺮﺑ داﺪﺴﻧا رﺎﺸﻓ ﺮﺜﮐاﺪﺣ ،ﯽﻧدﻮﻣزآ
ﺪﺷ ﯽﻧدﻮﻣزآ زا ،رﻮﻈﻨﻣ ﻦﯾا ياﺮﺑ .
ﺎﺗ ﺪﺷ ﻪﺘﺳاﻮﺧ ﻪﺑ
ترﻮﺻ قﺎﻃ زﺎﺑ ﺑ ﺑاﻮﺨ ﺪ ﻪﺑ فﺎﮐ .ﺪﺷ ﻪﺘﺴﺑ ﺎﭘ لﺎﻤﯾﺰﮔوﺮﭘ ﺖﻤﺴﻗ رود رﺎﺸﻓ فﺎﮐ و ةزاﺪﻧا
50 ﻣ ﯿﻠ ﯽ ﺮﺘﻣ ياﺮﺑ هﻮﯿﺟ 30
دﺎﺑ ﻪﯿﻧﺎﺛ
دﺎﺑ ناﺰﯿﻣ ﺲﭙﺳ و ﺪﺷ ﻪﺑ
ترﻮﺻ بوﺎﻨﺘﻣ 40 ﻣ ﯿﻠ ﯽ ﺮﺘﻣ ﺎﺗ ﺪﺷ ﻪﻓﺎﺿا هﻮﯿﺟ ﻧﺎﻣز
ﯽ ﻪﮐ .ﺪﺷﺎﺒﻧ دﻮﻬﺸﻣ ﺎﭘ ﯽﻠﺧاد كزﻮﻗ ﺖﻤﺴﻗ رد ﯽﻧﺎﯾﺮﺷ ﺾﺒﻧ
ﺮﮕﯾد رﺎﺑ فﺎﮐ رﺎﺸﻓ ﻪﺑ
ترﻮﺻ ﻪﺑ بوﺎﻨﺘﻣ ةزاﺪﻧا
10 ﻣ ﯿﻠ ﯽ ﺮﺘﻣ ﻢﮐ هﻮﯿﺟ ﺪﺷ
ﺾﺒﻧ نآ رد ﻪﮐ يرﺎﺸﻓ ﻦﯾﺮﺗﻻﺎﺑ .دﻮﺷ راﺮﻗﺮﺑ هرﺎﺑود ﺾﺒﻧ ﺎﺗ
دﻮﺒﻧ ﺺﺨﺸﻣ ﯽﻧﺎﯾﺮﺷ
، ﻪﺑ ناﻮﻨﻋ داﺪﺴﻧا رﺎﺸﻓ ﺮﺜﮐاﺪﺣ ﺪﺷ ﻦﯿﯿﻌﺗ
) 27 ( . ﻪﺑ رﻮﻈﻨﻣ تﻮﻠﯾﺎﭘ ﺶﯾﺎﻣزآ ﮏﯾ رد ،نﻮﺧ نﺎﯾﺮﺟ داﺪﺴﻧا زا نﺎﻨﯿﻤﻃا ﺪﻨﭼ
ﺮﻔﻧ زا ﻧدﻮﻣزآ ﯽ ﺎﻫ ﺎﺑ نار رود توﺎﻔﺘﻣ ﻂﺳﻮﺗ هﺎﮕﺘﺳد ﻓاﺮﮔﻮﻧﻮﺳاﺮﺘﻟوا ﯽ
ﺪﻧﺪﺷ ﯽﺳرﺮﺑ .
