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Formulasi dan Uji Efek Anti-Aging dari Krim Mengandung Ekstrak Kulit Buah Delima (Punica granatum L)

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Lampiran 2.

Surat pernyataan persetujuan ikut serta dalam penelitian

SURAT PERNYATAAN PERSETUJUAN IKUT SERTA DALAM

PENELITIAN

Saya yang bertandatangan di bawah ini :

Nama

:

Umur

:

Alamat

:

Telah mendapat penjelasan secukupnya bahwa saya akan melakukan uji

krim ekstrak kulit buah delima terhadap kulit sebagai sediaan krim anti-aging.

Setelah mendapat penjelasan secukupnya tentang manfaat penelitian ini dan efek

sampingnya, maka saya menyatakan

SETUJU

untuk ikut serta dalam penelitian

dari

Nailul Ramadhilla dengan judul “FORMULASI DAN UJI EFEK ANTI

-AGING DARI KRIM MENGANDUNG EKSTRAK KULIT BUAH DELIMA

(Punica granatum L), sebagai usaha untuk mengetahui apakah sediaan krim

anti-aging dari ekstrak kulit buah delima mampu atau tidak dalam memulihkan kulit

yang telah mengalami penuaan. Saya menyatakan sukarela dan bersedia untuk

mengikuti prosedur penelitian yang telah ditetapkan.

Persetujuan ini saya buat dengan penuh kesadaran dan tanpa paksaan dari

pihak manapun. Demikian surat pernyataan ini dibuat untuk dapat dipergunakan

sebagaimana mestinya.

Medan, 26 November 2014

Peneliti,

Sukarelawan,

(3)

Lampiran 3.

Gambar sampel

A

(4)

Lampiran 3.

(Lanjutan)

C

D

Keterangan: A: Buah delima

(5)

Lampiran 4.

Gambar alat

A B

C

Keterangan:

(6)

Lampiran 5.

Gambar sediaan krim

Krim sediaan setelah dibuat

Keterangan:

A : Krim A (blanko)

B : Krim B (ekstrak kulit buah delima 2,5%)

C : Krim C (ekstrak kulit buah delima 5%)

D : Krim D (ekstrak kulit buah delima 7,5%)

E

: Krim E (ekstrak kulit buah delima 10%)

(7)

Lampiran 6.

Gambar hasil uji evaluasi sediaan krim

A

B

Keterangan:

A: Gambar uji homogenitas sediaan

B: Gambar uji tipe emulsi sediaan

Blanko Krim 2,5% Krim 5% Krim 7,5% Krim 10%

(8)

Lampiran 7.

Gambar sediaan krim yang dibuat pada awal pembuatan dan gambar

krim penyimpanan 12 minggu

Gambar krim awal pembuatan

Gambar krim minggu ke 12

Keterangan:

A : Krim A (blanko)

B : Krim B (ekstrak kulit buah delima 2,5%)

C : Krim C (ekstrak kulit buah delima 5%)

D : Krim D (ekstrak kulit buah delima 7,5%)

E

: Krim E (ekstrak kulit buah delima 10%)

C

D

E

B

A

E

D

C

B

(9)

Lampiran 8.

Bagan Alir Proses Ekstraksi kulit buat delima

Diiris, dikeringkan dilemari

pengering (suhu 40-50

o

C), lalu

dihaluskan

Dimasukkan kedalam bejana

Ditambahkan pelarut etanol 70%

3,75L

Ditutup dengan penutup wadah dan

kemudian didiamkan selama 5 hari

Diaduk sehari sekali

Setelah 5 hari maserat disaring

dengan kain kemudian pada ampas

tambahkan cairan penyari 1,25 L

kemudiaan dimasukkan ke dalam

jerigen

Diuapkan dengan alat rotary

evaporator

500 g kulit buah

delima

Maserat kulit buah

delima

(10)

Lampiran 9.

