Uji Efektifitas Beberapa Senyawa Sebagai Peningkat Penetrasi Terhadap Laju Difusi Krim Asam Kojat Tipe Minyak Dalam Air Secara in Vitro

! " #

$

!

#

%

&# ! #

'&

(

%

)&

" '&#& &%

'#

%

&%

* ((

# ! #

%

)&

" %&#& &%

'#

+ , $

%

! % "

! #

- .&

"

/

' #0

- /

* #

&

1#

2 # #

345(#

# 6

7

8

0&

(% " 0& &"

#& 0 %

9 " " #

$

( #&#

"

:

"

#& &; "

" " # %

& # * <

0& & "

" % #& (&"

&:&%

0& ((

0 0 & ( %

,

=

0 0 #

" " & (

&

(

%

& "

&

(

0&

(% " 0& &"

# 0

&

:

# % < " &

' #

#

% < "

"

& (

.

%

& "

0 0 & ( %

,

=

0 0

#

" "

#

(>#

(

?

? 4?

3?

& "

"

0

0&

(% " 0& &"

)& ( <

"

"

% # #& 0 "

(

&0"

0& & "

" 0& &#

0/

. %

"

-<

:

& (

"

&

:

!

#& ((

%

#&#

%

" " %

6

7

:

# % < "

#

% #0 "&#&

& &0"

0

"& .

; %"

4

+

#& "

%

& (

#& ((

%

0&%" : " #&"& -

/

<

"

"

#&

< %%

"

%

0&

& & #

&

0& $ #0

0& &0 " "&

0

(

&0"

0& & "

" 0& &#

0/ "&" 0 . %

"

& &

( " ( : %

%

" .

%

& "

0&

(% " 0& &"

,

: #

% #

# % < " $

( #& (

( ,

= 3? 0 0 &

( %

?

0 0

#

" " 3? $

(

: #

0 "

% "&(

%

"

&

: %

0

( &:&%" :

( : #

$

2 0&

(% " 0& &"

<

:

# % < "

!

"# $# %#

&#

'

(

'

)

*

+

, "- ., %- /, 0- 1,

",-"$,

'

23

'

'

( '

&#

"#

&#

'

4

'

+

! " # $

'

" #& 0 %

(

"

0

(

(

%

&

(

0&

(

& "

#&

& # %

%& &

"

%&

0

& &

(

= &

&

"

%

" 0&

0&

"

%

"& " #

0

(

; <

"&

%"

& (

&# %

$ % $

0

% 0

% %

#&" % 0&# "

%

"

$

( #& <

< %

%

#&

& (

;

%

" $

( &

&

&"&

0&# %

0

%

# <

(%

; %"

"& "& "

)

&

%

#&" % 0&# "

#0

&#

% "

"&# %

#

& " %

% #

' #

&

&"& (

0

" $

( #& (

(

"

"

&

"&

" "

"&

0&

#

$

( &

' #

$

( %

" $ " % # " 0& # $ %

#

)

# # $ % #

&

$ %

%

% &

"&

"

&

#&

% #

& %

0

%

"

#

&

"& &

"

$

#& ((

%

>

% #

$

(

" #

%

0

%

#&" %

0&# "

%

"

8

# # $

%

#&" %

0& (

#

" 0 (#& "

"

$

# % < " 6 &

& %

"&0

+ @ 8

#

(

+ 7

#

% < "

"

< #

$

(

&

: "

: %

$

(

(

%

&

(

" %

#& ( "

(

((

0& 0 (#& "

)

&

% #

&

%

& "

# % # #

# % < " $

(

(

%

? 1:&%" . "

% #

# % < "

0 "

" (% "%

& (

#&

#

%

9 "

0& &"

" %

#&#

"

0& &"

# % < "

6

<&&

37

8

0&

(% "

0& &"

#& 0 %

9 "

" #

$

(

#&#

"

:

" #& &; "

" " #

%

& #

)&

(% " 0& &"

0 "

#&

(% "%

%&

"

%" :

0

%

"

#&

(% "%

:

%&

#

" " #

%

& #

& (

#&%

#& #&

"%

%" : %&

# %

" "

#&

&

"

0 "&

%

" 6

<&&

3@

#

%%

47

8

$

(

0 "

(

%

&

(

0&

(% " 0& &"

"

: %

& $ ;

&<&

4

#

&# %

%

( %

: %"

:

:

0

# $ % "

) 0 & ( %

0 "

(

%

&

(

0&

(% "

0& &"

0

%

& "

?