هرود ﺎﻫ ي ﺎﺑ ﻪﺑﺎﺸﻣ رﺎﺸﻓ نوﺪﺑ ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا
مﺎﺠﻧا ،ﺖﻓﺮﮔ ﺎﻬﻧآ رد فﺎﮐ رﺎﺸﻓ ﻪﮐ توﺎﻔﺗ ﻦﯾا ﺎﺑ 20
ﻣ ﯿﻠ ﯽ ﺮﺘﻣ .دﻮﺑ هﻮﯿﺟ
ﻞﮑﺷ 1 :ﻖﯿﻘﺤﺗ ﮏﯿﺗﺎﻤﺷ حﺮﻃ . ﻫ
يدﻮﻤﻋ ﺶﻠﻓ ﺮ نﺎﺸﻧ
ﺪﻨﻫد ة نﻮﺧ ﮔﯿ ﺮ ي ﻠﺻﺎﻓ و ﮥ ياﺮﺟا ﻦﯿﺑ تﺎﻘﺑﺎﺴﻣ
30 ﻪﻘﯿﻗد .ﺖﺳا
،ﻪﻧازور يژﻮﻟﻮﯿﺑ ﻢﺘﯾر ﺮﺛا زا يﺮﯿﮔﻮﻠﺟ ياﺮﺑ نﻮﻣزآ
ﺎﻫ ﻬﺑﺎﺸﻣ نﺎﻣز رد ﯽ
ﻠﺻﺎﻓ ﺎﺑ تﺎﺴﻠﺟ ﻦﯿﻨﭽﻤﻫ و زور زا ﮥ
ﺞﻨﭘ ﺎﺗ .ﺪﺷ اﺮﺟا زور ﺖﻔﻫ
ﯽﻟﺎﻤﺘﺣا ﺮﺛا زا يﺮﯿﮔﻮﻠﺟ ياﺮﺑ ﻪﻠﺧاﺪﻣ
ﺎﻫ حﺮﻃ زا ، ﻪﯾﻮﺳود
ﯽﻧدﻮﻣزآ ﺮﻫ ياﺮﺑ تﺎﺴﻠﺟ ياﺮﺟا ﺐﯿﺗﺮﺗ زا ﻖﻘﺤﻣ ﻢﻫ نآ رد ﻪﮐ ﺪﺷ هدﺎﻔﺘﺳا رﻮﮐ
ﺶﯿﭘ ﺮﺛا هدﺎﻣآ زﺎﺳ ﻞﮑﺗوﺮﭘ ﺮﺑ ﻒﻠﺘﺨﻣ ﺮﺗاﻮﺗ ﺎﺑ ﯽﻤﮑﺴﯾا ي ﺒﺷ
ﯿ ﻪ زﺎﺳ ي ﺪﺷ ودﻮﺟ ة ...
57
ﺑ ﯽ عﻼﻃا ﻢﻫ و دﻮﺑ ﻧدﻮﻣزآ
ﯽ ﺎﻫ ﺪﻧدﻮﺒﻧ ﻊﻠﻄﻣ ﻖﯿﻘﺤﺗ ﻖﻄﻨﻣ و ﻞﯾﻻد زا )
12 ( ﻦﯿﻨﭽﻤﻫ . ﻪﺑ
رﻮﻈﻨﻣ ﺎﯾ ﻦﯾﺮﻤﺗ ﯽﻟﺎﻤﺘﺣا ﺮﺛا فﺬﺣ زﺎﺳﺎﻨﺷآ
ي ،
ياﺮﺟا ﺐﯿﺗﺮﺗ ﻪﻠﺧاﺪﻣ
ﺎﻫ ﻪﺑ ترﻮﺻ مﺎﺠﻧا ﻊﻃﺎﻘﺘﻣ ﺖﻓﺮﮔ
تﻼﻤﺣ داﺪﻌﺗ عﻮﻤﺠﻣ . ﺮﺛﺆﻣ
ﻪﻘﯿﻗد ﮏﯾ و ﻪﻠﺻﺎﻓﻼﺑ ﺐﻠﻗ نﺎﺑﺮﺿ ،ﻪﻘﺑﺎﺴﻣ ﻪﺳ رد ﺲﭘ
نﻮﻣزآ زا ةﮋﯾو ودﻮﺟ ﻪﺑ ﺳو ﯿﻠ ﮥ نﺎﺑﺮﺿ ﯽﺑﺎﯾزرا رﻻﻮﭘ ﺞﻨﺳ ﺪﺷ
.
تﻼﻤﺣ داﺪﻌﺗ ﯽﺑﺎﯾزرا ياﺮﺑ ﺆﻣ
ﺮﺛ رد ﮥﻘﺑﺎﺴﻣ ﺒﺷ ﯿﻪ زﺎﺳ ي ﺪﺷ ة ﻒﯾﺮﺣ ﮏﯾ ﺎﺑ ﯽﻧدﻮﻣزآ ﺮﻫ ،ودﻮﺟ ﻢﻫ
نزو و ﺮﻘﺗ ﯾًﺎﺒ ﻢﻫ ﺢﻄﺳ ﺮﮐ ﺖﺑﺎﻗر ﺮﮔا .د
لﻮﻃ رد ﻘﺑﺎﺴﻣ ﻪ ) نﻮﭙﯾا زﺎﯿﺘﻣا ﮥﺑﺮﺿ
ﯽﻨﻓ ﻞﺻﺎﺣ ( ﻣ ﯽ ﺪﺷ
، مﺎﻤﺗ ﻪﻘﺑﺎﺴﻣ ﻤﻧ
ﯽ ﺪﺷ رﺎﻬﭼ نﺎﻣز مﺎﻤﺗا ﺎﺗ و د
ﻪﻣادا ﻪﻘﯿﻗ ﻣ
ﯽ ﯾ ﺖﻓﺎ ،ﻪﻘﺑﺎﺴﻣ ﺰﯿﻟﺎﻧآ رد .
