- asam stearat
- sorbitol
- setil alkohol
- propilen glikol
- dimasukkan ke dalam cawan
- trietanolamin
penguap
- metil paraben
- dilebur di atas penangas air pada suhu 70
°
C - dilarutkan dalam air
panas yg telah ditakar
pada suhu 70
°
C
- digerus konstan di dalam lumpang panas
- ditambahkan 3 tetes pengaroma
Fase air
Fase minyak
Fase minyak + fase air
- asam stearat
- sorbitol
- setil alkohol
- propilen glikol
- dimasukkan ke dalam cawan
- trietanolamin
penguap
- metil paraben
- dilebur di atas penangas air pada suhu 70°C - dilarutkan dalam air
panas yg telah ditakar
pada suhu 70
°
C
- digerus konstan di dalam lumpang panas
- ditambahkan minyak alpukat
- ditambahkan 3 tetes pewangi
Fase air
Fase minyak
Fase minyak + Fase air
Keterangan : A: Moisture Checker (Aramo-SG), B: Skin Analyzer (Aramo-SG),
C: pH meter (Hanna Instrument)
A
B
-setelah selesai dibuat
-setelah penyimpanan 12 minggu
Keterangan: Krim A: blanko, Krim B: krim minyak alpukat 5%, Krim C: krim
minyak alpukat 10%, Krim D: krim minyak alpukat 15%, Krim E: krim minyak
alpukat 20%.
Krim A
Krim B
B
Krim C
Krim D
Krim E
Krim A
Krim B
Krim C
Gambar uji homogenitas sediaan
Gambar uji penentuan tipe emulsi
Keterangan: Krim A: blanko, Krim B: krim minyak alpukat 5%, Krim C: krim
minyak alpukat 10%, Krim D: krim minyak alpukat 15%, Krim E: krim minyak
alpukat 20%.
Krim A
Krim B
Krim C
Krim D
Krim E
Kadar air (moisture)
Kondisi awal :
Pemulihan minggu I :
Pemulihan minggu II :
Pemulihan minggu III :
Kehalusan (evenness)
Kondisi awal :
Pemulihan minggu I :
Pemulihan minggu III :
Noda (spot)
Kondisi awal :
Pemulihan minggu II :
Keriput (wrinkle)
Kondisi awal :
Pemulihan minggu II :
SURAT PERNYATAAN PERSETUJUAN IKUT SERTA DALAM
PENELITIAN
Saya yang bertandatangan dibawah ini :
Nama
:
Umur
:
Alamat
:
Telah mendapat penjelasan secukupnya bahwa saya akan melakukan uji krim
minyak alpukat terhadap kulit sebagai sediaan krim anti-
aging
. Setelah
mendapat penjelasan secukupnya tentang manfaat penelitian ini dan efek
sampingnya, maka saya menyatakan SETUJU untuk ikut serta dalam penelitian
dari Cut Putri Arhandhi dengan judul “FORMULASI DAN UJI EFEK ANTI
-AGING
DARI KRIM YANG MENGANDUNG MINYAK ALPUKAT
(Avocado oil)
, sebagai usaha untuk mengetahui apakah sediaan krim anti-
aging
dari minyak alpukat yang dihasilkan mampu atau tidak dalam memulihkan kulit
yang telah mengalami penuaan. Saya menyatakan sukarela dan bersedia untuk
mengikuti prosedur penelitian yang telah ditetapkan.
Persetujuan ini saya buat dengan penuh kesadaran dan tanpa paksaan dari pihak
manapun. Demikian surat pernyataan ini dibuat untuk dapat dipergunakan
sebagaimana mestinya.
Medan, 27 November 2014
Peneliti,
Sukarelawan,
1.
