vd dugc thgc hipn dudi hudng d i n cua sieu dm, m l u bpnh phIm Id djch di vd gai rau, thudng ed ty ip xdy thai to- 0,5-1%. B i t lgi chinh ciia thii thupt ehpc l i Id thdi dilm chin dodn mupn, d tuin thai 16-18 tuin. Sd lugng djch di cQng ddi khi khIng dii lugng DNA c l n thilt eho chin dodn, c l n phdi nudi c i y tp bdo cho d i n khi dii lugng t l bdo e I n thiet, Idm chdm thSm thdi gian trd kit.
K£T LUAN
Ap dyng thdnh cdng ky thudt gidi trinh t g gen trang CDTS bpnh Wilson
Chin dodn tnj-dc sinh thdnh cdng cho 3 thai nhi:
02 thai mang gen bpnh, 01 thai nhi bj bpnh Kilu gen ciia 3 thai nhi dugc chin dodn tm-dc sinh lln Iugt Id S105X/N; P1273Q/N; S105X/S105X.
TAI LI$U THAM KHAO
1. Nguyin Thj Mai Huvnq, Trin Huy Thjnh, Phan Vdn Chi, Tg 'Hidnh Van, T ^ n Van Khdnh, "Xdc
^nh dpt biln gen ATP7B trSn bpnh nhan vd phdt hipn ngudi mang gen bpnh tren thdnh vidn gia dinh bpnh nhdn Wilson", Tgp ehi nghien cipu Y hpc, Tpp 100, thdng 4- 2016,sd2,tr.3341.
2. Thi Mai Huong Nguyen, Ngo Diem Ngoc, Thi Phuong Mai Nguyen, Nguyen Pham Anh Hoa, Tran Van Khanh, Ta Thanh Van, Phan Van Chi. "Mutation analysis of 16 Vietnamese Wilson patients". 11th Asia Pacific Conference on Human Genetics, Hanoi, Vietnam (APCHG2015), Sep 16-18, 2015. Vol 3, Suppl 2 Sep 2015.
3. Ferenci P. 2006. Regional distribution of mutations of the ATP7B gene in patients with Wilson disease: impact on genetic testing. Hum Genet.
120(2):151-9.
4. Ala A Walker AP, Ashkan K, Dooley JS, Schilsky ML. 2007. Wilson's disease, lancet . 369(9559):397-408.
5. Li XP, Yin JY, Wang Y, He H, Li X, Gong WJ, Chen J, Qian CY, Zheng Y, U F, Yin T, Gong ZC, Zhou BT, Zhang Y, Xiao L, Zhou HH, Uu ZQ. 2014. The ATP7B genetic pol^oiphi^ns predict clinical outcome to platinum-based diemotherapy in lung cancer patients.
Tumour Biol. 35{8):825&*5.2014 May 23.
6. Cossu P, Pirastu M, Nucaro A Figus A Balestrieri A BcHTone C, Giacchino R, Devoto M, MonnI G, Cao A 1992, Prenatal diagnosis of Wilson's disease by analysis of DNA pdymorphism. N Engl J Med.
327(1 ):57
NGHIEN CU'U THU'C TRANG D\tU KIEN LAO DONG VA CAC Y^U T 6 MOI TRU'ONG TAC DONG GAY CANG THANG THAN KINH vA TAM LY
COA NGU'ai LAO DONG TREN CAC PHU'aNG TIEN VAN TAI THUt.
D^XUAT GIAI PHAP GIAM THI^U
7. Rolaerts EA Schilsky ML. 2008. A practice guideline on Wilson disease. H^atology. 47(6):2089-111.
8. Forbes JR, Cox DW. 1998. Functional characterization of missense mutations in ATP7B: Wilson disease mutation or nonnal variant? Am J Hum Genet.
63(6): 1663-74.
g. Shyamal K Das, Kunal Ftay 2006. Nat Clin Pract Neurol. 2(9):482-93.
10. Ferenci P. Pathophysiology and clinical features of Wilson disease. Metab Brain Dis. 2004 Dec;19(3- 4):229-39.
11. Kumar SS, Kurlan G, Eapen CE, Roberts EA Geneticsof Wilson's disease: a clinical perspective. Indian J Gastroenterol. 2012.31(6):285-93. Epub 2012 Sep 1.
