Hubungan Rasio Trombosit Limfosit Dengan Penyempitan Pembuluh Darah Pada Penyakit Jantung Koroner

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Lampiran 2

LEMBAR PENJELASAN KEPADA CALON SUBJEK

Selamat pagi/siang Bapak/Ibu, pada hari ini, saya, dr. Enny Marziah akan

melakukan penelitian yang berjudul “ Hubungan Antara Rasio Trombosit

Limfosit Dengan Penyempitan Pembuluh Darah Pada Penyakit Jantung Koroner

“ Penelitian ini bertujuan untuk melihat bagaimana hubungan antara rasio

trombosit limfosit dengan persentase penyempitan pemmbuluh darah Bapak/Ibu.

Manfaatnya adalah untuk memprediksi penyempitan pembuluh darah yang di

alami oleh Bapak/Ibu sebelum dilakukan tindakan Angiografi, sehingga dapat

memperbaiki penangan dan terapi lanjutan Bapak/Ibu.

Pada Bapak/Ibu yang bersedia mengikuti penelitian ini, nantinya akan

diharuskan mengisi surat persetujuan ikut dalam penelitian, wawancara Bapak/Ibu

Mengenai penyakit yang dialami, dan dilakukan pemeriksaan fisik secara

menyeluruh. Bapak/Ibu nantinya akan juga diminta melakukan pemeriksaan darah,

yang dilakukan oleh saya sendiri, dengan menggunakan alat vacuntainer, yang

saya bawa sendiri. Darah akan saya ambil dari pembuluh darah lengan sebanyak 3

cc, dimana terlebih dahulu daerah lengan yang akan laukan pengambulan darah,

akan saya sterilkan terlebih dahulu dengan menggunakan alkohol. Pemeriksaan

darah ini dilakukan untuk menilai jumlah trombosit dan limfosit Bapak/Ibu. Biaya

pemeriksaan ditanggung oleh saya, peneliti sendiri, tanpa dibebankan kepada

Bapak/Ibu

Bila masih terdapat pertanyaan, maka bapak/Ibu dapat menghubungi saya

pada:

