MICROBIOLOGY PPT LECTURE NOTES | Karya Tulis Ilmiah

(1)

Actinomyces &

(2)

Actinomyces



A.israelii,

A.naeslundii;



Gram positive;

sulfur granule;



Related to

decay tooth

and

(3)

ACTINOMYCES

Anaerobic, filamentous, gram

positive bacillus

• _{Exhibit true branching}_{Exhibit true branching}

 ““Mykes” – Greek for “fungus”Mykes” – Greek for “fungus”

 Thought by early microbiologist to Thought by early microbiologist to

be fungi because of:

• _Morphology_Morphology

(4)

Clinical specimens:Actinomycosis-pus

(5)

ACTINOMYCOSIS

Not highly virulent

(Opportunist)

• Component of Oral Flora_{Component of Oral Flora}

 Periodontal pocketsPeriodontal pockets  Dental plaqueDental plaque

 Tonsilar cryptsTonsilar crypts

• Take advantage of injury _{Take advantage of injury}

to penetrate mucosal

barriers

 Coincident infectionCoincident infection  TraumaTrauma

(6)

Actinomycosis

 A chronic suppurative and granulomatous 肉肉A chronic suppurative and granulomatous

肉 disease of the cervico-facial, thoracic or disease of the cervico-facial, thoracic or abdominal areas

(7)

ACTINOMYCOSIS

Form indurated masses with fibrous

walls and central loculations with

pus

• Pus contains "Sulfur Granules"_{Pus contains "Sulfur Granules"}

 Gritty, yellow whiteGritty, yellow white

 Average diameter - 2mmAverage diameter - 2mm

 Composed of mineralized “mycelial” massComposed of mineralized “mycelial” mass

Chronic infection

• Form burrowing sinus tracts to skin or _{Form burrowing sinus tracts to skin or}

mucus membranes

(8)

Actinomycosis - sulfur granule

(9)

Pulmonary Actinomycosis

 15% of cases15% of cases

 Aspiration of organism Aspiration of organism

from the oropaharynx

 Slowly progressive Slowly progressive

process involving lung

and pleura

• May be mistaken for _{May be mistaken for} malignancy

malignancy

 Chest pain, fever, wgt Chest pain, fever, wgt

loss and hemoptysis

(10)

Mycetoma

(

足足足足

_足足足足

Streptomyces Streptomyces

(11)

Nocardiosis

 Subcutaneous Subcutaneous

infections, pulmonary

infections, and brain

abscesses

 N. asteroides; N. N. asteroides; N.

brasiliensis

(12)

Lab. Diagnosis

 Clinical Clinical

Specimens:Sputum,Pus,Biopsy tissue

Sulfamethoxazole-Trimethoprim