BAB VII SIMPULAN DAN SARAN
7.2 Saran
Sebagai saran dalam penelitian ini adalah perlu dilakukan penelitian lebih lanjut untuk mengetahui pemberian krim ekstrak biji markisa dalam menghambat peningkatan jumlah kolagen dan penurunan kadar MMP-1 pada manusia.
Perlu juga penelitian lebih lanjut menggunakan dosis selain 100% untuk mendapatkan efek maksimal dari krim ekstrak biji markisa.
DAFTAR PUSTAKA
DAFTAR PUSTAKA
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Lampiran 1. Ethical Clearance
LAMPIRAN
Lampiran 2
Lampiran 3
Lampiran 4 Data Hasil Penelitian
Lampiran 4a. Kadar MMP-1 Kelompok Kontrol
Kadar MMP-1 Kelompok Kontrol
no sample absorbance sample kadar (ng/ml)
1 0,452 2,18 2 0,469 2,26 3 0,658 3,18 4 0,471 2,27 5 0,36 1,63 6 0,431 2,08 7 0,646 3,12 8 0,49 2,36 9 0,059 0,06 10 0,668 3,23 11 0,725 3,50 12 0,846 4,10 13 0,357 1,61 14 0,542 2,62 15 0,559 2,70 16 0,661 3,19 17 0,662 3,20 18 0,716 3,46 46,76 2,597784
Lampiran 4b. Kadar MMP-1 Kelompok Perlakuan
Kadar MMP-1 Kelompok Perlakuan no sample absorbance sample kadar (ng/ml)
1 0,686 3,32 2 0,549 2,65 3 0,346 1,53 4 0,442 2,13 5 0,435 2,10 6 0,059 0,06 7 0,623 3,01 8 0,517 2,50 9 0,617 2,98 10 0,605 2,92 11 0,53 2,56 12 0,486 2,34 13 0,659 3,18 14 0,61 2,95 15 0,671 3,24 16 0,509 2,46 17 0,065 0,09 18 0,554 2,67 42,70 2,372036
Lampiran 4c Uji Normalitas Data
Uji Normalitas Data
Kelompok
Kolmogorov-Smirnova Shapiro-Wilk
Statistic df Sig. Statistic df Sig.
Kolagen Kontrol Perlakuan Kontrol Perlakuan .096 18 18 .200* .964 .921 .942 .929 18 .673 .161 .200* 18 .134 MMP_1 .161 18 18 .200* 18 .311 .137 .200* 18 .183
a. Lilliefors Significance Correction *. This is a lower bound of the true significance.
Lampiran 4d Uji t-independent Data Kolagen dan MMP-1
Group Statistics
Kelompok N Mean Std. Deviation Std. Error Mean Kolagen Kontrol Perlakuan 18 63.6284 2.60447 .61388 18 70.3178 2.24880 .53005 MMP_1 Kontrol Perlakuan 18 2.9861 .58711 .13838 18 2.3161 .70062 .16514
Independent Samples Test Levene's Test for Equality of
Variances t-test for Equality of Means F Sig. t df Sig. (2tailed) Mean Differen ce Std. Error Differen ce 95% Confidence Interval of the Difference Lower Upper Kola gen Equal variances assumed
Equal variances not assumed .576 .453 -8.248 34 .000 -6.68939 -6.68939 .81105 -8.33764 -5.04114 -8.248 33.2 9 .000 .81105 -8.33893 -5.03985 MMP Equal variances _1 assumed
Equal variances not assumed .349 .559 3.110 34 .004 .67000 .67000 .21545 .23214 1.10786 3.110 32.9 90 .004 .21545 .23165 1.10835
Lampiran 5 Kumpulan Foto Penelitian
Biji Markisa dalam buah markisa ungu
Pemisahan Biji Markisa dari Daging Buah
Pemeliharaan tikus dalam kandang
Pakan Tikus Pemberian Minum
Pengolesan krim ekstrak biji markisa
Lampu UV-B Type KN-4003
Simulator UVB & box penyinaran tikus Penyinaran UV-B pada tiku
Euthanasia Tikus Wistar Eksisi Kulit Tikus
Eksisi kulit tikus
Eksisi kulit tikus Dekapitasi tikus