تﻼﻤﺣ ﻂﻘﻓ ﺮﺛﺆﻣ
هﺪﺷاﺮﺟا ﯾا ﺖﻟﺎﺣ رد دﻮﺷ ﺮﺠﻨﻣ زﺎﯿﺘﻣا ﺐﺴﮐ و ﮏﯿﻨﮑﺗ ياﺮﺟا ﻪﺑ دﻮﺑ ﻦﮑﻤﻣ ﻪﮐ هدﺎﺘﺴ
، رد ﺮﮔ ﺮﻈﻧ ﻫ .ﺪﺷ ﻪﺘﻓ رﺎﮐودﻮﺟ ﺮ
ﻪﻘﺑﺎﺴﻣ ﻞﻣﺎﮐ ﺰﮐﺮﻤﺗ ﺎﺑ و ﯽﻌﻗاو ﻂﯾاﺮﺷ رد ﺪﯾﺎﺑ ﻣ
ﯽ داد . ﻪﺑ رﻮﻈﻨﻣ ﯽﺑﺮﻣ ود ،ﻪﻘﺑﺎﺴﻣ ﺰﯿﻟﺎﻧآ ﻪﺑ
ترﻮﺻ داﺪﻌﺗ ﻞﻘﺘﺴﻣ تﻼﻤﺣ
ﺆﻣ ﺮﺛ و ﺪﻧدﺮﮐ ﺖﺒﺛ ار
را ﺮﺗﻻﺎﺑ ﻪﺟرد ﺎﺑ ﺮﮕﯾد ﯽﺑﺮﻣ ﮏﯾ ﺰﯿﻧ نﺎﯾﺎﭘ رد مﺎﺠﻧا ار ﯽﺑﺎﯾز
ﻣ ﯽ داد ) 25 (.
نﻮﻣزآ ةﮋﯾو ،ﮏﯾ ﮥﻠﺣﺮﻣ :ﻪﻠﺣﺮﻣ ﻪﺳ ﻞﻣﺎﺷ ودﻮﺟ ﯽﻧﺎﻤﺴﺟ 15
،ﻪﺳ و ود ﮥﻠﺣﺮﻣ ،ﻪﯿﻧﺎﺛ 30
ﻪﻠﺣﺮﻣ ﺮﻫ ﻦﯿﺑ ﻪﮐ ﺖﺳا ﻪﯿﻧﺎﺛ 10
ﻪﯿﻧﺎﺛ
اﺮﺟا ترﻮﺻ ﻦﯾا ﻪﺑ نﻮﻣزآ .دراد دﻮﺟو ﺖﺣاﺮﺘﺳا ﻣ
ﯽ دﻮﺷ ﻮﺟ ود يور ﯽﻧدﻮﻣزآ ﻪﻠﺣﺮﻣ ﺮﻫ رد ﻪﮐ رﺎﮐود
ﻢﻫ و ﺪﻗ ﻢﻫ ﺶﻧزو ﺶﺷ ﮥﻠﺻﺎﻓ رد ﻪﮐ
ﮏﯿﻨﮑﺗ ،ﺪﻧراد راﺮﻗ ﻢﻫ زا يﺮﺘﻣ اﯾ
نﻮﭙ ﺋﻮﺳ ﯽ ﻪﮔﺎﻧ اﺮﺟا ﻦﮑﻤﻣ داﺪﻌﺗ ﺮﺜﮐاﺪﺣ ﺎﺗ و شﻼﺗ ﺮﺜﮐاﺪﺣ ﺎﺑ ار1
ﻣ ﯽ ﺪﻨﮐ رد ﯽﻧدﻮﻣزآ .
رد و رﺎﮐودﻮﺟ ود ﻦﯿﺑ رد نﻮﻣزآ عوﺮﺷ ﮥﻠﺻﺎﻓ
راﺮﻗ ماﺪﮐ ﺮﻫ زا يﺮﺘﻣ ﻪﺳ ﯽﻣ
دﺮﯿﮔ نﺎﻣﺮﻓ مﻼﻋا ﺎﺑ و ر
و ﻪﺑ ﺖﻋﺮﺳ ﻪﺑ فﺮﻃ لوا رﺎﮐودﻮﺟ
ﯽﻣ دور ﺪﻌﺑ و هدﺮﮐ اﺮﺟا ار ﮏﯿﻨﮑﺗ و ﻪﺑ
ﺖﻋﺮﺳ ﺮﮕﯾد رﺎﮐودﻮﺟ فﺮﻃ ﻪﺑ ﯽﻣ
دور ا يور ﺮﺑ ار ﮏﯿﻨﮑﺗ و اﺮﺟا و
ﻣ ﯽ ﺪﻨﮐ ياﺮﺟا ﻦﯾا و ﺎﺗ ﮏﯿﻨﮑﺗ
:ﻪﻠﺣﺮﻣ ود رد ﯽﻧدﻮﻣزآ ﺐﻠﻗ نﺎﺑﺮﺿ .دراد ﻪﻣادا ﻪﻠﺣﺮﻣ ﺮﻫ نﺎﻣز نﺎﯾﺎﭘ 1
. ﻪﻠﺻﺎﻓﻼﺑ ﺲﭘ
ﻣزآ مﺎﻤﺗا زا و نﻮ
2 . ﻪﻘﯿﻗد ﮏﯾ ﺲﭘ
آ مﺎﻤﺗا زا نﻮﻣز
ﻪﺑ ﺳو ﯿﻠ ﮥ شرﺎﻤﺷ 15 ﻧﺎﺛ ﯿﻪ ا ي لﺎﯿﮐاﺮﺑ ﺾﺒﻧ هزاﺪﻧا
ﮔﯿ ﺮ ي و نﻮﻣزآ زا ﺪﻌﺑ ﺐﻠﻗ نﺎﺑﺮﺿ سﺎﺳاﺮﺑ .ﺪﺷ رد ﺎﻫاﺮﺟا ﻞﮐ داﺪﻌﺗ
ﮥﻠﺣﺮﻣ ﻪﺳ آ
،نﻮﻣز
ﻟدﺎﻌﻣ زا نﻮﻣزآ ﺺﺧﺎﺷ ﮥ
ﺪﺷ دروآﺮﺑ ﺮﯾز )
28 (:
ﺶﯿﭘ ﻪﻠﺻﺎﻓﻼﺑ و ﺲﭘ
زا ﮥﻘﺑﺎﺴﻣ ودﻮﺟ زا ، ﻧدﻮﻣزآ ﯽ ﺎﻫ 5 ﻣ ﯿﻠ ﯽ ﻟﯿ ﺮﺘ .ﺪﺷ ﻪﺘﻓﺮﮔ ﯽﯾوزﺎﺑ ﺪﯾرو زا نﻮﺧ ﻪﻧﻮﻤﻧ
ﺎﻫ ي تﺪﻣ ﻪﺑ ﯽﻧﻮﺧ 10
و ﻪﻘﯿﻗد
ﺖﻋﺮﺳ ﺎﺑ 3000
ﺎﻣد رد و ﻪﻘﯿﻗد رد رود ي
رﺎﻬﭼ ﺟرد ﮥ ﺘﻧﺎﺳ ﯽ داﺮﮔ زﺎﺳاﺪﺟ ﺖـﻬﺟ ي
ﺷ ژﻮﯿﻔﯾﺮﺘﻧﺎﺳ ،مﺮﺳ ﺪﻧﺪ
هزاﺪﻧا. ﮔﯿ ﺮ ي ﯽﻣﺮﺳ Bcl-2 ) ﺎـﺑ
ﺖﯿﺳﺎﺴﺣ 08
/1 ﺪﺣاو ﺑﯿ ﻦ ﻞﻠﻤﻟا رد ﻣﯿ ﻠ ﯽ ﻟﯿ ﺮﺘ و ( ﺎﺑ) Bax
ﺖﯿﺳﺎﺴﺣ 26
/5 ﺪﺣاو ﺑﯿ ﻦ ﻞﻠﻤﻟا رد ﻣﯿ ﻠ ﯽ ﻟﯿ ﺮﺘ ﮐﺮﺷ ﺖﯿﮐ زا و اﺰﯾﻻا شور ﺎﺑ ( ﺖ
ﺖﺴﯾز يژﻮﻟﻮﻨﮑﺗ ﯽﻫﺎﮕﺸﯾﺎﻣزآ ﻨﺳ
ﺎﺑ) ﯽﺠ
نورد CV
ﺳ و ﯽﺠﻨ نوﺮﺑ زا ﺮﺘﻤﮐ ﯽﺠﻨﺳ 8
و 10 ﺪﺷ مﺎﺠﻧا (ﺪﺻرد )
29 ( . ﻪﺑ رﻮﻈﻨﻣ ﺒﺳﺎﺤﻣ ﮥ تاﺮﯿﯿﻐﺗ
ﻢﺠﺣ
،ﺎﻤﺳﻼﭘ راﺪﻘﻣ ﻦﯿﺑﻮﻠﮔﻮﻤﻫ و ﺖﯾﺮﮐﻮﺗﺎﻤﻫ ﻞﺒﻗ رد
ﺖﯿﻟﺎﻌﻓ زا ﺪﻌﺑ و هزاﺪﻧا
ﮔﯿ ﺮ ي ﺪﺷ ﻦﯾا. هداد ﺎﻫ ياﺮﺑ دروآﺮﺑ ﺗ ﺎﻤﺳﻼﭘ ﻢﺠﺣ تاﺮﯿﯿﻐ
ﻖﺑﺎﻄﻣ ﻟدﺎﻌﻣ ﮥ ﻞﯿﺘﺳﺎﮐ و ﻞﯾد )
1974 ﺪﺷ هدﺎﻔﺘﺳا ( )
30 ( ،ﯽﻗﻼﺧا تﺎﻈﺣﻼﻣ ﺖﯾﺎﻋر ياﺮﺑ . ﺖﮐﺮﺷ
نﺎﮔﺪﻨﻨﮐ زا ﻪﻠﺣﺮﻣ ﺮﻫ رد ﺪﻧدﻮﺑ رﺎﺘﺨﻣ
ﻖﯿﻘﺤﺗ .ﺪﻨﻫد فاﺮﺼﻧا
ﻦﯿﻨﭽﻤﻫ ﮥﺘﯿﻤﮐ
قﻼﺧا ﺪﮑﺸﻧاد ة ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد
ﺎﺑ يرﺎﺳ دازآ ﮥﺳﺎﻨﺷ
قﻼﺧا
)
IR.IAU.SARI.REC.1399.157
ﻞﺣاﺮﻣ ﯽﻣﺎﻤﺗ ﺮﺑ ( ﻖﯿﻘﺤﺗ
.ﺖﺷاد ترﺎﻈﻧ
رﺎﻣآ شور ي
ﻪﺑ رﻮﻈﻨﻣ ﺰﺠﺗ ﯾﻪ ﻠﺤﺗو ﯿ ﻞ ﻃا زا تﺎﻋﻼ شور
ﺎﻫ ي رﺎﻣآ ي ﻪﮐ ﺪﺷ هدﺎﻔﺘﺳا ﯽﻃﺎﺒﻨﺘﺳا و ﯽﻔﯿﺻﻮﺗ آ
اﺮﺑ ﯽﻔﯿﺻﻮﺗ رﺎﻣ ي
ﻦﯿﯿﻌﺗ ﻣ و ﻦﯿﮕﻧﺎﯿ ا
فاﺮﺤﻧ
هدﺎﻔﺘﺳا رﺎﯿﻌﻣ ﺪﺷ
لﺎﻣﺮﻧ . ﻊﯾزﻮﺗ ندﻮﺑ هداد
ﺎﻫ نﻮﻣزآ ﻖﯾﺮﻃ زا ﺰﯿﻧ ﮐ
ﺮﮔﻮﻤﻟﻮ و ﯽﺳرﺮﺑ فﻮﻧﺮﯿﻤﺳا ـ ف ﺷ
ﺪ . هوﻼﻋ ﺮﺑ اﯾ ﻦ ، ياﺮﺑ زآ نﻮﻣ
ﺿﺮﻓ ﯿﻪ ﺎﻫ ي ﺎﺑ ﺲﻧﺎﯾراو ﻞﯿﻠﺤﺗ شور زا ﺶﻫوﮋﭘ اﺪﻧا
هز ﮔﯿ ﺮ ي ﺎﻫ ي ﺳا ﯽﻧوﺮﻔﻧﻮﺑ ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ و رﺮﮑﻣ هدﺎﻔﺘ
ﺷ ﺪ ﺢﻄﺳ . رادﺎﻨﻌﻣ ي ﻧ ﺰﯿ 05 /0
≤ P
رد ﺪﺷ ﻪﺘﻓﺮﮔ ﺮﻈﻧ .
Ipon Seoi Nage
1.