Bagan Alir Proses Pembuatan Sediaan Krim Anti-aging

Ditimbang 12 gram asam stearat

5 gram sorbitol

Ditimbang 0,5 gram setil alkohol

1gram trietanolamin

Dimasukkan kedalam cawan

0,2 gram nipagin

penguap

ad akuades

Dilebur di atas penangas air

Dilarutkan dengan air

panas yang telah ditakar

pada suhu 70

0

C

Digerus konstan di dalam

Ekstrak kulit buah

lumpang panas hingga

delima ditambahkan

terbentuk massa krim

3 g propilen glikol

digerus sampai homogen

Massa II ditambahkan Massa I

digerus sampai homogen

Ditambahkan 3 tetes pewangi

Fase air

Fase minyak

Fase minyak + fase air

Massa I

(Dasar krim)

Bahan aktif

Massa II

(11)

Lampiran 10.

Gambar hasil pengukuran menggunakan skin analyzer

Kadar air

Kondisi awal

Pemulihan ke-1

Pemulihan ke-2

Pemulihan ke-3

(12)

Lampiran 10.

(Lanjutan)

Kehalusan (Evennes) dan pori (pore)

Kondisi awal

Pemulihan ke-1

(13)

Lampiran 10.

(Lanjutan)

Pemulihan ke-3

(14)

Lampiran 10.

(Lanjutan)

Noda (spot)

Kondisi awal

(15)

Lampiran 10.

(Lanjutan)

Pemulihan ke-2

(16)

Lampiran 10.

(Lanjutan)

(17)

Lampiran 10.

(

Lanjutan)

Keriput (Wrinkle)

Kondisi awal

(18)

Lampiran 10.

(Lanjutan)

Pemulihan ke-2

(19)

Lampiran 10.

(Lanjutan)

(20)

Lampiran 11.

Data hasil uji statistik

Kelembaban (Moisture)

ANOVA

Sum of Squares df Mean Square F Sig.

Sebelum Between Groups 11.611 5 2.322 1.548 .247

Within Groups 18.000 12 1.500

Total 29.611 17

MingguI Between Groups 28.667 5 5.733 3.559 .033

Within Groups 19.333 12 1.611

Total 48.000 17

MingguII Between Groups 51.611 5 10.322 10.322 .001

Within Groups 12.000 12 1.000

Total 63.611 17

MingguIII Between Groups 87.611 5 17.522 10.513 .000

Within Groups 20.000 12 1.667

Total 107.611 17

MingguIV Between Groups 126.444 5 25.289 65.029 .000

Within Groups 4.667 12 .389

Total 131.111 17

Sebelum

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula A 3 26.33

Formula B 3 27.33

Formula C 3 27.67

Formula D 3 27.67

Formula E 3 28.67

Formula F 3 28.67

(21)

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguI

PEMULIHAN N

Subset for alpha = 0.05

1 2

Tukey HSDa Formula A 3 28.33

Formula B 3 29.33 29.33

Formula C 3 30.33 30.33

Formula D 3 30.33 30.33

Formula E 3 31.67 31.67

Formula F 3 32.00

Sig. .063 .178

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguII

PEMULIHAN N

Subset for alpha = 0.05

1 2 3

Tukey HSDa Formula A 3 29.67

Formula B 3 31.00 31.00

Formula C 3 31.33 31.33 31.33

Formula F 3 33.67 33.67

Formula D 3 34.00

Formula E 3 34.00

Sig. .376 .058 .058

Means for groups in homogeneous subsets are displayed.

(22)

Lampiran 11.

(Lanjutan)

MingguIII

PEMULIHAN N

Subset for alpha = 0.05

1 2 3

Tukey HSDa Formula A 3 29.67

Formula B 3 31.67 31.67

Formula C 3 32.67 32.67

Formula D 3 34.67 34.67

Formula E 3 34.67 34.67

Formula F 3 36.33

Sig. .116 .116 .624

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguIV

PEMULIHAN N

Subset for alpha = 0.05

1 2 3

Tukey HSDa Formula A 3 30.00

Formula B 3 32.00

Formula C 3 33.33

Formula D 3 36.33

Formula E 3 36.33

Formula F 3 37.33

Sig. 1.000 .166 .413

Means for groups in homogeneous subsets are displayed.

