Plasma Levels of Lipoprotein (a) in Patients with Major Depressive Disorder

(1)

10

10 لﺎﺳ ،ناﺮﻳا ﻲﻨﻴﻟﺎﺑ ﻲﺳﺎﻨﺸﻧاور و ﻲﻜﺷﺰﭙﻧاور ﻪﻠﺠﻣ

ﻢﻫدﺰﻧﺎﭘ هرﺎﻤﺷ ، 1

، رﺎﻬﺑ 1388 ، 17 - 10

ــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ ـــــــــــــــــــــــــــــــــــــ

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ﻲﻳﺎﻤﺳﻼﭘ ﺢﻄﺳ نارﺎﻤﻴﺑ رد (a)

لﻼﺘﺧا ﻪﺑ ﻼﺘﺒﻣ دﺮﺴﻓا

ﻲﮔ ﻲﺳﺎﺳا

يﺪﻴﻤﺣ هراﺮﺷ

1دﺮﻓ ، يرﺎﺨﻓ ﻲﻠﻋ ﺮﺘﻛد بﻮﺒﺤﻣ ﻲﻠﻌﻧﺎﻄﻠﺳ ﺮﺘﻛد ،2

يﺮﮔﺮﮔ ﻢﺳﺎﻗرﻮﭘ ماﺮﻬﺑ ﺮﺘﻛد ،3 4

Plasma Levels of Lipoprotein (a) in Patients with Major Depressive Disorder

Sharareh Hamidifard ^a, Ali Fakhari ^b, Soltanali Mahboob ^c, Bahram Pourghassem Gargari*

هﺪﻴﻜﭼ

فﺪﻫ

نآ زا

:

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ﺖﻈﻠﻏ ﺶﻳاﺰﻓا ﻪﻛ ﺎﺟ ﻪﺑ

(a)

ﻞـﻣﺎﻋ ﻚـﻳ ناﻮـﻨﻋ

يرﺎﻤﻴﺑ ﺖﻓﺮﺸﻴﭘ ﻲﻟﺎﻤﺘﺣا

ﻲﺒﻠﻗ يﺎﻫ - ﺖﺳا هﺪﺷ حﺮﻄﻣ ﻲﻗوﺮﻋ

، ﻦﻴﻴﻌﺗ ياﺮﺑ

ناﺰــﻴﻣ ﻦﻴﺌﺗوﺮﭘﻮــﭙﻴﻟ ﻲــﺑﺮﭼ و

(a)

داﺮــﻓا رد نﻮــﺧ يﺎــﻫ ﻪــﺑ ﻼﺘــﺒﻣ

لﻼﺘــﺧا

ﺪـﺷ مﺎـﺠﻧا ﻲـﺳرﺮﺑ ﻦـﻳا ﻢﻟﺎـﺳ داﺮـﻓا ﺎـﺑ ﺎـﻬﻧآ ﻪﺴـﻳﺎﻘﻣ و ﻲﺳﺎﺳا ﻲﮔدﺮﺴﻓا .

شور

ﻲﺳرﺮﺑ ﻦﻳا

:

عﻮﻧ زا

درﻮﻣ - يﺪﻫﺎﺷ ﺖﺳا . ﺢﻄﺳ ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ

(a)

و

ﻲﺑﺮﭼ رد نﻮﺧ يﺎﻫ 35

ﻪﺑ ﻼﺘﺒﻣ رﺎﻤﻴﺑ لﻼﺘﺧا

و ﻲـﺳﺎﺳا ﻲﮔدﺮﺴـﻓا 35

دﺮـﻓ

شور ﺎــﺑ ﻢﻟﺎــﺳ دراﺪﻧﺎﺘــﺳا يﺎــﻫ

ا هزاﺪــﻧ ﺪﻧﺪــﺷ يﺮــﻴﮔ .

هداد ﺎــﻫ ﻪــﺑ ﻪﻠﻴــﺳو

نﻮﻣزآ ﻲﺧ يرﺎﻣآ يﺎﻫ ود

نﻮـﺳﺮﻴﭘ ﻲﮕﺘﺴﺒﻤﻫ ﺐﻳﺮﺿ ، و

نﻮـﻣزآ ﻞـﻴﻠﺤﺗ

t

ﺪﻧﺪﻳدﺮﮔ .

ﺘﻓﺎﻳ ﻪ ﺎﻫ

و مﺎﺗ لوﺮﺘﺴﻠﻛ

:

)

LDL

ﻦﻴﻳﺎـﭘ ﻲﻟﺎـﮕﭼ ﺎـﺑ ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ (

ﻪــﺑ رﻮــﻃ ﻲــﻨﻌﻣ راد ﻦﻴﻳﺎــﭘ نارﺎــﻤﻴﺑ رد ي ﺮــﺗ

دﻮــﺑ ) 74 / 3 65

±

/ 144 ﺮــﺑاﺮﺑ رد

82 / 5 14

±

/ 186 و 00 / 3 78

±

/ 72 ﺮـــﺑاﺮﺑ رد 27 / 5 21

±

/ 110

mg/dl

، 001 / 0

p<

(.

ﻦﻴﮕﻧﺎﻴﻣ

(a)

نارﺎﻤﻴﺑ رد نﻮﺧ

Lp

74

% دﻮـﺑ ﻢﻟﺎﺳ داﺮﻓازا ﺮﺘﺸﻴﺑ )

04 / 3 94

±

/ 34

ﺮــﺑاﺮﺑ رد 90 / 1 08

±

/ 20

mg/dl

، 001 / 0

p<

.(

ﻪــﺠﻴﺘﻧ يﺮــﻴﮔ

ﺶﻳاﺰــﻓا

:

Lp(a)

ﺮـﻄﺧ ﺶﻳاﺰﻓا ياﺮﺑ ﻲﻠﻣﺎﻋ ﺖﺳا ﻦﻜﻤﻣ يرﺎـﻤﻴﺑ زوﺮـﺑ

ﺎـﻫ ﻲـﺒﻠﻗ ي -

ﺪﺷﺎﺑ ﻲﺳﺎﺳا ﻲﮔدﺮﺴﻓا ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﻴﺑ رد ﻲﻗوﺮﻋ .

هژاوﺪﻴﻠﻛ

ﺳﺎﺳا ﻲﮔدﺮﺴﻓا

:

ﻲ

؛ ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ )

(؛

a

يرﺎـﻤﻴﺑ ﺎـﻫ ﻲـﺒﻠﻗ ي -

ﻲﻗوﺮﻋ

ﻪﻟﺎﻘﻣ ﺖﻓﺎﻳرد] :

17 / 7 / 1386 ﻪﻟﺎﻘﻣ شﺮﻳﺬﭘ ؛ :

19 / 1 / 1387 [ Abstract

Abstract Abstract Abstract

Objectives: Raised lipoprotein (a) concentration is known as a probable cause of development of cardiovascular disease. Therefore, the present study was carried out to measure lipoprotein (a) in individuals with major depressive disorder and to compare them with normal individuals.

Method: In this case-control study, plasma levels of lipoprotein (a) and the lipid profile was measured in 35 patients with major depressive disorder and 35 normal individuals (control group) using standard methods. Data were analyzed using chi-square, Pearson’s correlation coefficient and student’s t-test. Results: Total Cholesterol and LDL-c was significantly lower in patients (144.65±

3.74 vs. 186.14±5.82, and 72.78±3.00 vs. 110.21±5.27 mg/dl, p=0.001). The mean of lipoprotein (a) in patients with major depressive disorder was 74% higher than healthy controls (34.94±3.04 vs. 20.08±1.90 (mg/dl), p=0.001). Conclusion: The increase of lipoprotein (a) may contribute to higher risk of cardiovascular disease in patients with major depressive disorder.

Key words: major depression; lipoprotein (a); cardiovascular disease

[Received: 9 October 2007; Accepted: 7 April 2008]

_______________________________________

ﻪﻳﺬﻐﺗ ﺪﺷرا ﻲﺳﺎﻨﺷرﺎﻛ يﻮﺠﺸﻧاد 1

، ؛ﺰﻳﺮﺒﺗ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻪﻳﺬﻐﺗ و ﺖﺷاﺪﻬﺑ هﺪﻜﺸﻧاد ؛ﺰـﻳﺮﺒﺗ ﻲﻜـﺷﺰﭘ مﻮـﻠﻋ هﺎﮕﺸـﻧاد رﺎﻳدﺎﺘـﺳا ،ﻚـﺷﺰﭙﻧاور 2

و ﻪـﻳﺬﻐﺗ مﻮـﻠﻋ ياﺮـﺘﻛد 3

؛ﺰﻳﺮﺒﺗ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد دﺎﺘﺳا ،ﻲﻤﻴﺷﻮﻴﺑ ياﺮﺘﻛد 4

ﺰﻳﺮﺒﺗ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد رﺎﻳدﺎﺘﺳا ،ﻪﻳﺬﻐﺗ مﻮﻠﻋ .

