Hubungan Antara Red Blood Cell Count (Rbc) Dan Retinopati Diabetik Pada Pasien Diabetes Melitus Tipe 2

(1)

(2)

LAMPIRAN 2

LEMBAR PENJELASAN KEPADA CALON SUBJEK PENELITIAN

Selamat pagi/siang Bapak/Ibu, pada hari ini saya, dr.Irmayani, peserta

Pendidikan Pasca Sarjana Ilmu Penyakit Dalam / Magister Klinik FK USU Medan akan

melakukan penelitian yang berjudul ”Hubungan HbA1c, RBC dan retinopati pada pasien

Diabetes Melitus”.

Kepada Bapak/Ibu yang bersedia mengikuti penelitian ini nantinya akan diminta

mengisi surat persetujuan ikut dalam penelitian, mengikuti wawancara untuk mencari

adanya hal-hal yang dapat mengganggu penelitian, dilakukan pengukuran tekanan darah

(TD), berat badan (BB), tinggi badan (TB), parameter kegemukan (IMT) , pemeriksaan

laboratorium berupa pemeriksaan darah sebanyak 15 cc (1 sendok makan) yang akan

diambil dari lengan oleh ahlinya untuk menilai parameter darah rutin, kadar gula darah

puasa dan 2 jam setelah makan, HbA1c, profil lipid. Tahapan untuk pemeriksaan darah

ini adalah pasien dipuasakan selama 8-10 jam sebelum pengambilan darah, kemudian

akan dilakukan pemeriksaan mata yang disebut funduskopi untuk menilai apakah sudah

terdapat kelainan pada mata, 4 jam sebelum dilakukan funduskopi pada kedua mata

diberikan obat tetes untuk melebarkan biji mata.

Manfaat penelitian ini adalah dapat memantau dan memberi informasi tentang

progresifitas DM TIPE 2, melihat apakah gula darah sudah terkontrol, meringankan

biaya pemeriksaan laboratorium untuk pemantauan penyakit DM TIPE 2 dan

pemeriksaan menjadi lebih sederhana, murah dan tidak membutuhkan waktu yang

lama.

Pada penelitian ini tidak menimbulkan efek samping apapun namun risiko yang

dapat terjadi dari penelitian ini adalah terjadinya lebam setelah pengambilan darah, juga

tidak dijumpai efek samping pada mata hanya efek akibat obat tetes untuk melebarkan

pupil yaitu pandangan menjadi kabur sementara sampai efek obat tersebut habis.

(3)

yaitu komplikasi pada mata. Bapak dan ibu dapat menolak kesediaan untuk mengikuti

penelitian ini.

Bila masih terdapat pertanyaan atau keluhan sewaktu penelitian ini berjalan,

maka Bapak/Ibu dapat menghubungi saya pada:

Nama

: dr. Irmayani

Alamat

: Jl. Harapan Pasti Timur Perumahan Jasari Park no 1Simpang Limun

Medan

Telepon

: 08126911508/08116191508

Peneliti,

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LAMPIRAN 3

SURAT PERSETUJUAN SETELAH PENJELASAN

(INFORMED CONCERN )

Saya yang bertanda tangan dibawah ini :

Nama

:...

Alamat

:...

Umur

:... Tahun

Jenis Kelamin: Laki-laki/ Perempuan.

No Telp/HP

:

Setelah mendapat penjelasan dari peneliti tentang kebaikan dan keburukan prosedur

penelitian ini, menyatakan bersedia

Demikianlah surat persetujuan bersedia ikut dalam penelitian ini saya buat, untuk dapat

digunakan seperlunya.

ikut serta dalam penelitian tentang ” Hubungan

HbA1c, RBC dan retinopati pada pasien Diabetes Melitus”. Apabila sewaktu-waktu saya

mengundurkan diri dari penelitian ini, kepada saya tidak dituntut apapun.

Medan, ...2014

Saksi

Yang Memberi Pernyataan

(5)

LAMPIRAN 4

KERTAS KERJA PROFIL PESERTA PENELITIAN

I.IDENTITAS PRIBADI

Nama

: Kode : X / Y

Tempat/Tanggal Lahir :

Jenis Kelamin

: Laki-laki/Perempuan.

Pendidikan Terakhir

:

Pekerjaan

:

Status

: Kawin/Belum Kawin. No Telp/Hp:...

Riwayat Penyakit

: DM TIPE 2 / Hipertensi / Sakit jantung / Stroke

Durasi/lama menderita DM TIPE 2

:

Merokok

: Ya / Tidak

Jika Ya: ...Batang/hari

II.PEMERIKSAAN FISIK

Tekanan Darah : ... mmHg

.

(6)

Parameter Antropometri

Nilai

Berat Badan (kg)

Tinggi Badan (m

2

)

Indeks Massa Tubuh (kg/m

2

)

III.PEMERIKSAAN LABORATORIUM

Parameter

Nilai

Hb (gr/dl)

Leukosit (mm

3

)

Trombosit (mm

3

)

RBC

KGD puasa

KGD 2 jam PP

HbA1c

Total Cholesterol

Trigliserida

HDL

LDL

(7)

LAMPIRAN 7

DAFTAR RIWAYAT HIDUP

I. DATA PRIBADI

Nama

: dr. Irmayani

Tempat/Tgl. lahir

: Peureulak, 02 Mei 1982

Jenis kelamin

: Wanita

Agama

: Islam

Pekerjaan

: Dokter

NIP

: 19820502 200904 2 009

Pangkat/Gol.