Nama

: dr. Enny Marziah

Alamat

: Jl. Suluh No.65 Kel.Sidorejo Ilir, Medan Tembung,

Medan, 20222

Handphone

: 081375013922

Peneliti,

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Lampiran 4

DAFTAR RIWAYAT HIDUP

I. Identitas Pribadi

Nama

: dr. Enny Marziah

Tempat/Tanggal Lahir

: Medan, 22 Juli 1972

NIP

: 19720722 201001 2 002

Status

: Peserta PPDS Patologi Klinik FK USU

Alamat

: Jl. Suluh No.65 Kel. Sidorejo Ilir, Medan

Tembung, Medan, 202222

HandPhone

: 081375013922

II. Keluarga

Nama Suami

: Arief Budiman

Anak

: 1. Amira Rifni Yasmi

2. Aziz Muhammad Arkan

3. Andhieni Zillan Khalila

III. Pendidikan

1. SDN Hagu Teungoh Lhokseumawe

Ijazah 1985

2. SMP Taman Siswa PT. Arun Lhokseumawe

Ijazah 1988

3. SMA Taman Siswa PT.Arun Lhokseumawe

Ijazah 1991

4. FK UISU Medan

Ijazah 2002

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IVI. Riwayat Pekerjaan

1. Dokter PTT Tanjung Jabung Timur, Jambi

2002-2004

2. Dokter Puskesmas Dendang TanjabTim,Jambi

2004-2007

3. Dokter Umum PetroChina Jabung International 2007-2008

Jambi

4. Dokter Puskesmas Matangkuli, Aceh Utara 2010-2012

5. PNS Kabupaten Aceh Utara

2010-Sekarang

V. Keanggotaan Profesi

1. Anggota Ikatan Dokter Indonesia

2. Perhimpunan Dokter Spesialis Patologi Klinik

VI. Publikasi Ilmiah

1. Hubungan Rasio Trombosit Limfosit Dengan Penyempitan Pembuluh

Darah Pada Penyakit Jantung Koroner. Kongres Nasioanal IX dan PIT

XV, Solo, 2016

VII. Partisipasi Dalam Kegiatan Ilmiah

1. Peserta Symposium : A New Novel DPP-4 Inhibitor For TD2M Treatment,

01 April 2012,Hotel JW Mariot, Medan

2. Peserta Workshop : Pendidikan Kedokteran Berkelanjutan Patologi Klinik

(Regional Sumbagut), 14 Mei 2012, Hotel Santika Premiere Diandra &

Convention, Medan

3. Peserta Symposium I: Pendidikan Kedokteran Berkelanjutan Patologi

Klinik (Regional Sumbagut), 15 Mei 2012, Hotel Santika Premiere

Diandra & Convention, Medan

4. Peserta Symposium II: Pendidikan Kedokteran Berkelanjutan Patologi

Klinik (Regional Sumbagut), 16 Mei 2012, Hotel Santika Premiere

Diandra & Convention, Medan

5. Peserta Symposium : PIT Penyakit Dalam XIII & Infection Update V,”

Diagnostik dan Manajemen Terkini Di Bidang Ilmu Penyakit Dalam,

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6. Workshop 1 : Advance Knowlegde to Improve hepatitis B Management

Jeanne latu Conference, 19 April 2012 , Hotel Santika Premiere Dyandra

& Convetion, Medan

7. Peserta Workshop : Management in MDR,XDR and TDR of Pulmonary

Tuberculosis in Daily Practice, The 3

rd

8. Symposium : The

Medan Respiratory Care Meeting

Annual ( MERCY) 2013, 02 Maret 2013, Hotel JW Marriott, Medan

3rd

9. Peserta Symposium : The 8

Medan Respiratory Care Meeting Annual (MERCY),

03 maret 2013, Hotel JW Marriott, Medan

th

National Congress The 12

th

10. Peserta Symposium: Update Hepatology. Peningkatan Kompetensi

Patologi Klinik, 30Nov 2013, Hotel JS Luwansa, Jakarta

Annual Scientific

Meeting Indonesian Association Of Clinical Pathologists and Medical

Equipment Exhibition, 26-28 Sept 2013, Hotel Sahid Rich, Yogyakarta

11. Symposium : The Metabolic & Endocrine Disease and It’s Analysis-1,

12-15 Feb 2014, Hotel JW Mariot, Medan

12. Peserta Workshop :Mikrobilogi PKB Sumbagut Reg V, 03 Maret 2016,

Hotel Aryaduta, Medan

13. Peserta Symposium: PKB Sumbagut Reg V, 04 s/d 05 Mar 2016, Hotel

Aryaduta, Medan

14. Peserta Symposium :The Role of point-Of –Care Testing (POCT) in

Cardiovascular Disease, 24 Sept 2016, Hotel JW Marriott, Medan

15. Peserta Symposium The 9

th

National Congress And 15

th

16. Symposium The 9

Annual Scientific

Meeting Of Indonesian Association Of Clinical Pathology And

Laboratory Medicine 2016, 19-21 Okt, 2016, Hotel Alila, Solo

th

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Lampiran 5

HASIL STATISTIK

Karakteristik Dasar Subjek Penelitian

Descriptives

Statistic Std. Error

Umur Mean 55,67 1,289

95% Confidence Interval for Mean

Lower Bound 53,08 Upper Bound 58,25

5% Trimmed Mean 55,82

Median 56,00

Variance 89,736

Std. Deviation 9,473

Minimum 32

Maximum 75

Range 43

Interquartile Range 11

Skewness -,244 ,325

Kurtosis ,099 ,639

JK Mean 1,31 ,064

Median 1,00

Variance ,220

Std. Deviation ,469

Minimum 1

Maximum 2

Range 1

Skewness ,820 ,325

Kurtosis -1,379 ,639

Kelompok Mean 1,50 ,069

Median 1,50

Variance ,255

Std. Deviation ,505

Minimum 1

Maximum 2

Range 1

Skewness ,000 ,325

Persentase Mean 62,39 4,507

Median 70,00

Variance 1097,072

Minimum 20

Maximum 100

Range 80

Skewness -,154 ,325

Hemoglobin Mean 13,709 ,2207

(8)

