Chairman of department: Professor D. O. White Professors ALFRED JAMES PITTARD
DAVID OGILVIE WHITE Readers W I L L I A M BOYLE
I A N H A M I L T O N HOLMES NANCY M I L L I S
Senior Lecturers CHRISTINA CHEERS JOAN FORREST GARDNER DORIS MARY GRAHAM BRIAN HODGSON
RUSSELL GEORGE WILKINSON
GWENDOLYN LESLEY GILBERT (Part-time) DOROTHY JOAN SCHIAVONE (Part-time) Senior Tutors ROSEMARY DAVIDSON (Part-time)
LYNETTE HOWDEN (Part-time) ENE READE
DOROTHY SLATER (Part-time) NEVILLE JOHN TUDROSZEN
Senior Associate and Director, Microbiological Diagnostic Unit JOCELYN ROBERT LANE FORSYTH
Research Fellows ELIZABETH MARGOT ANDERS HERBERT JOHN BAVOR
ROBERT BERNATZKY A L A N BRESCHKIN HELEN CAMAKARIS ROBERT BRENT DAVEY GEOFFREY KELLOW DAVID JACKSON IEVA LAZDINS SUZANNE RODGER ROGER DIETER SCHNAGL
RESEARCH TOPICS IN PROGRESS A. BACTERIAL GENETICS AND PHYSIOLOGY
1. Comparative studies of the three isofunctional DAHP synthetases from Escherichia coli K12.
2. Regulation of aromatic biosynthesis in Escherichia coli K12.
3. Transmissible antibiotic resistance in enteric organisms.
4. Metabolic control mechanisms in Bacillus brevis:
(a) function of polypeptide antibiotics;
(b) biosynthesis of diaminopimelic acid, dipicolinic acid and lysine.
B. INDUSTRIAL AND APPLIED MICROBIOLOGY 1. Microbial studies in Westernport and Port Phillip bays.
2. Metabolism of a-pinene by a pseudomonad.
3. Evaluation of chemical disinfectants.
4. Laminar flow ventillation and hospital infection control.
C. MEDICAL MICROBIOLOGY 1, The role of Chlamydia in genital infection.
2, Trachoma:
(a) Clinical, microbiological and immunological investigation among Australian aborigines.
(b) Immune response of mice to trachoma.
3. Brucella serology.
4. Antibiotic resistance in anaerobic bacteria.
157
158 FACULTY OF MEDICINE
D. IMMUNOLOGY 1. Theoretical immunology and human biology.
2. Transplantation immunology.
(a) An analysis of the role cf the antigen signal in allograft immunity.
(b) The production and analysis of hybridomas.
3. Genetic and cellular determinants regulating immunity to intracellular bacteria.
E. VIROLOGY
1. Biochemistry, serology and epidemiology of rotaviruses and corona-like viruses. Aetiology of diarrhoea! disease in aboriginals, and feasibility studies for rotavirus immunization.
2. In vitro studies of antiviral immunity:
(a) Antigenic determinants on influenza viral hemagglutinin;
(b) T-B cell interaction in immunological memory;
(c) Natural killer cells and ADCC;
(d) Fc receptors in herpes virus infection;
(e) Recovery and persistence in reovirus infections.
PUBLISHED WORK Books
1. BURNET. F. M . and WHITE, D. O. - Natural History of Infectious Disease. Italian and Spanish translations, Cambridge University Press, (I978).
2. FENNER, F. J. and WHITE, D. O. - Medical Virologv. Russian translation. Academic Press. New York, (1978).
Chapters of Books
3. BURNET, F. M . - Clonal Selection and After, in Theoretical Immunotogv, ed G. I . Bell, Marcel Dekker, New York, 63-83 (1978).
4. HOLMES, I . — Reoviridae: Orbiviruses, in C.R.C. Handbook of Clinical Laboratory Science:
Virology and Ricketlsiologv, eds G. D. Hsiung and R. H. Green, CRC Press Inc., Palm Beach (1978).
