HOWARD FLOREY INSTITUTE 185 11. The metabolism of angiotensin.
12. Ovine renin substrate purification.
13. Regulation of renin and antidiuretic hormone and the renal excretion of sodium and water during changes in body fluid balance.
14. Hypothalamic control of salt and water balance.
15. Factors influencing salt appetite in sodium deficiency.
16. Renal and adrenal morphology in salt deficiency.
17. Hormonal control of salt appetite during pregnancy and lactation.
18. Phosphate appetite in phosphorus deficiency.
19. The mechanism of ACTH and adrenal steroid hypertension.
20. Renal hypertension.
21. Synthesis of human chorionic gonadotrophin peptides for the study of immunological regulation of human fertility.
22. Isolation and sequence determination of relaxin.
23. Synthesis of relaxin.
24. Development of radioreceptor assay for relaxin.
25. Sequence determination of human prolactin.
26. Development of radioreceptor assay for prolactin.
27. Synthesis of structural analogues and fragments of human parathyroid hormone.
28. Development of improved methodologies for solid state synthesis of peptides.
29. The measurement and pharmacokinetics of psychotropic drugs.
PUBLISHED WORK Chapters of Books
1. W I N T O U R , E. M . , B R O W N . E. H . , D E N T O N , D. A . , H A R D Y . K. J., McDOUGALL, J. G., ROBINSON, P. M„ ROWE. E. J. and WHIPP, G. T. - In vitro and in vivo Adrenal Cortical Steroid Production by Foetal Sheep: Effect of Angiotensin I I , Sodium Deficiency, ACTH, in Research on Steroids, VII. ed Conti, Elsevier-North Holland, 475-485 (1977).
2. DENTON, D. A., McKINLEY, M . H.. NELSON, J. F. and WEISINGER, R. S. - Pregnancy, Lactation and Hormone Induced Mineral Appetites, in Food Intake and Chemical Senses, eds Y. Katsuki, M.Sato, S. Taki and Y. Oomura, University of Tokyo Press, Tokyo, 247-261 (1977).
3. MOUW, D. R., VANDER, A. J., A B R A H A M , S. F„ BLAIR-WEST, J. R., COGHLAN, J. P., DENTON, D. A., McKINLEY, M . J. and SCOGGINS. B. A. - Effects of Changing CSF-NaCl Concentration on Renal Function, Renin, Angiotensin, and Aldosterone, in Central Actions of Angiotensin and Related Hormones, eds J. P. Buckley and C. M . Ferrario, Pergamon Press, Great Britain (1977).
4. N I A L L , H. D. - Automated Methods for Sequence Analysis in The Proteins, Vol. I l l , eds H. Neurath and R. L. Hill, Academic Press, New York, 179-238 (1977).
5. N I A L L , H. D. — Evolution of Structure and Function in Natural Peptides, in Peptides, eds M . Goodman and J. Meienhofer, John Wiley and Sons, New York, 127-135 (1977).
6. N I A L L . H. D. - Modern Micromethods for Sequence Analysis, in Protein Structure and Evolution, eds L. Fox, Z. Deyl and A. Blazej. Marcel Dekker, New York, 5-22 (1976).
7. N I A L L , H. D. - Peptide Hormones: Evolutions of a Sequence Dependent Communications Svstem, in Protein Structure and Evolution, eds L. Fox, Z. Deyl and A. Blazej, Marcel Dekker, New York, 429-438 (1976).
8. SCOGGINS, B. A. - Adrenal Steroid Production by the Koala, in Taronga Symposium on Koala Biology Management and Medicine (Svdnev). Publ. Zoological Parks, Board of NSW, ZI98(I978).
9. de KRETSER, D. M„ BREMNER, W. J., BURGER, H . G., HUDSON, B.. IRBY. D. C , KERR, J. B. and LEE, V. W. K. - The Interaction Between the Hypothalamus, Hypophyseal System and the Testis in Mammalian Species, in Reproduction and Evolution. Proc. 4th Symposium of Comparative Biologv of Reproduction, eds J. H. Calabv and C. I I. Tvndale-
Biscoc. Australian Acad. Sci. Press, 111-119 (1977).
10. SCOGGINS, B. A. and MAGUIRE. K. P. - Measurement of Tricyclic Antidepressant Drugs, in Handbook o f Studies on Depression, ed G. D. Burrows, Excerpta Medica, Amsterdam, 151-157 (1977).