12. Maleki I, Zaii R M, Abadi NH. 2013. Novel mutation of ATP7B gene in Iranian patients with Wilson 's disease. Res Moi Med.1(1):44-47.
13. Tongsong T, lAbnapirak C, Sirivatanapa P, Piyamongkol W, Sirichotiyakul S, Yampochai A Amniocentesis-related feta! loss: a cohort study. Obstet Gynecol. 1998;92(1):64-7.
14. Tabor A Philip J, Madsen M, Bang J, Obel EB, Norgaard-Pedersen B. Randomised controlled trial of genetic amnloeenfesis in 4606 low-nsk women. Lancet, 1986;1(8493):1287-93.
15. Loudianos G l , Figus AL, Loi A Anglus A Dessi V, Deiana M, De Vlrglliis S, Monni G, Cao A Pirastu M. 1994. Improvement of prenatal diagnosis of Wilson disease using microsateiiite markers. Prenat Diagn. 14(10):999-1002.
16. Ll XH, Lu Y, Ling Y, Fu QC, Xu J, Zang GQ, Zhou F, De-Min Y, Han Y, Zhang DH, Gong QM, Lu ZM, Kong XF, Wang JS, Zhang XX. 2011. 'Clinical and molecular characterization of Wilson's disease in China' identification 14 novel mutations'.BMC Med Genet. 12(6)' 1471-2350-12-6.
17. Mak CM, Lam CW, Tam S, et al, (2008), Mutational analysis of 65 Wilson disease patients in Hong Kong Chinese: Identification of 17 novel mutations and its genetic heterogeneity, J Hum Genet, 53(1 ):55-63.
18. Kenney SM, Cox DW. 2007. Sequence variation database for the Wilson disease copper transporter, ATP7B. Hum Mutat. 28(12):1171-7.
19. European Association for the study of the liver,
"EASL Clinical practice gulddines: Wilson's disease, J Hepatology, vol. 56, no. 3, f^. 671-685, Mar. 2012.
PHAM TUNG LAM, NGUY§N DIJC TAi, PHAN TRQNG HdA Trung tam Bao v$ swc khoi lao dgng va Mil trw&ng GTVT
Chju trich nhiym: Phym Tung Lam Email: [email protected] Ngiy nh$n: 20/12/2017
Ngiypbin biyn: 03/1/2018 Ngiy duyit bii: 10/1/2018 Ngiy xuit bin: 20/1/2018
h
HQC THirC HANH (1066) - SO 1/2018TOM T A T
Ket qui nghien cOu eOa di tii dinh gii dwgc tiiyc tryng dieu kiin vi mdi tnr&ng lao dgng, sue khde va cang tiling thin kinh tim 1^ cOa ngudi lao dgng tren phuung ti^n vin tii thOy. Cd 60% miu do nhiyt dg, 26,6% mau do tdc dd gid, 40%, miu do tiing dn, 20%, miu do mng xdc vwgt tiiu chuin vi sinh cho phep.
Diiu kign lao dgng d|c thii trin sdng nw&c, khdng gian gd bd. mdi trw&ng vi xi hdi bit thuang^ cdng viyc nham chin, dan diiu. thiiu thdn vi tinh than, sinh hoyt van hda di giy dng thing thin kinh tim /j?. Bynh rang him m$t 41,9%,; B$nh mat 40,9%,; Bynh tuin hoin 21,3%; B$nh tiiu hda 20,9; Bynh tiit niiu. sinh due 11.3%. Cic yiu td inh hwdng din cang thing lliin kinh. tim /y cua ngw&i lao dgng: lo cho tinh mang eua minh (72,2%), lo sg g$p hda hoan (72,2%), mdi tardng lam viyc khic nghi$t (64,9%), cam giic co dem (50,3%), dm giic tieh bidt (35,8%). to ling ginh nang vi lanh ti (43%). T^ li ngud» lao 0ng trin phuang tien thOy co bieu hi$n cing thing than kinh a muc tiiing binh li 38.4%o-45,7%, rit dng thing 19,2%- 22.5% va dng thing qui mire 1.3%-2.0%.
Cic tic gii da di xuit mdt sd giii phip dw phdng cic binh nghe nghidp, b$nh liin quan den nghi nghiyp vi dng thing thin kinh tam ly' cho ngw&i lao ddng trin phwang tiyn v$n tii thdy.
