ﻲﺸﻫوﮋﭘ ﻞﻴﺻا ﻪﻟﺎﻘﻣ
رد ﻲﺗراﺮﺣ ﺶﻨﺗ زا ﻲﺷﺎﻧ ﻮﻴﺗاﺪﻴﺴﻛا ﺶﻨﺗ ﺶﻫﺎﻛ رد ﻪﺑﻮﭼدرز ردﻮﭘ ﻲﻳاﺬﻏ ﻢﻳژر ﺮﻴﺛﺄﺗ ﻪﺟﻮﺟ لﺪﻣ
داﻮﺟﺪﻴﺳ ﻲﻨﻴﺴﺣ
نﺎﺷاو ،1
ا بﻮﻘﻌﻳ ﺮﺒﻛ
2ﺮﻓ ، نﺎﻴﻠﮔ ﻢﺳﺎﻘﻟاﻮﺑا ،3
ﻲﺟار ﺎﺿرﺪﻤﺣا ،4
يﺮﻴﺼﻧ ﺎﺿرﺪﻤﺤﻣ نﺎﻤﻴﭘ ،5
ﻲﻠﻴﻋﺎﻤﺳا
6ﺐﺴﻧ
هﺪﻴﻜﭼ
فﺪﻫ و ﻪﻨﻴﻣز ناﺰﻴﻣ ﻮﻴﺗاﺪﻴﺴﻛا ﺶﻨﺗ ﻂﻳاﺮﺷ رد :
ﻪﻧﻮﮔ ﺪﻴﻟﻮﺗ ﺶﻨﻛاو نﮋﻴﺴﻛا يﺎﻫ ﻲﻣ ﺶﻳاﺰﻓا ﺮﻳﺬﭘ
يرﺎﻤﻴﺑ زا يرﺎﻴﺴﺑ ﺪﻳﺪﺸﺗ ﺮﺑ ﻪﻛ ﺪﺑﺎﻳ ﺎﻫ
ﻲﻣ ﺮﻴﺛﺄﺗ ﻲﻌﺿﻮﻣ ﻲﻧﻮﺧ ﻢﻛ و ﻲﻤﺴﻴﺗﺎﻣر ﻞﺻﺎﻔﻣ بﺎﻬﺘﻟا ،ﺖﺑﺎﻳد ﺪﻨﻧﺎﻣ دراﺬﮔ
. ﻪﺘﻓﺎﻳ ﺶﻫوﮋﭘ يﺎﻫ ﻲﺘﻧآ ﺶﻘﻧ ﺮﮕﻧﺎﻴﺑ ﻦﻴﺸﻴﭘ يﺎﻫ
ﻲﻧاﺪﻴﺴﻛا
ﻲﻣ ﻪﺑﻮﭼدرز ردﻮﭘ ﺪﺷﺎﺑ
. ﻦﻳا ﻖﻴﻘﺤﺗ ﺖﻬﺟ ﭼدرز ردﻮﭘ ﺮﻴﺛﺄﺗ ﻲﺳرﺮﺑ رد ﻲﺗراﺮﺣ ﺶﻨﺗ زا ﻲﺷﺎﻧ ﻮﻴﺗاﺪﻴﺴﻛا ﺶﻨﺗ ﺶﻫﺎﻛ ﺖﻬﺟ رد ﻪﺑﻮ
ﻪﺟﻮﺟ مﺎﺠﻧا ﻲﺘﺷﻮﮔ يﺎﻫ ﺪﺷ
.
ﻖﻴﻘﺤﺗ شور رد:
ﻦﻳا ﻪﻌﻟﺎﻄﻣ
،ﻲﺑﺮﺠﺗ 264 ﻪﻌﻄﻗ هزور ﻚﻳ ﻪﺟﻮﺟ ﻪﺑ
3 هوﺮﮔ ﻞﻣﺎﺷ هوﺮﮔ يﺎﻫ ،ﻪﺑﻮﭼدرز ردﻮﭘ نوﺪﺑ هﺮﻴﺟ ﺎﺑ هﺪﺷ ﻪﻳﺬﻐﺗ
ﺢﻄﺳ 4 / 0 و ﺪﺻرد 8 / 0 ﻢﻴﺴﻘﺗ ﻪﺑﻮﭼدزر ردﻮﭘ ﺪﺻرد ﺪﺷ
. ﻛا ﺶﻨﺗ دﺎﺠﻳا ياﺮﺑ زور زا ﻮﻴﺗاﺪﻴﺴ
28 شروﺮﭘ هرود مود و ﻞﻬﭼ زور ﺎﺗ
ﻪﺟرد ،
ﻪﻧازور شروﺮﭘ ﻂﻴﺤﻣ تراﺮﺣ 5
ﺖﻋﺎﺳ ) ﺖﻋﺎﺳ رد 11 ﺎﺗ ﺢﺒﺻ 4 ﺮﻬﻇزاﺪﻌﺑ ( ﻪﺑ 33 ﺖﻓﺎﻳ ﺶﻳاﺰﻓا ﻪﺟرد .
