AUSTIN HOSPITAL AND REPATRIATION GENERAL HOSPITAL
Professor (Repatriation General Hospital) THOMAS JOHN MARTIN
Merck Sharp and Dohme Professor of Clinical Pharmacology and Therapeutics W I L L I A M JOHN LOUIS
Reader I A N FARQUHAR CAMPBELL McKENZIE Reader in Psychiatry RUSSELL AINSLIE MEARES
First Assistant (Austin Hospital) FREDERICK ARTHUR OSCAR MENDELSOHN First Assistant (Repatriation General Hospital) RICHARD GRAEME LARKINS Second Assistant NEVILLE DAVID YEOMANS
Second Assistant in Psychological Medicine (Repatriation General Hospital) PAUL EDWARD DEBENHAM
Senior Lecturer in Clinical Pharmacology and Therapeutics BEVYN JARROTT Third Assistant in Psychiatry EDWIN HARARI
National Health and Medical Research Council Research Fellow PHILIP MARK BEART National Health and Medical Research Council C. J. Martin Research Fellow
JOHN A L L A N EISMAN
National Heart Foundation of Australia Research Fellow GREGORY JAMES DUSTING University of Melbourne Research Fellow RICHARD JOHN HEAD
National Health and Medical Research Council Senior Research Officers SADANAND NAGESHRAO ANAVEKAR
ELIZABETH LYNNE CONWAY A N N E JULIA CULVENOR JEFFREY STUART HUTCHINSON
National Health and Medical Research Council Postgraduate Medical Research Scholars DUNCAN JOHN CAMPBELL
NICHOLAS CHRISTOPHIDIS
National Heart Foundation of Australia Postgraduate Medical Research Scholar JOHN JAMES McNEIL
Director National Blood Pressure Study MARY ROSE STEWART
Postgraduate Research Scholars ADRIANNE ILA ELISABETH ANDERSON ANDREW BUI
OLAF HEINO OSKAR DRUMMER STUART GRANT DUFFY
MARIA KATHLEEN DYNON ANDREW SIMON GIRAUD
ANDREW LAWRENCE GUNDLACH THOMAS HEANEY
PHILLIP MARK HOGARTH BRUCE EDWARD LOVELAND URVINE I A N LUCAS
ARLIE EDITH McQUEEN MARY MICHAELIDES GEORGE W I L L I A M M I H A L Y G I L L I A N MARGARET MORGAN ROGER NOLAN
TERRANCE A D R I A N POTTER A L A N GREGORY RIGLAR MAURO SERGIO SANDRIN ELIZABETH SHER
CHRISTOPHER HENRY THOMPSON Professorial Associates PETER FRANCIS BLADIN
JOHN KINGSLEY DAWBORN RICHARD A L A N SMALLWOOD
Senior Associate in Social Medicine DAVID GEORGE LEGGE Senior Associates (Austin Hospital) PETER RAEY BULL
RICHARD ASKIN CHENOWETH JOHN PAUL COGHLAN
138
MEDICINE 139 W I L L I A M DAVIS
BRIAN ROGER ENTWISLE ANDREW NOEL FRASER KEVIN JAMES FRASER A L A N JAMES GOBLE JOHN GREEN
DAVID LESLIE HARDING WALTER FRANCIS HEALE ROBERT NEIL HOPE
RONALD ATKINSON HURLEY GEORGE JERUMS
ELIZABETH ROMA LENEGHAN W I L L I A M JOHN McKAY WALTER JOSEPH MOON
ROBIN MACINTOSH LATHROP MURRAY ANDREW COLGATE NEWELL
PETER ANTHONY SINCLAIR JOHNATHAN ARTHUR STREETON MARY ROSE STEWART
BERNARD SWEET BERNARD TREISTER
FRANK JOHN EMERY VAJDA JOHN VERNEA
JAMES SAVILLE WILEY DIANNE MARIE WILSON
Senior Associates (Repatriation General Hospital) W I L L I A M ROBERT ADAM LIONEL BARRY ARKLES
COLIN EDWIN BARTER
ALAISTAIR HERIOT CAMPBELL LEWIS W I L L I A M FAULKS JOHN DESMOND PARKIN PETER JAMES PARSONS N E W M A N PINCUS
Senior Associates (Box Hill and District Hospital) PETER ALFRED BERGER EDWARD FRANCIS O'SULLIVAN
G R A H A M THEODORE SCHMIDT
MICHAEL PHILIP KENDAL SCHOOBRIDGE Associates (Austin Hospital) JOHN BERNARD BRENNAN
ANTHONY DORTIMER JOHN COURTNEY DUGGAN DAVID H I L L
ROBERT LEFKOVITS LAWRENCE MORAN LESLIE EDWARD OLIVER ROBERT PIERCE
GANASEN RAJAH RAM RAJENDRA PETER McINTOSH ROBERTSON JEFFREY MAX SLONIM
BRUCE JOHN TONGE GERALD UNGER
Associates (Repatriation General Hospital) DOUGLAS ROBERT GAULD GARY DAVID GILL
HUGH WARWICK GREVILLE PETER W I L L I A M HOLMES JAMES GEOFFREY HINDHAUGH JOHN HENRY ISER
JOHN MICHAEL O'CONNELL ROBERT GORDON N E W N H A M NEVILLE W I L L I A M QUINN GWYNNE WILTON THOMAS
140 FACULTY OF MEDICINE
RESEARCH TOPICS IN PROGRESS
MEDICINE - AUSTIN HOSPITAL 1. Role of prostaglandin intermediates in regulation of vascular tone.
