• Tidak ada hasil yang ditemukan

BAB 5 : PENUTUP

5.2 Saran

5.2.1 Untuk penelitian selanjutnya :

• Perlu dilakukan penelitian serupa lebih mendalam untuk melihat hubungan PPHNA dan status gizi lebih serta faktor resiko lainnya. • Perlu dilakukan penelitian serupa dengan menggunakan data primer

• Perlu dilakukan penelitian lebih lanjut di institusi lainnya dengan jumlah sample yang lebih banyak sehingga dapat menggambarkan prevalensi populasi.

5.2.2 Untuk RSUP Fatmawati

• Perlu dicurigai adanya kemungkinan PPHNA pada pasien obesitas

• Selalu dilakukan pencatatan berat badan dan tinggi badan pada pasien PPHNA

Daftar Pustaka

1. McCance KL, Huether SE, Brashers VL, Rote NS. Pathophysiology; The

Biologic Basis for Disease in Adult and Children. 6th ed. USA: Elsevier, 2010. 2. Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The

Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. AGA. 2012;142:1592–1609.

3. Ratziu V, Bellentani S, Cortez-Pinto H, Day C, Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. Journal of Hepatology. 2010;53:372–384.

4. Angulo P, Lindor KD. Quadrennial Review; Non-Alcoholic Fatty Liver Disease.

Journal of Gastroenterology and Hepatology. 2002;(17): 186-190.

5. Farrell, McCullough. Non-alcoholic Fatty Liver Disease. Singapore: Willey-Blackwell, 2013.

6. Nurman A, Huang MA. Perlemakan hati non alkoholik. Universa Medicina. 2007; 26: 205-15.

7. Gill HK, Wu GY. Non-alcoholic fatty liver disease and the metabolic syndrome: Effects of weight loss and a review of popular diets. Are low carbohydrate diets the answer? . World J Gastroenterol. 2006 January 21; 12(3): 345-353.

8. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014 August 30; 384: 766–81.

9. RISKESDAS 2013. Riset Kesehatan Dasar. Badan Penelitian dan

Pengembangan Kesehatan Kementrian Kesehatan RI. 2013.

10. Yeh MM, Brunt EM. Pathology of Nonalcoholic Fatty Liver Disease. Am J Clin

Pathol 2007;128:837-847.

Complex Disorders. Int. J. Mol. Sci. 2014;15:9924-9944.

12. Sulaiman, Akbar, Lesmana, Noer. Buku Ajar Ilmu Penyakit Hati. Jakarta: Jayabadi, 2007.

13. Inoue S, Zimmet P. The Asia-Pacific Perspective: Redefining Obesity and Its Treatment. Australia: Health Communications Australia, 2000.

14. Fan JG, Farrell GC. Review; Epidemiology of non-alcoholic fatty liver disease in China. Journal of Hepatology. 2009; 50: 204–210.

15. Hsiao TJ, Chen JC, Wang JD. Paper; Insulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in apparently healthy obese patients. International Journal of Obesity . 2008; 28: 167–172 .

16. Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Am J Gastroenterol. 2012; 107: 811–826.

17. Cheah WL, Lee PY, Chang CT, Mohamed HJ, Wong SL. Prevalence Of

Ultrasound Diagnosed Non- Alcoholic Fatty Liver Disease Among Rural Indigenous Community Of Sarawak And Its Association With Biochemical And Anthropometric Measures. Southeast Asian J Trop Med Public Health. 2013 March; 44: 309-317.

18. Dowman JK, Tomlinson JW, Newsome PN. Review; Pathogenesis of

non-alcoholic fatty liver disease. Q J Med . 2010; 103: 71-83.

19. Bellentani S, Marino M. Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD). Annals of Hepatology. 2009; 8(1): S4-S8.

20. Sass DA, Chang P, Chopra KB. Nonalcoholic Fatty Liver Disease: A Clinical Review. Digestive Diseases and Sciences. 2005 January; 50(1): 171-180.

21. Amarapurkar DN, Hashimoto E, Lesmana LA, Sollano JD, Chen PJ, and Goh KL. How common is non-alcoholic fatty liver disease in the Asia– Pacific region and are there local differences? J of Gastroenterol Hepatol. 2007;22:788–793. 22. World Gastroenterology Organisation. World gastroenterology organization

global guideline; Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. USA: World Gastroenterology Organisation, 2012.

23. Porth CM, Matfin G. Pathophysiology Concepts of Altered Health States. 8th ed. China: Wolters Kluwer Health | Lippincott Williams & Wilkins, 2009.

24. Chitturi S, Farrell GC, George J. Review; Non-alcoholic steatohepatitis in the Asia–Pacific region: Future shock?. Journal of Gastroenterology and Hepatology. 2004; 19: 368-374.

25. Farrel GC, Chitturi S, Lau GK, Sollano JD. Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia–Pacific region: Executive summary. Journal of Gastroenterology and Hepatology . 2007; 22: 775–777.

26. Schreuder TC, Verwer BJ, Nieuwkerk, Mulder CJ. Review; Nonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis and treatment. World J Gastroenterol. 2008 April 28; 14(16): 2474-2486.

27. Abenavoli L, Milic N, Peta V, Alfieri F, Lorenzo AD, Bellentani S. WJG 20th Anniversary Special Issues (12): Nonalcoholic fatty liver disease; Alimentary regimen in non-alcoholic fatty liver disease: Mediterranean diet. World J Gastroenterol. 2014 December 7; 20(45): 16831-16840.