Kadar air (moisture)
ANOVA
Sum of Squares df Mean Square F Sig. Sebelum Between Groups 2.500 5 .500 1.500 .261
Within Groups 4.000 12 .333
Total 6.500 17
MingguI Between Groups 5.111 5 1.022 2.300 .110
Within Groups 5.333 12 .444
Total 10.444 17
MingguII Between Groups 10.944 5 2.189 2.627 .079
Within Groups 10.000 12 .833
Total 20.944 17
MingguIII Between Groups 15.611 5 3.122 6.244 .004
Within Groups 6.000 12 .500
Total 21.611 17
MingguIV Between Groups 17.778 5 3.556 5.818 .006
Within Groups 7.333 12 .611
Sebelum
PEMULIHAN N
Subset for alpha = 0.05 1
Tukey HSDa Formula A 3 27.67
Formula B 3 27.67
Formula C 3 28.33
Formula D 3 28.33
Formula E 3 28.33
Formula F 3 28.67
Sig. .339
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguI
PEMULIHAN N
Subset for alpha = 0.05 1
Tukey HSDa Formula A 3 29.67
Formula B 3 30.00
Formula C 3 30.33
Formula D 3 30.67
Formula E 3 30.67
Formula F 3 31.33
Sig. .082
MingguII
PEMULIHAN N
Subset for alpha = 0.05
1 2
Tukey HSDa Formula A 3 29.67
Formula B 3 31.00 31.00
Formula C 3 31.00 31.00
Formula D 3 31.00 31.00
Formula E 3 31.33 31.33
Formula F 3 32.33
Sig. .506
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguIII
PEMULIHAN N
Subset for alpha = 0.05
1 2 3
Tukey HSDa Formula A 3 30.33
Formula B 3 30.67 30.67
Formula C 3 32.00 32.00 32.00
Formula D 3 32.00 32.00 32.00
Formula E 3 32.33 32.33
Formula F 3 33.00
Sig. .538
MingguIV
PEMULIHAN N
Subset for alpha = 0.05
1 2
Tukey HSDa Formula A 3 30.33
Formula B 3 31.67 31.67
Formula C 3 32.33 32.33
Formula D 3 32.67
Formula E 3 33.00
Formula F 3 33.33
Sig. .168
2.
Kehalusan (evenness)
ANOVA
Sum of Squares df Mean Square F Sig. Sebelum Between
Groups
60.944 5 12.189 1.180 .375
Within Groups 124.000 12 10.333
Total 184.944 17
MingguI Between Groups
44.278 5 8.856 1.147 .389
Within Groups 92.667 12 7.722
Total 136.944 17
MingguII Between Groups
32.278 5 6.456 .993 .462
Within Groups 78.000 12 6.500
Total 110.278 17
MingguIII Between Groups
67.778 5 13.556 1.807 .186
Within Groups 90.000 12 7.500
Total 157.778 17
MingguIV Between Groups
155.611 5 31.122 4.554 .015
Within Groups 82.000 12 6.833
Sebelum
PEMULIHAN N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 38.67
Formula E 3 39.33
Formula D 3 40.33
Formula C 3 41.33
Formula B 3 41.67
Formula A 3 44.33
Sig. .322
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguI
PEMULIHAN N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 37.33
Formula E 3 37.67
Formula D 3 38.67
Formula C 3 38.67
Formula B 3 40.00
Formula A 3 42.00
Sig. .368
MingguII
PEMULIHAN N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 35.00
Formula E 3 35.33
Formula D 3 36.00
Formula C 3 36.67
Formula B 3 38.00
Formula A 3 38.67
Sig. .522
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguIII
PEMULIHAN N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 32.33
Formula E 3 33.33
Formula D 3 34.00
Formula C 3 35.00
Formula B 3 36.67
Formula A 3 38.00
Sig. .189
MingguIV
PEMULIHAN N
Subset for alpha = 0.05
1 2
Tukey HSDa Formula F 3 29.00
Formula E 3 29.33
Formula D 3 33.00 33.00
Formula C 3 33.33 33.33
Formula B 3 34.00 34.00
Formula A 3 37.67
Sig. .310
3.