2. Studies of the mucoid cells of the gastric mucosa.
3. Phylogeny of gastric mucosa in Chordates.
4. Mechanism of the peptic ulcerogenic effects of tobacco smoking.
5. Study of the protein core material in exocrine secretion granules of alimentary tract.
6. Control of secretion of aldosterone from isolated zona glomerulosa cells.
7. The role of the tissue renin-angiotensin system in hypertension.
8. Cell surface la and Ly antigens in the mouse.
9. Cell surface antigens of normal and tumour cells in man.
10. Production of antisera by secretionary hybridomas.
11. Detection of circulating immune complexes.
12. Transplantation immunity in mouse and man.
13. Evolution of diabetic nephropathy.
14. Influence of thyroid status on cell surface enzymes.
15. Effects of cranial irradiation on hypothalamic-pituitary function.
16. Bile acid structure and biliary lipid secretion.
17. Foetal and neonatal bile acid metabolism.
18. Hepatic transport of organic compounds.
19. Renal bone disease — definition, natural history and treatment.
20. Glomerulonephritis — trial of different treatment regimes.
21. Continuous ambulatory peritoneal dialysis - use in treatment of chronic renal failure.
22. Hormone responsiveness in uremia.
23. Effect of exposure to hormones on cell hormone responsiveness.
24. Neuropsychological assessment of patients with renal failure and their response to dialysis.
25. Cytosine arabinoside transport in acute myeloid leukaemia in man.
26. The effect of sulphinpyrazone on platelet function.
MEDICINE - REPATRIATION GENERAL HOSPITAL 1. Regulation of adenylate cyclase.
2. Hormone receptors in cancer cells.
3. Prostaglandins in malignant hypercalcaemia.
4. Synthesis and action of the new prostaglandins.
5. Platelet abnormalities in diabetic vascular disease.
6. Regulation of insulin secretion.
7. Regulation of Vitamin D metabolism.
8. Pathogenesis of metabolic bone disease.
9. The renal response to aldosterone and mineralocorticoids including — (a) Factors modifying this response
(b) The importance of an altered response in hypertension.
C L I N I C A L PHARMACOLOGY A N D THERAPEUTICS 1. Mechanisms and sites of action of anti-hypertensive drugs.
2. Molecular properties of alpha-adreno receptors in brain and smooth muscle.
3. The importance of Y "a m'n° t> u tyr'c a ci d and dopamine in brain centres involved in neurological diseases.
4. The regulation of dopamine metabolism and the sites of action of neuroleptic drugs.
5. Structural basis of action of drugs on beta adreno receptors in heart, lung and blood vessels.
6. Immunoassay and distribution of Clonidine.
7. Pharmacokinetics of anti-hypertensive anti-cancer drugs and anti-arrhythmic drugs.
8. Steady state kinetics of anti-epileptic drugs.
MEDICINE 141 PSYCHIATRY
1. Studies of mother-infant interaction.
2. Studies of cortical evoked potentials in mental illness.
3. The cerebral effects of tobacco smoking.
4. Psychological aspects of hypertension.
5. Habituation in normality and mental illness.
PUBLISHED WORK Chapters in Books
1. EISMAN. J. A. and DELUCA, H. F. - Determination ofVilamin D metabolites. Methods in Enzymology, Vol. 52. Part C, ed Colamick and Kaplan, Academic Press Inc., New York Publishers, 388 (1978).