- " %

#&

"

3

" : #

% #

# % < " 6 &

8

37

, #&"

: %

6,

=7

"

0&

(% " 0& &"

$

(

(

%

,

=

&

: "

(

% 0 %

$

(

0 "

#&

%%

0

" " # %

& # ,

=

#& $&

%

& " #

" $

" " # %

& #

#&#

" %

"

( " 0& #&

&

'&# #0

"

&

" 0 %

& (

"

(

0

0& $&

60& ( &

7

6 &

8

3@ A

#

%%

+ 7

0 0

#

" "

"

0&

(% " 0& &"

$

(

(

%

#

&

" 0 %

0 0 #

" "

0& &#

" "

%

& # $ % $

( #

& 0

&

%

"

8

(

%

&

(

0& $

&

&# 0

"

&

(

0&

" 0

&

" 0 %

#

(

%

#&

& (

%

"

#

# ; %"

#

#

(

#&

(

0& ((

" %

#&

&(

( $ %& &#

6 &

8

3@ A

#

%%

+

) 0

#

7

8&

%

"

# %

0& & "

(

#& (&"

& (

0&

#

0 0 #

" " 0 0 &

( %

,

=

0 %

0 " &:&%" :

"

"&

0 % #

# % < "

0

" <

0& & "

" % #&

0 "%

: #

$

( "

& (

0&

#

0 0

#

" "

0 0 & ( %

,

= "&

0

<

:

#

% < "

#& (&"

%

& "

%&" (

9 " "& &

"

&

(

0&

(% " 0& &"

$

( 0

(

&:&%" :

# 0

&

:

# % < "

&

/

0& & "

0%

0 "

& #

:

"

" % #&# & %

"

: #

(

0& (&#

(

: #

&

" 0 %

& (

0& &"

$

( &:&%" :

! %"! ! !$

5

">

" $

(

(

%

(&

0

#A 60$ &B7 (&

%

#A

#A 60$ &B7

# (& 9&

#

(% % 6 $ &B7 0&

(

0 "

0& (

%

# ( &" %

0&%" : " #&"&

-

"& # #&"&

" #

(

" %

6

"

7

. % #&"& 68

%: & 7

6

8

$

(

(

%

%

&

#

% < "

#

"&

" &"

%

( &

"

%

" " %

6

*

#&"

0

&

0

"

0

::

#

" "

#&"

: %

6,

=7

. " #

1

)& $ 0

%

#& 0 "

0&#& %

$

(

% %

&

(

&0"

#& 0 "

0&#&

& "

%&

"

$

& "

(%

& (

#

( : $

(

(

7 '

'

'

* %

$

( "&

%

%

& (

(%

(

$

"& &

%&#

0 " %

"

%

& $ ;

&"&

"

%

"

&

%

" " %

%&

(

% %

%&0

& (

#& ((

%

0

(

" (

&

8 (

%

"

$

(

0 "

(

&

%

&# % &# %

$

(

#

(%

#

#& &#0&

(

" (

$

%

#& ((

%

0

0&

%

& (

"

"

#0

%

" " %

&

&"&

" %

"

& (

#& ((

%

(

& (

"

C

?

" % #& &0 %

<

(

$

( #

#& &% "

'

!

5

!

,

"

& &" %

& "

#

% < "

#

6 00# 4 00#

00# 3

00#

00#7

# % < "

" #

(

&

$ %

#(

"%

#

#A %

&

"

" %

00#

&

& %

(

" %

00# 4 00#

00# 3 00#

00# $

(

0 0&"

&

0&

"

(

8

'

5

!

)& & "

0

<

( (& #

(

# % # #

% %

& (

#& ( %

"

%

& "

0

& &"

%

& "

# % < " %&#

%

0

0

<

( (& #

(

"

> 3

#

'

!

6

5

!