5. HOLMES, I . and SHOPE, R. E. - Bunyaviridac, in C.R.C. Handbook of Clinical Laboratorv Science: Virology and Ricketlsiologv. eds G. D. Hsiung and R. H. Green, CRC Press Inc., Palm Beach (1978).
6. MILLIS, N . F: - Microbial Corrosion of Metallic and Non-Metallic Structural Materials, in Fundamentals of Corrosion: lis Cases and Preventions. Vol. VII., Monash University (1978).
Articles
7. BRITZ, M . L. and WILKINSON, R. G. - Purification and Properties of Bcta-Lactamasc from Bacteroides fragilis. Antimicrob. Agents Chemother. 13: 373-382 (1978).
8. BRITZ, M . L. and WILKINSON, R. G. - Chloramphenicol Acetyl Transferase of Bacteroides fragilis. Antimicrob. Agents Chemother. 14: 105-111 (1978).
9. BURNET, F. M . - Man and his Genes. Biol. Med. 21: 505-514 (1978).
10. BURNET, F. M . - Cancer: Somatic-Genetic Considerations. Adv. Cancer Res. 28: 1-29 (1978).
11. CAMERON, D. J. S., BISHOP, R. F., VEENSTRA. A. A., BARNES, G. L., HOLMES, I . H. and RUCK. B.J. - Pattern of Shedding of Two Noncultivable Viruses in Stools of Newborn Babies. J. Med. Virol. 2: 7-13 (1978).
12. CHEERS, C. and McKENZIE, I. F. C. - Studies ofthe Resistance/Susceptibility of Mice to Bacterial Infection. I . Genetics of Listeriosis. Inf. Imm. 19: 755-762 (1978).
13. CHEERS, C , McKENZIE, I . F. C , PAVLOV, H., WAID, C. and YORK, J. - Studies of the Resistance/Susceptibilitv of Mice to Bacterial Infection. I I . Course of Listeriosis in
Resistant or Susceptible Mice. Inf. Imm. 19: 763-770 (1978).
14. CHEERS, C , McKENZIE, I . F. C. and MANDEL, T. E. - Genetics and Mechanisms of Resistance or Susceptibility to Murine Listeriosis. Zeitschrift Immunilalsforsch. 154: 305 (1978).
15. GHOSE. L. H., SCHNAGL, R. D. and HOLMES, I . H. - Comparison of an Enzyme- Linked Immunosorbent Assay for Quantitation of Rotavirus Antibodies with Complement Fixation in an Epidemiological Survey. J. Clin. Microbiol. 8: 268-276 (1978).
MICROBIOLOGY 159 16. HUTCHINSON, E. M . S. and TAPLIN. J. - Bacillus Cereus in Food. Food Tech. Ausi. 30:
329-333 (1978).
17. JACKSON, D. C , RUSSELL, R. J., WARD, C. W. and DOPHEIDE, T. A. - Antigenic Determinants of Influenza Virus Hemagglutinin. I . Cyanogen Bromide Peptides Derived from A/Memphis/72 Hemagglutinin Possess Antigenic Activity. Virology 89: 199-205 (1978).
18. MADRASO. E. D. and CHEERS, C. - Polyadenylic Acid - Polyuridylic Acid (Poly A:U) and Experimental Murine Brucellosis. I . Effect of Single- and Double-Stranded Polynucleotides on Brucella abortus in vivo and in vitro. Immunol. 35: 77-85 (1978).
19. MADRASO, E. D. and CHEERS, C. - Polyadenylic Acid-Polyuridylic Acid (Poly A:U) and Experimental Murine Brucellosis. I I . Macrophages as Target Cells of Poly A:U in Experimental Brucellosis. Immunol. 35: 77-85 (1978).
20. McTAGGART, S. P., BURNS, W. H„ WHITE, D. O. and JACKSON, D. C. - Fc Receptors Induced by Herpes Simplex Virus. I . Biological and Biochemical Properties. J.
Immunol. 121: 726-730 (1978).
21. PEEL, M . M . . EDSALL. G., WHITE, W. G. and BARNES. G. M . - Relationship between Lymphocyte Response to Tetanus Toxoid and Age of Lymphocyte Donor. J. Hvg. (Camb.) 80:
259-265 (1978).
