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Supplemental Digital Content

Table S1. Associations between periventricular WMH and cognitive decline in cognitive domains

B ^{95% CI} p ^{R2 change}

Executive functioning* Baseline MRI 0.24 -0.03 to 0.50 0.077 2.1%

Progression MRI 0.29 0.10 to 0.49 0.004 5.6%

Information processing speed † Baseline MRI 0.23 -0.13 to 0.58 0.210 1.1%

Progression MRI 0.26 -0.01 to 0.53 0.060 2.5%

Memory ‡ Baseline MRI -0.10 -0.40 to 0.20 0.497 0.3%

Progression MRI 0.20 -0.02 to 0.42 0.080 1.7%

Corrected for age, sex, educational level, HADS total score, patient group, baseline cognition, and potential vascular risk factors

* Total R² of the model = 23.5%

† Total R² of the model = 17.8%

‡ Total R² of the model = 37.6%

Table S2. Associations between subcortical WMH and cognitive decline in cognitive domains

B ^{95% CI} p ^{R2 change}

Executive functioning* Baseline MRI 0.49 0.18 to 0.80 0.002 6.7%

Progression MRI 0.02 -0.17 to 0.20 0.876 0.0%

Information processing speed † Baseline MRI 0.40 -0.02 to 0.82 0.061 2.6%

Progression MRI -0.11 -0.36 to 0.14 0.401 0.5%

Memory ‡ Baseline MRI -0.07 -0.42 to 0.28 0.695 0.1%

Progression MRI 0.11 -0.10 to 0.31 0.316 0.6%

Corrected for age, sex, educational level, HADS total score, patient group, baseline cognition, and potential vascular risk factors

* Total R² of the model = 21.3%

† Total R² of the model = 16.0%

‡ Total R² of the model = 36.4%

Table S3. Associations between microbleeds and cognitive decline in cognitive domains

B ^{95% CI} p ^{R2 change}

Executive functioning* Baseline MRI 0.09 -0.14 to 0.33 0.432 0.4%

Progression MRI 0.20 -0.11 to 0.50 0.203 1.2%

Information processing speed † Baseline MRI 0.20 -0.11 to 0.51 0.198 1.2%

Progression MRI 0.34 -0.05 to 0.73 0.090 2.1%

Memory ‡ Baseline MRI 0.15 -0.11 to 0.41 0.253 0.7%

Progression MRI -0.12 -0.47 to 0.22 0.485 0.3%

Corrected for age, sex, educational level, HADS total score, patient group, baseline cognition, and potential vascular risk factors

* Total R² of the model = 16.1%

† Total R² of the model = 17.4%

‡ Total R² of the model = 36.7%

Table S4. Associations between lacunes and cognitive decline in cognitive domains

B ^{95% CI} p ^{R2 change}

Executive functioning* Baseline MRI 0.22 0.02 to 0.41 0.031 3.3%

Progression MRI 0.04 -0.25 to 0.32 0.812 0.0%

Information processing speed † Baseline MRI -0.04 -0.30 to 0.22 0.758 0.1%

Progression MRI 0.29 -0.09 to 0.68 0.134 1.7%

Memory ‡ Baseline MRI 0.10 -0.11 to 0.31 0.361 0.5%

Progression MRI 0.15 -0.17 to 0.46 0.357 0.5%

Corrected for age, sex, educational level, HADS total score, patient group, baseline cognition, and potential vascular risk factors

* Total R² of the model = 17.7%

† Total R² of the model = 14.2%

‡ Total R² of the model = 36.9%