A

"

# % < " %

& "

00# 4 00#

00# 3 00#

00#

%

& 0

$

0

0

<

(

(& #

( # % # # %&#

"

% .

(

"

& 0

%

& "

& "

0&

#

(

&

$

9

# % < "

?

: #

%

#

% # $

( "&

&"

%

?

# "&

" ? ( &

?

) 0 & ( %

,

=

0 0

#

" "

60&

(% " 0& &"

7

& (

.

%

& "

?

? 4? 3?

"

0

0 0 & ( %

,

=

0 0 #

" "

0

::

? 0

"

3

?

#&" 0

&

?

0 0 0

&

?

"

3? . " #

1

'

!

5

!

"

0%

&

%&

"

( #

(

" #

(

&

& (

0&

"

(

! & # $ %

"

& (

#& &

# "&

" 0

:

&"

%

# "&

"

"

0 0 0

&

"

"

(

0& "

%

0

+

C

! &

" & (

#&

"%

#&" 0

&

%&

#

$

( "&

0

%

%&#

#0 %

( &

0

"

0& "

%

+

C 8

% #

" & (

#&

#

%

: & # $ % %&

# : &

#

%

& (

# (& 9&

#0

"& & " % &#

$

(

# (&

8

% #

#%

#0

4

C

%&#

" #

%

#

% < "

& % "

&#

& % "

#

%

#0

# (&

, " #

%

# $ %

<& %

D " % :&

%

# (&

:

!

5

!

1.

&

% %

& (

0&#& %

(

&0"

0& ( %

. %

"

0& ( %

0/

0& ( %

"&"&

"&

0&

.&

: &

0& & "

" 0&

% #

0&#& %

%

# % < "

5

!

"

:

% %

& (

#& ((

%

&

:

!

9

' #0 "&#&

0& & # 0

"

&

:

!

9

& (

"

0

0/ + 4

#0

0&

6#A7

&

" #

(

(

& %

&

#& "

0

%

" " %

$

(

&" %%

0

"

&

:

!

9

"& &

"

( &" %

#

%%

%&

#

&

:

!

9

&

:

!

9

%&#

&" %%

0

&<

%

&

$

(

& (% 0

& (

"& #

" "

"& # #&"&

" %

0& ( "

0

&<

%

"

0

+E

C

( &" %

0%

"

%

" %

& 0 "

0#

< (

E + C

0& ( #

0 %

&

"& .

; %" "& "& " 6

4

+

#& "7

#

#&

#

0& & #

6

"

0

:

: " 0/ + 47

&

$ %

#A

(

"

& (

#&

#

0& & #

< (

&

$ %

#A

)& ( #

#0&

# %

" %

&" 0

0& ( <

#0&

$

( "&

0&

&

%

& 0

$

& (

#& ((

%

0&%" : " #&"&

" .

&"

0

0

<

( (& #

( # % # #

#

% < " +

#

5

, "

% #0 %

'

!

'& #0

#

&

%

0

0& & "

0&#

& $

(

2 !

'

9

!

5

!

'!$ ( )& ( # "

(

&0" % #

# % < " & & # 0& $ #0

'!$ )( )& ( # "

(

&0" % #

# % < " &"&

0& $ #0

%*+ $ ! , + %*, %$!- & &! !$ # -! .

+-* ! & * % & & ! &

' " 6! 7 *&" 0 *&" 0 *&" 0 *&" 0

, =

! *&" 0 *&" 0 *&" 0 *&" 0 ! *&" 0 *&" 0 *&" 0 *&" 0 !4 *&" 0 *&" 0 *&" 0 *&" 0 ! *&" 0 *&" 0 *&" 0 *&" 0 ) 0 & %

! *&" 0 *&" 0 *&" 0 *&" 0 !+ *&" 0 *&" 0 *&" 0 *&" 0 !3 *&" 0 *&" 0 *&" 0 *&" 0 ! *&" 0 *&" 0 *&" 0 *&" 0 0 0

" "

! *&" 0 *&" 0 *&" 0 *&" 0 ! *&" 0 *&" 0 *&" 0 *&" 0 ! *&" 0 *&" 0 *&" 0 *&" 0 ! *&" 0 *&" 0 *&" 0 *&" 0

%*+ $ ! , + %*, %$!- & &!'!$ + -! .

