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Fig. 1. Exemplary flow scheme of a typical AOP, starting from the molecular initiating event (MIE), inducing a variety of Key Events (KEs) connected by Key EventRelationships (KERs, red arrows) and resulting in a single specific Adverse Outcome (AO).
Fig. 2. AOP ‘‘The Adverse Outcome Pathways from protein alkylation to liver fibrosis”. AOP under development in the AOP wiki under the OECD framework titled ‘‘TheAdverse Outcome Pathways from Protein Alkylation to Liver Fibrosis”
Fig. 3. Putative AOP applicable to metal oxide NMs leading to hepatitis. AOP under development in the AOP wiki under the OECD framework titled ‘‘Lysosomal damageleading to liver inflammation”

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