Articles
11. McKINLEY, M . J., DENTON, D. A. and WEISINGER, R. S. - Sensors for Antidiuresis and Thirst - Osmoreceptors or CSF Sodium Detectors. Brain Res. 141: 89-103 (1978).
12. TREGEAR, G. W. - The Chemistry and Physiology of Parathy roid Hormone. Proc. 6th Asia and Oceania Congress o f Endocrinology I : 53-56 (1978).
186 FACULTY OF MEDICINE
13. BRADSHAW, R. A. and N I A L L , H. D. - Insulin-Related Growth Factors. Proc. 6th Asia and Oceania Congress o f Endocrinology I : 358-364 (1978).
14. ISAACS. N . . JAMES. R.. N I A L L , H. D.. BRYANT-GREEN-WOOD, G., DODSON. G., EVANS, A. and NORTH, A. C. T. - Relaxin and Its Structural Relationship lo Insulin.
Nature 27i: 2/S-28 i (i 978).
15. LINGWOOD, B., HARDY, K. J.. COGHLAN, J. P. and WINTOUR. E. M . - Thc Effect or Aldosterone on Urine Composition in the Chronically Cannulated Ovine Foetus. J. Endocr.
76: 553-554 (1978).
16. DENTON, D. A., McKINLEY, M . , NELSON. J. and WEISINGER, R. S. - Thc Hormonal Genesis of Mineral Appetites. Xlth Acta Endocrinologica Congress (Lausanne), Acta Endocrinologica 85. (S2I2): 3-4 (1977).
17. DENTON, D. A., BLAINE. E. H.. McKINLEY, M . J., NELSON, J. F. and WEISINGER, R. S. - The Chemical and Hormonal Control of Salt and Water Intake. Proc. 27th Int.
Congr. Phvsiol. Sci. (Paris). X I I : 31-32 (1977).
18. McKINLEY, M . J., BLAINE. E. H., DENTON, D. A., HATZIKOSTAS, S. and WEISINGER, R. S. - Furosemide Induced Water Drinking in Sheep. Proc. Vlth International Conference on the Physiology of Food and Fluid Intake (Paris) (1977).
19. WEISINGER, R. S., DENTON, D. A. and McKINLEY, M. J. - Effect of Sell-Determined Intravenous Infusion of Various Solutions in the Satiation of Sodium Appetite of Sodium Deficient Sheep. Proc. Vlth International Conference on the Phvsiologv of Food and Fluid Intake (Paris) (1977).
20. N I A L L . H. D. - Microscquence Analysis of Biologically Active Proteins and Peptides. Pure and Appl. Chem. 49: 1323-1328 (1977).
21. WANG, C , YOUNG. R. T. T., COGHLAN, J. P., ODDIE, C. J.. SCOGGINS. B. A. and STOCKIGT, J. R. — Hypertension Due to 17a Hydroxylase Deficiency in a Chinese Female.
Aust. N.Z. J. Med. 8: 295-299 (1978).
22. BAKER, H . W. G., BURGER, H. G., de KRETSER, D. M . , EDDIE, L. W., HIGG1NSON, R. E., HUDSON, B. and LEE, V. W. K. - Studies on Purification of Inhibin from Ovine Testicular Secretions Using an in vitro Bioassay. Intern. J. Adnrologv. Suppl. 2:
115-124 (1978).
23. SCOGGINS, B. A., BUTKUS, A., COGHLAN, J. P., DENTON, D. A., FAN, J. S. K„
HUMPHERY, T. J. and WHITWORTH, J. A. - ACTH-induced Hypertension in Sheep:
A Model (or the Study or the Effect of Steroid Hormones on Blood Pressure. Circ. Res.43(]):
176-81 (1978).
24. BROWN, E. H., COGHLAN, J. P., HARDY, K. J. and WINTOUR. E. M . - Aldosterone, Corticosterone, Cortisol, 11-Deoxycorticosterone, 11-Deoxycortisol Concentrations in the Blood orChronically-Cannulatcd Ovine Foetuses: Effect of ACTH. Acta Endocrinologica 88:
364-374 (1978).
25. BLAIR-WEST, J. R., BROOK, A. H., GIBSON, A., MORRIS. M . and PULLAN, P. T.
-Antidiuretic Hormone/Plasma Renin Concentralion (PRC) Relation in Rehydration. Proc.