+-* ! & * % & & ! &

' " 6! 7 ) " & % A&# " &"& ( 0 "

, =

! ) " & % A&# " &"& ( 0 " ! ) " & % A&# " &"& ( 0 " !4 ) " & % A&# " &"& ( 0 " ! ) " & % A&# " &"& ( 0 " ) 0 &

%

! ) " & % A&# " &"& ( 0 " !+ ) " & % A&# " &"& ( 0 " !3 ) " & % A&# " &"& ( 0 " ! ) " & % A&# " &"& ( 0 " 0 0

" "

! ) " & % A&# " &"& ( 0 " ! ) " & % A&# " &"& ( 0 " ! ) " & % A&# " &"& ( 0 " ! ) " & % A&# " &"& ( 0 "

$

:

'!$ / )& & "

" 0& &#

% #

# % < " & & #

&"&

0& $ #0

0& &0 "

%*+ $ -! + $& !'!$ + % " & ! . +- " -!* !-! !-!$ # % " & !-! . +-" -!* !-0 ! ,! !* 0 &-!*& 1 * 0 ! ,! !* 0 &-!*& 1 * ' " 6! 7 F F F F , = ! F F F F ! F F F F !4 F F F F ! F F F F ) 0 & % ! F F F F !+ F F F F !3 F F F F ! F F F F 0 0 " " ! F F F F ! F F F F ! F F F F ! F F F F

.

(

'!$ 2( )& ( %

0/ % #

# % < " & & #

&"&

0& $ #0

0& &0 "

%*+ $ -!'!$ + % " & ! . +- " -!* !-! !-!$ # % " & ! . +- " -!* !-' " 6! 7 , = ! 4 4 ! 4 4 !4 4 4 ! 4 4 ) 0 & ( % ! !+ !3 ! 0 0 # " " ! 4 4 ! 4 4 ! 4 4 ! 4 4

:

!

'

9

"

3

!

'!$ 3( )& ( # "

.

#& % # ( % #

# % < " &"&

0& $ #0

0& &0 "

%*+ $ ! !$ # % " & ! . +- " -!* !-' " 6! 7 * % #& ( # % # ( , = ! * % #& ( # % # ( ! * % #& ( # % # ( !4 * % #& ( # % # ( ! * % #& ( # % # ( ) 0 & % ! * % #& ( # % # ( !+ * % #& ( # % # ( !3 * % #& ( # % # ( ! * % #& ( # % # ( 0 0 " " ! * % #& ( # % # ( ! * % #& ( # % # ( ! * % #& ( # % # ( ! * % #& ( # % # (

$

3

'!$ 4( )& ( %

. %

"

% #

# % < " & & #

&"&

0& $ #0

0& &0 "

%*+ $

5 & %& & 6-% &!7 !'!$ + % " & ! . +- " -!* !-! !-!$ # % " & !-! . +-" -!* !-' " 6! 7 4 , = ! + + ! !4 + 3 ! ) 0 & % ! !+ 4 !3 ! 4 4 0 0 " " ! ! ! ! 4

4

.

;

9

8&

%

0& ( # "

*

&

#&

< %%

"

% "& <

.&

: &

& & #

&

0& $ #0

0& &0 "

(

2

!

5

!

'!$ 8 ) :

:

% #

# % < "

%*+ $ ! , -! ! * & 0 " 9 & : 6;,<+! 7 !*

! * 0 0& (% " 0& &" 6% " 7 + 3 3 4 + 33

! , = ? 4 ! , = ? 3 3 + 3 + 3 !4 , = 4? 4 ! , = 3? 43 4 + 4 + ! ) 0 & ( % ? 4+ + 4 3 !+ ) 0 & ( % ? + 4+4 + + + 3 4 + !3 ) 0 & ( % 4? 3 ++ 3 3 4 3 3 ! ) 0 & ( % 3? 3 4 3 +3 3 3+ 3 4 ! 0 0 # " " ? 4 3 43 + ! 0 0 # " " ? 4 4 3 4 ! 0 0 # " " 4? 3 3 3 3 3 3 3 3 3 ! 0 0 # " " 3? 44 + + 4

!+' # &

8&

%

" <

0& & "

$ "

" % #& (&"

& $ ; 0&

(% " 0& &"

#

$

(

&

&:&%" :

"

"&

0 % #

# % < "

# %

" % # " 0&

# $ %

#

&

$ %

: #

#& ((

%

0&

(% " 0& &"

$ " ,

= 0 0 & ( %

0 0

#

" "

& (

.