2. SMALLWOOD, R. A. - Other liver diseases associated with increased liver copper concentrations. Metals and the Liver, ed L. W. Powell, Marcel Dekker, New York, 313-329 (1978).
Articles
3. A D A M , W. R., FUNDER, J. W., MERCER, J. and ULICK, S. - Amplification ofthe action of aldosterone by 5 a-dihydrocortisol. Endocrinology 103: 465-471 (1978).
4. A D A M , W. R. and MENDELSOHN, F. A. O. - Measurement of the end organ response to aldosterone in man: Diversity of response and its possible biological significance. Aust. N.Z. J.
Med. 8: 673 (1978).
5. ARMSTRONG, J. M., DUSTING, G. J., MONCADA, S. and VANE, J. R. - Cardiovascular actions of prostacyclin (PGL), a metabolite of arachidonic acid which is synthesized by blood vessels. Circ'Res. 43(\): 11-112-119 (1978).
6. ARNOTT, R. D. and JERUMS, G. — The lymphocyte sodium pump in hypothyroidism.
Proc. Endocr. Soc. Aust. 21: 13 (1978).
7. BEART, P. M . and BILAL, K. - Allvlgylcine: intranigral effects and reappraisal of actions on the GABA system. Biochem Pharmacol. 27: 1891-1896 (1978).
8. BREEN, K. J„ WHELAN, G. and SMALLWOOD, R. A. - Viral hepatitis in general hospitals: Guidelines for control and prevention. Med. J. Aust. 2: 18 (1978).
9. BROWN, D. J., CRAICK, C. C , DAVIES, S. E., JOHNSON, M . L., DAWBORN, J. K.
and HEALE, W. F. — Physical emotional and social adjustments to home dialysis. Med. J.
Aust. 1: 245-247 (1978).
10. BILEZIKIAN, J. P., CRANFIELD, R. E., JACOBS, T. B., POLAY, J. S., D'ADAMS, A.
P.. EISMAN, J. A. and DELUCA, H. F. - Response to l a 25-dihyroxyvitamin D to hypocalcemia in human subjects. New Eng. J. Med. 299: 437-441 (1978).
11. CHAPPLE, D. J., DUSTING. G. J., HUGHES. R. and VANE, J. R. - A vagal reflex contributes to the hypotensive effect of prostacyclin (PGIi) in anaesthetized dogs. J. Physiol.
281: 43P (1978).
12. CHESNEY, R. W., MOORTHY, A. V., EISMAN, J. A., JAX, D. K., MAZESS, R. B. and DELUCA, H. F. - Increased growth after long term oral lo 25 vitamin Ds in childhood renal osteodystrophy. New Eng. J. Med., 238-242 (1978).
13. CHRISTOPHIDIS, N . . DAWBORN, J. K. and VAJDA, F. J. E. - Studies of intravenous Cefoxitin (MK 306), Med. J. Aust. I : 512-514 (1978).
14. CHRISTOPHIDIS, N., LUCAS, I . , VAJDA, F. J. E. and LOUIS, W. J. - Excessive lacrimation due to 5-fluorouracil. Letter Annals of Internat Med. (1978).
15. CHRISTOPHIDIS, N„ VAJDA, F. J. E., LOUIS, W. J. and MOON, W. - Fluorouracil therapy in patients with carcinoma of the large bowel: A pharmacokinetic comparison of various rates and routes of administration. Clin. Pharmacokinetics 3: 330-336 (1978).
16. CLARK, S„ DE LUISE, M., LARKINS, R. G., MELICK, R. A. and HARRISON, L. C. - Thc effects of digestive enzymes on placental insulin receptor characteristics comparison of particulate and soluble receptor preparations. Biochem. J. 174: 37-43 (1978).
17. CONWAY, E. L., JARROTT, B. and LOUIS, W. J. - Effect of acute alpha-methyldopa administration on catecholamine level in anterior hypothalamic-preoptic and medullary nuclei in the rat brain. Brit. J. Pharmac. 62: 405P (1978).
18. CONWAY. E. L., JARROTT. B. and LOUIS, W. J. - Effect of alpha methyldopa on dopaminergic transmission in the corpus straitum. Neuropharmacology 17: 335-361 (1978).