22. PORTERFIELD, J. S., CASALS, J., CHUMAKOV, M . P., GAIDAMOVICH, S. Ya., H A N N O U N , C , HOLMES, I . H., HORZINEK, M . C , MUSSGAY, M . . OKER- BLOM, N„ RUSSELL, P. K. and TRENT, D. W. - Togaviridac. Intervirologv 9: 129-148 (1978).
23. RANA, C , FORSYTH, J. and SEMMENS, K. - Non-Specific (Non-Gonococcal) Urethritis. Med. J. Aust. 1: 409-410 (1978).
24. REICHERT, C. - Variables Affecting the Results of Kelscy-Sykes Tests. Aust. J. Hosp.
Pharm. 8: 126-132 (1978).
25. RUSSELL, R. J. and JACKSON, D. C. - Direct Solid Phase Radioimmunoassay for Measuring Antigenic Differences between the Hemagglutinins of Influenza Virus. / Immunol.
Meth. 22: 201-209 (1978).
26. SCHNAGL, H. Y. and BOYLE, W. - A Micro-Version of the MCr-Release Assay for Cytotoxic Lymphocytes. J. Immunol. Meth. 24: 79 (1978).
27. SCHNAGL, R. D. and HOLMES, I . H. - Coronavirus-Like Particles in Stools from Dogs, from Some Country Areas of Australia. Vet. Rec. 102: 528-529 (1978).
28. SCHNAGL, R. D., HOLMES, I . H. and MACKAY-SCOLLAY, E. M . - A Survey of Rotavirus Associated with Gastroenteritis in Aboriginal Children in Western Australia. Med.
J. Aust. 1: 304-307 (1978).
29. SCHNAGL. R. D., HOLMES, I . H. and MACKAY-SCOLLAY, E. M . - Coronavirus-Like Particles in Aboriginals and Non-Aboriginals in Western Australia. Med. J. Aust. I : 307-309 (1978).
30. SHIELD, L. K., WILKINSON, R. G. and RITCHIE, M . - Infant Botulism in Australia.
Med. J. Aust. 2: 157 (1978).
31. SHIELD, L. K., WILKINSON, R. G. and RITCHIE, E. M . - Infant Botulism - A New- Disease from an Old Organism. Med. J. Aust. 2: 238-239 (1978).
32. SMART, I . J., BOYLE, W. and MORRIS, P. J. - Daily Monitoring of the Immune Response to Various Allografts in Rats. Tissue Antigens I I : 20 (1978).
33. TAPLIN, J. - Typhoid and Other Overseas Acquired Infections. Food Tech. Aust. 30: 466- 469 (1978).
34. WATANABE, H., GUST. I . D. and HOLMES, I . H. - Human Rotavirus and its Antibody:
Their Coexistence in Faeces of Infants. / . Clin. Microbiol. 7: 405-409 (1978).
35. WHITE, D. O. and MACFARLAN, R. I . - Virus-Induced Killer Cells of Broad Specificity.
Internat. Virol. 4: 70 (1978).
Reports
36. BAULD. J. and M I L L I S , N. F. - Nitrification-Denitrification in Sediments of Port Phillip Bay. Internat. Symp. Microbial Ecology. Dunedin (1978).
37. FORSYTH. J. R. L. — Gilbert Islands: South Tarawa Sewerage Project. Commonwealth Department of Construction (1978).
38. FORSYTH, J. R. L., PINKARD, K. J. and STEWART. J. - The Prevalence of Helminthiasis in the Population of Melbourne. Reclaimed Water Committee, Victorian Ministry of Water Resources and Water Supply (1978).