%

& "

?

?

4?

3?

)

: #

!

6%

"

7 "

% #& ((

%

0&

(% "

0& &"

! !

#& ((

%

0&

(% "

0& &"

,

=

! >!

#& ((

%

0&

(% "

0& &"

0 0 & ( %

!

>!

#& ((

%

0&

(% "

0& &"

0 0 #

" "

' # $

( "&

" "& &

% %

&.

&

% #

& (

0&#& %

(

&0"

0& ( %

. %

"

0& ( %

0/

0& ( %

"&"&

0& &

.& & : &

0& & "

" 0& % #

0&#& %

%

# % < "

&#

$

(

(

%

#

0& & "

%

" " %

0 "

&#

0

% &

(

%

0

<

:

&

(

#&#

#0

#& $& 0

0& #&

"

%

" #

'

" " %

0 "

0 "

0&

&

"

0

%

"

(

%

&

%

& (

#& ((

%

( %&#

& (

"

# %

?

" %

#& &0 %

<

(

$

( #& &% "

'

" $

(

&

%

#0

#

&#

&

" %

#&

&(

"& <

$ %&

%

/

0& & "

0

<

(

(& #

(

# % # #

#

% < "

0&

&

& 0

# % # #

0

0

<

( (&

(

+

# 6G # B7

)

<

( (& #

(

$

( &

< " $

(

%

" % 0&#

"

% .

%

0& ( %

%

#

0 %

#0&

# % < "

/

<

"

"

% #

#

% < " & (

.

%

& "

?

?

4? 3?

"

0 0&

(% " 0& &"

& (

0& ( <

0& ( # "

(

&0"

%&

#&

< %%

;

: #

"

% #& (

#

0&

;

"&% "

%

"&

&"&

%

0& $ #0

0& &0 "

H

"&" 0 0 "

$

"

%

(

<& % )& ( %

0/

& & #

&"&

&

%

0& &0 " 0

: #

! 6%

"

7 !

#0

!

"

% #& (

# 0&

$ " )/

0

: #

!

!

!4

!

!

!

!

!

"

%

#& (

#

0&

$ "

0/ 4

)& ( %

.

#& % # (

" % % #

$

(

"

& (

.

%

& "

?

? 4? 3?

"

0

0&

(% "

0& &"

&

%

0& $ #0

$

(

0& &0 "

"

%

#& (

#

% # ( /

0& ( %

. %

"

% #

$

(

"

& (

.

%

& "

?

? 4? 3?

"

0

0&

(% " 0& &"

& & #

&"&

%

0& $ #0

0& &0 "

#&

< %%

$

0&

. %

"

)

0& ( <

" 0& &#

% #

& (

#& ((

%

#&"

&

<

0& (&

&

<

0&

9 " ;

#& ((

%

#&" &

& & #

%

0& $ #0

0& &0 "

#&

< %%

" 0& &#

F

6# $ %

#

7

/

$

(

# < ( "& <

0

0& ( <

( " 0& &#

&"&

% #

&

%

0& $ #0

0& &0 " $ "

" 0&

F

6"

%

0&

" 0& &#

7

/

&

"

"

% "& <

.&

: &

"

:

% %

& (

#& ((

%

&

:

!

9

' #0 "&#&

0& & # 0

"

&

:

!

9

& (

"

0

0/ + 4

#0

0&

6#A7

&

" #

(

(

& %

&

#& "

0

%

" " %

$

(

&" %%

0

"

&

:

!

9

"& &

"

( &" %

#

%%

%&

%&#

&" %%

0

&<

%

&

$

(

& (% 0

& (

"& #

" "

"& # #&"&

" %

0& ( "

0

&<

%

"

0

+E

C

( &" %

0%

"

%

" %

& 0 "

0#

< (

E + C

0& ( #

0 %

&

"& .