: Penata Muda Tk I/ IIIb

Suami

: dr. Danny Dasraf SpA

Anak

: Ihsan Dasraf

Alamat pekerjaan

: Fakultas Kedokteran Universitas Sumatera Utara

Jl. dr. Mansyur no. 5 Medan Departemen Ilmu

Penyakit Dalam RSUP. H. Adam Malik Medan Jl.

Bunga Lau no.17 Medan

Alamat rumah :

Jl. Harapan Pasti Timur Perumahan Jasari Park

Simpang Limun Raya Kompleks Taman Anggrek

Medan

Telepon selular

: 08126911508

II. PENDIDIKAN

1. SD Negeri BTN Seuriget (1988-1994) di Kota Langsa- NAD

2. SMPN 3 Langsa (1994-1997) di Kota Langsa –NAD

3. SMU Negeri 1 Langsa (1997-2000) di Kota Langsa - NAD

4. Fakultas Kedokteran Universitas Syiah Kuala (2000-2007) di Banda Aceh- NAD

5. PPDS Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Sumatera Utara

(2011- sekarang) di Medan-Sumatera Utara

III. RIWAYAT PEKERJAAN

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Dokter IGD RSU Cut Meutia Langsa– NAD, Kota Langsa 2007-2009.

Dokter IGD RSUD Idi Rayeuk- Aceh Timur-NAD,Idi Rayeuk 2009-2011

IV. KEANGGOTAAN PROFESI

1.Ikatan Dokter Indonesia (IDI)

2.Perhimpunan Ahli Penyakit Dalam Indonesia (PAPDI)

V. KURSUS PENATARAN

1. Kursus Advanced Cardiac Life Support Course. PERKI, Banda Aceh 2008

VI. KARYA ILMIAH

1. Irmayani, Santi Syafril.

Hipokalsemia in Hipoparathyroid Patients.

KOPAPDI.

Medan, Desember 2012.

PARTISIPASI DALAM KEGIATAN ILMIAH

1. Peserta Simposium

Rationale Strategy in the Management of Pancreatic B

Dysfunction and Role of Oral Incretin Based Therapy in Type 2 Diabetes

Mellitus

PERKENI. Medan 29 Januari 2012.

2. Peserta Simposium

Diabetic Neuropathy

PERKENI. Medan, 08 September

2012.

3. Peserta Seminar

Penatalaksanaan Disfungsi Ereksi pada Pasien Diabetes

Mellitus

Columbia Asia. Medan 29 November 2012.

4. Panitia dan peserta Kongres Nasional XV Perhimpunan Dokter Spesialis

Penyakit Dalam Indonesia (KOPAPDI XV). Medan, 12-15 Desember 2012.

5. Panitia dan Peserta Pertemuan Ilmiah tahunan dan Pertemuan ilmiah

(9)

LAMPIRAN 6

(10)

19 2

1

55

3

25

110

70

143

168 6,9

59

165

243

166 7,51

5,25

15,5

14,0

2

(11)

16 1

2

73

6 26,5

150

60

164

258 7,7

60

152

215

120 6,40

4,39 13,9

12,9

1 17 2

2

60

20 29,4

130

60

146

262 7,9

66

197

253

87 10,3

4,78 14,2

13,4

2 18 2

1

66

15 22,4

130

80

172

290 7,2

42

153

198

94 5,37

4,42 13,7

13,3

2 19 1

2

77

20 21,7

140

70

143

208 7,1

87

230

302

125 5,32

4,71 13,4

13,3

1 20 1

2

50

17 17,9

120

70

177

252 10,5

52

107

123

169 6,51

4,75 13,3

12,8

2 21 2

2

73

30 22,8

150

60

143

260 7,6

46

75

122

54 8,26

4,81 13,8

12,3

2 22 1

2

67

17 26,6

140

70

89

334 8,3

34

119

184

292 6,46

4,49 13,6

13,9

1 23 2

2

77

18 32,4

130

60

253

374 12,3

50

165

228

95 9,27

4,39 13,1

12,7

1 24 1

2

75

14 21,7

130

70

151

317 7,7

80

240

310

191 7,33

4,03 12,1

13,4

2 25 1

2

57

5 23,8

170

90

351

402 12,1

43

120

185

232 8,89

4,32 12,0

13,0

1

(12)

LAMPIRAN 7

OUTPUT ANALISIS

Frequency Table

Hipertensi

Frequency Percent Valid Percent

Cumulative

Percent

Valid Ya 18 36,7 36,7 36,7

tidak 31 63,3 63,3 100,0

Total 49 100,0 100,0

Case Processing Summary

Cases

Tekanan darah

Sistolik (mmHg) 49 100,0% 0 0,0% 49 100,0%

Kebiasaan Merokok

Cumulative

Percent

Valid laki-laki 30 61,2 61,2 61,2

perempuan 19 38,8 38,8 100,0

(13)