ناﺰﻴﻣ ،ﺶﻳﺎﻣزآ نﺎﻳﺎﭘ رد
ﻪﺠﻨﺳاﺮﻓ و ﻲﻧﻮﺧ يﺎﻫﺪﻴﭙﻴﻟ ﻲﺘﻧآ يﺎﻫ
ﻢﻳﺰﻧآ ﺖﻴﻟﺎﻌﻓ ﻞﻣﺎﺷ نﻮﺧ ﻲﻧاﺪﻴﺴﻛا
Glutathione peroxidase يﺎﻫ
GPx ) (
Superoxide ،
dismutase SOD )
( ﺺﺧﺎﺷ و
Tiobarbituric acid reaction score TBARS )
( ﺪﻳدﺮﮔ ﻲﺑﺎﻳزرا نﻮﺧ مﺮﺳ .
ﻪﺘﻓﺎﻳ ﺎﻫ يﺮﺗ ﺮﻴﻴﻐﺗ مﺪﻋ ﺮﮕﻧﺎﻴﺑ ﺞﻳﺎﺘﻧ: هﺮﻴﺟ ﺮﻴﺛﺄﺗ ﺖﺤﺗ مﺎﺗ لوﺮﺘﺴﻠﻛ و ﺪﻳﺮﺴﻴﻠﮔ
ﻲﻣ ﻲﺸﻳﺎﻣزآ يﺎﻫ ﺖﻈﻠﻏ ﻲﻟو ،ﺪﺷﺎﺑ
هوﺮﮔ رد مﺮﺳLDL
ﺎﺑ هﺪﺷ ﻪﻳﺬﻐﺗ 4
/ 0 ﻪﺑﻮﭼدرز ﺪﺻرد )
01 /
±3 7 / 46 ( ﻪﻳﺎﭘ هوﺮﮔ ﺎﺑ ﻪﺴﻳﺎﻘﻣ رد )
17 /
±2 0 / 52 ( ﺖﻓﺎﻳ ﺶﻫﺎﻛ
HDL . ردﻮﭘ ﺮﻴﺛﺄﺗ ﺖﺤﺗ
ﻪﺑﻮﭼدرز ) 87 /
±3 0 / 74 ( ﻪﻳﺎﭘ ﺎﺑ ﻪﺴﻳﺎﻘﻣ رد )
98 /
±2 7 / 63 ( ﺖﻓﺎﻳ ﺶﻳاﺰﻓا .
زاﺪﻴﺴﻛاﺮﭘ نﻮﻴﺗﺎﺗﻮﻠﮔ ﻢﻳﺰﻧآ ﺖﻴﻟﺎﻌﻓ ناﺰﻴﻣ
GPx) ( رد
ﻪﺟﻮﺟ ﻪﺑﻮﭼدرز ردﻮﭘ ﺎﺑ هﺪﺷ ﻪﻳﺬﻐﺗ يﺎﻫ )
52 /
±11 9 / 225 ( ﭘ ﺎﺑ ﻪﺴﻳﺎﻘﻣ رد ﻪﻳﺎ
) 52 /
±8 1 / 183 ( ﺪﻴﺴﻛاﺮﭘﻮﺳ ﺖﻴﻟﺎﻌﻓ ﺮﺑ ﻲﻟو ،ﺖﻓﺎﻳ دﻮﺒﻬﺑ
زﺎﺗﻮﻤﺳد
SOD) ( ﻲﻨﻌﻣ ﺮﻴﺛﺄﺗ ﺖﺷاﺪﻧ يراد )
05 /
>0 .(P
يد نﻮﻟﺎﻣ ناﺰﻴﻣ ﺎﻳ يﺪﻴﭙﻴﻟ يﺎﻫﺪﻴﺴﻛاﺮﭘ ناﺰﻴﻣ ﺺﺧﺎﺷ ،ﻪﺑﻮﭼدرز ردﻮﭘ ﺪﻴﺋﺪﻟآ
ﺎﻤﺳﻼﭘ
TBARS) ( ﻪﻳﺎﭘ هوﺮﮔ رد ار )
0052 /
±0 76 / 0 ( هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ 8
/ 0 ﻪﺑﻮﭼدرز ﺪﺻرد )
0032 /
±0 49 / 0 ( داد ﺶﻫﺎﻛ .