ودﻮﺟ نﻮﻣزآ ﺺﺧﺎﺷ 1(
ﮏﯾ ﺐﻠﻗ نﺎﺑﺮﺿ + نﻮﻣزآ زا ﺪﻌﺑ ﻪﻠﺻﺎﻓﻼﺑ ﺐﻠﻗ نﺎﺑﺮﺿ نﻮﻣزآ زا ﺪﻌﺑ ﻪﻘﯿﻗد
÷ ﮏﯿﻨﮑﺗ داﺪﻌﺗ اﺮﺟا يﺎﻫ
هﺪﺷ
58 ﺰﯿﯾﺎﭘ ،مﻮﺳ ةرﺎﻤﺷ ،ﻢﻫدرﺎﻬﭼ ةرود ،ﯽﺷزرو ﯽﺘﺴﯾز مﻮﻠﻋ
1401
ﯾ ﻪﺘﻓﺎ ﺎﻫ ي ﺶﻫوﮋﭘ
ﺎﻤﺳﻼﭘ ﻢﺠﺣ تاﺮﯿﯿﻐﺗ ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ ﺲﭘ
ﺖﯿﻟﺎﻌﻓ زا 1/
±2 4/
6 يﺎﻫﺮﯿﻐﺘﻣ ﻪﺑ طﻮﺑﺮﻣ ﺮﯾدﺎﻘﻣ .ﺖﻓﺎﯾ ﺶﻫﺎﮐ ﺪﺻرد ودﻮﺟ نﻮﻣزآ
و
رد زﻮﺘﭘﻮﭘآ يﺎﻫﺮﯿﻐﺘﻣ ﻦﯿﻨﭽﻤﻫ نﺎﻣز
ﺎﻫ ي لوﺪﺟ رد ﻒﻠﺘﺨﻣ 1
هﺪﻫﺎﺸﻣ ﻣ ﯽ دﻮﺷ لﺎﻤﻋا ﺮﺛا ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ . ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﯽﻤﮑﺴﯾا رد
داﺪﻌﺗ ﺮﺑ ﻒﻠﺘﺨﻣ يﺎﻫﺮﺗاﻮﺗ ﻨﮑﺗ
ﯿ ﮏ ﺎﻫ ي هﺪﺷاﺮﺟا ) 294 /0
=
، PES
026 /0
= ،P
982 /3
= ) ودﻮﺟ نﻮﻣزآ ﺺﺧﺎﺷ و (F
218 /0
=
PES
، 039 /0
= ،P
674 / 2
= (F
ﻨﻌﻣ ﺎ راد ود ﻪﺑ ود ﮥﺴﯾﺎﻘﻣ .دﻮﺑ هوﺮﮔ
ﺎﻫ داد نﺎﺸﻧ ﺗ داﺪﻌ ﻨﮑﺗ ﯿ ﮏ ﺎﻫ ي هﺪﺷاﺮﺟا ﺶﯿﭘ دﺎﯾز ﺮﺗاﻮﺗ رد هدﺎﻣآ
زﺎﺳ ي ﯽﻤﮑﺴﯾا
ﺶﯾاﺰﻓا ﻪﺑ ﺮﺠﻨﻣ ﻨﻌﻣ
ﺎ راد ي رﺎﺸﻓ نوﺪﺑ ﻢﮐ ﺮﺗاﻮﺗ ﻪﺑ ﺖﺒﺴﻧ )
031 /
P=0
رﺎﺸﻓ نوﺪﺑ دﺎﯾز ﺮﺗاﻮﺗ و (
) 012 P= /0 ﻦﯿﺑ .ﺪﺷ ( ﻌﺿو
ﯿ ﺖ ﺎﻫ ي ﻢﮐ ﺮﺗاﻮﺗ
ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﺎﺑ ﯽﻤﮑﺴﯾا رﺎﺸﻓ نوﺪﺑ ﻢﮐ ﺮﺗاﻮﺗ
) 086 /
P=0
ﺎﺸﻓ نوﺪﺑ دﺎﯾز ﺮﺗاﻮﺗ و (
ر ) 156 P= /0 توﺎﻔﺗ ( ﻨﻌﻣ ﺎ راد ي ﺪﺸﻧ هﺪﻫﺎﺸﻣ .
ﺞﯾﺎﺘﻧ
داد نﺎﺸﻧ ودﻮﺟ نﻮﻣزآ ﺺﺧﺎﺷ ياﺮﺑ دﺎﯾز ﺮﺗاﻮﺗ ﻪﮐ
ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﺶﻫﺎﮐ ﻪﺑ ﯽﻤﮑﺴﯾا ﻨﻌﻣ
ﺎ راد نوﺪﺑ ﻢﮐ ﺮﺗاﻮﺗ ﻪﺑ ﺖﺒﺴﻧ نﻮﻣزآ ﺺﺧﺎﺷ
رﺎﺸﻓ ) 041 /
0 (P=
رﺎﺸﻓ نوﺪﺑ دﺎﯾز ﺮﺗاﻮﺗ و )
008 P= /0 ( ﺮﺠﻨﻣ ﻦﯿﺑ .ﺪﺷ ﻌﺿو ﯿ ﺖ ﺎﻫ ي ﻢﮐ ﺮﺗاﻮﺗ ﺶﯿﭘ هدﺎﻣآ زﺎﺳ ي ﺎﺑ ﯽﻤﮑﺴﯾا نوﺪﺑ ﻢﮐ ﺮﺗاﻮﺗ
رﺎﺸﻓ ) 176 /0 (P=
رﺎﺸﻓ نوﺪﺑ دﺎﯾز ﺮﺗاﻮﺗ و )
213 /0 توﺎﻔﺗ (P=
ﻨﻌﻣ ﺎ راد ي ﺪﺸﻧ هﺪﻫﺎﺸﻣ .