Tekanan Darah

Kolesterol Total

(mg/dl) 49 100,0% 0 0,0% 49 100,0%

95% Confidence Interval for

Mean

Variance 95,003

Std. Deviation 9,747

Minimum 44

Maximum 84

Range 40

Interquartile Range 14

Skewness ,318 ,340

Kurtosis -,568 ,668

(14)

95% Confidence Interval for Mean Lower

Variance 56,792

Minimum 1

Maximum 30

Range 29

Skewness 1,464 ,340

Kurtosis 1,528 ,668

BMI (kg/m2) Mean 23,996 ,5192

Boun

Variance 13,208

Minimum 17,6

Maximum 32,9

Range 15,3

Interquartile Range 5,3

Skewness ,496 ,340

Kurtosis -,148 ,668

Tekanan darah Sistolik

(mmHg)

Mean 133,14 2,143

(15)

5% Trimmed Mean 132,48

Median 130,00

Variance 224,958

Minimum 110

Maximum 170

Range 60

Skewness ,605 ,340

Kurtosis -,026 ,668

Tekanan Darah

Diastolik (mmHg)

Mean 72,65 1,355

Boun

Variance 89,940

Minimum 60

Maximum 90

Range 30

Skewness ,197 ,340

Kurtosis -,873 ,668

KGDN (mg/dl) Mean 169,04 10,132

Boun

Variance 5030,66

5

(16)

Maximum 356

Range 274

Skewness 1,192 ,340

Kurtosis ,870 ,668

KGD 2 Jam PP (mg/dl) Mean

258,673 12,948 4

Boun

Median 260,000

Variance 8215,34

9

Minimum 109,0

Maximum 558,0

Range 449,0

Skewness ,754 ,340

Kurtosis 1,250 ,668

HbA1c (%) Mean 8,441 ,2801

Boun

Variance 3,845

Minimum 6,1

Maximum 14,8

Range 8,7

(17)

Kurtosis 1,398 ,668

HDL (mg/dl) Mean 55,94 1,885

Boun

Variance 174,184

Minimum 33

Maximum 90

Range 57

Skewness ,645 ,340

Kurtosis ,452 ,668

LDL (mg/dl) Mean 159,12 6,088

Mean

Variance 1816,27

6

Minimum 75

Maximum 295

Range 220

Skewness ,684 ,340

Kurtosis 1,202 ,668

Kolesterol Total

(mg/dl)

Mean 216,39 6,594

(18)

Median 215,00

Variance 2130,28

4

Minimum 122

Maximum 348

Range 226

Skewness ,373 ,340

Kurtosis ,712 ,668

Triliserida (mg/dl) Mean 137,61 7,416

Mean

Variance 2694,70

1

Minimum 54

Maximum 292

Range 238

Skewness 1,134 ,340

Kurtosis ,918 ,668

Leukosit (ribu/mm3) Mean 7,9173 ,20309

Mean

Variance 2,021

Minimum 5,32

Maximum 10,90

Range 5,58

(19)

Skewness ,120 ,340

Kurtosis -,683 ,668

Eritrosit (ribu/mm3) Mean 4,7092 ,07031

Mean

Std. Deviation ,49217

Minimum 3,65

Maximum 6,03

Range 2,38

Interquartile Range ,72

Skewness ,177 ,340

Kurtosis ,041 ,668

Hemoglobin (gr/dl) Mean 13,624 ,1865

Mean

Variance 1,704

Minimum 11,4

Maximum 17,4

Range 6,0

Skewness ,726 ,340

Kurtosis ,575 ,668

RDW (%) Mean 13,078 ,1017

(20)

Variance ,507

Minimum 11,5

Maximum 14,9

Range 3,4

Skewness ,358 ,340

Kurtosis ,041 ,668

Tests of Normality

Kolmogorov-Smirnova Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

Umur ,072 49 ,200* ,973 49 ,311

Durasi DM (tahun) ,237 49 ,000 ,798 49 ,000

BMI (kg/m2) ,089 49 ,200* ,972 49 ,292

Tekanan darah

Sistolik (mmHg) ,175 49 ,001 ,933 49 ,008

Tekanan Darah

Diastolik (mmHg) ,202 49 ,000 ,878 49 ,000

Kolesterol Total

(mg/dl) ,102 49 ,200

*. This is a lower bound of the true significance.

a. Lilliefors Significance Correction

Crosstabs

Cases

(21)

N Percent N Percent N Percent

Jenis Kelamin *

Retinopi Diabetik 49 100,0% 0 0,0% 49 100,0%

Kebiasaan Merokok *

Retinopi Diabetik 49 100,0% 0 0,0% 49 100,0%

Hipertensi * Retinopi

Diabetik 49 100,0% 0 0,0% 49 100,0%

**Jenis Kelamin * Retinopati Diabetik**

Chi-Square Tests

Continuity Correctionb ,013 1 ,909

Likelihood Ratio ,166 1 ,684

Fisher's Exact Test ,773 ,455

Crosstab

Retinopi Diabetik

Total

% within Retinopi

Diabetik 64,0% 58,3% 61,2%

perempuan Count 9 10 19

Expected Count 9,7 9,3 19,0

% within Jenis

Kelamin 47,4% 52,6% 100,0%

% within Retinopi

Diabetik 36,0% 41,7% 38,8%

Total Count 25 24 49

% within Jenis

Kelamin 51,0% 49,0% 100,0%

% within Retinopi

(22)