19. CONWAY, E. L., LOUIS, W. J. and JARROTT, B. - Acute and chronic administration of alpha methyldopa regional levels of endogenous and alpha methylated catecholamines in rat brain. Eur. J. Pharmac. 52: 271-280 (1978).
142 FACULTY OF MEDICINE
20. CRAWFORD, A., ATKINS, D. and M A R T I N , T. J. - Rat osteogenic sarcoma cells:
comparison of the effects of prostaglandins E,, E;, I , (prostacyclin), 6-keto F,Q and thrombozane B, on cyclic AMP production and adenylate cyclase activity. Biochem. Biophvs.
Res. Comm. 82: 1195-1201 (1978).
21. CRAWFORD, A., HUNT, N. H., DAWBORN, J. K.. MICH EL ANG ELI, V. P. and M A R T I N , T. J. - Membranes from a transplantable osteogenic sarcoma responsive lo parathyroid hormone and prostaglandins: regulation of adenylate cyclase and of hormone metabolism. J. Endocr. 77: 213-224 (1978).
22. DUSTING, G. J., MONCADA, S. and VANE, J. R. - Vascular actions of arachidonic acid and its metabolites in perfused mesenteric and femoral beds of the dog. Eur. J. Pharmac. 49:
65-72 (1978).
23. DUSTING, G. J., MONCADA, S. and VANE, J. R. - Recirculation of prostacyclin (PGI,) in the dog. Br. J. Pharmac. 64: 315-320 (1978).
24. DUSTING, G. J., MONCADA, S., MULLANE, K. M . and VANE, J. R. - Implications of prostacyclin generation for modulation of vascular tone. Clin. Sci. Mol. Med. 55(4): 001s-004s (1978).
25. DUSTING, G. J., MONCADA, S. and VANE, J. R. - Disappearances of prostacyclin (PGI,) in the circulation of the dog. Br. J. Pharmac. 62: 414P-4I6P (1978).
26. DUSTING, G. J., MONCADA, S., M U L L A N E , K. M . and VANE, J. R. - Biotransformation of arachidonic acid in thc circulation of the dog. Br. J. Pharmac. 63: 359P (1978).
27. FRIEDMAN, J. and MEARES, R. A. - Comparison of spontaneous and contraceptive menstrual cycles on a visual discrimination task. Aust. N.Z. J. Psvchial. 12: 233 (1978).
28. FUNDER, J. W., MERCER, J., INGRAM, B., FELDMAN, D., WYNNE, K. and A D A M , W. R. - 19 — Nor Deoxycorticosterone (19 - nor DOC): Mineralocorticoid receptor affinity higher than aldosterone. Electrolyte activity lower. Endocrinology 103: 1514-1517 (1978).
29. GIRAUD, A. S. and YEOMANS, N . D. - Ultrastructure and cytochemistry of the gastric mucosa of the river blackfish (Cadopsis marmoratus). Proc. Aust. Soc. Fish Biol.. PIO (1978).
30. HEYMA, P., LARKINS, R. G., STOCKIGT. J. R. and CAMPBELL, D. G. - The formation of tri-iodothyronine and reverse tri-idothyronine from thyroxine in isolated rat renal tubules. Clin. Sci. Molec. Med. 55: 567-572 (1978).
31. HOLMES, S. D., DIRMIKIS, S. M . , M A R T I N , T. J. and MUNRO, D. S. - Effects of human thyroid stimulating hormone and immunoglobulines on adenylate cyclase activity and the accumulation of cyclic AMP in human thyroid membranes and slices. J. Endocr. 79: 121-
130 (1978).
32. HUNT, N . H., MacNEIL, S. and MARTIN, T. J. - Response of human and chick kidney adenylate cyclase to biologically active fragments of human parathyroid hormone. Biochem.
Biophvs. Res. Comm. 81: 581-587 (1978).
33. HUNT, N . H., SHORTLAND, J. R., MICHELANGELI, V. P., HAMMONDS, J. C , ATKINS, D. and M A R T I N , T. J. — Adenylate cyclase activity of renal cortical carcinoma and its relation to histology and ultrastructure. Cancer Rei. 38: 23-31 (1978).
34. JARROTT, B. and SPECTOR, S. - Disposition of clonidine in rats as determined by radioimmunoassay. J. Pharmacol. Exp. Ther. 207: 195-202 (1978).