ﻪﺠﻴﺘﻧ يﺮﻴﮔ ﻲﺘﻧآ ﻢﺘﺴﻴﺳ دﻮﺒﻬﺑ ﺖﻬﺟ ﻲﺒﺳﺎﻨﻣ ﻲﻳوراد هﺎﻴﮔ ،ﻦﻴﻣﻮﻛرﻮﻛ ندﻮﺑ اراد ﻞﻴﻟد ﻪﺑ ﻪﺑﻮﭼدرز ردﻮﭘ: ﺶﻨﺗ ﻂﻳاﺮﺷ رد نﺪﺑ ﻲﻧاﺪﻴﺴﻛا
تراﺮﺣ ﻪﺟرد و ﻮﻴﺗاﺪﻴﺴﻛا ﻲﻣ ﻲﻄﻴﺤﻣ يﻻﺎﺑ يﺎﻫ
ﺪﺷﺎﺑ .
هژاو يﺪﻴﻠﻛ يﺎﻫ
،ﻪﺑﻮﭼدرز ردﻮﭘ :
،ﻲﺗراﺮﺣ ﺶﻨﺗ ﻪﺠﻨﺳاﺮﻓ
ﻲﺘﻧآ يﺎﻫ ﻮﺟ ،ﻲﻧاﺪﻴﺴﻛا ﻪﺟ
و ﻮﻴﺗاﺪﻴﺴﻛا ﺶﻨﺗ
ﺪﻨﺟﺮﻴﺑ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻲﻤﻠﻋ ﻪﻠﺠﻣ .
1391 ؛ 19 ) 2 :(
157 - 164
ﺖﻓﺎﻳرد : 28 / 01 / 1391 شﺮﻳﺬﭘ : 09 / 03 /
1391
يﻮﺠﺸﻧاد1
يﺮﺘﻛد ﻲﺼﺼﺨﺗ ﻪﻳﺬﻐﺗ
،رﻮﻴﻃ هوﺮﮔ مﻮﻠﻋ
،ﻲﻣاد هﺪﻜﺸﻧاد
،يزروﺎﺸﻛ هﺎﮕﺸﻧاد ﻲﺳودﺮﻓ
،ﺪﻬﺸﻣ ناﺮﻳا ،ﺪﻬﺸﻣ
لوﺆﺴﻣ هﺪﻨﺴﻳﻮﻧ2
، دﺎﺘﺳا ﺶﺨﺑ ،
،رﻮﺸﻛ ﻲﻣاد مﻮﻠﻋ تﺎﻘﻴﻘﺤﺗ ﻪﺴﺳﺆﻣ ،ماد ﻪﻳﺬﻐﺗ هﺪﻜﺸﻧاد
،يزروﺎﺸﻛ هﺎﮕﺸﻧاد ناﺮﻳا ،ﺪﻨﺟﺮﻴﺑ ،ﺪﻨﺟﺮﻴﺑ
سردآ : ﺪﻬﺸﻣ - هﺎﮕﺸﻧاد ﺪﻬﺸﻣ ﻲﺳودﺮﻓ -
يزروﺎﺸﻛ هﺪﻜﺸﻧاد -
هوﺮﮔ ﻲﻣاد مﻮﻠﻋ
ﻦﻔﻠﺗ : 4439292 - 0561 ﺲﻛﺎﻓ : 4439292 - 0561 ﭘ ﻜﻴﻧوﺮﺘﻜﻟا ﺖﺴ ﻲ
رﺎﻴﺸﻧاد3
هوﺮﮔ ، مﻮﻠﻋ
،ﻲﻣاد هﺪﻜﺸﻧاد هﺎﮕﺸﻧاد ،يزروﺎﺸﻛ ﻲﺳودﺮﻓ
ناﺮﻳا ،ﺪﻬﺸﻣ ،ﺪﻬﺸﻣ
هوﺮﮔ ،رﺎﻳدﺎﺘﺳا4