Vllth International Congress o f Nephrology (Montreal): U2 (1978).
26. DENNERSTEIN, L., WOOD, C , HUDSON, B. and BURROWS, G. - Clinical Features and Plasma Hormone Levels After Surgical Menopause. Obst. N.Z. J. Obst. and Gvn. 18: 202- 205 (1978).
27. WEISINGER, R. S., DENTON, D. A., McKINLEY, M . J. and NELSON, J. F. - ACTH Induced Sodium Appetite in the Rat. Pharmacol. Biochem. and Behav. 8: 339-342 (1978).
28. WINTOUR. E. M„ COGHLAN, J. P., ODDIE, C. J., SCOGGINS. B. A. and WALTERS, W. A. W. — A Sequential Studv of Adrenocorlicosleroid Levels in Human Pregnancy. Clin. Exp. Pharm. Physiol. 5: 399-403 (1978).
29. ROSENBLATT, M..SEGRE, G. V., TREGEAR, G. W., SHEPARD. G. I . . . TYLER, G. A.
and POTTS, J. T. Jr. - Human Parathyroid Hormone: Synthesis and Chemical, Biological, and Immunological Evaluation of the Carboxvl-Terminal Region. Endocrinology I03(i): 978- 984 (1978).
30. BURROWS, G. D., VOHRA, J., DUMOVIC, P., MAGUIRE, K., SCOGGINS, B. A. and DAVIES, B. - Tricyclic Antidepressant Drugs and Cardiac Conductions. Neuro- Psychopharmac. 1: 329-334 (1977).
31. BURROWS, G., MAGUIRE, K.. STEVENSON, J„ SCOGGINS, B. A. and DAVIES. B. - Plasma Nortriptyline and Clinical Response: A Study Using Changing Levels. Psychol. Med.
7: 87-91 (1977).
32. MAGUIRE, K. P., BURROWS, G. D., NORMAN, T. R. and SCOGGINS, B. A. - A Radioimmunoassav for Nortriptyline (and Other Tricyclic Antidepressants) in Plasma. Clin.
Chem. 24(4): 549 (1978).
33. EDDIE, L. W., BAKER, H. W. G., DULMANIS, A.. HIGGINSON, R. E. and HUDSON, B. - Inhibin from Cultures of Rat Seminiferous Tububles. J. Endocrin. 78(2):
207-224 (1978).
HOWARD FLOREY INSTITUTE 187 34. GOLTZMAN, D., C A L L A H A N , E. N„ TREGEAR, G. W. and POTTS, J. T. Jr. -
Influence of Guanvl Nucleotides on Parathyroid Hormone - Stimulated A'denylyl Cyclase Activity in Renal Cortical Membranes. Endocrinology, 103(4): 1352-1361 (1978).
35. BUTKUS, A., COGHLAN, J. P., DENTON, D. A.', FAN, J. S. K., HUMPHERY, T. J., SCOGGINS, B. A. and WHITWORTH, J. A. - ACTH induced Hypertension in Sheep: a Model for the Study of the Effect of Steroid Hormones on Blood Pressure. Proc. 6th Asia and Oceania Congress of Endocrinology 2: 557-565 (1978).
36. WEISINGER, R. S„ DENTON, D. A. and McKINLEY, M. J. - Effect of Self-Determincd Intravenous Infusion of Hypertonic NaCl on Na Appetite of Sheep. J. Comp. Phvsiol.
Psvchol. 92: 552 (1978).
37. LINGWOOD, B., HARDY, K. J., HORACEK, I . , McPHEE, M . L., SCOGGINS, B. A. and WINTOUR, E. M. - The Effect on Antidiuretic Hormone on Urine Flow and Composition in the Chronically-Cannulatcd Ovine Foetus. Qrtly. J. Exp. and Phvsiol. 63: 315-330 (1978).
38. WHIPP, G. T., C O G H L A N , J. P., SHULKES, A. A., SKINNER, S. L. and WINTOUR, E. M . - Regulation of Aldosterone in the Rat Effect of Oestrous Cvclc, Pregnancy, and Sodium Status. Aust. J. Exp. Biol. Med. Sci.. 56(5): 545-551 (1978).
39. FERNLEY, R. T., COGHLAN, J. P., CRAN. E. J., FEI, T. W., SCOGGINS, B. A. and McGREGOR, A. - Conversion of Angiotensin I to Angiotensin I I in the Sheep. Clin. Exp.