35. JARROTT, B. and SUMMERS, R. J. — Localisation of JH-clonidine binding in guinea pig kidney. Brit. J. Pharmacol. 64: 418-419 (1978).
36. JERUMS, G. and BROBERG, A. L. - Thyroid status and adenylate cyclase. Proc. Endocr.
Soc. Aust. 21: 16 (1978).
37. KONTIAINEN, S., SIMPSON, E., BOHRER, E„ BEVERLEY, P. C. L., HERZENBERG, L. A., FITZPATRICK, W. C , VOGT, P., TORANO, A., Mc KENZIE, I . F. C. and FELDMANN, M . — T-Cell lines producing antigen specific suppressor factor. Nature 274:
477-480 (1978).
38. LARKINS, R. G. - Perioperative problems in the diabetic. Aust. N.Z. J. Surg. 48: 238-241 (1978).
39. LARKINS, R. G., DeLUISE, M . and CLARK, S. - A review on the role of insulin receptor defects in the aetiology of diabetes. Proc. 6th Asia and Oceania Congress of Endocr.. ed J. S. Sheah, et. al., 133-137 (1978).
40. LARKINS, R. G., M A R T I N , F. I . R., ALFORD, F. P. and CHISHOLM, D. J. - Relationship between alpha and beta cell function before and after metabolic control in kctotic diabetic subjects. J. Clin. Endocr. Metab. 46: 131-139 (1978).
41. LARKINS, R. G., M A R T I N , F. I . R., HEDING, L. G. and TAIT, B. D. - Hormonal profile, blood sugar control and HLA patterns in long term insulin dependent diabetes with and without vascular disease. Aust. N.Z. J. Med. 8: 465-471 (1978).
42. LARKINS, R. G., M A R T I N , F. I . R. and TAIT, B. D. - HLA patterns and diabetic retinopathy. Brit. Med. J. 1: l l l l (1978).
43. LAZDINS, I . and DAWBORN, J. K. - Concentration of Guanidines in normal human plasma. Clin. and Exper. Pharmacol, and Physiol. 5: 75-80 (1978).
MEDICINE 143 44. LOUIS, W. J., BRIGNELL, M . B., McNEILL, J. J., CHRISTOPHIDIS, N . and
VAJDA, F. J. E. - Letter. The Lancet. Vol. I : 452-542 (1978).
45. LOUIS, W. J., CHRISTOPHIDIS, N., BRIGNELL, M . , VIJAYASEKARAN, V., McNEIL, J. and VAJDA, F. J. E. — Labetalol: Bioavailability, drug plasma levels, plasma renin and catecholamines in acute and chronic treatment of resistant hypertension. Aust. N.Z.
J. Med. 8: 602-609 (1978).
46. LOUIS, W. J., VAJDA, F. J. E., McNEIL, J. J. and DOYLE, A. E. - The combined use of L-alpha-methyldopa hydrazine and methyldopa in the treatment of hypertension. Clin. Exp.
Pharmac. Physiol. 4: 001-006 (1978).
47. M A N N , J. J., BRANTON, L. J. and LARKINS, R. G. - Hyperosmolality complicating recovery from lithium toxicity. Brit. Med. J. I : 1522-1523 (1978).
48. M A RI A N I , A . F., C L I F T O N , S., D A V I E S , D. J., D A W B O R N , J. K . , FITZGERALD, J. E., IHLE, B. U., N I A L L , J. F. and RYAN, G. B. - Membranous glomerulonephritis associated with sarcoidosis. Aust. N.Z. J. Med. 8: 420-425 (1978).
49. MARSHALL, A. W., SLONIM, J. M . , SMALLWOOD, R. A. and FRASER, K. J. - The association of chronic active hepatitis with pyoderma gangrenosum. A ust. N.Z. J. Med. 8:656- 658 (1978).
50. MARSHALL, A. W. and SMALLWOOD, R. A. - Oral contraceptives and liver tumours.
Med. J. Aust. 2: 240-241 (1978).
51. M A R T I N , T. J. - The therapeutic uses of calcitonin. Scot. Med. J. 23: 161-166 (1978).
52. MARTIN, T. J. - Pagets Disease. Hospital Update 4: 657-672 (1978).
53. M A R T I N , T. J., NAHORSKI, S. R., HUNT, N . H., DAWBORN, J. K., LOOMBES, R. S.
and UNDERWOOD, J. C. S. - Characterization of p-adrenergic receptor linked to adenylate cyclase in a human cancer cell line (COLO 16). Clin. Sci. Mol. Med. 55: 23-29 (1978).