Median 13,950

Variance 2,630

Minimum 9,5

Maximum 16,5

Range 7,0

Interquartile Range 2,5

Skewness -,534 ,325

Kurtosis -,276 ,639

Leukosit Mean 8517,04 398,793

Median 7835,00

Variance 8587957,093

Minimum 4600

Maximum 20320

Range 15720

Skewness 1,731 ,325

Kurtosis 4,412 ,639

Trombosit Mean 278,26 10,175

Median 275,00

Variance 5590,422

Minimum 140

Maximum 486

Range 346

Skewness ,740 ,325

Kurtosis 1,121 ,639

Limfosit_Absolut Mean 2,2517 ,09678

Median 2,1000

Variance ,506

Std. Deviation ,71116

Minimum 1,17

Maximum 4,47

Range 3,30

Interquartile Range ,79

Skewness 1,057 ,325

Kurtosis 1,445 ,639

Rasio_TL Mean 133,14235 6,710332

Median 122,34000

Variance 2431,542

Minimum 49,000

Maximum 280,800

Range 231,800

Skewness 1,209 ,325

Kurtosis 1,447 ,639

PDW Mean 11,337 ,2408

Median 11,000

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Minimum 8,9

Maximum 16,3

Range 7,4

Skewness 1,179 ,325

Kurtosis 1,164 ,639

**Kelompok * JK Crosstabulation**

Count

JK

Total

Laki-laki

Perempuan

Kelompok

<70%

15

12

27 >= 70%

22

5

27 Total

37

17

54

Statistics

Umur JK Kelo mpok

Hemoglo

bin Leukosit Trombosit

Limfosit_

Absolut Rasio_TL

N Valid 54 54 54 54 54 54 54 54

Missing 0 0 0 0 0 0 0 0

Mean 55,67 1,31 1,50 13,709 8517,04 278,26 2,2517 133,14235

Median 56,00 1,00 1,50 13,950 7835,00 275,00 2,1000 122,34000

Mode 59 1 1a _13,5a ₅₂₇₀a ₂₀₇a _2,04 _106,198a

Std. Deviation 9,473 ,469 ,505 1,6217 2930,522 74,769 ,71116 49,310667

Minimum 32 1 1 9,5 4600 140 1,17 49,000

Maximum 75 2 2 16,5 20320 486 4,47 280,800

a. Multiple modes exist. The smallest value is shown

Group Statistics

Kelompok N Mean Std. Deviation Std. Error Mean

Umur <70% 27 55,59 11,222 2,160

>= 70% 27 55,74 7,548 1,453

JK <70% 27 1,44 ,506 ,097

(10)

Correlations Correlation

1 ,122 ,008 ,082 -,293* -,030 -,019 -,214 ,099 ,071 -,009 Sig.

(2-tailed)

,380 ,955 ,553 ,031 ,828 ,894 ,120 ,475 ,612 ,949

N 54 54 54 54 54 54 54 54 54 54 54

JK Pearson

Correlation

,122 1 -,279* _-,209 _{-,227 -,096} _-,045 _{,039 -,100 ,213}

-,235 Sig.

(2-tailed)

,380 ,041 ,130 ,098 ,491 ,747 ,782 ,472 ,122 ,087

N 54 54 54 54 54 54 54 54 54 54 54

Kelom pok

Pearson Correlation

,008

-,279*

1 ,948** -,103 ,083 ,321* -,136 ,309* -,082 ,711*

*

Sig. (2-tailed)

,955 ,041 ,000 ,460 ,553 ,018 ,327 ,023 ,554 ,000

N 54 54 54 54 54 54 54 54 54 54 54

Perse ntase

Pearson Correlation

,082 -,209 ,948** ₁ _{-,086 ,087} _,335* _-,130 _,305*_{-,145 ,637}* *

Sig. (2-tailed)

,553 ,130 ,000 ,539 ,533 ,013 ,348 ,025 ,295 ,000

N 54 54 54 54 54 54 54 54 54 54 54

Hemo globin

Pearson Correlation

-,293*

-,227 -,103 -,086 1 ,172 ,036 ,387** -,302* -,001 -,073 Sig.