Tli- khoa: ngw&l lao ddng trin phwang tiyn thuy, mdi trw&ng lao ding, binh nghi nghiyp, benh liin quan den nghi nghiip, cing thing than kinh tam ly.
SUMMARY
RESEARCH ON WORKER CONDITIONS AND THE ENVIROMENTAL FACTORS THAT CAUSE MENTAL AND PSYCHOLOGICAL STRESS OF THE EMPLOYEES ON WATERWAY VEHICLES.PROPOSED PREVENTIVE SOLUTION
The research results of the project have assessed the wori<ing conditions and environmeri, health and psychologieal stress of wori^ers on waterway vehides.
There are 60 percent of temperature samples, 26.6 percent of velocity samf^es, 40 percent of noise samples 20 percent c^ vibration samples exceeding allowed standards. The woi1(ers work in special conditions on numerous rivers, constrained space, abnormal small social enwmnment, boring job, monotonie, mental privation, cultural activities easy to cause mental and psychological stress. Odonto- Stomatology disease accounts for 41.9%; eyes disease accounts for 40.9%; Circulatory disease accounts tor 21.3%; Gastmintestinal disease accounts for 20.9%,; Urinary tract and genital diseases accounted for 11.3%,. There am many /acto/s that affect the mental stress, the psychology of wori<ers:
fear for their life (72,2%). fear of fire (72.2%,). harsh wori<ing environment (64.9%). feeling lonely (50.3%,).
feeling separated (35,8%,). worried about the economic burden (43%). The percentage of wori<ers on watenvay vehicles exhibited of nervous tension in average level of 38.4%>-45.7%>; very tense 19.2%,-22 5% and excessive stress 1.3%,-2.0%.
The authors have proposed some measures to prevent occupational diseases, worif-reiated diseases and psychologieal sti^ss of workers on waterway vehicles.
Keywords: workers on waten/vay vehicles, working environment, occupational diseases, worit-relaled diseases, mental and psychological stress.
DATVAND£
Hipn nay chua ed nhilu cdng trinh nghiSn edu v&
dilu kipn lao dpng tde dpng gdy cdng thing thin kinh vd tdm ly cua ngudi lao dpng trSn cde phuang tipn v|n tdi thOy vd d l xult edc gill phap dg phdng. Vi v§y ehiing tdi tien hdnh "Nghien ciru thgc trgng dieu kign lao dpng vd cdc ylu t l mdi tm'dng tdc dpng gdy cdng thing than kinh vd tdm 1;^" cOa ngudi lao dpng trSn cac phuang tipn vpn t l i thuj. D l xult gldl phdp giam thilu'. Vdi cdc myc tiPu:
1. Nghiin ciru thyc tryng diiu kiin vi mdi tnrdng lao dgng cOa ngw&i lao ^ng trin cic phwang tiin v$n taitiiuy.
2. Nghien cwu ffiyc byrig site khde vi dng thing than kinh tim /j? cua ngw&i lao ddng trin dc phuong tiin vin tai thuy.
D 6 | TLfQ14G VA PHIKTNG P H A P NGHIEN CUU 1. Ddi t u v n g nghiSn cipu
- Ngudi lao ddng Idm vipc trSn cdc phuang tl$n vpn tai thCiy.
- Mli tm'dng vd dilu kipn Idm vipc ciia ngudi lao dpng tren phuang tipn vpn t l i thiiy.
2. Dja d i l m nghien cO>u - Cdng ty c l phin vpn tdi thiiy 4.
- Ting Cdng ty Bdo ddm an todn hdng hdi miln Ble.
3. Th64 gian nghien ciru
NghiSn ciru dugc tiln hdnh tO' thdng 01/2017 cl^n thdng 12/2017.
4. Phinyng phdp nghien ciru
- Phuang phdp nghiSn ciru: Sir dyng phuang phap mo td d t ngang d|nh tinh vd ^ n h lugng.
K £ T QUA NGHIEN CIJU 1. ThMV t r ^ n ^ moi tnrdng lao dgng Cd 60,0% mdu do nhipt dp vugt tISu chuan vp sinh cho phep tir 1,1-2,90C, 26,6% miu do tdc dp gii vugt tieu chuan vp sinh. ^ ^
Cudng dp tilng I n : Cd 40,0% mlu do tieng on vugt tiSu ehuIn vp sinh eho phdp tir 1-9 dBA.