THESES PASSED FOR HIGHER DEGREES Doctor of Medicine
1. SCHIAVONE, D. J. - Laminar Flow Ventillation and Hospital Infection Control
160 FACULTY OF MEDICINE
Doctor of Philosophy 2. BERTRAM, K. C. - Bacterial Degradation of 1,8-Cineole-
3. BRITZ, M. L. — Mechanisms of Drug Resistance in Anaerobic Gram-Negative Bacteria
**. \jL-ioiij^, ii. VJ/C"VIM fYificiiij i>y u i .tCuaomonaa on .ncr.Gi
5. RODGER, S. M. — Biochemical and Biophysical Characterization of Rotaviruses Master of Science
6. LEBEN, M. L. — T Cell Alloimmune Reactions In Vitro: A Study of the Specificities Involved 7. NG, K. M. — Studies on Genital Infection with Chlamydia Trachomatis in Selected Males in
Melbourne
THESES IN PROGRESS PhD Theses in Progress ACKERMAN, A. — Studies of Lymphocyte Membrane Antigens BASTARDO, J. W. — Characterization of Rotavirus Antigens BROWN, L. E. — Immune Response to Reovirus Infection COBBETT, C. — Control of Tyrosine Biosynthesis in E. coli DEFEYTER, R. - Shikimate Kinase in E. coli K12
GRANT, A. J. — Incompatibility and Other Interactions of Locally Isolated R Plasmids JENNINGS, S. — Immune Response of Mice to Trachoma
JOHNSON, I. — Studies of Polysaccharide Synthesising Enzymes of Oral Bacteria KELSO, M. A. - Role of Allo-antigen Preparations in Cell Mediated Immunity KENNY, P. - The Study of Hybridized Cells with Immunological Potential
MACFARLAN, R. I. — Specific and Non-Specific Cell-Mediated Immunity in Togavirus Infection
McLEAN, B. - Rotavirus Infection in Neonates
NISBET, I . — Epidemiological Studies of Trachoma in Aborigines in Northern Territory RAO, A. S. — Control o f the Flow of Carbon into Dipicolinate and Diaminopimelate During Sporulation in Bacillus brevis
RUSSELL, R. J. — Antigenic Determinants on Influenza Virus Hemagglutinins SCHNAGL, H. Y. — Methods of Specific Depletion of Allo-lmmune T Cells SMITH, M. L. - Studies on Rotaviruses
STEPHENS, J. H. G. - Nitrogen Transformations in Mangrove Sediments SYMONS, D. - Polypeptide Antibiotic Production and Sporulation in Bacillus brevis TUDROSZEN, N. J. — a-Pinene Metabolism by Pseudomonas putida
MSc Theses in Progress
CORNISH, E. C. - Isolation and Characterization of Plasmids Carrying Genes Concerned with Aromatic Amino- Acid Biosynthesis in E. coli
McTAGGART, S. M. - Fc Receptors Induced by Herpes Simplex Virus SUBSTANTIAL GRANTS RECEIVED Grants have been received as follows:
NH & MRC: Antigen Suppression of Allograft Response NH & MRC: Continuous Cell Lines Producing Specific Antibody
NH & MRC: Cellular Interactions in Cell Mediated Resistance to Bacterial Infection NH & MRC: Genetics and Mechanisms of Resistance and Susceptibility to Bacterial Infection NH & MRC: The Pathogenesis of Viral Infections: In Vitro Studies of Antiviral Immunity.
NH & MRC: Viral Enteritis
NH & MRC/Department of Aboriginal Affairs: Viral Gastroenteritis in Aboriginal Communities.
NH & MRC/Australian Department of Aboriginal Affairs: Clinical, Microbiological and Immunological Investigation of Trachoma in Aborigines at Three Centres in the Northern Territory.
ARGC: A Study of the Mechanisms Involved in the Establishment of a Flow of Carbon into Dipicolinate and Diaminopimelate during Sporulation in Bacillus brevis.
ARGC: Comparative Studies of the Three Isofunctional DAHP Synthetase from Escherichia coli KI2.
ARGC: Regulation of Aromatic Biosynthesis in Escherichia coli KI2.
Australian Department of Health/Royal Australian College of Ophthalmologists: Microbiological Investigation of Trachoma among Aborigines throughout Australia.
Ministry for Conservation, Victoria: Microbiological Investigation in Port Phillip and Westernport Bays.