Linear-by-Linear Association ,162 1 ,687

N of Valid Cases 49

a. 0 cells (0,0%) have expected count less than 5. The minimum expected count is 9,31.

b. Computed only for a 2x2 table

Risk Estimate

Value

95% Confidence Interval

Lower Upper

Odds Ratio for Jenis

Kelamin (laki-laki /

perempuan)

1,270 ,402 4,016

For cohort Retinopi Diabetik

= Ya 1,126 ,630 2,011

= Tidak ,887 ,500 1,573

N of Valid Cases 49

**Kebiasaan Merokok * Retinopi Diabetik**

Crosstab

Retinopi Diabetik

Total Ya Tidak

Kebiasaan Merokok ya Count 2 10 12

% within Kebiasaan

Merokok 16,7% 83,3%

100,0

%

% within Retinopi

Diabetik 8,0% 41,7% 24,5%

tidak Count 23 14 37

% within Kebiasaan

Merokok 62,2% 37,8%

100,0

%

% within Retinopi

Diabetik 92,0% 58,3% 75,5%

% within Kebiasaan

Merokok 51,0% 49,0%

100,0

(23)

% within Retinopi

Exact Sig.

(2-sided)

Exact

Sig.

(1-sided)

Pearson Chi-Square 7,505a 1 ,006

Continuity Correctionb 5,795 1 ,016

Likelihood Ratio 8,013 1 ,005

Linear-by-Linear

Association 7,352 1 ,007

N of Valid Cases 49

a. 0 cells (0,0%) have expected count less than 5. The minimum expected count is

5,88.

**Hipertensi * Retinopi Diabetik**

Crosstab

Retinopi Diabetik

Total

% within Retinopi

Diabetik 44,0% 29,2% 36,7%

Risk Estimate

Value

Lower Upper

Odds Ratio for Kebiasaan

Merokok (ya / tidak) ,122 ,023 ,638

= Ya ,268 ,074 ,974

= Tidak 2,202 1,357 3,575

(24)

tidak Count 14 17 31

% within

Hipertensi 45,2% 54,8% 100,0%

% within Retinopi

Diabetik 56,0% 70,8% 63,3%

% within

Hipertensi 51,0% 49,0% 100,0%

% within Retinopi

Diabetik 100,0% 100,0% 100,0%

Continuity Correctionb ,609 1 ,435

Likelihood Ratio 1,167 1 ,280

Linear-by-Linear Association 1,136 1 ,287

N of Valid Cases 49

a. 0 cells (0,0%) have expected count less than 5. The minimum expected count is

8,82.

Risk Estimate

Value

Lower Upper

Odds Ratio for Hipertensi

(Ya / tidak) 1,908 ,585 6,226

= Ya 1,353 ,792 2,311

= Tidak ,709 ,366 1,374

(25)

Tekanan darah

Sistolik (mmHg)

Ya 25 100,0% 0 0,0% 25 100,0%

Tidak 24 100,0% 0 0,0% 24 100,0%

Tekanan Darah

Diastolik (mmHg)

Ya 25 100,0% 0 0,0% 25 100,0%

Kolesterol Total

(26)

Descriptives

Retinopi Diabetik Statistic Std. Error

Umur Ya Mean 66,08 1,869

Mean

Lower Bound 62,22

Upper Bound 69,94

Median 66,00

Variance 87,327

Minimum 45

Maximum 84

Range 39

Skewness -,374 ,464

Kurtosis -,112 ,902

Tidak Mean 54,58 1,238

Mean

Lower Bound 52,02

Upper Bound 57,14

Median 55,00

Variance 36,775

Minimum 44

Maximum 66

Range 22

Skewness ,034 ,472

Kurtosis -,794 ,918

Durasi DM (tahun) Ya Mean 13,04 1,535

Mean

Lower Bound 9,87

Upper Bound 16,21

Median 10,00

Variance 58,873

(27)

Maximum 30

Range 29

Skewness ,803 ,464

Kurtosis ,162 ,902

Tidak Mean 2,75 ,173

Mean

Std. Deviation ,847

Minimum 1

Maximum 5

Range 4

Skewness ,527 ,472

Kurtosis 1,224 ,918

BMI (kg/m2) Ya Mean 24,311 ,7553

Mean

Lower Bound 22,752

Upper Bound 25,870

Median 24,170

Variance 14,263

Minimum 17,9

Maximum 32,4

Range 14,5

Skewness ,411 ,464

Kurtosis -,482 ,902

Tidak Mean 23,668 ,7206

Mean

Lower Bound 22,178

Upper Bound 25,159

Median 23,430

Variance 12,462

(28)