ﺖﻓﺎﺑ
،ﻲﺳﺎﻨﺷ هﺪﻜﺸﻧاد
،ﻲﻜﺷﺰﭙﻣاد هﺎﮕﺸﻧاد ﻲﺳودﺮﻓ
،ﺪﻬﺸﻣ
،ﺪﻬﺸﻣ ناﺮﻳا
،رﺎﻴﺸﻧاد5
هوﺮﮔ حﻼﺻا داﮋﻧ
،ماد هﺪﻜﺸﻧاد
،يزروﺎﺸﻛ هﺎﮕﺸﻧاد ﻲﺳودﺮﻓ
،ﺪﻬﺸﻣ
،ﺪﻬﺸﻣ ناﺮﻳا
،سﺎﻨﺷرﺎﻛ6
هوﺮﮔ ﺖﻳﺮﻳﺪﻣ و شروﺮﭘ
،رﻮﻴﻃ دﺎﻬﺟ يزروﺎﺸﻛ
،ﻞﻴﺑدرا
،ﻞﻴﺑدرا ناﺮﻳا
ﻪﻣﺪﻘﻣ ﻦﻴﻳﺎﭘ و ﺮﺗﻻﺎﺑ ﻲﻳﺎﻣد ﻂﻳاﺮﺷ رد ،ﻲﺗراﺮﺣ ﺶﻳﺎﺳآ ﻪﻨﻣاد زا ﺮﺗ
يﺪﻴﺋوﺮﺘﺳﻮﻜﻴﺗرﻮﻛ ﺢﺷﺮﺗ ﻲﻣ ﺶﻳاﺰﻓا ﺶﻨﺗ ﻪﺑ ﺦﺳﺎﭘ رد ﺎﻫ
ﺪﺑﺎﻳ .
ﺘﻨﺳ ﺶﻳاﺰﻓا ﺎﺑ تاﺮﺛا ث ﻦﻴﻣﺎﺘﻳو ،ﺎﻫﺪﻴﺋوﺮﺘﺳﻮﻜﻴﺗرﻮﻛ ﺢﺷﺮﺗ و ﺰ
ﻲﻣ لﺮﺘﻨﻛ ار ﺶﻨﺗ ﻲﻔﻨﻣ ﺪﻳﺎﻤﻧ
) 1 .(
ﻲﻄﻴﺤﻣ يﻻﺎﺑ يﺎﻣد
ﻲﻣ لﻮﻠﺳ يژﻮﻟﻮﻳﺰﻴﻓ و رﺎﺘﺧﺎﺳ ﺮﺑ ﻲﻔﻨﻣ ﺮﺛا ﺪﻧاﻮﺗ يرواﺮﻓ ،ﺎﻫ
يﺎﺸﻏ دﺮﻜﻠﻤﻋ و رﺎﺘﺧﺎﺳ ،ﻮﻴﺗاﺪﻴﺴﻛا مﺰﻴﻟﻮﺑﺎﺘﻣ ،ﻪﻤﺟﺮﺗ ،RNA دراﺬﮕﺑ ﻲﻳﺎﻤﺳﻼﭘ )
3 ، 2 .(
ﻄﺳ ﺶﻳاﺰﻓا ﺮﮕﻧﺎﻴﺑ ﺮﻴﺧا تﺎﻌﻟﺎﻄﻣ دازآ نوﺮﺘﺳﻮﻜﻴﺗرﻮﻛ ﺢ
ﻲﻣ ﻲﻳﺎﻣﺮﮔ ﺶﻨﺗ ﻂﻳاﺮﺷ رد هﺪﺷ ﺶﻳاﺰﻓا ﻪﺑ ﺮﺠﻨﻣ ﻪﻛ ﺪﺷﺎﺑ
ﻲﻣ بﺮﭼ يﺎﻫﺪﻴﺳا نﻮﻴﺳاﺪﻴﺴﻛاﺮﭘ دﻮﺷ
. ﺪﻴﻟﻮﺗ ،ﻲﺗراﺮﺣ ﺶﻨﺗ
لﺎﻜﻳدار ﻲﻣ ﺶﻳاﺰﻓا ار ﻲﻧﮋﻴﺴﻛا تﺎﻘﺘﺸﻣ دازآ يﺎﻫ ﻪﻛ ﺪﻫد
ﻲﻣ رﻮﻴﻃ ﺮﺑ ﻲﻔﻠﺘﺨﻣ ﻲﻔﻨﻣ تاﺮﺛا دراﺬﮔ
) 4 .(
ﻦﻴﻳﺎﭘ ﺢﻄﺳ
ﻦﻴﻣﺎﺘﻳو ