xv PERBEDAAN KADAR PROSTAGLANDIN F2Α CAIRAN DARAH HAID (MENSTRUAL FLUID) PADA DISMENORE PRIMER, SEKUNDER, DAN
NON DISMENORE
Apriza Prahatama Henry Salim Siregar, Muhammad Rusda, Hotma Partogi,
M. Rhiza Z. Tala, Sarah Dina
Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas
Sumatera Utara, Medan Indonesia, 2016
Abstrak
Pendahuluan: Dismenore adalah nyeri bagian bawah perut saat menstruasi
dengan prevalensi yang terus meningkat pada wanita reproduktif.
Prostaglandin berperan penting dalam rangsang nyeri tetapi belum pernah
diteliti perbedaanya pada setiap klasifikasi dismenore.
Tujuan: Untuk mengetahui perbedaan kadar prostaglandin F2αmenstrual fluid
pada dismenore primer, sekunder dan non dismenore.
Metode: Penelitian ini adalah penelitian analitik komparatif dengan desain
cross sectional di Rumah Sakit H. Adam Malik dari November 2015 sampai
Februari 2016. Sebanyak masing-masing 10 wanita dengan dismenore
primer, dismenore sekunder, dan non dismenore diperiksakan kadar PGF2α
dengan ELISA. Data ditabulasi dan dianalisis dengan SPSS 17.
Hasil: Pada karakteristik menarche, panjang siklus haid, lama haid, jumlah
darah haid dan ukuran BMI, tidak ditemukan perbedaan dalam ketiga
kelompok sampel. Ada perbedaan bermakna antara kadar PGF2α dalam
kelompok non dismenore, dismenore primer, dan dismenore sekunder
(4,80±4,60; 93,27±111,601; 154,08±134,40 pg/ml; p<0,001). Peningkatan
kadar PGF2α selaras dengan semakin beratnya derajat nyeri yang dialami
penderita dismenore (p<0,001)
xvi Simpulan: Ada perbedaan yang bermakna kadar PGF2α dalam kelompok non
dismenore, dismenore primer, dan dismenore sekunder dan peningkatan
kadar PGF2α selaras dengan semakin beratnya derajat nyeri.
Kata kunci: PGF2α, dismenore, nyerI
xvii DIFFERENCES OF PROSTAGLANDIN F2Α LEVEL IN PRIMERY
DISMENORHEA, SECONDARY DISMENORHEA AND NON-
DISMENORHEIC MENSTRUAL FLUID
Apriza Prahatama, Henry Salim Siregar, Muhammad Rusda, Hotma Partogi,
M. Rhiza Z. Tala, Sarah Dina
Department of Obstetrics and Gynecology, Faculty of Medicine University of
Sumatera Utara, Medan Indonesia, 2016
abstract
Introduction: Prevalence of dysmenorrhea, pain at lower abdomen during
menstruation, is increasing in reproductive women. Prostaglandin plays an
important role in pain stimuli, but no its level is unknown each classification
dysmenorrhea.
Objective: To determine differences of prostaglandin F2α levels between
primary, secondary and non dysmenorrhea.
Methods: This study is a comparative analytical study with cross sectional
design conducted in H. Adam Malik Hospital from November 2015 to
February 2016. A total of each 10 women with primary, secondary, and non
dysmenorrhea were examined their PGF2α levels by ELISA. Data were
tabulated and analyzed by SPSS 17.
Results: Based on the characteristics of menarche, menstrual cycle length,
duration of menstruation, menstrual blood volume, and BMI, no differences
were found among the samples groups. There wass a significant difference of
PGF2α levels among primary, secondary, and non dysmenorrhea groups
(4.80 ± 4.60; 93.27 ± 111.601; 154.08 ± 134.40 pg/ml; p <0.001). PGF2α was
increased along with the increasing severity degree of pain experienced by
patients with dysmenorrhea (p<0.001)
xviii
Conclusion: There were significant differences of PGF2α levels among
dysmenorrhea, primary dysmenorrhea and secondary dysmenorrhea and
PGF2α levels increased with the increasing severity of dysmenorrhea pain. Key words: PGF2α, dysmenorrhea, pain