ﻪﻳﺬﻐﺗ تﺎﻘﻴﻘﺤﺗ ﺰﻛﺮﻣ .

ﺖﺷاﺪﻬﺑ هﺪﻜﺸﻧاد ،ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،ﺰﻳﺮﺒﺗ

ﻲﺘﺴﭘﺪﻛ ،ﻲﻤﻴﺷﻮﻴﺑ و ﻪﻳﺬﻐﺗ هوﺮﮔ ،ﻪﻳﺬﻐﺗ و 5166614711

. رﺎﮕﻧرود : 3340634 - 0411 ) لﻮﺌﺴﻣ هﺪﻨﺴﻳﻮﻧ .(

E-mail :[email protected] .

* Corresponding author: PhD. in Nutritional Sciences, Assistant Prof. of Nutritional Research Center, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran, IR. Fax: +98411-3340634. E-mail: [email protected]; ^a Master's degree student in Nutrition, Faculty of Health and Nutrition, Tabriz University of Medical Sciences; ^b Psychiatrist, Assistant Prof. of Tabriz University of Medical Sciences; ^c PhD. in Nutrition and Biochemistry, Professor of Tabriz University of Medical Sciences.

Iranian Journal of Psychiatry and Clinical Psychology, Vol. 15, No. 1, Spring 2009, 10-17

ﻣ ﻲﺸﻫوﮋﭘ ﻪﻟﺎﻘ

ﻞﻴﺻا

Original Article

(2)

يﺪﻴﻤﺣ هراﺮﺷ نارﺎﻜﻤﻫ و دﺮﻓ

11

لﺎﺳﻢﻫدﺰﻧﺎﭘ /رﺎﻤﺷ ه 1 / رﺎــﻬﺑ1388 Vol. 15 / No. 1/ Spring 2009

ﻪﻣﺪﻘﻣ لﻼﺘﺧا ﻲﺳﺎﺳا ﻲﮔدﺮﺴﻓا

(MDD)1

يرﺎـﻤﻴﺑ و ﻲـﺒﻠﻗ ىﺎـﻫ

-

ﻲﻗوﺮﻋ ﻞﻴﻟد ود هﺪﻤﻋ ﺪﻨﺘﺴﻫ نﺎﻬﺟ ﺮﺳﺎﺗﺮﺳ رد ﻰﻧاﻮﺗﺎﻧ )

2

يرﻮﻣ

ﺰﭘﻮﻟ و

،

3

1997 ( . ﻦﻳا ﺞﻨﭘ زا يرﺎﻤﻴﺑ ود ﻲﻠﺻا يرﺎﻤﻴﺑ

ﻦﻣﺰـﻣ رد

ﺪﻨﻤﻟﺎﺳ ﻪﺑ نا ﻲﻣ رﺎﻤﺷ ﺪـﻧور ) نرﻮﺑﺮـﺷ

،

4

ﺰـﻟو ﺮﺘـﺳا و

5 6

م

، 1997 ؛

7

ﻲﻟوو

، 2006 ( . شﺮﺘﺴـﮔ ﺮﻄﺧ يرﺎـﻤﻴﺑ

ﺎـﻫ ﻗ ي ﻲـﺒﻠ - و ﻲـﻗوﺮﻋ

ﺮﻴﻣ و گﺮﻣ ﺶﻳاﺰﻓا رﺎـﻬﭼ ﺎـﺗ ود ﻲﮔدﺮﺴﻓا ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﻴﺑ رد

ﺖـﺳا يدﺎـﻋ داﺮـﻓا زا ﺮﺘﺸـﻴﺑ ﺮـﺑاﺮﺑ )

ﻮـﻳرآ نارﺎــﻜﻤﻫ و

8

، 2000 ؛

ﺖـــﻨﻴﺟ

،

9

ﻦـــﻟو رﻮـــﻨﻛا و

10

،

11

2003 ﺲﻧﺮﭙﺴـــﻟ ؛ ﺮـــﺷاﺮﻓ ،

12

-

ﺖﻴﻤﺳا ﻚﻴﺟﻼﺗ ،

13

ﺎﺳارﻮﺑ و

14

،

15

2002 ( . زا 30 لﺎﺳ رد ﺶﻴـﭘ

ﻪﻨﻴﻣز طﺎﺒﺗرا نﺎﻴﻣ و ﻰﮔدﺮﺴﻓا رﺎﻤﻴﺑ

ي ﺐﻠﻗ يﺮﻧوﺮﻛ )

16

(

CHD

ﻲﺳرﺮﺑ ﺖـﺳا هﺪـﺷ مﺎـﺠﻧا ﻲﻳﺎـﻫ )

ﺮـﺷاﺮﻓ - ﺖﻴﻤـﺳا ﺲﻧﺮﭙﺴـﻟ و ،

2006 .(

ﺖﺴﻳز يﺎﻫرﺎﻛوزﺎﺳ

ﻦﻴـﻴﺒﺗ ياﺮـﺑ يﺪﻨﭼ يرﺎﺘﻓر و ﻲﺘﺧﺎﻨﺷ

نﺎﻴﻣ طﺎﺒﺗرا هﺪﺷدﺎﻬﻨﺸﻴﭘ ﻰﮔدﺮﺴﻓا و

CHD

ﻧا ﺪ ) ﺖﻨﻳﻮﺟ

، و ﻦﻟو

رﻮــﻨﻛا

، 2003 .(

ﺎــﻬﻨﻳا ﻪــﻠﻤﺟ زا ﻲــﻣ

ﻪــﺑ ناﻮــﺗ ﻪــﻨﻴﻣز

ﻲــﻜﻴﺘﻧژ

) ﻚـﻣ يﺮﻓﺎـﻛ و

17

،نارﺎـﻜﻤﻫ 2006

(،

رﻮـﺤﻣ ﺖـﻴﻟﺎﻌﻓ ﺶﻳاﺰـﻓا

سﻮﻣﻻﺎــﺗﻮﭙﻴﻫ -

ﺰﻴﻓﻮــﭙﻴﻫ )

ُا

18

ت و نارﺎــﻜﻤﻫ

، 2004 (،

ﺶﻳاﺰــﻓا

ﺖﻴﻟﺎﻌﻓ ﺖﻛﻼﭘ ﺎـﻫ ) ﻲﻧاوﺮﺑﺮـﺳ و

19

(،

ﺶﻳاﺰـﻓا

ناﺰﻴﻣ ﻦﻴﻣﻻﻮﻜﺗﺎﻛ ﺎﻫ

)

ُا ت نﻼﻴﻧ ، ﻦﻴﻜﭙﻴﭘ ،

20

ﺮﻧوﺮﺑ ،

21

و

22

و ﻲﻟو

،

2005 (،

ﺶﻳاﺰــﻓا نﻮــﺧ ﻦﻴﻧﻮﺗوﺮــﺳ )

ﺰﻨﻴﭽــﺳا و

23

،نارﺎــﻜﻤﻫ

2004 ( ، يﺎﻫﺪــﻨﻳآﺮﻓ ﻲﺑﺎــﻬﺘﻟا

) ﺎــﻧﺎﭙﻣا و

24

نارﺎــﻜﻤﻫ ،

2005 ( ،

ﺶﻫﺎــﻛ ناﺰــﻴﻣ ﺎــﮕﻣا بﺮــﭼ يﺎﻫﺪﻴــﺳا 3

) ﺮــﺷاﺮﻓ - ،ﺖﻴﻤــﺳا

ﺲﻧﺮﭙﺴـــﻟ و

ﻦﻴﻟﻮـــﺟ

،

25

2004 (،

ﺖﻴﻣﻮﻤﺴـــﻣ ﺎـــﺑ

يﺎـــﻫوراد

ﻰﮔدﺮﺴــﻓاﺪﺿ يﻮــﻘﻠﺣ

) ﻦﻫﻮــﻛ

،

26

نﻮﺴــﺒﻴﮔ و

27

ﻦﻣرﺪــﻟآ

،

28

2000 ( ﻢــﻛ ، ﻲــﻛﺮﺤﺗ )

29

وور

، ﺪﻠﻔﺴــﻣار

،

30

ﻦﻴــﻜﭙﻴﭘ و ،ﻲــﻟوو

2004 (،

ﻊﻄﻗ نﺎﻣرد )

31

ﻲﻬﺟ

،

32

سﺎﻫ ، ﻲـﻟوو و ﻦﻴﻜﭙﻴﭘ

، 2005 ( ،

ﻒﻴﻌــﺿ ﻰﻋﺎــﻤﺘﺟا ﺖــﻳﺎﻤﺣ )