ﺴﯾﺎﻘﻣ ﮥ ﺢﻄﺳ و Bax
Bcl-2
رد نﺎﻣز ﺎﻫ ي ﻦﯿﺑ ﻒﻠﺘﺨﻣ ﻌﺿو
ﯿ ﺖ ﺎﻫ ي توﺎﻔﺘﻣ داد نﺎﺸﻧ ﺮﯾدﺎﻘﻣ رد
ﻦﯿﺑ ﺎﻫﺮﯿﻐﺘﻣ ﻦﯾا ﻪﻘﺑﺎﺴﻣ ﻞﺒﻗ
ﻌﺿو ﯿ ﺖ ﺎﻫ ي توﺎﻔﺗ ﻒﻠﺘﺨﻣ ﻨﻌﻣ
ﺎ راد ي ) دراﺪﻧ دﻮﺟو 05
P> /0 .(
ﺢﻄﺳ
BCL-2 ﺲﭘ دﺎﯾز و ﻢﮐ ﺮﺗاﻮﺗ ﺖﯿﻌﺿو رد ﻪﻘﺑﺎﺴﻣ زا ﺶﯾاﺰﻓا ﯽﻤﮑﺴﯾا
ﻨﻌﻣ ﺎ راد ي ﻪﺑ ﺖﺒﺴﻧ ﺶﯿﭘ
ﺖﺷاد ﻪﻘﺑﺎﺴﻣ زا
، ﻟﺎﺣرد ﯽ ﻪﮐ ﺢﻄﺳ
BCL-2
ﺲﭘ ﺖﯿﻌﺿو رد ﻪﻘﺑﺎﺴﻣ زا نوﺪﺑ ﻢﮐ ﺮﺗاﻮﺗ
) رﺎﺸﻓ 026 P= /0 ( ﺶﻫﺎﮐ
ﻨﻌﻣ ﺎ راد ي ﻪﺑ ﺖﺒﺴﻧ ﺶﯿﭘ
.ﺖﺷاد ﻪﻘﺑﺎﺴﻣ زا ﮥﺴﯾﺎﻘﻣ
ﺢﻄﺳ
BCL-2
ﮐ داد نﺎﺸﻧ ﻪﻘﺑﺎﺴﻣ ﺪﻌﺑ ﺮﺗاﻮﺗ ﻪﺑ ﺖﺒﺴﻧ ﯽﻤﮑﺴﯾا ﻢﮐ ﺮﺗاﻮﺗ ﺖﯿﻌﺿو رد ﻪ
نوﺪﺑ ﻢﮐ رﺎﺸﻓ
) 001 /0 P= نوﺪﺑ دﺎﯾز ﺮﺗاﻮﺗ و ( رﺎﺸﻓ
) 001 /0 P= (،
نوﺪﺑ ﻢﮐ ﺮﺗاﻮﺗ ﻪﺑ ﺖﺒﺴﻧ ﯽﻤﮑﺴﯾا دﺎﯾز ﺮﺗاﻮﺗ رد ﻦﯿﻨﭽﻤﻫ رﺎﺸﻓ
) 001 /0 P= نوﺪﺑ دﺎﯾز ﺮﺗاﻮﺗ و ( رﺎﺸﻓ
) 001 /0 P= ﺶﯾاﺰﻓا ( ﻨﻌﻣ
ﺎ راد ي .ﺖﺷاد
ﺢﻄﺳ ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ ﺲﭘBax
ﺑﺎﺴﻣ زا رد ﻪﻘ ﻢﮐ ﺮﺗاﻮﺗ ) رﺎﺸﻓ نوﺪﺑ
011 / 0 P= ( و نوﺪﺑ دﺎﯾز ﺮﺗاﻮﺗ ) رﺎﺸﻓ
019 /0 P= ( ﺶﯾاﺰﻓا
ﻨﻌﻣ ﯽ راد ي ﻪﺑ ﺖﺒﺴﻧ ﺶﯿﭘ
ﺖﺷاد ﻪﻘﺑﺎﺴﻣ زا
، ﻟﺎﺣرد ﯽ ﻪﮐ ﻢﮐ ﺮﺗاﻮﺗ ﺖﯿﻌﺿو رد ﯽﻤﮑﺴﯾا
) 163 /0 P= ﯽﻤﮑﺴﯾا دﺎﯾز ﺮﺗاﻮﺗ و ( )
128 /0 P= (
توﺎﻔﺗ ﻨﻌﻣ ﺎ راد ي هﺪﻫﺎﺸﻣ ﻪﻘﺑﺎﺴﻣ زا ﺪﻌﺑ و ﻞﺒﻗ ﺮﯾدﺎﻘﻣ ﻦﯿﺑ .ﺪﺸﻧ
ﺢﻄﺳ ﺲﭘBax
ﺶﻫﺎﮐ ﯽﻤﮑﺴﯾا ﻢﮐ ﺮﺗاﻮﺗ رد ﻪﻘﺑﺎﺴﻣ ﻨﻌﻣ
ﺎ راد ي ﻪﺑ ﺖﺒﺴﻧ
) رﺎﺸﻓ نوﺪﺑ ﻢﮐ ﺮﺗاﻮﺗ 021
/ 0 P= ) رﺎﺸﻓ نوﺪﺑ دﺎﯾز ﺮﺗاﻮﺗ و ( 016