2. Cdc d l u hipu l i l n quan d i n than kinh tam tj cDa ngu'd'i Idm vipc tren phipcng tipn van tdi thuy
Anh hudng cCia cdng vipc tdi tam ly cua ngudi lao ding: Cd 89,4% ngudi lao dpng nhd nhd khi di iSm trdn tdu, cdm gidc cd dan khi di tdu (50,3%), cdm gi^c tdch bipt khi di tdu (35,8%), lo lang gdnh npng v l kinh t l (43%).
Cde y l u t l dnh hudng d i n tdm \if ciia ngudi lam viSc tfSn phuang tipn vpn tdi thuy: Ngudi Idm vipc trier phuang tipn thuy cd tinh trgng cdng thang than kinh do lo cho tinh mgng cua minh khi Idm vipc tren m (72,2%), lo sg khi gpp hda hogn trSn tdu (72.2%) vS khd chju bdi tilng I n , mng trang mdi tm'dng (64,9%)._
3. Tinh trying sOx: khde vd t h i n kinh tam ly cua cOa ngud'i lao dgng
Kit qud khdm ddnh gid phdn logi sire khoe cho ngudi lao dgng cho thiy ti Ip sire khde logi II Id cao nhat chilm 58,1%, sire khde logi I chilm 22,6%, arc khde logi III chilm 17,9%. sire khde logi IV chilm 1,3%
Y H p c THV'C HANH (1066) - SO 1/2018
vd sire khde logi V khdng ed tnrdng hgp ndo. 17 Ip bpnh rang hdm mgt (41,9%), bpnh mat (40,9%), bpnh tuin hoan 21,3%.
Ddnh gid muc dp mpt mdi cdng thing than kinh tnang cdng vipc: T9 Ip ngudi lao dpng trdn phuang tipn thfly cd bilu hipn cdng thing t h i n kinh d mire tnjng binh Id 45,0%, rlt cdng thing ehllm 21,2% vd cdng thing qua mire chilm 2,0%.
B l n ^ 1:LiSn quan gl&a mdi tardng lao ddng khic nghipt (on, ndng, rung lie...) vd rdi logn thin kinh tdm 1^ ciia ngudi lao dpng
Chftiiu n NghiSn cOu C6 rdi loan nghien CiPU (Cdm giac kh6 TKTL p
chju khi Idm \riPc n % Kit qud trong mfii tru'dng
nghiSn ci>u khSc nghiSt)
Kheng 53 27 26,2 C6
Tong 151
76 73,8 < 0,05 101
Nhdm ngudi lao dpng trSn phuang tipn thOy elm thiy mdi trudng lao dpng khic nghipt nguy ca bj rdi logn than kinh tdm 1;^ cao g i p 1,52 Jan so vdi nhdm ngudi lao dpng khong cho la m l i tnjdng lao ddng trin phuang tipn thiiy khic nghipt. Sg khac bipt cd y nghTa tiling kS vdi p < 0,05.
Bang 2: LiSn quan giCi'a cdm giac cd dan vd r l i logn thin kinh tdm 1;^ eOa ngudi lao dpng trdn phuang tipn thuy
Chi tieu n Co r6i lo^n nghiSn cihj Nghien ci>u TKTL p K^ qua (Cim giac cd n % nghiSn CLFU don khi di tdu)
Khong 75 35 35,7 06
Tfing
76 151
63 64,3 <0,05
Nhdm ngudi lao dpng tren phuang tipn thuy ed elm thay cd dan gidy vd nguy ea bj rdi logn than kinh tdm ly eao g i p 1,77 l l n so vdi nhdm ngudi lao ddng trSn phuang tipn thiiy khdng elm thiy cd dan gidy vd khi tdu hdnh trinh. Sg khdc bipt cd y nghTa thong kS vdi p < 0,05.
