ATOM INDONESIA
Author's Responses
Article : #486
Name of All Authors :
Article Title : Technetium-99m Labeled Diethyl Carbamazine Citrate (99mTc-DEC) As a New Diagnostic Agent for Lymphatic Filariasis Detection
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Line # Referee’s Comments Author's Responses
12-13
… more than 40 million of them are inability unable to work beside to apart from disruption of aesthetic values.
….. to be parameters evaluated.
….. showed that the greatest accumulation was found ….
….. to the experimental animals shows showed a positive image that 99mTc-DEC was accumulated in the organ target…
It has been revised in accordance suggestions
16 …commonly known… It has been revised in accordance
suggestions 19 … all of over the world.
It has been revised in accordance suggestions
20 …Although, it is not fatal and caused rarely fatal or causes death, but a latest …
It has been revised in accordance suggestions
22 Fig. 1A is not necessary since almost everybody knows what lymphatic filariasis looks like.
Fig 1 A has been removed
175 Please state the animal ethic approval number here
Number of KEPPHP-BATAN has been added
282- 294
Please make sure that the captions in Figure 2 are placed correctly
It has been revised in accordance Suggestions
304-
306 Labeling efficiency.
Also in Table 1, column 3: labeling efficiency
It has been revised in accordance Suggestions
467 ….. Despite of While gamma camera …..
It has been revised in accordance Suggestions
469 ….. organs of rat, but the …..
It has been revised in accordance Suggestions
467- 476
The authors mention that the image results are still difficult to evaluate and are doubtful about the abnormalities determination as a result of the filarial. This research should need more animal tests until it gets positive
Yes, it should be done with more animals test. But from
biodistribution data (Fig.4) indicates the presence of filaria in the popliteal gland. This has been
results before going straight to clinical trials.
How do you comment on this issue?
discussed with a specialist doctor of nuclear medicine at Hasan Sadikin Hospital Bandung.