تﻮﻓرﺎــﺑ و

33

،نارﺎــﻜﻤﻫ 2003

( و

ﻢﻟﺎــﺳﺎﻧ ﻲﮔﺪــﻧز ﻚﺒــﺳ )

ﺖــﻧﻮﺑ و

34

( هرﺎــﺷا

دﺮﻛ . ﻦﻴﺌﺗوﺮﭘﻮــﭙﻴﻟ ﺖﺧﺎﻨــﺷ نﺎــﻣز زا

35(a)

نﺎﺴــﻧا ىﺎﻤــﺳﻼﭘ رد

)

36

گﺮﺑ

، 1963 ( ﻲﺳرﺮﺑ ﺮـﺑ ىور ﻲﮕﻧﻮـﮕﭼ

، ﺖﺧﻮـﺳ زﺎـﺳو و

نآ ﻲﻧژوﺮﺗآ ﺶﻘﻧ ـﺳا ﻪـﺘﻓﺎﻳ ﻪـﻣادا نﻮﻨﻛ ﺎﺗ

ﺖ . ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ

(a)

ﻚﻳ نژوﺮﺘﻫ لﻮﻜﻠﻣ و ﺖﺳا

ﺶﺨﺑ ﻪـﺑ نآ ﻲﺑﺮﭼ

37LDL

ﻪﻴﺒـﺷ

ﺖﺳا و لوﺮﺘﺴﻠﻛﺮﺘﺳا زا ﻲﻨﻏ ﺰﻛﺮﻣ ﻞﻣﺎﺷ ﻲﻣ

ﺪﺷﺎﺑ ) ﺎﻨﻳﻮﻛرﺎﻣ

،

38

ﻲﻜﺴﻨﻴﺷﻮﻛ

،

39

سﺮﺒﻟآ و

40

سﻮﺗﻻرﺎﻜﺳا ،

41

2003 .(

يرﺎﻴﺴﺑ رد

ﻲﺳرﺮﺑ زا ﺎﻫ ﺶﻳاﺰﻓا ناﺰﻴﻣ ﺮﺳ ﻲﻣ ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ يرﺎﻤﻴﺑ ﺎﺑ

(a)

ﺎﻫ ي

ﻲــﺒﻠﻗ - د طﺎــﺒﺗرا ﻲــﻗوﺮﻋ ﺖــﺳا ﻪﺘــﺷا

) ﮓــﻳاﺮﻛ ،

42

وﻮــﻧ ،

43

ﻲﻛﺎــﻣﻮﻟﺎﭘ ﺪــﻨﻟﻮﻠﻛ ،

44

ودﺎــﻫ و

45

،

46

1998 ﺶــﻧاد ؛ ﺰــﻨﻴﻠﻛ،

47

و

48

ﻮـــﺘﭘ

،

49

2000 سﺎـــﻧا ؛ و

50

رﻮﻣﺎﻜﻠﻴﺘﻨـــﺳ

،

51

2002 ﺮﻴﻬﺒﻣﺎـــﮔ ؛

،

52

رﺎــﻛ و ﺮﻴﻬﺒﻣﺎــﮔ ،

53

ﻮــﻬﺑاﺮﭘ

،

54

2000

؛ ﻲﻟﺎــﺠﻧﺎﺘﻴﮔ ،

55

هزﻮــﺟ و

56

ﺳﺎﮔﺎﻧﺎﻛ ﺎ ﻲﺗﺎﭘﺎﺑ ،

57

2002 ﺮـﻠﻛ ؛ ،

58

2007

؛ سﻮـﻟ و

59

،نارﺎـﻜﻤﻫ

2002

؛ نﺎـــﻫﻮﻣ و

60

،نارﺎـــﻜﻤﻫ 1998

.(

ندﻮﺑﻻﺎـــﺑ ناﺰـــﻴﻣ

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ﺎﺗ ﻪﺳ

(a)

10 ﺮـﻄﺧ لﺎـﻤﺘﺣا ﺮـﺑاﺮﺑ دﻮـﺟو

ار

CHD

ﻪﺑ ﻪﺘﺴﺑ دﻮـﺑ ن دﻮـﺒﻧ ﺎـﻳ ن ﻲـﻣ ﺶﻳاﺰـﻓا ﺮـﻄﺧ ﻞـﻣاﻮﻋ ﺮﻳﺎـﺳ ﺪـﻫد

) ﺰﻨﻴﻜﭘﺎــﻫ و

61

(.

ﻢــﻫ ﻦﻴــﻨﭼ ناﺰــﻴﻣ ﺮــﺳ ﻲﻣ

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ زا ﺮﺗﻻﺎﺑ

(a)

mg/dl

25 ، ﻚـﻳ ﻞﻘﺘﺴـﻣ ﻞـﻣﺎﻋ ياﺮـﺑ

زوﺮﺑ وﺮﻠﻜﺳاوﺮﺗآ ز

هدﻮﺑ ﺖﺳا ) ﻞﺋﻮﻧﺎﻣا و

62

.(

يرﺎﻤﻴﺑ يﺎﻫ ﻪـﺑ ﻼﺘـﺒﻣ نارﺎـﻤﻴﺑ نﺎـﻴﻣ رد ﺐـﻠﻗ يﺮﻧوﺮﻛ لﻼﺘـﺧا

ﻲــﺳﺎﺳا ﻲﮔدﺮﺴــﻓا ﺞــﻳار

ﺖــﺳا ) و ﺖــﻧﻮﺑ نارﺎــﻜﻤﻫ

، 2005 ؛

ﺖﺴﻳرﻮﻣ

،

63

2000 ﺰﻨﻴﭽﺳا ؛ و

،نارﺎﻜﻤﻫ 2004

(،

ﻲﻠﺻا ﻞﻴﻟد ﺎﻣا

نآ ﺖﺳا هﺪﺸﻧ ﻦﺷور نﻮﻨﻛ ﺎﺗ .

ﺮﺳ حﻮﻄﺳ ﻲﻣ

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ﺎﺗ

(a)

ﻪﺑ ﺮﻣا ﺖﺸـﮕﻧا ﻲـﺳرﺮﺑ ﺪـﻨﭼ رد زو

رﺎﻤـﺷ ﻪـﺑ ﻼﺘـﺒﻣ نارﺎـﻤﻴﺑ رد

ﺖﺳا هﺪﺷ شراﺰﮔ

MDD

) و ﻞﺋﻮﻧﺎﻣا

(.

ﻦﻳا زا

ور ﻦــﺷور ياﺮــﺑ نﺪــﺷ

حﻮﻄــﺳ ﺎــﻳآ ﻪــﻛ عﻮــﺿﻮﻣ ﻦــﻳا ﺮــﺘﻬﺑ

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﻴﺑ رد

(a)

توﺎﻔﺗ ﻢﻟﺎﺳ داﺮﻓا ﺎﺑ

MDD

ﺮﻴﺧ ﺎﻳ دراد

، ﺪﺷ مﺎﺠﻧا ﻲﺳرﺮﺑ ﻦﻳا

1

.

_______________________________________

1- major depressive disorder 2- Murray

3- Lopez 4- Sherbourne

5- Wells 6- Sturm

7- Whooley 8- Ariyo

9- Joynt 10- Whellan

11- O’Connor 12- Lesperance

13- Frasure-Smith 14- Talajic

15- Bourassa 16- coronary heart disease

17- McCaffery 18- Otte

19- Serebruany 20- Neylan

21- Pipkin 22- Browner

23- Schins 24- Empana

25- Julien 26- Cohen

27- Gibson 28- Alderman

29- Ruo 30- Rumsfeld

31- Gehi 32- Haas

33- Barefoot 34- Bonnet

35- lipoprotein (a) 36- Berg 37- low-density lipoprotein 38- Marcovina

39- Koschinsky 40- Albers

41- Skarlatos 42- Craig

43- Neveux 44- Palomaki

45- Cleveland 46- Haddow

47- Danesh 48- Collins

49- Peto 50- Enas

51- Senthilkumar 52- Gambhir

53- Kaur 54- Prabhu

55- Geethanjali 56- Jose 57- Kanagasabapathy 58- Keller

59- Luc 60- Mohan

61- Hopkins 62- Emanuele

63- Morrisett

(3)

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ﻲﻳﺎﻤﺳﻼﭘ ﺢﻄﺳ ﻲﺳﺎﺳا ﻲﮔدﺮﺴﻓا لﻼﺘﺧا ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﻴﺑ رد (a)

12

لﺎﺳﻢﻫدﺰﻧﺎﭘ /رﺎﻤﺷ ه 1 / رﺎــﻬﺑ 1388

Vol. 15 / No. 1/ Spring 2009

شور زا ﻲﺳرﺮﺑ ﻦﻳا عﻮﻧ

درﻮـﻣ - يﺪﻫﺎـﺷ و ﻲـﻌﻄﻘﻣ دﻮـﺑ . ﻦـﻳا رد

ﺶﻫوﮋﭘ 70 هوﺮﮔ ود رد ﺮﻔﻧ )

35 ﻪﺑ ﻼﺘﺒﻣ رﺎﻤﻴﺑ لﻼﺘﺧا

ﻲﮔدﺮﺴﻓا

و ﻲــﺳﺎﺳا 35

دﺮــﻓ ﻢﻟﺎــﺳ ( ﺪﻧﺪــﺷ ﻲــﺳرﺮﺑ .