Bdng 3: LiSn quan giOa lo ling do tai ngn hay thdm hpa khi Idm vipc tren tdu vd r l i logn thin kinh tdm ly ciia ngudi lao dpng
Chftiiu NghiSn CLPU C6 r& logn nghiSn ciru (Lo cho tinh mgng TKTL p
cCia minh khi Idm n % K^qud vipc trSn tdu)
nghiSn ci>u
KhSng 42 19 18,6 C6 109 82 81,2 <0,05 Tdng
OR 1.67
Nhdm ngudi lao dpng tren phuang tipn thuy cd lo ling do tai ngn hay thim hpa trPn bien ed nguy ea bj rli logn t h i n kinh tam ly cao g i p 1,67 l l n so vdi nhdm ngudi lao dpng trSn phuang tipn thiiy khdng lo lang do tai ngn hay thdm hpa trPn tdu. Sg khdc bipt cd if nghTa thdng kS vdi p < 0,05.
BANLUAN
K i t qua nghiSn ciru cho thay cd 60% mdu do nhipt dd. 26.6% mdu do toe dp gid, 40% m l u do cudng dp tieng I n (NguIn phat sinh tieng I n 6 day chd y l u do hogt dgng eua may tdu), 20% m l u do rung xdc tren phuang tipn thuy vugt tIPu chuan vp sinh cho phdp, day Id cde y l u t l anh hudng tm'c tilp d i n sire khde vd t h i n kinh tdm \if cua_ ngudi lao dpng. PhO hgp vdi nghiPn cuu ciia Nguyen Thj Hai Hd (2014) v l dieu kipn lao dpng, sire khde va bpnh tdt ciia thuyin vien tdu viin duang ndm 2011-2012 [3].
NghiSn CLPU ve ca d u bpnh tpt ciia ngudi lao dpng trdn phuang tipn thuy eho thiy t f Ip ngudi bj bpnh rang hdm mpt 41,9%; bpnh mat chilm 40.9%; Bpnh tuin hodn 21,3%; Bpnh tiSu hda 20,9%; Bpnh tilt nipu, sinh dye 11,3%. So sdnh vdi nghiSn cO'u ciia Nguyin Thj Hdi Ha (2014) nghiSn eil'u v l sire khde, benh tpt ciia thuyen viSn [3], NguySn Bdo Nam, Nguyen Hal Hd (2012), nghiSn eiru thuc trgng sire khde va ca elu bpnh tpt ciia thuyin viSn Vipt Nam [5]
eho thiy ca c i u mpt sd nhdm bpnh tgt cua ngudi lao ddng trSn phuang tipn thiiy cd ty Ip thIp ban.
Qua nghiSn ciPU v l gdnh ndng thin kinh tdm \if eho thiy ed nhilu y l u td dnh hudng d i n cdng thing thin kinh tpm ly cua ngudi lao dpng nhu dieu kipn vi khi hdu, dilu kipn lao ddng khic nghipt: I n , rung, idm vipc ea kip, cdng vipc dan dipu, eule sdng buIn td... T? Ip ngudi lao dpng nhd nhd khi di tdu (89,4%), lo cho tinh mang ciia minh khi Idm viyc tren tdu (72,2%), lo sg gpp hda hogn trSn tdu (72,2%), khd chju khi phai Idm
\flpe trong m i l tm'dng khac nghipt: tilng dn, rung, nong... (64,9%), cdm gidc cd dan khi dl tdu (50,3%).
cam gidc tdch bipt khi di tdu (35.8%), to ling gdnh ngng ve kinh t l (43%). phCi hpp vdi nghiSn ciPU cCia Trin Thj Quv'nh Chi, Nguyin Tm'dng San [1] khi nghiSn cuu ve dpc dilm tdm ly eiia thuyin viSn khi hdnh trinh tren bien. BSn cgnh dd m i l tm'dng vi xa hpi trSn tdu bat binh thudng, chi g i m mpt gidi nam. Do dd, nhO'ng chuyin hanh trinh dai ngdy trSn sing, bien thudng xult hipn tdm trgng buIn chdn, tCi tiing, khdng duge thod mdn nhu elu tinh cdm vd sinh 1^, gdnh ngng ndy keo ddi sS gdy cdc roi logn ve tam sinh ly ngng ne.
Qua ddnh gid mO'e dd cdng thing thim kinh tdm ly' cua ngudi lao dpng trdn phuang tipn thiiy cho thiy ^ IS ngudi lao dpng cd bilu hipn cang thing thin kinh d mO'e trung binh id 38,4%-45,7%, rlt cang thang 19,2%-22,5% vd cang thing qua mire 1,3%-2.0%. PhO hgp vdi k i t q u i nghiSn cdu cOa NguySn Tm'dng San.