(23)

Lampiran

11.

(Lanjutan)

Kehalusan (Evennes)

ANOVA

Sum of Squares df Mean Square F Sig.

Sebelum Between Groups 171.611 5 34.322 5.566 .007

Within Groups 74.000 12 6.167

Total 245.611 17

MingguI Between Groups 114.444 5 22.889 2.382 .101

Within Groups 115.333 12 9.611

Total 229.778 17

MingguII Between Groups 119.833 5 23.967 2.201 .122

Within Groups 130.667 12 10.889

Total 250.500 17

MingguIII Between Groups 142.944 5 28.589 3.431 .037

Within Groups 100.000 12 8.333

Total 242.944 17

MingguIV Between Groups 208.278 5 41.656 4.600 .014

Within Groups 108.667 12 9.056

Total 316.944 17

Sebelum

PEMULIHAN N

Subset for alpha = 0.05

1 2

Tukey HSDa Formula F 3 35.33

Formula E 3 36.67

Formula D 3 37.00 37.00

Formula C 3 41.00 41.00

Formula B 3 42.00 42.00

Formula A 3 43.67

Sig. .056 .056

Means for groups in homogeneous subsets are displayed.

(24)

Lampiran 11.

(Lanjutan)

MingguI

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 35.00

Formula E 3 36.00

Formula D 3 36.67

Formula C 3 37.00

Formula B 3 41.00

Formula A 3 41.67

Sig. .162

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguII

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 33.33

Formula E 3 33.33

Formula D 3 36.67

Formula C 3 37.00

Formula B 3 38.00

Formula A 3 40.67

Sig. .141

Means for groups in homogeneous subsets are displayed.

(25)

Lampiran 11.

(Lanjutan)

MingguIII

PEMULIHAN N

Subset for alpha = 0.05

1 2

Tukey HSDa Formula F 3 32.00

Formula E 3 32.00

Formula D 3 34.67 34.67

Formula C 3 35.33 35.33

Formula B 3 36.00 36.00

Formula A 3 40.33

Sig. .558 .229

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguIV

PEMULIHAN N

Subset for alpha = 0.05

1 2

Tukey HSDa Formula F 3 30.00

Formula E 3 30.00

Formula D 3 34.00 34.00

Formula C 3 34.67 34.67

Formula B 3 35.00 35.00

Formula A 3 40.00

Sig. .379 .216

Means for groups in homogeneous subsets are displayed.

(26)

Lampiran 11.

(Lanjutan)

Pori (pore)

ANOVA

Sum of Squares df Mean Square F Sig.

Sebelum Between Groups 912.667 5 182.533 2.237 .118

Within Groups 979.333 12 81.611

Total 1892.000 17

MingguI Between Groups 139.167 5 27.833 1.580 .239

Within Groups 211.333 12 17.611

Total 350.500 17

MingguII Between Groups 33.778 5 6.756 1.013 .451

Within Groups 80.000 12 6.667

Total 113.778 17

MingguIII Between Groups 213.611 5 42.722 1.529 .253

Within Groups 335.333 12 27.944

Total 548.944 17

MingguIV Between Groups 506.944 5 101.389 14.600 .000

Within Groups 83.333 12 6.944

Total 590.278 17

Sebelum

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 21.33

Formula E 3 26.33

Formula D 3 26.67

Formula C 3 31.00

Formula B 3 35.33

Formula A 3 43.33

Sig. .093

(27)

MingguI

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 20.67

Formula E 3 23.67

Formula D 3 24.33

Formula C 3 26.00

Formula B 3 26.67

Formula A 3 29.67

Sig. .164

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguII

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 19.33

Formula E 3 20.00

Formula D 3 20.00

Formula C 3 20.67

Formula B 3 22.00

Formula A 3 23.33

Sig. .448

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

Lampiran 11.

