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Figure 1. Overview of the formation of the �-amyloid (A�) peptide from the amyloid precursor protein (APP), including the aminoacid sequences for the A�(1–40) and A�(1–42) peptides
Figure 2. Upfield regions of the proton nuclear magnetic resonance (1H NMR) spectra (600 MHz) for the �-amyloid (A�) (1–42) (A)alone (0.5 mM) and with (B) 0.25 mM, (C) 0.50 mM, (D) 1.0 mM, and (E) 2.0 mM nicotine
Figure 3. The two-dimensional (1–42) (0.20 mM) in 9:1 H1H-15N heteronuclear single-quantum coherence spectra of recombinant 15N-labeled �-amyloid (A�)2O:D2O phosphate buffer at pH 7.2 and 5°C
Figure 4. The expanded 1H-15N heteronuclear single-quantum coherence spectra of recombinant 15N-labeled �-amyloid (A�) (1–42)[0.20 mmol/L alone and with (S)-(�)-nicotine (0.60 mmol/L)] (for complete spectrum, see Figure 3)
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