ار هدﺮﺴــﻓا نارﺎــﻤﻴﺑ

ﻚـﺷﺰﭙﻧاور ﻪـﻳﺎﭘ ﺮـﺑ

رﺎــﻴﻌﻣ ﺎـﻫ ي ﻲﺼـﻴﺨﺸﺗ

DSM-IV

)

1

ﻦــﻤﺠﻧا

،ﺎـﻜﻳﺮﻣآ ﻲﻜﺷﺰﭙﻧاور 1994

( نارﺎـﻤﻴﺑ نﺎـﻴﻣ زا ﻪـﻌﺟاﺮﻣ

ﻪـﺑ هﺪـﻨﻨﻛ

رﺎﻤﻴﺑ ﺰــﻳﺮﺒﺗ يدﺎﺑآﺪــﺳا نﺎﺘــﺳ بﺎــﺨﺘﻧا

دﻮــﻤﻧ . ﻪــﻤﻫ ﺎــﺑ نارﺎــﻤﻴﺑ

ﺶﺳﺮﭘ ﻪـﻣﺎﻧ ﻲﮔدﺮﺴـﻓا

2

ﻚـﺑ

(BDI)

) دراو ،ﻚـﺑ نﻮﺴـﻟﺪﻨﻣ ،

3

،

4

5

كﻮﻣ گﺎﺑرا و ،

6

1961 ( ﺮـﺑ ﻲﻜـﺷﺰﭙﻧاور يرﺎﺘﺧﺎـﺳ ﻪﺒﺣﺎﺼﻣ و

ﻪﻳﺎﭘ

7SADS

) تﺎﻜﻳﺪـﻧا رﺰﺘﻴﭙـﺳا و

8

،

9

1978 ( ﺺﺼـﺨﺘﻣ ﻂـﺳﻮﺗ

ﻲﻜﺷﺰﭙﻧاور ﺪﻧﺪﺷ ﻲﺑﺎﻳزرا

. ﻪﻌﺟاﺮﻣ داﺮﻓا ﻦﺳ ﻦﻴﺑ هﺪﻨﻨﻛ

18 ﺎـﺗ 65

دﻮﺑ لﺎﺳ . زا جوﺮﺧ يﺎﻫرﺎﻴﻌﻣ ﺶﻫوﮋﭘ

ﻞﻣﺎﺷ ﻦﺘﺷاد زا ﺮـﺘﻤﻛ ﻦﺳ

18 زا ﺮﺗﻻﺎﺑ و 65

لﺎﺳ

، ﻲﺒﻠﻗ يرﺎﻤﻴﺑ ﻪﭽﺨﻳرﺎﺗ

، نﺎـﻣرد ﻪـﭽﺨﻳرﺎﺗ

ﻢﻛ يﺎﻫوراد ﺎﺑ نﻮﺧ لوﺮﺘﺴﻠﻛ هﺪﻨﻨﻛ

، دﻮﺟو لﻼﺘﺧا طﻮـﺑﺮﻣ يﺎﻫ

دﺪﻏ ﻪﺑ نورد ﺰﻳر

، يرﺎﻤﻴﺑ ﻲﻧﺪﺑ ﻲـﻌﻴﺒﻃﺮﻴﻏ ،ﺖﺨـﺳ

ندﻮـﺑ نﻮـﺧ

،

دﺮـــﻜﻠﻤﻋ ﻲـــﻌﻴﺒﻃﺮﻴﻏ

ﺪـــﺒﻛ و ﻪـــﻴﻠﻛ ،

ﻼﺘـــﺧا ل يﺎـــﻫ ندرﻮـــﺧ

،

لﻼﺘــﺧا يﺎــﻫ ﺑاﺮﻄــﺿا ﻲ

، ﻲــﻨﻫذ ﻲﮔﺪــﻧﺎﻣ ﺐــﻘﻋ

، ﻪــﭽﺨﻳرﺎﺗ

فﺮﺼﻣءﻮﺳ ﻧآ ﻪـﺑ ﻲﮕﺘﺴـﺑاو ﺎﻳ رﺪﺨﻣ داﻮﻣ و ﻞﻜﻟا

ﺎـﻬ

، ﺎـﺑ نﺎـﻣرد

يﺎﻫوراد ﻲﻜﺷﺰﭙﻧاور رد

ﺶﺷ ﻪﺘﺷﺬﮔ هﺎﻣ ﻢﻫ دﻮﺟو و

ﺪـﻨﭼ نﺎﻣز

ﻲﻧاور لﻼﺘﺧا

، دﻮﺑ . رد هوﺮﮔ هاﻮـﮔ 35 ،ناﺪـﻨﻣرﺎﻛ زا ﻢﻟﺎـﺳ دﺮـﻓ

و نﺎﺘﺳرﺎﻤﻴﺑ رد نﺎﺒﻠﻃواد و نﺎﻳﻮﺠﺸﻧاد هﺎﮕﺸﻧاد

ﺪﻧﺪﺷ هداد يﺎﺟ .

ﻪﻧﻮﻤﻧ شور ﻪﺑ يﺮﻴﮔ

دﻮـﺑ ﻲﻓدﺎﺼﺗ ترﻮﺻ .

زا جوﺮـﺧ يﺎـﻫرﺎﻴﻌﻣ

هوﺮﮔ داﺮﻓا ياﺮﺑ ﻲﺳرﺮﺑ هاﻮﮔ

، دﻮـﺑ رﺎـﻤﻴﺑ هوﺮﮔ ﺪﻨﻧﺎﻣ .

ﺮـﺑ نوﺰـﻓا

نآ

، ياراد هوﺮﮔ ﻦﻳا ﻲـﻧاور يرﺎـﻤﻴﺑ ﻪﭽﺨﻳرﺎﺗ

ﺮـﻈﻧ زا و ﺪـﻧدﻮﺒﻧ

و ﻦﺳ ﺪﻧﺪـﺷ يزﺎـﺳﺎﺘﻤﻫ رﺎـﻤﻴﺑ هوﺮـﮔ ﺎـﺑ ﺲﻨﺟ .

ﻲـﺳرﺮﺑ فﺪـﻫ

ﻪﺑ ياﺮﺑ ﻞﻣﺎﻛ رﻮﻃ ﺪـﺷ هداد ﺢﻴـﺿﻮﺗ داﺮـﻓا ﻪـﻤﻫ

و ﺖﻳﺎـﺿر ﻪـﻣﺎﻧ

ﺪﺷ ﻪﺘﻓﺮﮔ ﺎﻬﻧآ زا ﻲﺒﺘﻛ .

ياﺮﺑ ﺺﺧﺎﺷ ﺖﻴﻌﺿو ﻦﻴﻴﻌﺗ

ﺎﻫ رﺎـﻤﻴﺑ ﺮـﻫ زا ﻲﻳﺎﻴﻤﻴـﺷﻮﻴﺑ ي

10

cc

ﺖﻋﺎﺳ رد ﺎﺘﺷﺎﻧ ﺖﻟﺎﺣ رد نﻮﺧ ﺖﺸﻫ

و ﺪـﺷ ﻪﺘﻓﺮﮔ ﺢﺒﺻ

ﺲــﭘ ژﻮﻴﻔﻳﺮﺘﻧﺎــﺳ زا

، يﺎﻤــﺳﻼﭘ آ

يﺎــﻣد رد و يزﺎــﺳاﺪﺟ ﺎــﻬﻧ

70 - ﺶﻳﺎﻣزآ مﺎﺠﻧا نﺎﻣز ﺎﺗ داﺮﮕﻴﺘﻧﺎﺳ ﻪﺟرد ﺎﻫ

ﺪﻬﮕﻧ ﺪﺷ يرا .