Trin Thj Quynh Chl [6], NguySn Th| Hdi Ha [3] vd mpt sd tdc gid khde.
KtT LUAN
1. ThiFC trgng d i l u kipn va mdi Inrdrng lao dpng - Cd 60.0% m i u do nhipt dp, 26.6% mdu do tdc dp gid vugt tiSu ehuIn vp sinh eho phPp,
- 40% m l u do cudng dp tilng I n , 20% mdu do mng xdc vugt tiPu chuin vP sinh eho phep.
- Dilu kipn lao dpng dpc thti trin sdng, bien vdi khong gian gd bd, mdi tardng vi xd hpi b i t thudng (chi cd gidi nam), cdng vipc nhdm chdn, dan dipu, thieu
Y H p c THV'C HANH (1066) - SO 1/2018
thin ve tinh thin, sinh hogt van hda de gdy cdng thing thin kinh, tdm ly cho ngudi lao dpng. ^
2. Thyc trang si>c khoe vd dpc diem than kinh tam ly cOa ngirdi lao dpng fren phuvng tipn thuy
- Phdn logi sire khoP: Logi II ehllm 58,1%; Loai I chiem 22,6%; Logi III chilm 17,9%; Logi IV chiem 1.3%; Khdng cd tm'dng hgp ndo sO'c khoe logi V. ^
- Bpnh rdng hdm mpt 41,9%; Bpnh mdt ehlem 40,9%; Bpnh tuan hodn 21,3%; Bpnh tiSu hda 20,9%;
Bpnh tilt nipu, sinh dye 11,3%.
- Ngudi lao dpng Idm vipc trSn phuang tipn thiiy cd ti Ip mac bpnh cao han ngudi Idm cdng vipc phy trg trSn bd. Sg khdc bipt ndy ed if nghTa thdng kS vdi P<0,05.
- Cde ylu t l anh hudng d i n cdng thing thin kinh tdm ly cOa ngudi lao dpng: mong dugc tin tO'C cua gia dinh (91,4%), nhd nhd khi dl tdu (89,4%), lo cho tinh mang eOa minh khi Idm viSc trin tdu (72,2%), lo sg gpp hda hogn tren tdu (72,2%), khd chju khi phai Idm vipc trang mli trudng khac nghipt: filng dn. mng, ndng... (64,9%), cdm gidc cd dan khi di tdu (50,3%), cdm gidc tdch bipt khi di tau (35,8%). lo ling gdnh npng v l kinh t l (43%).
- TJ ip ngudi lao dpng tren phuang tipn thuy ed bilu hipn cdng thing thin kinh d muc tmng binh Id 38,4%-45,7%, rlt cdng thing 19.2%-22.5% vd cang thing qud muc 1,3%-2,0%.
TAI LI$U THAM K H A O
1. Trin Thj Qujnnh Chi, Nguyin Tnrdvig So>n, Trin Thj Chinh (2003), "SwSc i^u nghiin ciiu rr^tsd die ffiki tim shh ty da thuyin van V^( Nam". Tap ehi Y hi^ttvc hdnh, Bp Y te xuat bdn, Hd Npi, sd 444, tr. 71-73.
2. BOI Thj Hd, Nguyen Trud'ng Son (2003), Qjc diim sQc khde vi ca du b$nh t$t cua thuyin viin congt^
vin tii Xing diu dw&ng thiiy I Hii Phmg, Tgp chi Y hjc thgc hanh, so444, tr. 177-184.
3. NguySn Thj Hdi Hd (2014), Diiu kiin lao d$ng, siic khde vi b$nh tit cOa thuyen viin tiu viin duang hSrn 2011-2012. Vipn Vp sinh djch te 7W.
4. Nguyin Lung (1995), "iWpt sd vin di sOc khoi, binh tytvi tai nan sTquan, thu^tiiH VietNanf. TgpdilY hpc Vipt Nam, Tong hpi Y Dugc hpc Vipt Nam, so 12, Ir 2-8.