Maximum 32,9

Range 15,3

Skewness ,611 ,472

Kurtosis ,608 ,918

Tekanan darah Sistolik (mmHg) Ya Mean 136,52 2,909

Mean

Lower Bound 130,52

Upper Bound 142,52

Median 131,00

Variance 211,593

Minimum 110

Maximum 170

Range 60

Skewness ,453 ,464

Kurtosis -,048 ,902

Tidak Mean 129,63 3,051

Mean

Lower Bound 123,31

Upper Bound 135,94

Median 130,00

Variance 223,375

Minimum 110

Maximum 170

Range 60

Skewness ,938 ,472

Kurtosis ,819 ,918

Tekanan Darah Diastolik (mmHg) Ya Mean 70,40 2,024

Mean

Lower Bound 66,22

Upper Bound 74,58

Median 70,00

Variance 102,417

(29)

Maximum 90

Range 30

Skewness ,701 ,464

Kurtosis -,480 ,902

Mean

Lower Bound 71,48

Upper Bound 78,52

Median 80,00

Variance 69,565

Minimum 60

Maximum 90

Range 30

Skewness -,245 ,472

Kurtosis -,343 ,918

KGDN (mg/dl) Ya Mean 175,96 14,985

Mean

Lower Bound 145,03

Upper Bound 206,89

Median 164,00

Variance 5613,457

Minimum 82

Maximum 351

Range 269

Skewness 1,068 ,464

Kurtosis ,559 ,902

Tidak Mean 161,83 13,746

Mean

Lower Bound 133,40

Upper Bound 190,27

Median 142,00

Variance 4535,014

(30)

Maximum 356

Range 268

Skewness 1,418 ,472

Kurtosis 1,886 ,918

KGD 2 Jam PP (mg/dl) Ya Mean 282,480 17,7535

Mean

Lower Bound 245,839

Upper Bound 319,121

Median 267,000

Variance 7879,677

Minimum 128,0

Maximum 558,0

Range 430,0

Skewness 1,176 ,464

Kurtosis 2,773 ,902

Tidak Mean 233,875 17,8711

Mean

Lower Bound 196,906

Upper Bound 270,844

Median 216,500

Variance 7665,071

Minimum 109,0

Maximum 443,0

Range 334,0

Skewness ,518 ,472

Kurtosis -,338 ,918

HbA1c (%) Ya Mean 8,788 ,3890

Mean

Lower Bound 7,985

Upper Bound 9,591

Median 8,200

Variance 3,784

(31)

Maximum 12,8

Range 6,5

Skewness ,867 ,464

Kurtosis -,495 ,902

Tidak Mean 8,079 ,3984

Mean

Lower Bound 7,255

Upper Bound 8,903

Median 7,250

Variance 3,809

Minimum 6,1

Maximum 14,8

Range 8,7

Skewness 2,132 ,472

Kurtosis 5,320 ,918

HDL (mg/dl) Ya Mean 55,16 2,584

Mean

Lower Bound 49,83

Upper Bound 60,49

Median 54,00

Variance 166,973

Minimum 34

Maximum 87

Range 53

Skewness ,837 ,464

Kurtosis ,529 ,902

Mean

Lower Bound 50,96

Upper Bound 62,54

Median 59,00

Variance 187,935

(32)

Maximum 90

Range 57

Skewness ,503 ,472

Kurtosis ,783 ,918

LDL (mg/dl) Ya Mean 158,80 10,619

Mean

Lower Bound 136,88

Upper Bound 180,72

Median 155,00

Variance 2818,917

Minimum 75

Maximum 295

Range 220

Skewness ,744 ,464

Kurtosis ,438 ,902

Tidak Mean 159,46 5,947

Mean

Lower Bound 147,16

Upper Bound 171,76

Median 161,50

Variance 848,781

Minimum 95

Maximum 213

Range 118

Skewness ,045 ,472

Kurtosis ,153 ,918

Kolesterol Total (mg/dl) Ya Mean 215,32 11,502

Mean

Lower Bound 191,58

Upper Bound 239,06

Median 215,00

Variance 3307,143

(33)

Maximum 348

Range 226

Skewness ,470 ,464

Kurtosis -,001 ,902

Tidak Mean 217,50 6,430

Mean

Lower Bound 204,20

Upper Bound 230,80

Median 215,50

Variance 992,348

Minimum 147

Maximum 276

Range 129

Skewness -,166 ,472

Kurtosis ,116 ,918

Triliserida (mg/dl) Ya Mean 139,16 12,118

Mean

Lower Bound 114,15

Upper Bound 164,17

Median 120,00

Variance 3670,890

Minimum 54

Maximum 292

Range 238

Skewness 1,114 ,464

Kurtosis ,772 ,902

Tidak Mean 136,00 8,631

Mean

Lower Bound 118,15

Upper Bound 153,85

Median 115,00

Variance 1787,913

(34)