54. MEARES, R. and GROSE, D. - On depersonalization in adolescence: A consideration from the viewpoint of habituation and "Identity", Brit. J. Med. Psychol. (December 1978).
55. MEARES, R. and HOBSON, R. - The persecutory therapist. Digest of Neurology and Psychiatry, Institute of Living, Connecticut, 52 (1978).
56. MEARES, R., GRIMWADE, J. and WOOD, C. - A possible relationship between anxiety in pregnancy and peripheral depression. Inventory of Marriage and Family Literature, Vol. 5, ed D. Olson, and K. Dahl, St. Paul, University of Minnisota, Family of Social Science (1978).
57. MENDELSOHN, F. A. O. and KACHEL, C. D. - Stimulation of aldosterone production from zona glomerulosa cells in vitro by angiotensins I , I I and I I I . Proc. Endocr. Soc. Aust. 21:
69 (1978).
58. MORGAN, T., A D A M , W. R., GILLIES, A., WILSON, M . , MORGAN, G. and CARNEY, S. - Hypertension treated by salt restriction. Lancet 8058: 227-230 (1978).
59. MORGAN, T., GILLIES, A., MORGAN, G. and A D A M , W. R. - The effect of a and P adreno receptor blocking drug (Labetalol) in the treatment of severe resistant hypertension.
Med. J. Aust. I : 393-396 (1978).
60. MURRAY, R. M . L., WIGG, D. W. and PITT, P. - Hypothalamic-pituitary function following cranial irradiation of non-pituitary tumours. Proc. Endocr. Soc. Aust. 21: 46 (1978).
61. McKENZIE, I . F. C. and HENNING, M . - The differential destructive and enhancing effects of anti-H-2K, H2D and anti-la antisera on murine skin allografts. J. Exp. Med. 147:
611 (1978).
62. McNEIL, J. and LOUIS, W. J. - An open study of the anti-hypertensive efficacy of metoprolol. Med. J. Aust. 2: 123-125 (1978).
63. McPHERSON, A. J., McKENZIE, I . F. C , FRASER, K. and CASTALDI, P. A. - Hereditary C2 deficiency associated with immune complex disease. Aust. J. Exp. Biol. and Med. Sci. 56: 81-98 (1978).
64. PARISH, C. R., HIGGINS, T. J. and McKENZIE, I . F. C. - Comparison of antigens recognized by xenogeneic and allogeneic anti-la antibodies. Evidence for two classes of la antigens. Immunogenetics 6: 343-354 (1978).
65. PARISH, C. R. and McKENZIE, I . F. C. - A detailed serological analysis of a xenogeneic anti-la serum. Immunogenetics 6: 183-196 (1978).
66. PARISH, C. R. and McKENZIE, I . F. C. - A sensitive rosetting method for detecting subpopulations of lymphocytes which react with alloantisera. J. Immunol. Methods 20: 173-
183 (1978).
67. SANDRIN, M . S., POTTER, T. A., MORGAN, G. M . and McKENZIE, I . F. C. - Detection of mouse alloantibodies by rosetting with protein-A coated sheep red cells.
Transplantation 26: 126 (1978).
68. SEEMAN, E. and JERUMS, G. - Urinary protein patterns in acute and long term diabetes.
Proc. Aust. Diabetes Soc., Abstract 54 (1978).
69. SEWELL, R. B. and SMALLWOOD, R. A. - The recognition and treatment of the irritable bowel syndrome. Aust. Family Physician 7: 899 (1978).
144 FACULTY OF MEDICINE
70. SEWELL, R. B„ HOFFMAN, N . E. and SMALLWOOD. R. A. - Bile acid structure and biliary lipid secretion I I . A comparison of three hydroxy and two keto bile acids. Amer. J.
Phvsiol. 234: E637 (1978).
71. SEWELL, R. B., HOFFMAN, N . E. and SMALLWOOD. R. A. - The consequences of ileal dysfunction: An approach to management. Med. J. Ausi. 2: 598 (1978).
72. SEWELL, R. B., SMALLWOOD, R. A. and HOFFMAN. N . E. - The management of diarrhoea due to ileal dvsfunction. Ausi. N.Z. J. Med. 8: 555 (1978).
