Hemorrhogic Fever Virus
Dept. of microbiology and parasitology
Hantaar Virus or HEMORRHAGIC FEVER with renal syndrome virus ( HFRS ）
Hantaar Virus
Spherical, 80-120nm
Nucleocapsid: Helical,
3 segments, 2 proteins
- nucleocapsid ('N'),
RNA polymerase ('L')
Envelope: 2
glycoproteins, G1 and
G2,
Biological properties
1. ssRNA with long, medium,short segments
2. Antigens 6 serotypes (I- VI)
Epidemiology
1. Natural host : rodents (deer mouse
(Peromyscus maniculatus), cotton rat
(Sigmodon hispidus), marsh rice rat (Oryzomys
palustris) , white-footed mouse (Peromyscus
leucopus), other carriers)
2. Transmission : Droplet and rodent excreta
spread
Clinical syndromes
Headache;
Pink in face , neck
Fever
marked bleeding tendency
Lower blood pressure Urine with Protein
multi-organ failure
Pathogenicity
Clinical manifestations: 5 phases
Fever phase
Hypotension phase Auria phase
Pathogenesis
Viral direct damage
Immunopathogenesis
Laboratory diagnosis
Cultivation: Vero-E6 cell and A549 cell
Serological diagnosis: IgM/IgG
indirect immunofluorescent assay ELISA-IgM
Spherical, 80-120nm
Nucleocapsid: Helical,
3 segments, 2 proteins - nucleocapsid ('N'),
RNA polymerase ('L')
Envelope: 2
glycoproteins, G1 and G2,
Vector and Host
Animal Host
Hyalomma asiaticum
Season: April and May