Maximum 232

Range 142

Skewness 1,019 ,472

Kurtosis -,143 ,918

Leukosit (ribu/mm3) Ya Mean 7,6992 ,31961

Mean

Lower Bound 7,0396

Upper Bound 8,3588

Median 7,8000

Variance 2,554

Minimum 5,32

Maximum 10,90

Range 5,58

Skewness ,306 ,464

Kurtosis -,760 ,902

Tidak Mean 8,1446 ,24557

Mean

Lower Bound 7,6366

Upper Bound 8,6526

Median 8,2050

Variance 1,447

Minimum 6,07

Maximum 10,50

Range 4,43

Skewness ,154 ,472

Kurtosis -,672 ,918

Eritrosit (ribu/mm3) Ya Mean 4,3568 ,06388

Mean

Lower Bound 4,2249

Upper Bound 4,4887

Median 4,3700

Variance ,102

(35)

Maximum 4,81

Range 1,16

Skewness -,218 ,464

Kurtosis -,704 ,902

Tidak Mean 5,0763 ,07173

Mean

Lower Bound 4,9279

Upper Bound 5,2246

Median 5,0200

Variance ,123

Minimum 4,22

Maximum 6,03

Range 1,81

Skewness ,544 ,472

Kurtosis 2,593 ,918

Hemoglobin (gr/dl) Ya Mean 13,056 ,1553

Mean

Lower Bound 12,736

Upper Bound 13,376

Median 13,200

Variance ,603

Minimum 12,0

Maximum 14,2

Range 2,2

Skewness -,125 ,464

Kurtosis -1,430 ,902

Tidak Mean 14,217 ,3034

Mean

Lower Bound 13,589

Upper Bound 14,844

Median 14,000

Variance 2,209

(36)

Maximum 17,4

Range 6,0

Skewness ,139 ,472

Kurtosis -,149 ,918

RDW (%) Ya Mean 12,980 ,1450

Mean

Lower Bound 12,681

Upper Bound 13,279

Median 12,900

Variance ,526

Minimum 11,5

Maximum 14,6

Range 3,1

Skewness ,225 ,464

Kurtosis ,130 ,902

Tidak Mean 13,179 ,1427

Mean

Lower Bound 12,884

Upper Bound 13,474

Median 12,950

Variance ,489

Minimum 12,0

Maximum 14,9

Range 2,9

Skewness ,601 ,472

(37)

Tests of Normality

Retinopi

Diabetik

Kolmogorov-Smirnova Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

Tekanan darah

Sistolik (mmHg)

Ya ,168 25 ,067 ,955 25 ,325

Tidak ,199 24 ,015 ,902 24 ,023

Tekanan Darah

Diastolik

Kolesterol Total

(mg/dl)

*. This is a lower bound of the true significance.

a. Lilliefors Significance Correction

Notes

Output Created 11-JUN-2015 22:18:57

Comments

Input Data D:\PROJECT\STATISTIK\PENY DALAM\IRMA 2\Data

dasar dr Irma.sav

Active Dataset DataSet1

Filter <none>

Weight <none>

Split File <none>

N of Rows in Working

Data File 49

Missing Value

Handling

Definition of Missing User defined missing values are treated as missing.

Cases Used Statistics for each analysis are based on the cases with

no missing or out-of-range data for any variable in the

analysis.

Syntax T-TEST GROUPS=RetinopatiDiabetik(1 2)

/MISSING=ANALYSIS

/VARIABLES=umur BMI KGD2JPP HDL LDL TK WBC

RBC RDW

/CRITERIA=CI(.95).

Resources Processor

Time 00:00:00,02

Elapsed

(38)

Independent Samples Test

Levene's Test

for Equality of

Variances t-test for Equality of Means

F Sig. t df

95% Confidence

Interval of the

Difference

variances not

assumed

variances not

assumed

variances not

assumed

variances not

assumed

variances not

assumed

-,054 37,560 ,957 -,658 12,171 -25,306 23,989

Kolesterol

Total (mg/dl)

Equal

variances

assumed

5,280 ,026 -,164 47 ,871 -2,180 13,326 -28,988 24,628

Equal

variances not

assumed

(39)

Leukosit

variances not

assumed

variances not

assumed

variances not

assumed

(40)

T-Test

Group Statistics

Retinopi

Diabetik N Mean Std. Deviation

Std. Error

Mean

Umur Ya 25 66,08 9,345 1,869

Tidak 24 54,58 6,064 1,238

BMI (kg/m2) Ya 25 24,311 3,7766 ,7553

Tidak 24 23,668 3,5302 ,7206

KGD 2 Jam PP (mg/dl) Ya 25 282,480 88,7675 17,7535

Tidak 24 233,875 87,5504 17,8711

HDL (mg/dl) Ya 25 55,16 12,922 2,584

Tidak 24 56,75 13,709 2,798

LDL (mg/dl) Ya 25 158,80 53,093 10,619

Tidak 24 159,46 29,134 5,947

Kolesterol Total (mg/dl) Ya 25 215,32 57,508 11,502

Tidak 24 217,50 31,502 6,430

Leukosit (ribu/mm3) Ya 25 7,6992 1,59806 ,31961

Tidak 24 8,1446 1,20303 ,24557

Eritrosit (ribu/mm3) Ya 25 4,3568 ,31942 ,06388

Tidak 24 5,0763 ,35142 ,07173

RDW (%) Ya 25 12,980 ,7251 ,1450

(41)

(42)

ANALISIS MULTIVARIAT

Logistic Regression

Unweighted Casesa N Percent

Selected Cases Included in Analysis 49 100,0

Missing Cases 0 ,0

Total 49 100,0

Unselected Cases 0 ,0

Total 49 100,0

a. If weight is in effect, see classification table for the total number of

cases.