73. SYMINGTON, G., LEONARD, J. and VAJDA, F. J. E. - Sodium valproate in Huntington's Chorea. Am. J. Phvchiatrv 135(3): 352-354 (1978).
74. VAJDA, F. J. E., DRUMMER, O. H. O., MORRIS. P. M„ McNEIL. J. J. and BLADIN, P. F. - Gas chromatographic measurement of plasma levels of sodium valproate:
tentative therapeutic range of a new anticonvulsant in thc treatment of refractory epileptics.
Clin. Exp. Pharmacol. Physiol. 5: 67-73 (1978).
75. VAJDA, F. J. E., McNEIL. J.. MORRIS. P. M., DRUMMER, O. H. O. and BLADIN, P.
F. - Sodium valproate in refractory epilepsy. Ausi. N.Z. J. Med. 8: 46-51 (1978).
76. VAJDA, F. J. E., M I H A L Y , G., MILES, J., DONNAN, G. and BLADIN, P. F. - Rectal administration of sodium valproate in status epilepticus. Neurologv (Minneapolis) 28: 897 (1978).
77. WARK, J. D. and LARKINS, R. G. - Pulmonary oedema following propranolol therapy in two cases of phaeochromocvtoma. Brit. Med. J. I : 1395-1396 (1978).
78. WILEY, J. S. - Cation fluxes in Rh null red cells. Blood. 555-556 (1978).
79. YAP, K. L., ADA, G. L. and McKENZIE, I . F. C. - Transfer of specific cytotoxic T lymphocytes protects mice innoculatcd with influenza virus. Nature 273: 238 (1978).
80. YEOMANS, N . D. — Secretory granules in differentiating mucous cells in rat fundic mucosa.
Gastroenterol. Clin. Biol. (Paris) 2: 925 (1978).
281. YEOMANS, N . D. and MILLAR, S. J. — Transport and secretion of mucus in antral surface cells: role of microfilaments. Aust. N.Z. J. Med. 8: 554 (1978).
82. YEOMANS, N . D. and MILLAR, S. J. - Effects of cytochalasin B on transport and secretion of mucus by surface cells of gastric antrum. Gastroenterology 74: 1114 (1978).
83. YEOMANS, N . D. and MILLAR, S. J. - Synthesis, transport and secretion of mucus by- surface mucous cells of gastric antrum: effect of cytochalasin B. Proc. VI World Congress Gastroenterol., Editorial Garsi. Madrid, 99 (1978).
THESES PASSED FOR HIGHER DEGREES Doctor of Philosophy
1. CONWAY, E. L. — Interactions of a-methyldopa with aminergic pathways in the central nervous system
2. CULVENOR, A. C. — The subcellular distribution and regulation of noradrenaline synthesizing enzymes
3. HOROWITZ, J. — Reactivity of an isolated vein preparation and its use to characterise vasoactivity of plasma proteins
Master of Science 4. BUTTIGIEG, C. F. — Control of renin release in vitro
THESES IN PROGRESS
MEDICINE - AUSTIN HOSPITAL PhD Theses in Progress CAMPBELL, D. C. — Control of aldosterone secretion
DUFFY, S. — Exchangeable sodium and experimental hypertension
GI RA U D, A. S. — Comparative structural and functional studies ofthe gastrointestinal tract in the phylum chordata
HOGARTH, M. — Hybridoma production as a source of alloantibodies LOVELAND, B. - Graft rejection in the mouse
MICHAELIDES, M. — Functional studies bv Lv antigens in the mouse MORGAN, G. - Studies of H-2 mutants
POTTER, T. M. — Genetics of Ly antigens in the mouse SANDRIN, M. — la antigens in man
MEDICINE 145 BSc (Hons) Thesis in Progress
THOMSON, C. — Surface phenocyte of a suppressor cell in delayed type hypersensitivity MSc Theses in Progress
RIGLAR, A. — Detection of circulating immune complexes
BUI, A. - Mechanism of volume regulation and membrane fluidity of human lymphocytes MD Theses in Progress
MARSHALL. A. W. — Hepatic transport of endogenous and xenobioiic organic compounds SEWELL. R. B. — The ontogeny and physiology of bile formation
REPATRIATION GENERAL HOSPITAL PhD Theses in Progress
FINDLAY, D. M. — Calcitonin in human tumours
WARK, J. D. - The hormones of calcium and bone homeostasis
CLINICAL PHARMACOLOGY AND THERAPEUTICS PhD Theses in Progress
CHRISTOPHIDIS, N. - Pharmacokinetics of cytotoxic drugs
DRUMMER, O. H. O. - Structure activity relationships on adrenoceptors DYNON, M. — Noradrenaline synthesizing enzymes
GUNDLACH, A. L. - Interaction between central neurotransmitters MIHALY, G. — Clinical pharmacology of anli-convulsants
McNEIL, J. J. - Clinical and pharmacokinetic studies of beta blockers
McQUEEN, A. — The effects of serotonin on blood pressure and social dominance in rats MSc Thesis in Progress
LUCAS, U. I. — Pharmacology of cancer chemotherapy drugs SUBSTANTIAL GRANTS RECEIVED Grants have been received as follows:
National Health and Medical Research Council: A physiological study of attachment.
