Hoi nghi Khoa hoc ky- niim 35 ndm \ 'ien Khoa hoc vd Cong nghi Viet Nam - Hd Noi 10 2010
VAT LIEU NANO LAI HUtJ CO VO CO
VA iTNG DUNG TRONG QUANG DIEN TLT VA Y SINH HOC NANOMATERIALS AND NANOHYBRID ORGANIC AND INORGANIC
AND APPLICATION FOR OPTOELECTRONICS AND BIOMEDICINE
Le Qudc Minh ' ^ Trin Kim A n h \ Nguyen Thanh Binh'
Tran Thu Huong', Nguyen Thanh Huong', Nguyen Vii', Hoang Thi Khuyen' Lam Thj Kieu Giang', Le Die Tuyen', Dinh Xuan Loc'
Phan Viet Phong', Pham Anh Tuin', va Hoang Viet Hung'
1) Viin khoa hgc vdt liiu. Viin Khgg hgc vd Cdng nghi Viet ngm 2) Dgi hgc Cdng kinghi. Dgi hgc Qudc gig Hd ndi
Emgil; lequgcminh@ims. vgst. ac. vn Tom tat
Trinh bdy Idm tdt kit qud nghiin ciru vi cdc vdt lieu nang lgi cdm itng qugng vd veil lieu nano phdt quang chira ddt hiim. Tir cdc vdt lieu led nctnd cdm irng quang dd chi tgo thdnh cdng edu tnic vd ddn sdng planar nhu phdn chia. Id hgp vd each lit Dd kit hgp hai ki thudt tdng hgp ngnd Id thuy nhiet vd khudn mim di diiu chinh dugc kich thude vd hinh dgng ciig vdt liiu ngno ciig cdc ddt hiim Y, Tb, Eu, vd Zr. Hi thdng ddnh ddu bdng huynh quang bdg mdt dd dugc phdt triin trin vidl lieu ngnd lu che vd ki thudt in phun vd in ludi. Cdc nghiin ciru phdt triin Idc nhdn ddnh ddu huynh quang miin dich nhdm nhdn dgng virus dd dgt kit qud budc ddu ed triin vgng.
Abstract
A brief review of new photo responsive nang hybrid and fiuorescent nano materials containing rare earth ions will be presented. Some plcincir photonic wave guide structures such as splitter, combiner, grating have been fabricated by photo imprint and laser writing in using the photo responsive nanohybrids
obtained. The creative fabrication has been performed by hydrolhermal synthesis combined with soft template for controlling the size and shape of Y, Tb, Eu and Zr-nanomaterials. The security label system manufactured on the fluorescent nanomaterials in using jet- or screen-printing technique has been developed. The investigation for developing a fluorescence label in immunoassay has shown a promising results for recognize virus.
1. MO DAU
Nhirng nam gan day khoa hpc \'a cdng nghe dya tren ca sd vat lieu va cau triic kfch thude nanomet, da phat trien nhanh chdng va dugc dua vao img dyng trong mpi ITnh vyc khoa hpc cdng nghe. kinh te dan sinh va an ninh qudc phdng. Trong dd cac nghien cim che tao vat lieu nano cho quang dien tir va nham trien khai img dyng trong y sinh hpc ngay cang dugc quan tam tren the gidi va d nude ta.
Dudi day chiing tdi tdm luge cac ket qua nghien cuu ve vat lieu nand lai hiin ca- vd ca nhay quang \'a \'at lieu \'d ca chira dat hiem phat huynh quang nham che tao cac cau true va linh kien dan sdng quang [1] va phat trien cdng nghe danh dau bao mat va img dyng trong sinh y.
109
Tiiu ban: Khoa hoc Vdt liiu ISBN: 978-604-913-01
II. NQl DUNG
ILI Nghien ciru che tgo vgt lieu nano lai vd cdu trdc dan sdng planar
De xay dyng mang thdng tin tdc dp cao, da truyen thdng va qui md toan ciu, phai nghien cuu loai vat lieu mdi nham che tao cac cau tnic dan sdng planar cd kha nang cbl tao cac vi linh kien dieu hanh, phan chia, td hgp va trdn & phan kenh, khuyech dai cho mang thdng tin quang hpcv.v. Den nay chi rat ft loai vat lieu cd the dap iing dugc yeu cau tren. Mpt trong dd la vat lieu lai hiin ca va vd ca che tao bang qua trinh solgel. Dac tfnh ndi trpi cua vat lieu nay la cd the che tao cac loai mang nhay quang tir vai chuc nanomet den hang chyc micromet vdi chat lugng quang hgc cao [2]. Cau tao va thanh phan vat lieu nano lai nhay quang dugc trinh bay d hinh 1. Chiing tdi da lam chii dugc cdng nghe che tao tir vat lieu nand lai Acrylate- Silica-Zirconia (ASZ), cd the trai mang dien ticb Idn, va chat lugng quang hpc cao. Dya tren vat lieu ASZ da che tao thanh cdng cau tnic dan sdng phan chia va td hgp quang theo cdng nghe quang hda ly vi hinh.