Dependent Variable Encoding

Original Value Internal Value

0 0

Retinopati Diabetik 1

Block 0: Beginning Block

Classification Tablea,b

Observed

Predicted

Retinopi Diabetik

Percentage

Overall Percentage 51,0

a. Constant is included in the model.

b. The cut value is ,500

Variables in the Equation

B S.E. Wald df Sig. Exp(B)

(43)

Variables not in the Equation

Omnibus Tests of Model Coefficients

Chi-square df Sig.

Step 1 Step 67,908 7 ,000

Block 67,908 7 ,000

Model 67,908 7 ,000

Model Summary

Step -2 Log likelihood

Cox & Snell R

Square

Nagelkerke R

Square

1 ,000a ,750 1,000

a. Estimation terminated at iteration number 20 because maximum

iterations has been reached. Final solution cannot be found.

Classification Tablea

Observed

Predicted

Retinopi Diabetik

Percentage

a. The cut value is ,500

(44)

95% C.I.for

EXP(B)

Lower Upper

Step 1a JenisKelaminR

L(1) 57,926 38173,674 ,000 1 ,999

a. Variable(s) entered on step 1: JenisKelaminRL, rokokRL, HipertensiRL, umur, durasiDM, BMI, RBC.

Categorical Variables Codings

Frequency

Parameter coding

(1)

HipertensiRL tidak 31 ,000

ya 18 1,000

rokokRL tidak 37 ,000

ya 12 1,000

JenisKelaminRL perempuan 19 ,000

laki-laki 30 1,000

Logistic Regression

Missing Cases 0 ,0

Total 49 100,0

(45)

0 0

Frequency

Parameter coding

(1)

ya 18 1,000

rokokRL tidak 37 ,000

ya 12 1,000

Block 0: Beginning Block

Observed

Predicted

Retinopi Diabetik

Percentage

Step 0 Constant ,041 ,286 ,020 1 ,886 1,042

Score df Sig.

Step 0 Variables rokokRL(1) 7,505 1 ,006

HipertensiRL(1) 1,159 1 ,282

umur 17,391 1 ,000

(46)

BMI ,391 1 ,532

RBC 26,710 1 ,000

Overall Statistics 35,687 6 ,000

Block 1: Method = Enter

Chi-square df Sig.

Step 1 Step 67,908 6 ,000

Block 67,908 6 ,000

Model 67,908 6 ,000

Model Summary

Cox & Snell R

Square

Nagelkerke R

Square

1 ,000a ,750 1,000

Observed

Predicted

Retinopi Diabetik

Percentage

(47)

Logistic Regression

Missing Cases 0 ,0

Total 49 100,0

cases.

0 0

Frequency

Parameter coding

(1)

ya 18 1,000

Block 0: Beginning Block

Observed

Predicted

Retinopi Diabetik

Percentage

Constant 582,569 62997,986 ,000 1 ,993 1,016E+253

(48)

Step 0 Constant ,041 ,286 ,020 1 ,886 1,042

Score df Sig.

Chi-square df Sig.

Step 1 Step 67,908 5 ,000

Block 67,908 5 ,000

Model 67,908 5 ,000

Model Summary

Cox & Snell R

Square

Nagelkerke R

Square

1 ,000a ,750 1,000

(49)

Observed

Predicted

Retinopi Diabetik

Percentage

Logistic Regression

Missing Cases 0 ,0

Total 49 100,0

cases.

0 0

Frequency

Parameter coding

(1)

ya 18 1,000

Block 0: Beginning Block

Observed

Predicted

Retinopi Diabetik

Percentage

Correct 0

Retinopati

(50)

Step 0 Retinopi Diabetik 0 0 24 ,0

Retinopati Diabetik 0 25 100,0

Step 0 Constant ,041 ,286 ,020 1 ,886 1,042

Score df Sig.

Chi-square df Sig.

Step 1 Step 67,908 4 ,000

Block 67,908 4 ,000

Model 67,908 4 ,000

Model Summary

Cox & Snell R

Square

Nagelkerke R

Square

1 ,000a ,750 1,000

Observed

Predicted

(51)

0

a. Variable(s) entered on step 1: HipertensiRL, durasiDM, BMI, RBC.

Logistic Regression

Missing Cases 0 ,0

Total 49 100,0

cases.

0 0

Frequency

Parameter coding

(52)

ya 18 1,000

Block 0: Beginning Block

Observed

Predicted

Retinopi Diabetik

Percentage

Step 0 Constant ,041 ,286 ,020 1 ,886 1,042

Score df Sig.

Chi-square df Sig.