28. Puspitasari E. Evidence Based Case Report; Manfaat Probiotik pada Penatalaksanaan Penyakit Perlemakan Hati Non Alkoholik. Jakarta: FKUI. 2013. Tesis.

29. Iser D, Ryan M. Fatty Liver Disease; A Practical Guidline for GPs. AFP. 2013 July;42(7):444-447. Available at http://www.racgp.org.au/afp/2013/july/fatty-liver-disease/

30. Wilborn C, Beckham J, Campbell B, Harvey T, Galbreath M, Bountry PL, et al. Obesity: Prevalence, Theories, Medical Consequences, Management, and Research Directions. Journal of the International Society of Sports Nutrition. 2005; 2(2): 4-31.

31. Qureshi K, Abrams GA. Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease. World J

Gastroenterol. 2007 July 14; 13(26): 3540-3553.

32. AGA Technical Review on Nonalcoholic Fatty Liver Disease. Gastroenterology. 2002;123:1705–1725

33. Sass DA, Chang P, Chopra KB. Nonalcoholic Fatty Liver Disease: A Clinical Review. Digestive Diseases and Sciences 2005; 50: 171-180.

34. Fabbrini E, Sullivan S, Klein S. Obesity and Nonalcoholic Fatty Liver Disease: Biochemical, Metabolic and Clinical Implications. Hepatology. 2010 February; 51(2): 679–689.

35. Amirkalali B, Poustchi H, Keyvani H, et al. Prevalence of Non-Alcoholic Fatty Liver Disease and Its Predictors in North of Iran. Iranian J Publ Health. 2014 September; 43(9): 1275-1283.

36. Rafique T, Zeba Z, Zinnat R, Ali L. Core Components of the Metabolic Syndrome in Nonalcohlic Fatty Liver Disease. IOSR Journal of Biotechnology and Biochemistry. 2015;1 (2): 21-25.

37. Younossi ZM, Stepanova M, Negro F, Hallaji S, Younossi Y, Lam B, Srishord M. Nonalcoholic fatty liver disease in lean individuals in the United States. Medicine (Balti- more) 2012; 91: 319-327.

38. Pan JJ, Fallon MB. Gender and racial differences in nonalcoholic fatty liver disease. World J Hepatol. 2014 May 27; 6(5): 274-283.

39. Lazo M, Clark JM. The Epidemiology of Nonalcoholic Fatty Liver Disease: A Global Perspective. Semin Liver Dis. 2008; 28(4): 339-350.

40. Hamaguchi M, Kojima T, Ohbora A, et al. Aging Is A Risk Factor Of Nonalcoholic Fatty Liver Disease In Premenopausal Women. World J Gastroenterol. 2012 January 21; 18(3): 237-243.

41. RISKESDAS 2007. Riset Kesehatan Dasar. Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan RI. 2008.

42. Li G, Cheng Z, Wang C, Liu A, He Y, Wang P. Prevalence Of And Risk Factors For Non-Alcoholic Fatty Liver Disease In Community-Dwellers Of Beijing, China. OA Evidence-Based Medicine. 2013 August 1; 1(1):10.

Non-alcoholic fatty liver disease is associated with higher levels of objectively measured sedentary behaviour and lower levels of physical activity than matched healthy controls. Frontline Gastroenterology. 2014 May 12; 0: 1-8.

LAMPIRAN 1

a. Jadwal Penelitian

b. Anggaran Penelitian

No Keterangan Total Biaya (Rp)

1 Biaya ATK 1.000.000

2 Biaya Administratif 1.250.000 3 Biaya Pengambilan rekam

medis

500.000

4 Biaya tidak terduga 500.000

Total Biaya 3.250.000

No Kegiatan Bulan ke-

1 2 3 4 5 6 1 Proposal dan Pengajuan Izin

2 Pelaksanaan Penelitian

3 Analisis Data

4 Penulisan Laporan

LAMPIRAN 2

LAMPIRAN 3

1. Hasil Analisis Data

a. Grafik Gambaran Kadar Trigliserida dan High Density Lipoprotein (HDL) pada Pasien PPHNA dengan Obesitas

b. Grafik Gambaran Kadar Gula Darah Puasa (GDP) dan Gula Darah Darah 2 Jam Postprandial (GD2PP) pada Pasien PPHNA dengan Obesitas

LAMPIRAN 4 DAFTAR RIWAYAT HIDUP

DATA PRIBADI

Nama : Noor Shabrina

Jenis Kelamin : Perempuan

Tempat Tanggal Lahir : Tangerang, 22 Desember 1994

Status : Belum menikah

Agama : Islam

Alamat : Perumahan Benda Baru, Jalan Bhayangkara Blok

E26, Pamulang, Tangerang Selatan

Nomor Telepon/HP : 085775222789

Email : Noorshabrinaa@yahoo.com

RIWAYAT PENDIDIKAN

1) Tahun 2000 – 2006 : Sekolah Dasar Negeri Sarua 06

2) Tahun 2006 – 2009 : Sekolah Menengah Pertama Negeri 2 Pamulang

3) Tahun 2009 – 2012 : Madrasah Aliyah Al-Hamidiyah Depok

4) Tahun 2012 – sekarang : Program Studi Pendidikan Dokter UIN Syarif Hidayatullah Jakarta

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