MICROBIOLOGY PPT LECTURE NOTES | Karya Tulis Ilmiah

Similar to Viruses Atypical

Similar to Viruses Atypical

Agents

Agents



Small

Small



Filterable

Filterable



Need host cells

Need host cells



No machinery for energy generation of

No machinery for energy generation of

protein synthesis

protein synthesis

Different from viruses

Different from viruses



No dectectable virions in infected tissues

No dectectable virions in infected tissues



No detectable virions in purified infectious

No detectable virions in purified infectious

material

material



Resistant to or only _{Resistant to or only} partially inactivated partially inactivated by by

1.

1.

FormaldehydeFormaldehyde

2.

2.

Ethanol Ethanol

3.

3.

GlutaraldehydeGlutaraldehyde

4.

4.

Ultraviolet and ioniziUltraviolet and ionizi ng irradiation

ng irradiation

5.

5.

Non-ionic detergentsNon-ionic detergents



Inactivated by_{Inactivated by}

1.

1.

AutoclavingAutoclaving

2.

2.

5%sodium 5%sodium hypochlorite

hypochlorite

3.

3.

Sodium hydroxideSodium hydroxide

4.

4.

Proteases, urea, Proteases, urea, other protein

other protein

denaturants

Pathogensis

Pathogensis



Kuru_Kuru



CJD(Creutzfeldt Jakob disease)_{CJD(Creutzfeldt Jakob disease)}



GSS(Gerstmann Straussler-Scheinker syndrom_{GSS(Gerstmann Straussler-Scheinker syndrom}

e)

e)



FFI(Fetal familial insomnia)_{FFI(Fetal familial insomnia)}



Scrapie(sheep and goats)_{Scrapie(sheep and goats)}



Bovine spongiform encephalopathy_{Bovine spongiform encephalopathy}



Transmissible mink encephalopathy_{Transmissible mink encephalopathy}

How can this model explain the sporadic, acquired or How can this model explain the sporadic, acquired or

Why are there differences in prion dise

Why are there differences in prion dise