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“PENGARUH KOMBINASI
HEMODIALISIS (HD) / HEMOPERFUSI (HP)
TERHADAP KUALITAS HIDUP YANG DINILAI DENGAN SF36 PASIEN HEMODIALISIS REGULER”
Yusleny Yusuf, Alwi Thamrin Nasution, Abdurrahim Rasyid Lubis Divisi Nefrologi dan Hipertensi - Departemen Ilmu Penyakit Dalam
Fakultas Kedokteran Universitas Sumatera Utara Medan
ABSTRAK
Latar Belakang: Akumulasi toksin uremik berat molekul kecil,sedang dan berat dan efek biologisnya pada pasien penyakit ginjal tahap akhir sudah jelas diketahui menyebabkan komplikasi jangka pendek, menengah dan jangka panjang . Metode hemodialisis (HD) hanya dapat membersihkan toksin uremik berat molekul kecil sehingga menyebabkan komplikasi jangka panjang yang akan menurunkan kualitas hidup dan meningkatkan mortalitas pasien hemodialisis. Metode hemoperfusi (HP) dapat membersihkan toksin uremik berat molekul sedang, besar dan racun yang terikat protein. Penelitian sebelumnya menunjukkan kombinasi HD+HP meningkatkan clearance LMWP (low molecular weight protein).
Tujuan: Untuk mengetahui pengaruh kombinasi HD+HP terhadap kualitas hidup pasien hemodialisi regular.
Metode: Penelitian kohort prospektif dari bulan Desember 2013 hingga Maret 2014 terhadap 20 pasien hemodialisis reguler dan dilakukan penilaian kualitas hidup dengan kuisioner SF-36
Hasil: Dari 20 subjek yang diamati 1 subjek keluar dari penelitian. Terdapat perbedaan bermakna antara rerata skor kesehatan fisik sebelum dan setelah kombinasi Hemodialisis/Hemoperfusi (p<0,05). Terdapat pula perbedaan bermakna antara rerata skor kesehatan mental sebelum dan setelah kombinasi Hemodialisis/Hemoperfusi (p<0,05). Terdapat perbedaan perasaan nyeri (bodilypain) setelah kombinasi HD+HP berdasarkan lamanya menjani HD (p<0,05).
Kesimpulan: Kombinasi HD+HP meningkatkan kualitas hidup pasien yang menjalani hemodialisis regular baik status kesehatan fisik maupun status kesehatan mental dan mengurangi rasa nyeri berdasarkan lamanya menjalani HD.
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“ COMBINATION HEMODIALYSIS (HD) / HEMOPERFUSION (HP) EFFECT TO QUALITY OF LIFE ASSESSED WITH SF-36
ON REGULAR HEMODIALYSIS”
Yusleny Yusuf, Alwi Thamrin Nasution, Abdurrahim Rasyid Lubis Division of Nephrology and Hypertension - Department of Internal Medicine
Faculty of Medicine University of Sumatera Utara Medan
ABSTRACT
Background: Accumulation of small, medium and heavy molecular weight uremic toxin and its biological effects on end-stage renal disease patients has been clearly known to cause short, medium and long term complications. Hemodialysis (HD) can only clean small molecular weight uremic toxins and can cause long-term complications that would decreased the quality of life and increased mortality of patients on hemodialysis. Haemoperfusion (HP) can clean medium and large molecular weight uremic toxins and also protein-bound toxins. Previous studies have shown the combination of HD + HP improve clearance LMWP.
Objective: To determine combination hemodialysis (HD) / hemoperfusion (HP) effect to quality of life of patients undergoing regular hemodialysis.
Methods: This prospective cohort study from December 2013 to March 2014 on 20 regular hemodialysis patient and and quality of life assessment by SF-36 questionnaire.
Results: Twenty subjects were observed and one subject was out of the study at the end of observation. There is a significant difference between the mean score of physical health before and after the combination of HD+HP (p <0.05). There is also a significant difference between the mean score of mental health before and after the combination of HD+HP (p <0.05). There are differences in bodily painafter the combination of HD+HP based on duration of regular hemodialysis(p<0.05).
Conclusion: Combination of HD / HP increased quality of life both of physical health and mental health in patients undergoing regular hemodialysis and decreased bodily pain based on duration of HD.