High PbotsSensitive HYBRID
High Photosensitive HYBRID
ZrOj, TIO2 Nanoclustery
^ Main matnx
Silica network containing side chains with terminal methacryloxy-group & pei^uoro-alkyt group, Zirconium oxo.clusters (MFZ)
Monomer precursors and small molecular weight oligomer?
^ PbotofnitiatorS Photoactive monomer Main matrix OR
?"o »i «, • "' - . ^
l_
HI - - _
...^
"'f.^f.^f.'^-
Photoiniliator(DPA)
Photoreactive monomer (MMA) 0
OCH3
Hinh 1; Vdt lieu nand lai nhgy quang chi tgo cdu triic ddn sdng planar Tren ca sd vat lieu nand nhay quang cung da nghien cuu cbl tao thanh cdng cac loai each tir quang hpc khac nhau. Diing laser tir ngoai trong dilu kien giao thoa, cd thi ehl tao cac each tir vach cd nanomet. Ket qua che tao cac each tir va cac sang quang hpc, dugc trinh biy d hinh 2.
Cach tir budc 150nm va dp cao la 50nm, da cbl tao dugc vdi dp chfnh xac va lap lai cao, dap ung yeu cau kT thu|t ciia vi linh kien quang hpc hay quang tir nand. Cdn sang quang hpc che tao vdi kich tbudc Id dudi micromet va khoang each cac lo dudi 500 nm.
Hgi nghi Khoa hoc ky niem 35 ndm Viin Khoa hoc vd Cong nghi Viet Nam - Hd Noi 10 2010
/ i -^
IT-k-K'.
20min radiation & 3 min. developing AS ISOnm, heigtit= SOnm
Surface topography of printed convex lens array 10 min. radiation & 7min. developing H u d n g t d i n a n o p h o t o n i c s ''•' ^'""' height = l u m
Hinh 2; Hi chi tgo cdch tit vd sdng quang hgc tit vdt lieu lai ASZ
Hien nay che tao linh kien dan sdng va each tir tren ca sd vat lieu nano lai nhay quang da chuyen sang giai doan che thir cdng nghiep va rat cd trien vpng iing dyng trong cdng nghe thdng tin quang hpc bang thdng rdng. Mpt hudng nghien cuu mdi ciing da dugc bat dau la sir dyng cac cau true dan sdng planar tich cyc d viing phd hdng ngoai nham che tao cac bp khuech dai quang cho mang thdng tin [4].
II.2 Nghien cuu phdt trien cdc phuang phdp tong hffp nano cd dieu khien
De xay dyng cac cdng nghe nand mdi, trudc het phai phat hien cac vat lieu mdi. Da nghien cuu phat trien cac phuang phap hoa ly: solgel [3], thuy nhiet, bpc Idi/vd (core/shell), tao phirc, lai ghep hiin ca va vd ca ( hybrid) [2], khudn mem [6] (soft template) v.v nham tdng hgp cac vat lieu nand vdi myc dich dieu khien chinh xac kich tbudc va hinh dang ciia chiing.
Da che tao dugc vat lieu nand dang hat, thanh, day va dng cd dudng kfnh tir vai chyc nanomet va chieu dai den vai micromet ciia Ytri, Ziecon, Titan, Tecbi, va Europi. Trudng hgp dien hinh la hydroxit ytri Y(0H)3,vdi dieu kien che tao thich hgp thu dugc cac dang cau tnic la, thanh, day, dng trdn va dng lyc lang, mdt sd dang dugc trinh bay d hinh 3.
(a) (b) (c)
Hinh 3; Anh FESEM cua vdt lieu thanh Y(0H)3 (a); thanh Y(0H)3: 4Eu^yTb^^ (b) vd dng sdu cgnh Y(0H)3 (c)
Da nghien cuu ca che chuyen hoa va hinh thanh cac cau tnic nand khac nhau nham lam chu cdng nghe che tao cac dang nand cau tnic thap chieu va dac biet dang qua cau nano, dua
111
Tiiu ban: Khoa hoc \ 'dl lieu ISBN: 978-604-913-01
vao do che tao cac cau tnic tinh the quang tu lam nen tang cho cac img dung trong )' sinh trong tucmg lai [5].
Vdi hgp chat ciia tecbi chiing tdi da che tao dugc cac thanh nand Tb(0H)3. Tb304 \'a cac TbP04.H20. San pham che tao dugc da sir dyng kT thuat bpc \'d core/ shell, nham muc dich nang cao dp dn dinh va hieu qua phat quang. Ket qua cho thay cac dng cua Tb(0H)3 dugc bgc bang silica va silica pha tap ion dat hiem cd dp ben va kha nang phat quang tang manh.
Dudi day chiing tdi trinh biy kit qua tdng hgp vat lieu phat quang chira dat hiem nham cbl tao tac nhan danh diu huynh quang trong cdng nghe in bao mat \'a trong kT thuat danh dau huynh quang mien dich nhan dang cac virus.