لﻮﺒﻠﮔ ﺎﻫ ي ﺪﻴﻔﺳ ﺰﻣﺮﻗ و نﻮﺧ

، ﻦﻴﺑﻮﻠﮔﻮﻤﻫ

، ﺗﺎﻤﻫ ﻮ ﺖـﻳﺮﻛ

،

ﺰـــﻣﺮﻗ لﻮـــﺒﻠﮔ ﻂـــﺳﻮﺘﻣ ﻢـــﺠﺣ )

10

،

(MCV

ناﺰـــﻴﻣ ﻂـــﺳﻮﺘﻣ

ﺰـــﻣﺮﻗ لﻮـــﺒﻠﮔ ﻦﻴﺑﻮـــﻠﮔﻮﻤﻫ )

11

(

MCH

و ﺖـــﻈﻠﻏ ﻦﻴﮕﻧﺎـــﻴﻣ

ﺰــﻣﺮﻗ لﻮــﺒﻠﮔ ﻦﻴﺑﻮــﻠﮔﻮﻤﻫ )

12

(

MCHC

ﻪــﺑ ﻚــﻤﻛ هﺎﮕﺘــﺳد

شرﺎﻤﺷ ﺮﮔ لﺪﻣ

Cell Tacа

ﻦﭘاژ ﺖﺧﺎﺳ هزاﺪﻧا

ﺪﻧﺪـﺷ يﺮـﻴﮔ .

ﻪﺑ مﺮﺳ ﻦﻴﻨﻴﺗاﺮﻛ ﻨﻋ

ﻂﺳﻮﺗ ﻪﻴﻠﻛ دﺮﻜﻠﻤﻋ ﻲﺑﺎﻳزرا زا ﻲﺼﺧﺎﺷ ناﻮ

هزاﺪﻧا نﻮﻣزآ سرﺎﭘ ﺖﻛﺮﺷ ﺖﻴﻛ ﺪﺷ يﺮﻴﮔ

. ﺎﻤـﺳﻼﭘ ﺰﻛﻮـﻠﮔ

،

مﺎــﺗ لوﺮﺘﺴــﻠﻛ

، ﺪﻳﺮﻴﺴــﻴﻠﮔ يﺮــﺗ و

HDL-c

شور ﻪــﻳﺎﭘ ﺮــﺑ

13

ﮓﻧر و ﻚﻴﺗﺎﻤﻳﺰﻧآ و ﻲﺠﻨـﺳ

ﻪـﺑ ﻚـﻤﻛ سرﺎـﭘ ﺖﻛﺮـﺷ ﺖـﻴﻛ

روﺰﻴﻟﺎـﻧآ ﻮـﺗا هﺎﮕﺘـﺳد ﺎﺑ و نﻮﻣزآ

Alcyon 300

هزاﺪـﻧا يﺮـﻴﮔ

ﺪﻧﺪﺷ و

LDL-c

هﺮـﻬﺑ ﺎـﺑ

14

ﻪﺒـﺳﺎﺤﻣ ﺪـﻟاوﺮﻳﺎﻓ لﻮـﻣﺮﻓ زا يﺮـﻴﮔ

ﺪــﻳدﺮﮔ ) ﺪــﻟاوﺮﻳﺎﻓ يﻮــﻟ ،

15

نﻮﺴــﻜﻳردﺮﻓ ،

16

،

17

1972 .(

ياﺮــﺑ

نﺪﺑ هدﻮﺗ ﻪﻳﺎﻤﻧ ﻲﺑﺎﻳزرا )

18

(،

BMI

داﺮـﻓا ﺪـﻗ و نزو ﻪـﺑ

ﻚـﻤﻛ

ﺖــﻗد ﺎـﺑ ﻲﻟﻮﻜــﺳﺎﺑ يوزاﺮـﺗ 5

/ 0 ﺞﻨــﺳﺪﻗ ﻪـﺑ ﻞﺼــﺘﻣ مﺮﮔﻮـﻠﻴﻛ

ﺖــﻗد ﺎــﺑ جرﺪــﻣ 1

/ 0 ﻲﺘﻧﺎــﺳ هزاﺪــﻧا ﺮــﺘﻣ يﺮــﻴﮔ

ﺪــﺷ . ﻦــﻳا

هزاﺪﻧا يﺮﻴﮔ ﺎﻫ ﺎﺑ ﻦﻳﺮﺘﻤﻛ ﻟ ﺶـﻔﻛ نوﺪﺑ و سﺎﺒ و ﺪـﺷ مﺎـﺠﻧا

BMI

ﻪﺑ ﻚﻤﻛ ﻪﺒﺳﺎﺤﻣﺮﻳز ﻪﻄﺑار ﺪﻳدﺮﮔ

: ﺪﻗ

2

) /(

m

نزو )

=(

kg

.

BMI

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ )

(

a

شور ﺎﺑ ﻚﻳﺮﺘﻤﻳﺪﻴﺑرﻮﺗﻮﻧﻮﻤﻳا ﻪﺑ

19

ﺖـﻴﻛ ﻪﻠﻴﺳو

ﺲﻛوﺪﻧار روﺰﻴﻟﺎـﻧآﻮﺗا هﺎﮕﺘـﺳدﺎﺑ نﺎﺘﺴﻠﮕﻧا ﺖﺧﺎﺳ

20

Alcyon 300

هزاﺪﻧا ﺪﻳدﺮﮔ يﺮﻴﮔ .

ﻦـﻳا شور هزاﺪـﻧا ﻚـﻳﺮﺘﻣﻮﺘﻓ شور زا يﺮـﻴﮔ

ﻧآ ﺶﻨﻛاو ﻲـﺘ نژ - ﻲـﺘﻧآ ﻲـﺘﻧآ ﻦﻴـﺑ يدﺎـﺑ ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ يدﺎـﺑ

) (

a

و

ﻦﻴﺌﺗوﺮﭘﻮــﭙﻴﻟ )

(

a

ﻪــﻧﻮﻤﻧ رد دﻮــﺟﻮﻣ ﻲــﻣ هﺮــﻬﺑ

دﺮــﻴﮔ ) يرﺎــﻨﻴﻟﻮﻣ ،

21

ﺮﻠﭽﻴﭘآ ﺮﻓﻮﻬﻠﻳﺮﮔ ،

22

ﺮﻨﺘﺳﺎﻛ و

23

،

24

1995 (.

هداد ﻪﺑ ﺎﻫ نﻮﻣزآ ﻚﻤﻛ ﻲﺧ

ود نﻮﺳﺮﻴﭘ ﻲﮕﺘﺴﺒﻤﻫ ﺐﻳﺮﺿ ،

نﻮﻣزآ و ﻞﻴﻠﺤﺗ

t

ﺪﻧﺪﺷ .

1

ﻪﺘﻓﺎﻳ ﺎﻫ ﻲﻧدﻮﻣزآ ﻲﻨﺳ ﻦﻴﮕﻧﺎﻴﻣ

يﺎـﻫ ﻢﻟﺎـﺳ هوﺮـﮔ و هدﺮﺴـﻓا هوﺮـﮔ

ﻪﺑ ﺐﻴﺗﺮﺗ 2 / 35 و 7 / 33 دﻮﺑ . ﻲـﺳﺎﺳا هدﺮﺴـﻓا هوﺮﮔ رد 1

/ 17 % و

ﻢﻟﺎﺳ هاﻮﮔ هوﺮﮔ رد 1

/ 17 % ﺪﻧدﻮﺑ دﺮﻣ .

توﺎﻔﺗ رد ﺺﺧﺎﺷ ﺎﻫ لﻮﺒﻠﮔ ﻪﺑ طﻮﺑﺮﻣ ﻲﻧﻮﺧ ي و ﺰﻣﺮﻗ يﺎﻫ

ﺪﻴﻔﺳ رد هوﺮـﮔ ود توﺎﻔﺗ و ،ﺎﻤـﺳﻼﭘ ﺰﻛﻮـﻠﮔ ،مﺮـﺳ ﻦﻴﻨﻴﺗاﺮـﻛ

ﺢﻄﺳ ىﺮﺗ و

HDL

ﺎﻫﺪﻳﺮﺴﻴﻠﮔ ﻲﻨﻌﻣ

دﻮﺒﻧ راد . ﻣا ﺎ مﺎـﺗ لوﺮﺘﺴـﻠﻛ

و ﺑ نارﺎﻤﻴﺑ رد

LDL

ﻪ ترﻮﺻ ﻲﻨﻌﻣ راد ي هوﺮـﮔ زا ﺮـﺘﻤﻛ هاﻮـﮔ

دﻮﺑ ) 001 / 0

p<

( )

ﻞﻜﺷ

(

1

. ﻢﻫ ﻦﻴﻨﭼ ﺢﻄـﺳ ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ )

(

a

رد

ـﺑ هدﺮﺴﻓا نارﺎﻤﻴﺑ ﻪ

رﻮـﻃ ﻲـﻨﻌﻣ راد ي هوﺮـﮔ زا ﺮﺘﺸـﻴﺑ هاﻮـﮔ

دﻮـﺑ

)

لوﺪﺟ

(.