Step 1 Step 67,908 3 ,000

Block 67,908 3 ,000

Model 67,908 3 ,000

Model Summary

Cox & Snell R

Square

Nagelkerke R

(53)

1 ,000a ,750 1,000

Observed

Predicted

Retinopi Diabetik

Percentage

95% C.I.for EXP(B)

Lower Upper

HipertensiRL(1) -86,556 4159,713 ,000 1 ,983 ,000 ,000 .

durasiDM

37,124 1550,363 ,001 1 ,981 13260369259698

660,000 ,000 .

RBC -143,705 5885,394 ,001 1 ,981 ,000 ,000 .

Constant

562,836 23596,093 ,001 1 ,981 2,734E+244

a. Variable(s) entered on step 1: HipertensiRL, durasiDM, RBC.

Logistic Regression

Missing Cases 0 ,0

Total 49 100,0

a. If weight is in effect, see classification table for the total number of cases.

(54)

0 0

Block 0: Beginning Block

Observed

Predicted

Retinopi Diabetik

Percentage

Step 0 Constant ,041 ,286 ,020 1 ,886 1,042

Score df Sig.

Step 0 Variables durasiDM 23,305 1 ,000

RBC 26,710 1 ,000

Block 1: Method = Enter

Chi-square df Sig.

Step 1 Step 60,126 2 ,000

Block 60,126 2 ,000

Model 60,126 2 ,000

Model Summary

Cox & Snell R

Square

Nagelkerke R

(55)

1 7,782a ,707 ,943

a. Estimation terminated at iteration number 11 because parameter

estimates changed by less than ,001.

Observed

Predicted

Retinopi Diabetik

Percentage

Logistic Regression

Missing Cases 0 ,0

Total 49 100,0

cases.

(56)

0 0

Block 0: Beginning Block

Observed

Predicted

Retinopi Diabetik

Percentage

Step 0 Constant ,041 ,286 ,020 1 ,886 1,042

Score df Sig.

Step 0 Variables RBC 26,710 1 ,000

Block 1: Method = Enter

Chi-square df Sig.

Step 1 Step 40,078 1 ,000

Block 40,078 1 ,000

Model 40,078 1 ,000

Model Summary

Cox & Snell R

Square

Nagelkerke R

(57)

1 27,830a ,559 ,745

a. Estimation terminated at iteration number 7 because parameter

estimates changed by less than ,001.

Observed

Predicted

Retinopi Diabetik

Percentage

95% C.I.for EXP(B)

Lower Upper

Step 1a RBC -8,261 2,533 10,631 1 ,001 ,000 ,000 ,037

Constant 39,239 12,135 10,456 1 ,001 1099

a. Variable(s) entered on step 1: RBC.

ROC Curve

Notes

Output Created 11-JUN-2015 23:26:37

Comments

Input Data D:\PROJECT\STATISTIK\PENY

DALAM\IRMA 2\Data dasar dr Irma.sav

Active Dataset DataSet1

Filter <none>

Weight <none>

Split File <none>

N of Rows in Working Data

File 49

Missing Value Handling Definition of Missing User-defined missing values are treated

as missing.

Cases Used Statistics are based on all cases with

valid data for all variables in the

(58)

Syntax ROC RBC BY RDRL (1)

/PLOT=CURVE(REFERENCE)

/PRINT=SE COORDINATES

/CRITERIA=CUTOFF(INCLUDE)

TESTPOS(SMALL)

DISTRIBUTION(FREE) CI(95)

/MISSING=EXCLUDE.

Resources Processor Time 00:00:00,22

Elapsed Time 00:00:00,25

Retinopi Diabetik

Valid N

(listwise)

Positivea 25

Negative 24

Smaller values of the test result

variable(s) indicate stronger evidence

for a positive actual state.

a. The positive actual state is

(59)

Area Under the Curve

Test Result Variable(s): Eritrosit (juta/mm3)

Area Std. Errora Asymptotic Sig.b

Asymptotic 95% Confidence Interval

Lower Bound Upper Bound

,954 ,030 ,000 ,895 1,000

The test result variable(s): Eritrosit (ribu/mm3) has at least one tie between the positive actual state group and

the negative actual state group. Statistics may be biased.

a. Under the nonparametric assumption

(60)

Coordinates of the Curve

Test Result Variable(s): Eritrosit (juta/mm3)

Positive if Less Than or Equal Toa Sensitivity 1 - Specificity

(61)

5,2750 1,000 ,833

5,4050 1,000 ,875

5,6200 1,000 ,917

5,8800 1,000 ,958

7,0300 1,000 1,000

The test result variable(s): Eritrosit (juta/mm3) has at least one tie between the positive actual state

group and the negative actual state group.

a. The smallest cutoff value is the minimum observed test value minus 1, and the largest cutoff value

is the maximum observed test value plus 1. All the other cutoff values are the averages of two

consecutive ordered observed test values.

RBCROC * Retinopati Diabetik Crosstabulation

Retinopati Diabetik

Total Ya Tidak

RBCROC <4,8 Count 24 3 27

% within Retinopati Diabetik 96,0% 12,5% 55,1%

>=4,8 Count 1 21 22

% within Retinopati Diabetik 4,0% 87,5% 44,9%