(2-tailed)

,031 ,098 ,460 ,539 ,214 ,798 ,004 ,027 ,996 ,602

N 54 54 54 54 54 54 54 54 54 54 54

Leuko sit

Pearson Correlation

-,030

-,096 ,083 ,087 ,172 1 ,413** _,272* _{,060 -,073 ,012}

Sig. (2-tailed)

,828 ,491 ,553 ,533 ,214 ,002 ,047 ,665 ,602 ,933

N 54 54 54 54 54 54 54 54 54 54 54

Tromb osit

Pearson Correlation

-tailed)

,894 ,747 ,018 ,013 ,798 ,002 ,061 ,000 ,006 ,393

N 54 54 54 54 54 54 54 54 54 54 54

Limfos it_Abs olut

Pearson Correlation

-tailed)

,120 ,782 ,327 ,348 ,004 ,047 ,061 ,000 ,965 ,866

Limfosit_Absolut <70% 27 2,3474 ,87255 ,16792

>= 70% 27 2,1559 ,50057 ,09633

Rasio_TL <70% 27 118,02511 43,907588 8,450019

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Rasio _TL

Pearson Correlation

,099 -,100 ,309* _,305* _-,302*_{,060 ,520}** _-,609** ₁

-,334* ,013

Sig. (2-tailed)

,475 ,472 ,023 ,025 ,027 ,665 ,000 ,000 ,014 ,928

N 54 54 54 54 54 54 54 54 54 54 54

PDW Pearson Correlation

,071 ,213 -,082 -,145 -,001 -,073 -,371**

-,006 -,334* 1 -,108 Sig.

(2-tailed)

,612 ,122 ,554 ,295 ,996 ,602 ,006 ,965 ,014 ,437

N 54 54 54 54 54 54 54 54 54 54 54

*. Correlation is significant at the 0.05 level (2-tailed). **. Correlation is significant at the 0.01 level (2-tailed).

Correlations globin

Leuko

Umur Correlation Coefficient

1,000 ,072 -,038 ,037 -,249 ,000 ,00

JK Correlation Coefficient

,072 1,000 -,279* -,200 -,255 -,032

-Correlation Coefficient

-,038 -,279* 1,000 ,874** -,128 ,013 ,35

Correlation Coefficient

,037 -,200 ,874** _1,000 _-,057 _,037 _,32

-,249 -,255 -,128 -,057 1,000 ,170

-Correlation Coefficient

,000 -,032 ,013 ,037 ,170 1,000 ,42

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N 54 54 54 54 54 54 54 54 54 54 54

Limfosit _Absolu t

-,190 ,118 -,056 -,028 ,319* ,258 ,20

,090 -,106 ,322* _,276* _-,159 _,071 _,58

PDW Correlation Coefficient

,150 ,252 -,042 -,087 ,031 -,180

-*. Correlation is significant at the 0.05 level (2-tailed). **. Correlation is significant at the 0.01 level (2-tailed).

Statistics > 70

Umu

2,1559 148,2 5959

11,1 93

2,15

Median 56,0

0

1,00 2,00 95,00 13,800 7480, 00

297,0 0

2,1800 134,0 0000

2,42 106,1 98 Deviation

7,54

,50057 50,53 7976

Statistics < 70

Um

254,48 2,3474 118,02 511

(13)

Median 56,0 0

1, 00

1,00 30,00 14,200 8820, 00

253,00 2,0800 109,61 000

10,9 00

Mode 56a ₁ ₁ ₂₀ _14,2 ₄₆₀₀a ₁₄₀a _2,04a _49,000

a 9,6

Std. Deviatio n

11,2 22

,5 06

,000 13,558 1,8239 2404, 068

76,461 ,87255 43,907 588

1,86 88

Minimu m

32 1 1 20 9,5 4600 140 1,17 49,000 9,1

Maximu m

74 2 1 60 16,5 14980 486 4,47 244,44

0 16,3

Tests of Normalityb

Kolmogorov-Smirnova Shapiro-Wilk

Statistic Df Sig. Statistic df Sig.