1

_______________________________________

1- Diagnostic and Statistical Manual of Mental Disorders (4th. ed.) 2- Beck Depression Inventory

3- Ward 4- Mendolson

5- Mock 6- Erbaugh

7- Schedule for Affective Disorders and Schizophrenia

8- Endicott 9- Spitzer

10- mean cell volume 11- mean cell hemoglobin 12- mean cell hemoglobin concentration

13- high-density lipoprotein-cholesterol 14- low-density lipoprotein

15- Friedewald 16- Levy

17- Fredrickson 18- body mass index 19- Immunoturbidimetric 20- Randox

21- Molinari 22- Apichler

23- Grillhofer 24- Kostner

(4)

13

رد

ﻞﻜﺷ

ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ عﻮﻴـﺷ ،

2

) (

a

يﻻﺎـﺑ 25 ﻲـﻠﻴﻣ رد مﺮـﮔ

ﻲﺳد وﺮﮔ ود رد ﺮﺘﻴﻟ ﺖـﺳا هﺪﺷ هداد نﺎﺸﻧ رﺎﻤﻴﺑ و ﻢﻟﺎﺳ ه

. 4 / 31

%

) 11 ﺮﻔﻧ ( رﺎﻤﻴﺑ و نا 4 / 71

% ) 25 ﺮﻔﻧ ( هوﺮﮔ

،هاﻮﮔ ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ )

(

a

زا ﺮﺘﻤﻛ 25 ﻲﻠﻴﻣ ﻲﺳد رد مﺮﮔ ﺪﻨﺘﺷاد ﺮﺘﻴﻟ

ﺮﻈﻧ ﻦﻳا زا و ود توﺎﻔﺗ

ﻲﻨﻌﻣ هوﺮﮔ

دﻮﺑ راد ) 21 / 11

= 2

،

χ

1 = ،

df

01 / 0

p<

.(

ﻲﺳرﺮﺑ ﻦﻳا ﻲﻨﻌﻣ طﺎﺒﺗرا

ﻦﺳ ﻦﻴﺑ يراد و

ﺲﻨﺟ ﺎﺑ ﺘﻓﺎﻳ ﻪ يﺎـﻫ

ﻲﻫﺎﮕﺸﻳﺎﻣزآ داﺪﻧ نﺎﺸﻧ

، نﺎـﻴﻣ ﻪـﻄﺑار ﻲﻟو ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟو

BMI

) (

a

ﻲﻨﻌﻣ يرﺎﻣآ ﺮﻈﻧ زا ﻢﻟﺎﺳ داﺮﻓا رد دﻮﺑ راد

) 54 / 0

= .(

r

لوﺪــﺟ 1 - ﻲــﮔﮋﻳو ﻦﻴﺌﺗوﺮﭘﻮــﭙﻴﻟ ﻲﻳﺎﻤــﺳﻼﭘ ﺢﻄــﺳ و ﻲﻳﺎﻴﻤﻴــﺷﻮﻴﺑ و ﻲﻧﻮــﺧ يﺎــﻫ هوﺮــﮔ رد(a)

ﻲــﺳرﺮﺑ درﻮــﻣ يﺎــﻫ

) ﻦﻴﮕﻧﺎﻴﻣ رﺎﻴﻌﻣ يﺎﻄﺧ ± (

ﻲﺳﺎﺳا ﻲﮔدﺮﺴﻓا

35) (n=

ﻨﻛ ﻢﻟﺎﺳ لﺮﺘ

) 35 (n=

ﺢﻄﺳ

ﻲﻨﻌﻣ يراد

نﺪﺑ هدﻮﺗ ﻪﻳﺎﻤﻧ (kg/m²)

74 / 0 82± / 25 22 / 1 77± / 24

*N.S.

نﻮﺧ ﺪﻴﻔﺳ لﻮﺒﻠﮔ )

10³/ul ( 27

/ 0 05± / 6 20 / 0 72± / 5 N.S.

نﻮﺧ ﺰﻣﺮﻗ لﻮﺒﻠﮔ )

10⁶/ul ( 08

/ 0 01± / 5 06 / 0 82± / 4 08 / 0

ﻦﻴﺑﻮﻠﮔﻮﻤﻫ (g/dl)

21 / 0 81± / 13 18 / 0 05± / 14 N.S.

ﺖﻳﺮﻛﻮﺗﺎﻤﻫ (%)

65 / 0 38± / 40 44 / 0 72± / 41 N.S.

ﺰﻣﺮﻗ لﻮﺒﻠﮔ ﻂﺳﻮﺘﻣ ﻢﺠﺣ )]

(FL MCV [ 04

/ 1 54± / 82 02 / 1 9± / 84 N.S.

ﺰﻣﺮﻗ لﻮﺒﻠﮔ ﻦﻴﺑﻮﻠﮔﻮﻤﻫ ﻂﺳﻮﺘﻣ راﺪﻘﻣ )

( MCH 53 (pg)

/ 0 34± / 28 47 / 0 69± / 29 N.S.

ﺰﻣﺮﻗ لﻮﺒﻠﮔ ﻦﻴﺑﻮﻠﮔﻮﻤﻫ ﺖﻈﻠﻏ ﻦﻴﮕﻧﺎﻴﻣ (MCHC) (g/dl)

21 / 0 99± / 32 33 / 0 20± / 33 N.S.

ﭘ ﺰﻛﻮﻠﮔ ﺎﻤﺳﻼ (mg/dl) 10

/ 1 34± / 92 48 / 2 91± / 88 N.S.

ﻦﻴﻨﻴﺗاﺮﻛ (mg/dl) 01

/ 0 80± / 0 01 / 0 85± / 0 N.S.

مﺎﺗ لوﺮﺘﺴﻠﻛ (mg/dl)

74 / 3 65± / 144 82 / 5 14± / 186 0001 / 0

يﺮﺗ ﺪﻳﺮﺴﻴﻠﮔ (mg/dl) 12

/ 16 8± / 120 72 / 12 08± / 120 N.S.

HDL (mg/dl) 59

/ 1 71± / 47 36 / 2 91± / 51 N.S.

LDL (mg/dl) 00

/ 3 78± / 72 27 / 5 21± / 110 0001 / 0

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ 04 (a)

/ 3 94± / 34 90 / 1 08± / 20 0001 / 0

* non-significant

ﻚﺷ

ﻜﺷ ﻞ 1 - ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ﺢﻄﺳ تﻼﭘ ﺲﻛﺎﺑ )

( a درﻮﻣ هوﺮﮔ ود رد ﻲﺳرﺮﺑ

) و ﻲﺳﺎﺳا هدﺮﺴﻓا هاﻮﮔ

(

ﻞﻜﺷ 2 - ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ياراد نارﺎﻤﻴﺑ ﺪﺻرد ﺘﺸﻴﺑ(a)

زا ﺮﺘﻤﻛ ﺎﻳ ﺮ 25

ﻲﻠﻴﻣ ﻲﺳد رد مﺮﮔ هوﺮﮔ ود رد ﺮﺘﻴﻟ

ﺪﺻرد ﻦﺌﻴﺗوﺮﭘﻮﭙﻴﻟ)a (ﻲﻠﻴﻣﻲﺳد رد مﺮﮔﺮﺘﻴﻟ

120

100

80

60

40

20

0

ﻢﻟﺎﺳ لﺮﺘﻨﻛ ﻲﺳﺎﺳا هدﺮﺴﻓا

) 35

= ) (n 35

= (n 0

10 20 30 40 50 60 70 80

درﻮﻣ هوﺮﮔ ﺪﻫﺎﺷ هوﺮﮔ

< 25 ﺮﺘﻴﻟ ﻲﺳد رد مﺮﮔ ﻲﻠﻴﻣ > 25 ﺮﺘﻴﻟ ﻲﺳد رد مﺮﮔ ﻲﻠﻴﻣ

(5)

14

Vol. 15 / No. 1/ Spring 2009

ﺚﺤﺑ ار ﻲﻧﻮـﺧ لوﺮﺘﺴﻠﻛ ﺢﻄﺳ ﻲﺳرﺮﺑ ﻦﻳا رد

نارﺎـﻤﻴﺑ ﻼﺘـﺒﻣ ﻪـﺑ

لﻼﺘﺧا ﻲﺳﺎﺳا ﻰﮔدﺮﺴﻓا ﻦﻴﻳﺎﭘ

زا ﺮﺗ هوﺮﮔ هاﻮﮔ ﻢﻟﺎﺳ داد نﺎﺸﻧ .