National Health and Medical Research Council: Lymphocyte and thyroid status.
National Health and Medical Research Council: Tissue renin-angiotensin system in experimental hypertension.
National Health and Medical Research Council: The mucoid cells ofthe gastric mucosa: their role in gastric physiology and pathophysiology.
National Health and Medical Research Council: Dopamine and the renal response to mineralocorticoids.
National Health and Medical Research Council: Bile acid structure and biliary lipid secretion.
National Health and Medical Research Council: Foetal bile acid metabolism.
National Health and Medical Research Council: Amino acid transmitters in central nervous system diseases.
National Health and Medical Research Council: The significance of brain adrenaline and its role in blood pressure regulation and hypertension.
National Health and Medical Research Council: Studies in transplantation immunology.
National Health and Medical Research Council: Cell surface antigens of lymphocytes and tumour cells in the mouse.
National Heart Foundation: Adrenergic transmitters and receptors and blood pressure regulation and treatment.
146 FACULTY OF MEDICINE
National Heart Foundation: Specific labelling and isolation of cardiac beta adreno receptors using radioactive phot-affinity agents.
National Heart Foundation: Pharmacokinetics and clinical evaluation of anti-arrhythmic drugs.
National Heart Foundation: Control of aldosterone secretion from isolated zona glomerulosa cells.
National Heart Foundation: Role of prostacyclin in thrombotic disease.
Life Insurance Medical Research Fund of Australia and New Zealand: Platelet abnormalities in diabetes.
Life Insurance Medical Research Fund of Australia and New Zealand: Structure activity relationship of beta adreno-receptor drugs and the relationship of alterations of beta adrenoreceptors to disease states.
Australian Kidney Foundation: Hormone responsiveness in renal failure.
Australian Kidney Foundation: Abnormalities of Vitamin D metabolism in renal failure.
Australian Tobacco Research Foundation: Studies of the mechanism of the peptic ulcerogenic effects of tobacco smoking.
Australian Tobacco Research Foundation: Effects of smoking on prostaglandin mediated platelet function.
Australian Tobacco Research Foundation: The production of la antigenic specificities in mouse and man and their relationship to smoking and lung cancer in man.
Australian Tobacco Research Foundation: A study of the effect of tobacco smoking on an individual's interrelationship with his sensory and social environment.
Anti-Cancer Council of Victoria: Pharmacokinetics of anti-cancer drugs.
Anti-Cancer Council of Victoria: Prostaglandins in the pathogenesis of malignant hypercalcaemia.
Anti-Cancer Council of Victoria: Phenotypic characterization of human leukaemias and lymphomas.
Anti-Cancer Council of Victoria: Cytosine arabinoside transport in acute myeloid leukaemia of man.
Clive and Vera Ramaciotti Foundation: Comparative ultrastructural and functional studies of the gastric mucosa.
Clive and Vera Ramaciotti Foundation: Equipment grant for biological research.
Department of Veterans' Affairs: Studies of Ragets' Disease, renal bone disease and metastatic bone cancer. Complications of diabetes.
Department of Veterans' Affairs: Role of altered renal sensitivity to aldosterone in hypertension.
John Claude Kellion Foundation: Diabetes and vascular disease.
John Claude Kellion Foundation: Diabetic nephropathy.
National Institutes of Health: Ia antigenic specificities in mouse and man.
Utah Foundation: Equipment grant for Vitamin D research programme.