/ 0 P= رﺎﺸﻓ نوﺪﺑ دﺎﯾز ﺮﺗاﻮﺗ ﻪﺑ ﺖﺒﺴﻧ ﯽﻤﮑﺴﯾا دﺎﯾز ﺮﺗاﻮﺗ رد ﻦﯿﻨﭽﻤﻫ و (
) 034 /0 P= .ﺖﺷاد (
ﻞﮑﺷ ﺞﯾﺎﺘﻧ 1
دﺎﯾز ﺮﺗاﻮﺗ لﺎﻤﻋا ﻪﮐ داد نﺎﺸﻧ ﺶﯿﭘ
هدﺎﻣآ زﺎﺳ ي ﻪﺑ ﯽﻤﮑﺴﯾا ﺪﻋ
م ﻐﺗ ﯿﯿ ﺮ ﻨﻌﻣ ﺎ راد عﻮﻤﺠﻣ تﻼﻤﺣ داﺪﻌﺗ ﺮﺛﺆﻣ
ﻪﺳ رد ﮥﻘﺑﺎﺴﻣ
لﺎﻤﻋا ﻪﺑ ﺖﺒﺴﻧ ودﻮﺟ ﯽﻟاﻮﺘﻣ هرود
ﺎﻫ ي رﺎﺸﻓ نوﺪﺑ ﺮﺠﻨﻣ
) ﺪﺷ 126 / 0 P= .(
لوﺪﺟ 1 . ﮥﺴﯾﺎﻘﻣ ﺺﺧﺎﺷ ﺎﻫ ي نﻮﻣزآ ةﮋﯾو رد يزﻮﺘﭘﻮﭘآ و ودﻮﺟ ﻌﺿو
ﯿ ﺖ ﺎﻫ ي ﻒﻠﺘﺨﻣ ﯽﻤﮑﺴﯾا
ﺺﺧﺎﺷ ﻢﮐ ﺮﺗاﻮﺗ
رﺎﺸﻓ نوﺪﺑ ﻢﮐ ﺮﺗاﻮﺗ
ﯽﻤﮑﺴﯾا دﺎﯾز ﺮﺗاﻮﺗ
ﯽﻤﮑﺴﯾا ﻮﺗ
نوﺪﺑ دﺎﯾز ﺮﺗا رﺎﺸﻓ
داﺪﻌﺗ ﻨﮑﺗ ﯿ ﮏ ﺎﻫ ي ﺪﺷاﺮﺟا ة نﻮﻣزآ
) ودﻮﺟ ng/ml ( 8/
0
± 15 / 24 4/
1
± 36 / 6/ 25
±1 01 / 26
* 1/ €
1
± 29 / 24
ودﻮﺟ نﻮﻣزآ ﺺﺧﺎﺷ 9/
0
± 01 / 13 8/
0
± 44 / 8/ 12
±0 11 / 12
* 9/ €
0
± 89 / 12
Bcl-2 زا ﺶﯿﭘ ) ﻪﻘﺑﺎﺴﻣ ( U/ml 7/
±33 8 / 189 2/
±27 7 / 196 4/
±33 5 / 203 1/
±27 4 / 191
Bcl-2 زا ﺲﭘ ) ﻪﻘﺑﺎﺴﻣ ( U/ml 1/
28
± 4 / 165 6/ †
47
± 1 / 248
* 6/ †€
74
± 5 / 302
* 5/ †€
±28 3 / 171
زا ﺶﯿﭘBax ) ﻪﻘﺑﺎﺴﻣ ( U/ml 3/
1
± 6 / 13 3/
1
± 3 / 13 9/
0
± 7 / 13 1/
1
± 1 / 14
زا ﺲﭘBax ) ﻪﻘﺑﺎﺴﻣ ( U/ml 7/
1
± 9 / 19 6/ †
1
± 8 / 13
* 8/ €
4
± 04 /
€14 5/
2
± 2 / 16
†
* توﺎﻔﺗ ﻨﻌﻣ ﺎ راد ﺎﺑ رﺎﺸﻓ نوﺪﺑ ﻢﮐ ﺮﺗاﻮﺗ
€ توﺎﻔﺗ ﻨﻌﻣ ﺎ راد رﺎﺸﻓ نوﺪﺑ دﺎﯾز ﺮﺗاﻮﺗ ﺎﺑ توﺎﻔﺗ†
ﻨﻌﻣ ﺎ راد ﺎﺑ ﺶﯿﭘ ﻪﻘﺑﺎﺴﻣ زا
