ABSTRACT
ASSOCIATION OF INTERLEUKIN-10 TITER AND SEVERITY OF DENGUE
HEMORRHAGIC FEVER
Dengue is the most important mosquito borne viral disease. High morbidity and mortality together with wide spread epidemic leads the disease to be exotic and invites scientist to continue explore it. One curiosity of the scientist is to find what influence the severity of dengue infection manifestation. Interleukin-10 is among cytokine that attracts many attention in recent decade as the controversy of its ability to determine severity of dengue clinical manifestation. This study aimed to see the association of IL-10 titer with severity of dengue hemorrhagic fever (DHF) clinical manifestation in the Department of Child Health Sanglah Hospital, Denpasar.
The study is an analytic cross sectional study delivered in subjects with either mild or severe DHF between December 2013 through December 2014. Subject were recruited when admitted to the hospital for management of dengue infection suspicion, experienced fever at least on the third day, recorded their clinical profiles and withdrawn blood sample for Complete Blood Count and IL-10 titer investigation. Blood samples for Dengue infection confirmation was withdrawn at the 7th day of fever. Relationship of IL-10 titer with severity of DHF clinical severity was determined by OR with statistical significance p<0,05, and 95% CI.
During study period there were 119 subjects included, 4 subject was excluded as dengue infection was not confirmed. As much as 75 subject eligible. The predominant subjects are those who ages beyond 6 years, male group and non obese. As much as 43 subjects with primary infection, while 32 subjects with secondary infection. Mild DHF was found in 27 subject, while severe DHF was found in 43 subjects. Mean (SB) IL-10 titer in overall subjects was 88,02 (9,22) pg/dL. Mean IL-10 titer for mild DHF group was 36,8 pg/dL, while mean IL-10 titer for severe DHF was 179,1 pg/dL. There was an association between IL-10 titer and severity of DHF clinical manifestation (OR 107,65 ; p<0,001; CI 95% 11,73-987,59).
Interleukin-10 titer in severe DHF is higher compared to mild DHF. Interleukin-10 titer has an association with severity of DHF clinical manifestation.