5. Nguyin Bao Nam, Nguyin Hai Hd (2012). Ttiifl:
tryng sue khoe vi ca ciu binh tit cOa thuyin viSn W!|
Warn lim viyc tren dc tiu v$n ^1 viin duong, Kj ySu cing trinh nghien ciru khoa hpe Y hpe biln, NXB Y hpc
6. Nguyin Trvdng Son, Tran Thj Qu^ti Chi (2003), E>ic diem mdi tmung lao dyng bin biin, kih huong cOa nd din st)c khoe vi ca cau b$r}h tit c6a thuyen viin Viyt Nam. Tap chl Y hoc thgc hdnh s6 444/2003 (YHTH).
7. Le Tmng (1994), Binh nghi nghiip, NXB Y hpc, Ha Npi, tr. 47-78.
8. International Maritime Health Association (2012), Newsletter. January 2012:14.
NGHIEN CU'U K^T QUA DI^U TRI UNG THU' PHdl T^ BAO N H C BANG HOA - XA TRI P H O I HOP TAI BENH VIEN DA KHOA T I N H THANH HOA
T 6 M TAT
Ung thw phdi ti bio nhd (UTP-TBN) chiim tiiy 15- 20%, niu khdng diiu bi kip th&i, khoing 60-70%
chuyin giai dOyn lan tiin [7]. Hdi cOv md tS, theo doi sdng thim 84 bynh nhin nhim dinh gii kit qua diiu tri (Etoposide, Cisplatin) + xy tii phdi hgp vi phwang phip xy tii UTP-TBN tyi tmng tim Ung Bw&u binh viin Da Khoa tinh Thanh Hda tir 1/1/2010 din 31/12^015.
Kit qui: T]? li nam/nO- li 2.5/1; tudi tmng binh li 56; ung thw biiu md ti bio nhd chiim 98,8%,; giai doan khu tni 82,1 %; chi sd KPS > 80% chiim 66,7%; ti ii dip img toan bd li 97,6%; giim bach ciu xa ddng th&i dd 3-4 li 5.4%; thiiu miu xy tri <Jdng dg 3-4 li 3,6%; sdng thim xy tq ddng thin 5 nam li 8.5%,, xa tri bd trg 5 nim 4% v&i p>0.05. Xy tn dw phdng nao.sdng thim 5 nim 21%,, khdng xa trj dy phdng nio 5 nim 0%, v&ip=0,001. Chisd KPS >80 sdngtiiim 5 Chiu trich nhiym: Li Vin Giao
Email: [email protected] Ngiy nh$n: 14/11/2017 Ngiypbin biin: 11/12/2017 Ngay duy$t bai: 26/12/2017 Ngiy xuit bin: 20/1/2018
LE VAN GIAO, L £ XUAN S A N H , L ^ DUY HUTiG Bynh viyn 71 Trung uong nam 10,7%,, KPS < 80 sdng thim 5 nim 0%.
Kit luin: Diiu tri, hda-xy tri phdi hgp vin phuur^
phip xy tri UTP-TBN cho tiiay tic dung dip Ong WiS tdt, giim nhe tri$u chiing vi kio dai thdi gian song thim cho ngw&i binh. Cic tic dung khdng mong mudn & mire an toin.
Twkh6a: Ung tiiwphdi ti bio nhd.
SUMMARY
Small ceil lung cancer accounts for 15-20%, ifiif^
treated pmmptiy about 60-70% of which move to fte spread period [7j. A refrospectfve sfudy of 84 pa^eris was conducted to assess the outixme of treabneri (Etoposide, Cisplatin) + concun^nt radiothempy. small cell lung cancer at the Center of Oncology of Ttianti Hda General Hospital from 1/1/2010 to 31/12/2015.
Results: The ratio of male to female is 2,5.1;
average age is 56; small cell eaminoma lung cancer accounts for 98.8%,; focal period is 82.1; KPS irvlmis
> 80% that acxounts for 66,7%>; The overall mspoim rate is 97.6%; Neutropenia at the scale of 3-4 is 5.4%
Radiotiierapy anemia at 3-4 is 3.6%; Live em J years is 8.5%, Complementary radiation iherapjf = yeare is 4% with p>0.05. Radiotherapy tor cersm prophylaxis, live extra 5 years is 21%, vwffw
Y HQC THV'C HANH (1066) - S6 iM^