Besar pori (pore)
ANOVA
Sum of Squares df Mean Square F Sig. Sebelum Between
Groups
21.778 5 4.356 .311 .897
Within Groups 168.000 12 14.000
Total 189.778 17
MingguI Between Groups
29.167 5 5.833 .418 .827
Within Groups 167.333 12 13.944
Total 196.500 17
MingguII Between Groups
142.500 5 28.500 4.622 .014
Within Groups 74.000 12 6.167
Total 216.500 17
MingguIII Between Groups
404.444 5 80.889 16.545 .000
Within Groups 58.667 12 4.889
Total 463.111 17
MingguIV Between Groups
489.778 5 97.956 18.367 .000
Within Groups 64.000 12 5.333
Sebelum
PEMULIHAN N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 24.33
Formula E 3 25.33
Formula D 3 25.67
Formula C 3 26.67
Formula B 3 27.33
Formula A 3 27.33
Sig. .915
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguI
PEMULIHAN N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 20.67
Formula E 3 22.33
Formula D 3 22.33
Formula C 3 23.00
Formula B 3 24.33
Formula A 3 24.33
Sig. .828
MingguII
PEMULIHAN N
Subset for alpha = 0.05
1 2
Tukey HSDa Formula F 3 16.00
Formula E 3 18.67 18.67
Formula D 3 20.67 20.67
Formula C 3 22.00 22.00
Formula B 3 23.67
Formula A 3 24.00
Sig. .163
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguIII
PEMULIHAN N
Subset for alpha = 0.05
1 2 3 4
Tukey HSDa Formula F 3 10.67
Formula E 3 14.00 14.00
Formula D 3 17.33 17.33
Formula C 3 17.33 17.33
Formula B 3 23.33 23.33
Formula A 3 24.00
Sig. .999
MingguIV
PEMULIHAN N
Subset for alpha = 0.05
1 2 3 4
Tukey HSDa Formula F 3 8.00
Formula E 3 10.67 10.67
Formula D 3 14.00 14.00 14.00
Formula C 3 14.67 14.67
Formula B 3 20.00 20.00
Formula A 3 23.33
Sig. .518
4.
Noda (spot)
ANOVA
Sum of Squares df Mean Square F Sig. Sebelum Between
Groups
172.944 5 34.589 2.256 .115
Within Groups 184.000 12 15.333
Total 356.944 17
MingguI Between Groups
17.333 5 3.467 .156 .974
Within Groups 266.667 12 22.222
Total 284.000 17
MingguII Between Groups
189.778 5 37.956 3.023 .054
Within Groups 150.667 12 12.556
Total 340.444 17
MingguIII Between Groups
437.111 5 87.422 11.921 .000
Within Groups 88.000 12 7.333
Total 525.111 17
MingguIV Between Groups
860.500 5 172.100 24.586 .000
Within Groups 84.000 12 7.000
Sebelum
PEMULIHAN N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 38.67
Formula E 3 41.67
Formula D 3 44.00
Formula C 3 45.00
Formula B 3 46.00
Formula A 3 48.33
Sig. .087
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguI
PEMULIHAN N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 38.33
Formula E 3 38.67
Formula D 3 38.67
Formula C 3 39.00
Formula B 3 40.33
Formula A 3 41.00
Sig. .979
MingguII
PEMULIHAN N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 29.67
Formula E 3 33.33
Formula D 3 35.67
Formula C 3 37.00
Formula B 3 38.67
Formula A 3 39.00
Sig. .062
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguIII
PEMULIHAN N
Subset for alpha = 0.05
1 2
Tukey HSDa Formula F 3 24.67
Formula E 3 27.00
Formula D 3 32.00 32.00
Formula C 3 35.33
Formula B 3 36.00
Formula A 3 38.33
Sig. .113
MingguIV
PEMULIHAN N
Subset for alpha = 0.05
1 2 3 4
Tukey HSDa Formula F 3 18.33
Formula E 3 22.33 22.33
Formula D 3 27.33 27.33
Formula C 3 32.00 32.00
Formula B 3 35.00
Formula A 3 38.00
Sig. .472 .260 .322 .129
5.