Pharm. and Physiol.. 5(5): 439-448 (1978).
40. McDOUGALL, J. G., BARNES, A. M . , C O G H L A N , J. P., DENTON, D. A., F A N . J . S . K., SCOGGINS, B. A. and W H I T W O R T H , J. A. - Thc Effect of Corticotropin (ACTH) Administration on the Pressor Action of Angiotensin I I , Noradrenaline and Tvramine in Sheep. Clin. Exp. Pharm. and Phvsiol.. 5(5): 449-455 (1978).
41. BURROWS, G. D'., N O R M A N . T. R., MAGUIRE, K . ' P . , RUBENSTEIN, G., SCOGGINS, B. A. and DAVIES, B. - A New Antidepressant Butriptyline: Plasma Levels and Clinical Response. Med. J. Aust. 2: 604-606 (1977).
42. BURROWS, G. D., VOHRA, J., DUMOVIC, P., SCOGGINS, B. A. and DAVIES, B. - Cardiological Effects of Nomifensine, A New Antidepressant. Med. J. Aust. I : 341-343 (1978).
43. CAHILL, F., COGHLAN, J. P., SCOGGINS, B. A., WHITWORTH, J. A. and WINTOUR, E. M. - Blood Pressure and Metabolic Effects of ACTH Administration in Pregnant Sheep. J. Endocrinol. 78: 301-302 (1978).
44. BRADSHAW. R. A. and N I A L L , H. D. - Insulin-Related Growth Factors. Trends in Biochem. Sci.. 3(12): 274-278 (1978).
45. COGHLAN, J. P., FAN, J. S. K., SCOGGINS. B. A. and SHULKES, A. A. - Measurement of Extracellular Fluid Volume and Blood Volume in Sheep. Aust. J. Biol. Sci.
30: 71-83 (1977).
46. WEISINGER, R. S.. COGHLAN, J. P., DENTON. D. A., FAN, J.. HATZIKOSTAS, S., McKINLEY, M. J., NELSON, J. F. and SCOGGINS, B. A. - ACTH Induced Sodium Appetite. Proc. Inter. Union Phvsiol. Sci. X I I I : 806 (1977).
47. McKINLEY, M. J., DENTON, D. A. and WEISINGER. R. S. - Sensors in thc Brain for Antidiuresis and Thirst - Osmoreceptors or CSF (Na) Detectors? Proc. Inter. Union. Phvsiol.
Sci. X I I I : 495 (1977).
48. BAKER, H. W. G. - Scientific Basis of Contraception in thc Male. Bulletin of The Post- Graduale Committee in Medicine, University of Sydney, 34(2): 34-41 (1978).
THESES PASSED FOR HIGHER DEGREES Doctor of Philosophy
1. FEI, D. T. — The Metabolism of Angiotensin
2. WHITWORTH, J. A. - Hormonal and Renal Factors in Experimental and Clinical Hypertension
Master of Science
3. BROWN, E. H. — Adrenal Steroidogenesis in the Ovine Foetus
4. HATZIKOSTAS, S. - Influence of the Central Nervous System on Sodium and Water M etabolism
PhD Theses in Progress
EDDIE, L. W. - Studies in the Regulation of Gonadotrophin Secretion HUMPHERY. T. J. — Experimental Hypertension in Sheep
18B FACULTY OF MEDICINE
MSc Theses in Progress
VERONI, M. O. - Synthesis and Evaluation of Relaxin Related Peptides LINGWOOD, B. — Regulation of Amniotic Fluid Volume and Composition GRAHAM, W. F. - Mechanisms of Steroid Induced Hypertension
SUBSTANTIAL GRANTS RECEIVED Grants have been received as follows:
NH & MRC: Institute Grant.
State Government of Victoria: Institute Grant.
Anti-Cancer Council of Victoria: Prolactin Receptor Studies.
Avenal Investments: Institute Grant.
Ford Foundation: Reproductive Endocrinology.
McGarrcn Trust Fund: Hypertension.
National Heart Foundation: Angiotensin Metabolism and ACTH Hypertension.
Searle (Australia): Hypertension.
Utah Foundation: Automatic Processing of Data from Hypertension Studies.
World Health Organization: Peptide Chemistry Research and Reproductive Research.