Umur ,129 27 ,200* _,961 ₂₇ _,381

JK ,495 27 ,000 ,476 27 ,000

Persentase ,203 27 ,006 ,836 27 ,001

Hemoglobin ,117 27 ,200* ,944 27 ,150

Leukosit ,200 27 ,007 ,783 27 ,000

Trombosit ,118 27 ,200* ,920 27 ,040

Limfosit_Absolut ,107 27 ,200* _,972 ₂₇ _,647

Rasio_TL ,202 27 ,006 ,819 27 ,000

PDW ,165 27 ,058 ,881 27 ,005

a. Lilliefors Significance Correction

(14)

Independent Samples Test

Levene's Test for Equality of

Variances t-test for Equality of Means

F Sig. t df

Sig. (2-tailed)

Mean Difference

Std. Error Difference

95% Confidence Interval of the

Difference

(15)

Ras io_ TL

Equal variance s assume d

,44 8

,506

-2,34 7

52 ,023 -30,234481 12,884046

-56,08821 1

-4,380752

Equal variance s not assume d

-2,34 7

51,0 04

,023 -30,234481 12,884046

-56,10023 0

-4,368733

PD W

Equal variance s assume d

,89 7

,348 ,596 52 ,554 ,2889 ,4845 -,6832 1,2610

Equal variance s not assume d

,596 51,4 62

(16)

Correlations

Umur JK

Kelom pok

Persent ase

Hemogl obin

Leuko sit

Tromb osit

Limfosit_ Absolut

Rasio

_TL PDW

Umur Pearson

Correlation

1 ,068 .a ,234 -,438* -,196 -,240 -,479* ,200 -,200

Sig. (2-tailed) ,735 . ,239 ,022 ,328 ,228 ,011 ,318 ,318

N 27 27 27 27 27 27 27 27 27 27

JK Pearson

Correlation

,068 1 .a ,023 -,043 -,229 -,147 ,072 -,204 ,221

Sig. (2-tailed) ,735 . ,909 ,831 ,251 ,464 ,722 ,306 ,268

N 27 27 27 27 27 27 27 27 27 27

Kelompok Pearson Correlation

.a .a .a .a .a .a .a .a .a .a

Sig. (2-tailed) . . . .

N 27 27 27 27 27 27 27 27 27 27

Persentase Pearson Correlation

,234 ,023 .a 1 ,361 ,128 ,009 -,064 ,077 -,230

Sig. (2-tailed) ,239 ,909 . ,064 ,524 ,965 ,752 ,704 ,248

N 27 27 27 27 27 27 27 27 27 27

Hemoglobi n

Pearson Correlation

-,438* -,043 .a ,361 1 ,311 -,078 ,111 -,174 ,082

Sig. (2-tailed) ,022 ,831 . ,064 ,115 ,697 ,582 ,386 ,685

N 27 27 27 27 27 27 27 27 27 27

Leukosit Pearson Correlation

-,196 -,229 .a ,128 ,311 1 ,237 ,127 ,042 -,016

Sig. (2-tailed) ,328 ,251 . ,524 ,115 ,234 ,528 ,836 ,938

N 27 27 27 27 27 27 27 27 27 27

Trombosit Pearson Correlation

-,240 -,147 .a _,009 _-,078 _,237 ₁ _,178 _,573** _-,352

Sig. (2-tailed) ,228 ,464 . ,965 ,697 ,234 ,374 ,002 ,072

N 27 27 27 27 27 27 27 27 27 27

Limfosit_A bsolut

Pearson Correlation

-,479* _{,072 .}a _-,064 _,111 _,127 _,178 _{1 -,678}** _,065

Sig. (2-tailed) ,011 ,722 . ,752 ,582 ,528 ,374 ,000 ,747

N 27 27 27 27 27 27 27 27 27 27

Rasio_TL Pearson Correlation

,200 -,204 .a ,077 -,174 ,042 ,573** -,678** 1 -,297

Sig. (2-tailed) ,318 ,306 . ,704 ,386 ,836 ,002 ,000 ,133

N 27 27 27 27 27 27 27 27 27 27

PDW Pearson

Correlation

-,200 ,221 .a -,230 ,082 -,016 -,352 ,065 -,297 1

Sig. (2-tailed) ,318 ,268 . ,248 ,685 ,938 ,072 ,747 ,133

N 27 27 27 27 27 27 27 27 27 27

a. Cannot be computed because at least one of the variables is constant. *. Correlation is significant at the 0.05 level (2-tailed).