Keriput (wrinkle)
ANOVA
Sum of Squares df Mean Square F Sig. Sebelum Between
Groups
316.944 5 63.389 2.145 .129
Within Groups
354.667 12 29.556
Total 671.611 17
MingguI Between Groups
448.278 5 89.656 4.546 .015
Within Groups
236.667 12 19.722
Total 684.944 17
MingguII Between Groups
102.944 5 20.589 .563 .727
Within Groups
438.667 12 36.556
Total 541.611 17
MingguIII Between Groups
91.111 5 18.222 1.929 .163
Within Groups
113.333 12 9.444
Total 204.444 17
MingguIV Between Groups
509.333 5 101.867 4.654 .014
Within Groups
262.667 12 21.889
Sebelum
Pemulihan N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 27.67
Formula E 3 34.67
Formula D 3 35.33
Formula C 3 36.67
Formula B 3 39.00
Formula A 3 41.00
Sig. .090
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguI
Pemulihan N
Subset for alpha = 0.05
1 2
Tukey HSDa Formula F 3 26.33
Formula E 3 27.67 27.67
Formula D 3 31.67 31.67
Formula C 3 34.67 34.67
Formula B 3 39.00
Formula A 3 39.00
Sig. .074
MingguII
Pemulihan N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 25.00
Formula E 3 27.67
Formula D 3 29.00
Formula C 3 30.67
Formula B 3 31.67
Formula A 3 31.67
Sig. .754
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguIII
Pemulihan N
Subset for alpha = 0.05 1
Tukey HSDa Formula F 3 22.33
Formula E 3 22.67
Formula D 3 26.33
Formula C 3 26.33
Formula B 3 27.67
Formula A 3 28.00
Sig. .281
MingguIV
Pemulihan N
Subset for alpha = 0.05
1 2
Tukey HSDa Formula F 3 14.00
Formula E 3 16.00 16.00
Formula D 3 22.33 22.33
Formula C 3 24.33 24.33
Formula B 3 27.67
Formula A 3 27.67
Sig. .145 .083
6.
Kedalaman keriput (wrinkle’s depth)
ANOVASum of Squares df Mean Square F Sig. Sebelum Between
Groups
1080.944 5 216.189 14.099 .000
Within Groups 184.000 12 15.333
Total 1264.944 17
MingguI Between Groups
988.944 5 197.789 11.597 .000
Within Groups 204.667 12 17.056
Total 1193.611 17
MingguII Between Groups
1082.278 5 216.456 29.517 .000
Within Groups 88.000 12 7.333
Total 1170.278 17
MingguIII Between Groups
866.278 5 173.256 10.465 .000
Within Groups 198.667 12 16.556
Total 1064.944 17
MingguIV Between Groups
1636.444 5 327.289 11.461 .000
Within Groups 342.667 12 28.556
Sebelum
PEMULIHAN N
Subset for alpha = 0.05
1 2 3
Tukey HSDa Formula F 3 39.00
Formula E 3 42.33
Formula D 3 43.33
Formula C 3 47.00 47.00
Formula B 3 56.00 56.00
Formula A 3 60.67
Sig. .694
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguI
PEMULIHAN N
Subset for alpha = 0.05
1 2 3
Tukey HSDa Formula F 3 35.67
Formula E 3 40.00
Formula D 3 42.33
Formula C 3 43.33 43.33
Formula B 3 54.33 54.33
Formula A 3 56.00
Sig. .995
MingguII
PEMULIHAN N
Subset for alpha = 0.05
1 2 3 4
Tukey HSDa Formula F 3 32.00
Formula E 3 33.67
Formula D 3 38.00 38.00
Formula C 3 42.33 42.33
Formula B 3 49.00 49.00
Formula A 3 53.33
Sig. .416
Means for groups in homogeneous subsets are displayed. a. Uses Harmonic Mean Sample Size = 3,000.
MingguIII
PEMULIHAN N
Subset for alpha = 0.05
1 2 3
Tukey HSDa Formula F 3 28.00
Formula E 3 33.00 33.00
Formula D 3 33.33 33.33
Formula C 3 42.33 42.33
Formula B 3 45.33
Formula A 3 46.33
Sig. .827
MingguIV
PEMULIHAN N
Subset for alpha = 0.05
1 2 3
Tukey HSDa Formula F 3 20.33
Formula E 3 24.00
Formula D 3 29.67 29.67
Formula C 3 42.00 42.00
Formula B 3 42.33 42.33
Formula A 3 44.33
Sig. .993