(Lanjutan)

(28)

Lampiran 11.

(Lanjutan)

MingguIII

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 12.00

Formula E 3 15.67

Formula D 3 18.67

Formula C 3 18.67

Formula B 3 20.67

Formula A 3 22.67

Sig. .207

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguIV

PEMULIHAN N

Subset for alpha = 0.05

1 2 3

Tukey HSDa Formula F 3 7.00

Formula E 3 9.33 9.33

Formula D 3 13.33 13.33

Formula C 3 14.67 14.67

Formula B 3 20.67

Formula A 3 21.33

Sig. .099 .205 .077

Means for groups in homogeneous subsets are displayed.

(29)

Lampiran 11.

(Lanjutan)

Noda (spot)

ANOVA

Sum of Squares df Mean Square F Sig.

Sebelum Between Groups 20.667 5 4.133 2.566 .084

Within Groups 19.333 12 1.611

Total 40.000 17

MingguI Between Groups 33.833 5 6.767 3.929 .024

Within Groups 20.667 12 1.722

Total 54.500 17

MingguII Between Groups 45.833 5 9.167 8.684 .001

Within Groups 12.667 12 1.056

Total 58.500 17

MingguIII Between Groups 83.611 5 16.722 13.682 .000

Within Groups 14.667 12 1.222

Total 98.278 17

MingguIV Between Groups 119.111 5 23.822 10.459 .000

Within Groups 27.333 12 2.278

Total 146.444 17

Sebelum

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 25.33

Formula E 3 26.00

Formula D 3 26.33

Formula C 3 26.33

Formula B 3 27.33

Formula A 3 28.67

Sig. .063

Means for groups in homogeneous subsets are displayed.

(30)

Lampiran 11.

(Lanjutan)

MingguI

PEMULIHAN N

Subset for alpha = 0.05

1 2

Tukey HSDa Formula F 3 25.00

Formula E 3 25.00

Formula D 3 25.33 25.33

Formula C 3 25.67 25.67

Formula B 3 27.33 27.33

Formula A 3 28.67

Sig. .314 .076

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguII

PEMULIHAN N

Subset for alpha = 0.05

1 2

Tukey HSDa Formula F 3 24.00

Formula E 3 24.33

Formula D 3 24.67

Formula C 3 25.00

Formula B 3 26.33 26.33

Formula A 3 28.67

Sig. .129 .129

Means for groups in homogeneous subsets are displayed.

(31)

Lampiran 11.

(Lanjutan)

MingguIII

PEMULIHAN N

Subset for alpha = 0.05

1 2 3

Tukey HSDa Formula F 3 22.33

Formula E 3 23.00

Formula D 3 23.33

Formula C 3 24.00 24.00

Formula B 3 26.67 26.67

Formula A 3 28.33

Sig. .475 .098 .475

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguIV

PEMULIHAN N

Subset for alpha = 0.05

1 2 3

Tukey HSDa Formula F 3 20.00

Formula E 3 21.33

Formula D 3 22.67 22.67

Formula C 3 23.33 23.33

Formula B 3 25.67 25.67

Formula A 3 27.67

Sig. .145 .219 .600

Means for groups in homogeneous subsets are displayed.

(32)

Lampiran 11.

(Lanjutan)

Keriput (Wrinkle)

ANOVA

Sum of Squares df Mean Square F Sig.

Sebelum Between Groups 551.611 5 110.322 3.162 .047

Within Groups 418.667 12 34.889

Total 970.278 17

MingguI Between Groups 850.944 5 170.189 6.176 .005

Within Groups 330.667 12 27.556

Total 1181.611 17

MingguII Between Groups 1065.778 5 213.156 9.788 .001

Within Groups 261.333 12 21.778

Total 1327.111 17

MingguIII Between Groups 1429.111 5 285.822 11.233 .000

Within Groups 305.333 12 25.444

Total 1734.444 17

MingguIV Between Groups 1983.611 5 396.722 16.454 .000

Within Groups 289.333 12 24.111

Total 2272.944 17

Sebelum

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 26.00

Formula E 3 33.67

Formula D 3 35.33

Formula C 3 40.67

Formula B 3 41.00

Formula A 3 41.67

Sig. .060

(33)

Lampiran 11.