ﺎﺑ ﻪﺘﻓﺎﻳ ﻦﻳا ﻪﺘﻓﺎﻳ

ﻲـﺳرﺮﺑ يﺎﻫ

ﻲﻳﺎـﻫ ﻦﻴﻳﺎـﭘ لوﺮﺘﺴـﻠﻛ ﻪـﻛ ار

ﺮـﺑ

ﺶﻫﺎﻛ ﻰﻧورﻮﻧ ءﺎﺸﻏ ﺖﻴﻟﺎﻴﺳ ﺮﺛﺆﻣ

ـﻤﻧ شراﺰـﮔ هدﻮ

ﺪـﻧا )

1

ﻮـﺟ

،

ﮓــــﻧﺎﻳ و

2

ﻦــــﭼ ،

3

2006 ؛ سواﺮــــﻛ كﺎــــﻫ ،

4

ﺪﻟﻮــــﺷ ،

5

،

6

ﺰﻨﻴﻫ - ﭻﻠﻜـﺳ ﺮﭼﺎـﻤﻟﻮﭘ و

7

،

8

2001 ( ﻢـﻫ ﺖـﺳا ﻮـﺳ .

ﺎـﺑ ﺶﻫﺎـﻛ

ءﺎﺸــﻏ ﺖﻴﻟﺎﻴــﺳ ﻰﻧورﻮــﻧ

، ﻲﻧورﻮــﻧ ﺖــﻴﻟﺎﻌﻓ 5

- ﻲﺴــﻛورﺪﻴﻫ

هﺎــﮕﻳﺎﺟ يور ﺮــﺑ ﻦﻴﻣﺎــﺘﭙﻳﺮﺗ ﺎــﻫ

ي ﺶﻴــﭘ ﻲﺴــﭘﺎﻨﻴﺳ نآ زا ﺲــﭘ و

ﻲﻣ ﺶﻫﺎﻛ

ﺪﺑﺎﻳ . ﺶﻫﺎﻛ ﻦـﻜﻤﻣ ىﺰـﻛﺮﻣ ﻚﻳژﺮﻧﻮﺗوﺮﺳ ﺖﻴﻟﺎﻌﻓ

رد ﺖﺳا يﺎﻫرﺎﺘﻓر و ،ﻲﮔدﺮﺴﻓا ﺎﺑ طﺎﺒﺗرا ﻪﺑ طﻮﺑﺮﻣ

ﻲﺸـﻛدﻮﺧ

ﺪﺷﺎﺑ ) ﻮﺟ ،نارﺎﻜﻤﻫ و 2006

؛ و سواﺮﻛ

(.

ﻦﻳا ﺮﮕﻳد ﻪﺘﻓﺎﻳ ندﻮﺑﺮﺗﻻﺎﺑ ﻲﺳرﺮﺑ

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ﺢﻄﺳ )

(

a

رد

نارﺎﻤﻴﺑ ﺎﺑ ﻪﺴﻳﺎﻘﻣ رد

MDD

هوﺮﮔ دﻮـﺑ ﻢﻟﺎـﺳ .

ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ )

(

a

هﺪﻴﭽﻴﭘ ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ﻚﻳ ﺖﺳا

ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟﻮﭘآ زا ﻪﻛ 100

-

،

B

) ﻪﻴﺒﺷ ﻪﻛ و

LDL

ﺮﻄﺧ ﻞﻣﺎﻋ ﺖـﺳا ﺲﻳزوﺮﻠﻜﺳاوﺮﺗآ ياﺮﺑ

( و

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟﻮﭘآ ﺪﻨﻧﺎﻤﻫ يرﺎﺘﺧﺎﺳ ﺮﻈﻧ زا ﻪﻛ

a

نژﻮﻨﻴﻤﺳﻼﭘ هدﻮﺑ

و ﻪﻳﺰﺠﺗ ﻪﻧﺎﻣﺎﺳ زا ﻲﺸﺨﺑ هﺪﻨﻨﻛ

ﻦﻳﺮﺒﻴﻓ ﻲـﻣ ﺪـﺷﺎﺑ

، ﻞﻴﻜﺸـﺗ هﺪـﺷ

ﺖﺳا ) ﺎﺘﻳرﻮﻣ

،

9

ﻮﻨﻤﻴﻫ

،

10

اﻮﻛﺎﻳ و

11

يﻮﺳﻮﻳ ،

12

2006 ( . ﻰﺳرﺮﺑ ﺎﻫ

هداد نﺎﺸﻧ ﻴﻟ يﻻﺎﺑ ﺢﻄﺳ ﻪﻛﺪﻧا ﻦﻴﺌﺗوﺮﭘﻮـﭙ

) (

a

مﺮـﺳ ﻞـﻣﺎﻋ ﻚـﻳ

گر ىرﺎﻤﻴﺑ ىاﺮﺑ ﺮﻄﺧ يﺮـﻧوﺮﻛ يﺎـﻫ

ﺐـﻠﻗ ﻲـﻣ ﺪـﺷﺎﺑ ) ﻮـﺟ و

نارﺎﻜﻤﻫ

، 2006

؛ ﺮﻴﺘﻠﭘ و

13

( و نارﺎـﻤﻴﺑ ﻼﺘـﺒﻣ

ﻪﺑ دﺮﺴﻓا ﻲﮔ يرﺎـﻤﻴﺑ ياﺮـﺑ ﻻﺎﺑ ﺮﻄﺧ ﺎﺑ هوﺮﮔ ﻚﻳ ﻲﺳﺎﺳا

ﺎـﻫ ي

ﻲﺒﻠﻗ - ﻲﻗوﺮﻋ ﺪﻨﺘﺴﻫ .

و ﻞـﺋﻮﻧﺎﻣا نارﺎــﻜﻤﻫ

) 2006 ( ﻦﻴﺌﺗوﺮﭘﻮــﭙﻴﻟ ﺢﻄــﺳ )

(

a

رد ار

ﺎﻬﭼ ر ﻲـﻧاور نارﺎـﻤﻴﺑ هوﺮﮔ )

ﻴﻧﺮﻓوﺰﻴﻜـﺳا ﺎ،

لﻼﺘـﺧا دﺮﺴـﻓا ﻲﮔ

ﻲﺳﺎﺳا

، لﻼﺘﺧا يﺎﻫ لﻼﺘﺧا و ﻲﺒﻄﻗود ﺎﻫ

ي ﺖﻴﺼﺨﺷ (

هوﺮـﮔ ﺎﺑ

هاﻮﮔ ﻪﺴﻳﺎﻘﻣ ﻢﻟﺎﺳ و

ﻨﻌﻣ توﺎﻔﺗ ﻲ

راد ي ار ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ﺢﻄﺳ رد

) (

a

ﻪﺑ ﻼﺘﺒﻣ داﺮﻓارد ﺮﻓوﺰﻴﻜﺳا

ﺎﻴﻧ ، و

MDD

رد ﻰـﺒﻄﻗود لﻼﺘﺧا

هوﺮﮔ ﺎﺑ ﻪﺴﻳﺎﻘﻣ هاﻮﮔ

ﻢﻟﺎﺳ ﺪﻧدﻮﻤﻧ شراﺰﮔ .

ﻪﺘﻓﺎﻳ ﻢـﻫ ﺮـﺿﺎﺣ ﻲـﺳرﺮﺑ يﺎﻫ

ﻪـﺘﻓﺎﻳ ﺎـﺑ ﻮـﺳ

و ﻞـﺋﻮﻧﺎﻣا يﺎـﻫ

نارﺎﻜﻤﻫ ) 2006 ( ﺖﺳا . داد نﺎﺸـﻧ ﺮﺿﺎﺣ ﻲﺳرﺮﺑ ﻪـﻛ

تاﺮـﻴﻴﻐﺗ

حﻮﻄــﺳ ﻦﻴﺌﺗوﺮﭘﻮــﭙﻴﻟ زا ﻲــﻜﻳ ﺪــﻧاﻮﺗ ﻲــﻣ ﻲﻳﺎﻤــﺳﻼﭘ

ﻞــﻣاﻮﻋ

ﻦﻴـﻴﺒﺗ نﺎـﻴﻣ طﺎـﺒﺗرا هﺪـﻨﻨﻛ ﺶﻳاﺰـﻓا و ﻲـﺳﺎﺳا ﻲﮔدﺮﺴـﻓا

ﺮــﻄﺧ

يرﺎـﻤﻴﺑ ﻲــﺒﻠﻗ يﺎـﻫ -

ﻲـﻗوﺮﻋ ﺪـﺷﺎﺑ . ﻢــﻫ ﻦﻴـﻨﭼ نارﺎــﻤﻴﺑ

MDD

ﻏ ياراد ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ زا يﺮﺗﻻﺎﺑ ﺖﻈﻠ )

(

a

هوﺮـﮔ ﺎـﺑ ﻪﺴـﻳﺎﻘﻣ رد

هاﻮﮔ ﻢﻟﺎﺳ ﺪﻨﺘﺴﻫ . ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ يﻻﺎﺑ ﺖﻈﻠﻏ )

(

a

رد يرﺎﻤﻴﺑ يﺎﻫ

ﻲﺒﻠﻗ - ﻲﻗوﺮﻋ ﺖـﺳا هﺪـﺷ هﺪﻳد ﺰﻴﻧ )

ﮓـﻳاﺮﻛ

، 1998 ﺶـﻧاد ؛ و نارﺎـــﻜﻤﻫ

، 2000

؛ سﺎـــﻧا و رﻮﻣﺎﻜﻠﻴﺘﻨـــﺳ

، 2002 و ﺮﻴﻬﺒﻣﺎـــﮔ ؛

نارﺎــﻜﻤﻫ

، 2000

؛ ﻲﻟﺎــﺠﻧﺎﺘﻴﮔ نارﺎــﻜﻤﻫ و

، 2002 ــﻨﻳﻮﻛرﺎﻣ ؛ ﺎ

و

نارﺎﻜﻤﻫ

، 2003

؛ فﻮﻬﻤﻳا نارﺎﻜﻤﻫ و

14

، 2003

؛ ،ﺮﻠﻛ 2007 (.

ﻪــﺘﻓﺎﻳ ﻲــﻣ ﻲــﺳرﺮﺑ ﻦــﻳا يﺎــﻫ نﺎﺸــﻧ ﺪــﻨﻧاﻮﺗ

ﺶــﻘﻧ هﺪــﻨﻫد

ﻦﻴﺌﺗوﺮﭘﻮـــﭙﻴﻟ )

(

a

طﺎـــﺒﺗرا رد نﺎـــﻴﻣ

و

MDD

ﺮـــﻄﺧ ﺶﻳاﺰـــﻓا

يرﺎــﻤﻴﺑ ﺎــﻫ ي ﻰــﺒﻠﻗ - ﻰــﻗوﺮﻋ ﺪــﺷﺎﺑ . ﻦﻴﺌﺗوﺮﭘﻮــﭘآ ﺪــﻧﺎﺑ ﺎــﺑ

a

يد ﺪﻴﻔﻟﻮــﺳ ي

، ﻪــﺑ ﻦﻴﺌﺗوﺮﭘﻮــﭘآ ﻲــﻣ

B

ﺪﺒﺴــﭼ . 34 مﺮــﻓوﺰﻳا

نﻮﮔﺎﻧﻮﮔ ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ

) (

a

ﻪـﻳﺎﭘ ﺮـﺑ هزاﺪـﻧا ﻮـﭘآ دراد دﻮـﺟو

a

.

ناﺰﻴﻣ ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ )

(

a

ﺗ ﺖﺤﺗ ﺄ ﻲﻠﭘ ﺮﻴﺛ ﻮﭘآ ﻢﺴﻴﻓرﻮﻣ ﻲﻣ

a

ﺪـﺷﺎﺑ .

ﻞﻣاﻮﻋ ﻲﻧﻮﮔﺎـﻧﻮﮔ ﺮﺑ

ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ حﻮﻄـﺳ )

(

a

ﻞـﻣاﻮﻋ ﻪـﻠﻤﺟ زا

ﻲﺛرا ﺪﻨﺘﺴﻫ راﺬﮔﺮﺛا )

،نارﺎﻜﻤﻫ و سﺎﻧا 1996

( . يﺎﻫرﺎﻛوزﺎـﺳ

يﺪﻨﭼ يرﺎـﻤﻴﺑ ياﺮـﺑ ﻲـﻳاز

ﺶﻳاﺰـﻓا ﻦﻴﺌﺗوﺮﭘﻮـﭙﻴﻟ )

(

a

ﻪـﻠﻤﺟ زا :

ﻪــﺘﺨﻟ ﺶﻳاﺰــﻓا ﻰــﻳاز

رد لﻼﺘــﺧا و

15

ﻦﻳﺮــﺒﻴﻓ ﻪــﻳﺰﺠﺗ ﻪــﺑ

ﻪﻠﻴــﺳو

نژﻮﻨﻴﻤﺳﻼﭘ )

ﺮﮕﻨﻳﺮﮔ و

16

( ﻰﺑ ، ﻛﻼﭘ ﻰﺗﺎﺒﺛ

17

ﻲ

،

ﻰﻟﻮﻠـﺳ ﺮﻴﺜﻜﺗ ﺶﻳاﺰﻓا رد

ﻪـﭽﻴﻫﺎﻣ يﺎـﻫ و فﺎـﺻ ﻲﻳﺎـﺠﺑﺎﺟ

نآ

) ﺖﺴﻳرﻮﻣ

، 2000 (،

گر ﻞﻴﻜﺸﺗرد لﻼﺘﺧا ﺶﻳاﺰﻓا ،ﻰﺒﻧﺎﺟ ىﺎﻫ

اﺪﻴﺴـــﻛا نﻮﻴﺳ و ﺖـــﺷادﺮﺑ و

سﺎـــﺒﺘﺣا

LDL-c

) ﺰﻨﮔﻮـــﻟ و

18

( ﻪﺘﺷاد ﺖﻟﺎﺧد ﺪﻧا

.

رد ﺶﻫوﮋﭘ ﻦﻳا ﭗﻴﺗﻮﻨﻓ ﻦﻴﻴﻌﺗ

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ )

(،

a

هزاﺪﻧا ﻦﻴﻴﻌﺗ

و تﺪﺷ ﺎﻬﻧآ زوﺮﻠﻜﺳاوﺮﺗآ ﻲﮔر ﻢﻳﻼﻋ زوﺮﺑ و ﻪـﻧﻮﻤﻧ ياﺮﺑ

ﺎـﺑ

مﺎﺠﻧا ﺮﻠﭘاد شور ﺪﺸـﻧ

. ﻦـﻳا ﻞـﻳﻻد ،ﺮـﺿﺎﺣ لﺎـﺣ رد اﺮـﭼ ﻪـﻛ

ﻦﻴﺌﺗوﺮﭘﻮﭙﻴﻟ ﺖﻈﻠﻏ )

(

a

نارﺎﻤﻴﺑ رد ﻻﺎﺑ

MDD

ﺖﺳا ﻪـﺑ ﻮـﺻ تر

ﻖﻴﻗد ﻦﺷور ﺖـﺳا هﺪﺸـﻧ

؛ ور ﻦـﻳا زا ﻪـﺑ ﻪـﺟﻮﺗ ﺎـﺑ

ﺖﻳدوﺪـﺤﻣ

،ﺮﺿﺎﺣ ﻲﺳرﺮﺑ ﻲﺳرﺮﺑ مﺎﺠﻧا

هدﺮﺘﺴﮔ يﺎﻫ

ﺮﺗ و ﻪـﻧﻮﻤﻧ ﻢـﺠﺣ ﺎـﺑ

دﺎﻬﻨﺸﻴﭘ ﺮﺘﺸﻴﺑ ﻲﻣ

دﻮﺷ

1

.

يراﺰﮕﺳﺎﭙﺳ

زا تﺎــﻘﻴﻘﺤﺗ ﺰــﻛﺮﻣ ﻪــﻳﺬﻐﺗ مﻮــﻠﻋ

ﺖــﺷاﺪﻬﺑ هﺪﻜﺸــﻧاد و و

ﻪﻳﺬﻐﺗ ﻰﻜـﺷﺰﭘ مﻮـﻠﻋ هﺎﮕﺸـﻧاد ﻲﺘـﺷاﺪﻬﺑ تﺎﻣﺪـﺧ و

- ﻲﻧﺎـﻣرد

ﻪﺑ ﺰﻳﺮﺒﺗ ﻳﺎﻤﺣ ﻞﻴﻟد ﻲﻟﺎﻣ ﺖ

رد ياﺮﺟا و حﺮﻃ ﻢﻫ زا ﻦﻴـﻨﭼ ﻪـﻤﻫ

نﺎﻨﻛرﺎﻛ ﺖﻛﺮﺷ و ﺰﻳﺮﺒﺗ يدﺎﺑآﺪﺳا نﺎﺘﺳرﺎﻤﻴﺑ ﻦﻳا رد نﺎﮔﺪﻨﻨﻛ

ﺪـــﻧدﻮﻤﻧ يرﺎـــﻜﻤﻫ ﻲــﺳرﺮﺑ ﻦـــﻳا ياﺮــﺟا رد ﻪـــﻛ ﺶﻫوﮋــﭘ ﻲﻣ يراﺰﮕﺳﺎﭙﺳ دﻮﺷ

.

_______________________________________

1- Jow 2- Yang

3- Chen 4- Kraus

5- Haack 6- Schuld

7- Hinzc-Sclch 8- Pollmacher

9- Morita 10- Himeno

11- Yakuwa 12- Usui

13- Peltier 14- Imhof

15- thrombogenesis 16- Grainger

17- plaque 18- Lugens

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15

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Vol. 15 / No. 1/ Spring 2009

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17

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