Conclusion - Disease or Genetic Predisposition

Disease or Genetic Predisposition

6.7 Conclusion

COVID-19 is a multisystem infectious disease (Jahanshahlu and Rezaei 2020a; Saleki et al.

2020) that has transmitted between people world- wide and triggered reactions and awareness among a variety of professionals oriented toward containing the disease spread along with its management and treatment (Rezaei 2020a, b; Lotfi et al. 2020; Moazzami et al. 2020). It causes mild to moderate symptoms in nearly 80% of people, even in specific populations who are usually treated special, e.g., children, pregnant women, and immunodeficient patients (Ahanchian et al.

2020; Mirbeyk and Rezaei 2020). However, it may have severe symptoms in people with under- lying diseases, like cancer (Ahmadi et al. 2020), and surprisingly, in people without any pre- existing problems (Yousefzadegan and Rezaei 2020; Sahu et al. 2020), and this would further worsen the situation that no formal treatment exists in practice (Fathi and Rezaei 2020;

Jahanshahlu and Rezaei 2020b; Saghazadeh and Rezaei 2020b; Mohamed et al. 2020b; Rabiee et al. 2020). In this condition, the genomic data would be a great tool in the tailoring of personalized medicine for the disease, for example, through stem cells (Basiri et al. 2020). For this purpose, well-controlled investigations of rare variants with complete penetrance involving host vulnerability and response to SARS-CoV-2 are

essential for predicting disease sensitivity, progression, and therapeutic strategies. Powerful bioinformatics techniques and high-throughput sequencing, now broadly available, have allowed affordable and rapid exploration of genetic predisposition to infectious diseases, including COVID-19, and are expected to contribute to the genetic basis of disease susceptibility continu- ously. Then, the translation of large-scale genomic results into practice is necessary, which would not be possible until a leap allows international and interdisciplinary collaboration (Momtazmanesh et al. 2020; Mohamed et al.

2020a; Moradian et al. 2020). The advantages of such collaboration are not only deemed worthy in the pandemic condition but are useful to drive a highly qualified personalized medicine into the future of infectious diseases (Rzymski et al.

2020; Kafieh et al. 2020), though inevitably root- ing in the past pandemic situations (Jabbari et al.

2020).

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