(Lanjutan)

a. Uses Harmonic Mean Sample Size = 3,000.

MingguI

PEMULIHAN N

Subset for alpha = 0.05

1 2

Tukey HSDa Formula F 3 24.00

Formula E 3 24.33

Formula D 3 29.00 29.00

Formula C 3 31.67 31.67

Formula B 3 39.67

Formula A 3 41.67

Sig. .506 .097

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguII

PEMULIHAN N

Subset for alpha = 0.05

1 2 3

Tukey HSDa Formula F 3 21.00

Formula E 3 22.00

Formula D 3 24.00 24.00

Formula C 3 25.00 25.00

Formula B 3 35.67 35.67

Formula A 3 41.67

Sig. .892 .082 .628

Means for groups in homogeneous subsets are displayed.

(34)

Lampiran 11.

(Lanjutan)

MingguIII

PEMULIHAN N

Subset for alpha = 0.05

1 2 3

Tukey HSDa Formula F 3 16.00

Formula E 3 18.67 18.67

Formula D 3 19.33 19.33

Formula C 3 20.67 20.67

Formula B 3 30.33 30.33

Formula A 3 41.67

Sig. .859 .119 .135

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguIV

PEMULIHAN N

Subset for alpha = 0.05

1 2 3

Tukey HSDa Formula F 3 10.67

Formula E 3 14.67

Formula D 3 17.00 17.00

Formula C 3 18.33 18.33

Formula B 3 29.33 29.33

Formula A 3 41.67

Sig. .440 .080 .080

Means for groups in homogeneous subsets are displayed.

(35)

Lampiran 11.

(Lanjutan)

Kedalaman keriput

ANOVA

Sum of Squares df Mean Square F Sig.

Sebelum Between Groups 610.278 5 122.056 2.477 .092

Within Groups 591.333 12 49.278

Total 1201.611 17

MingguI Between Groups 171.111 5 34.222 1.046 .435

Within Groups 392.667 12 32.722

Total 563.778 17

MingguII Between Groups 91.111 5 18.222 .422 .825

Within Groups 518.667 12 43.222

Total 609.778 17

MingguIII Between Groups 248.944 5 49.789 1.624 .228

Within Groups 368.000 12 30.667

Total 616.944 17

MingguIV Between Groups 190.944 5 38.189 1.322 .319

Within Groups 346.667 12 28.889

Total 537.611 17

Sebelum

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 31.33

Formula E 3 38.33

Formula D 3 40.67

Formula C 3 44.33

Formula B 3 47.00

(36)

Lampiran

11.

(Lanjutan)

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguI

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 31.33

Formula E 3 34.33

Formula D 3 35.67

Formula C 3 36.00

Formula B 3 38.00

Formula A 3 41.33

Sig. .330

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguII

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 29.67

Formula E 3 31.33

Formula D 3 32.33

Formula C 3 34.00

Formula B 3 35.00

Formula A 3 36.33

Sig. .809

Means for groups in homogeneous subsets are displayed.

(37)

Lampiran 11.

(Lanjutan)

MingguIII

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 24.00

Formula E 3 29.67

Formula D 3 30.33

Formula C 3 33.00

Formula B 3 34.00

Formula A 3 35.33

Sig. .197

Means for groups in homogeneous subsets are displayed.

a. Uses Harmonic Mean Sample Size = 3,000.

MingguIV

PEMULIHAN N

Subset for alpha

= 0.05

1

Tukey HSDa Formula F 3 19.67

Formula E 3 25.33

Formula D 3 26.33

Formula C 3 28.33

Formula B 3 29.00

Formula A 3 29.00

Sig. .336

Means for groups in homogeneous subsets are displayed.

Gambar

Gambar krim minggu ke 12

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