Vat lieu hat nanophosphor YVO4: Eu^^ kich tbudc dudi 20 nm, phat quang rat manh d viing dd xuit phat tir cac chuyen ddi giira cac mirc nang lugng cua ion Eu ^ [6]. Tir vat lieu dang keo nay, da phat trien thanh myc danh dau an ninh sir dyng kT thuat in ludi hoac kT thuat in phun. San pham chirc nang hda thu dugc bang phuang phap tdng hpp nano ldi vd sir dyng phan img solgel.
600 650 - 0 0
\ \ avelength (nm)
Hinh 4; Phd huynh quang cua hgt ngnd trudc vd sau khi bgc vo chirc ndng hod YVO4; Eu J -
i - 3- i-
YVO4: Eu'^fdsilica-NHj; YVO4: Eir (dsilica-SCN; YVO4: Eu''(dsilica-SCN/Biotin Phd huynh quang sau chirc nang hda vat lieu nano YVO4: Eu^" trinh bay d hinh 4 Cac .3*
nhdm chirc tren nhu amine, hydroxyl, cacboxylic axit. thiocyanat, cd the tuang tac manh vdi cac ddi tupng nhu protein, AND, te bao, virus va vi khuan v.v.
Hgp tac vdi Trung tam nghien cim san xuat vacxin Polyvac ciia Bd Y te, chiing tdi da thanh cdng budc dau trong viec xir dyng tac nhan danh dau huynh quang nano vao qui trinh phan tich mien dich nhan dang cac virus tieu chay, sdi v.v.
III. KET LUAN
Da lam chu dugc cdng nghe che tao vat lieu nand huynh quang chira dat hiim \'a vat lieu nand lai nhay quang. va trien kliai che thir cau true quang dien tu cd tiem nang irng dung trong thdng tin quang va y sinh hpc. Cac nghien cim ca ban dinh hudng irng dyng nay da phat huy tac dung trong dao tao ngudn nhan lyc chat lugng cao. tang cudng hgp tac khu \'yc va qudc te, gdp phan tiep thu. phat trien va chuyen giao cac cdng nghe quang dien tir va quang tir naudn vao thyc tien.
Htpi nghi Khoa hgc ky niem 35 ndm ) 'iin Khoa hoc vd Cong nghi Viet Nam - Hd Not 10''2010
Ldi cam on
Vien Khoa hpc Vat lieu va Vien Khoa hpc va Cdng nghe Viet nam da tao ra mdi trudng nghien cun khoa hpc thupc hang dau d nude ta. Cac co quan quan ly nha nude ve khoa hpc cdng nghe da cap kinh phf de thuc hien. Hgp tac ciia ddng nghiep, cac td chuc nghien cim, giang day dai hpc va cac ca sd hgp tac trien khai trong va ngoai nude.
TAI LIEU THAM KHAO
1. Luminescence Nanomaterials; Editors: Le Quoc Minh , Wieslaw Strek. Tran Kim Anh and Kui Yui, nha xuat ban: Hindawi Publishing Corp., Joumal Nanomaterials, 2007.
2. Nguyen Thanh Binh, Nguyen Tat Thanh, Duong Thanh Trung, Nguyen Thanh Huong, Le Quoc Minh "Fabrication of planar waveguide chip for splitting or combining infrared light beam" J. Korean Phys. Society (ISSN: 0374-4884 ) Vol. 52, 2008, pp.1501-1505
3. L. Q. Minh, N. T. Huong. C. Barthou, P. Benalloul, W. Strek, T. K. Anh Eu^^ and Er - doped Si02-Ti02 solgel films for active planar waveguides. Materials Science, Vol 20, No.2, 2002, pp. 47-52
4. T. Kim Anh, L. Quoc Minh, N. Vu, T. Thu Huong, N. Thanh Huong, C. Barthou (*) and W. Strek, Nanomaterilas contaning rare earth ions Tb, Eu, Er and Yb:
preparation,optical properties and application potential. Journal of Luminescence 102- 102,2003 391-394.
5. Cheng Yi Wul, Chia Chi Huang. Jia Sin Jhang, An Chi Liu, Chun-Chen Chiang, Ming-Lung Hsieb, Ping-Ji Huang. Le Dac Tuyen, Le Quoc Minh, Tzyy Schiuan Yang, Lai-Kwan Chau, Hung-Chih Kan, and.Chia Chen Hsu "Hybrid surface-enhanced Raman scattering substrate from gold nanoparticle and photonic crystal:
Maneuverability and uniformity of Raman spectra" 23 November 2009 / Vol. 17, No.
24 OPTICS EXPRESS, 21522.
6. Le Quoc Minh, Tamio Endo. Tran Thu Huong, Nguyen Thanh Huong, Lam Thi Kieu Giang, Le Dac Tuyen. Dinh Xuan Loc and Tran Kim Anh ; Synthesis, Structures and Properties of Emission Nanomaterials Based on Lanthanide Oxides and Mixoxides, Transaction MRS Japan, Vol. 35, No. 2, 2010, pp.417-422
113