; %" "& "& " 6

4

+

#& "7

#

#&

#

0& & #

6

"

0

:

: " 0/ + 47

&

$ %

#A

(

"

& (

#&

#

0& & #

< (

&

$ %

#A

)& ( #

#0&

# %

" %

&" 0

0& ( <

#0&

$

( "&

0&

&

%

& 0

$

& (

#& ((

%

0&%" : " #&"&

" .

&"

0

0

<

( (& #

( # % # #

#

% < "

/

"

:

# % < "

0&

&

% #

"

0

0&

(% "

0& &"

#&# %

<

:

+ 33

I(F#& " !

#&# %

<

:

4

I(F#& " !

#&# %

<

:

3

I(F#& " !4

#&# %

<

:

I(F#& " !

#&# %

<

:

+

I(F#& " !

#&# %

<

:

4 3

I(F#& " !+

#&# %

<

:

+

I(F#& " !3

#&# %

<

:

3

3

I(F#& " !

#&# %

<

:

3 4

I(F#& " !

#&# %

<

:

+

I(F#& " !

#&# %

<

:

4

I(F#& " !

#&# %

<

:

3 3

I(F#& "

!

#&# %

<

:

4

I(F#& "

/

" " " %

0&

&

; "

%

0& (

0& $ #0

"&

0 . %

"

% # *&" 0 .

%

& "

0&

(% "

0& &"

$

(

& &

#& $&

%

"& <

$

0& &

$

(

( "

( : %

,& (

! J!"

''

& &

3

4 ?

/

<

" " " %

<

:

# % < " #&

< %%

0

: #

!

6%

"

7

% # $

(

#& (

( 0&

(% " 0& &"

,

=

6! ! 7

"&

"

$

0& &

& # %

#

!/J!*

&

((

% %

< 8

6 &

$ " < < 7

$

(

0&

&

#&

< %%

$

0& &

( "

$ "

)

: #

$

(

#& (

(

0 0 &

( %

6! ! 7

& &

$ "

#

!/J!*

< 8

<

:

#

% < "

& (

&

(

%

& "

0 0

#

" " #&

< %%

$

0& &

( "

$ "

&

(%

0

% # $

( #& (

( 0&

(% "

0& &"

0 0

#

" "

"

%

#&

< %%

0& &

& # %

+

#&

< %%

$ 0& &

( "

$ "

!& +- $

8&

%

0& & "

$

(

"&

% %

"&

0

< &:&%" : "

& (

&

(

& $ ;

0&

(% "

0& &"

"&

0

<

:

#

% < " # %

0 "

#0 %

; 2

' #

& (

0&

(% " 0& &"

,

= 3?

% # $

(

"

#& 0 %

%

& "

0

(

&:&%" :

$

(

#& $&

%

0&

(% "

<

:

# % < "

< %

(%

& (

: #

$

' #

& (

0&

(% " 0& &"

0 0 &

( %

?

% # $

(

"

#& 0 %

%

& "

0

( &:&%" : $

( #& $&

%

0&

(% "

<

:

# % < "

< %

(%

& (

: #

$

' #

& (

0&

(% " 0& &"

0 0

#

" " 3?

% #

$

(

"

#& 0 %

%

& "

0

(

&:&%" :

$

(

#& $&

%

0&

(% "

<

:

# % < " < %

(%

& (

: #

$

9 *

&

&

&%

+

9

A

2

; ;$

"&

&

&

8

#

(

1

+

7

#&

&; L %2

H &$

<&&

3

5

% " 2

C 0

"

#

-

-

!

/

!

(

-

M

'

*

C

$

4

*$

&

"

: #

&

&""

#

" &

"

" &

" . "$

& "

0 6

7 "

&

7

6

6

72 4 3> 4

&

8

1 *

C #

3

& (

" "

& # " "

: #

% <

7

6 723 3+

A

#

A A & & #

/

'

(

A

+

)

& 0

2 A& N !& (&

) 0

/

#

1.

"

:

"

&

& & &

: #

"

: