COVID-19 and Cell Stress
10.5 Conclusion
Although the COVID-19 pandemic is not glob- ally characterized by stress (due to the lockdown and quarantine), it is associated with cellular stress. Human cells respond to stress through some key regulators, such as chaperone protein HSPA5. Cell response to stress may be beneficial to the virulence of the SARS-CoV-2, and hence an external supplement of chaperone inhibitors may help to fight COVID-19. In the current chap- ter, we summarized the current knowledge of the possible link between cell stress and COVID-19 infectivity. The use of HSPA5 inhibitors, in addi- tion to SARS-CoV-2 spike protein targets, can alleviate SARS-CoV-2 infectivity.
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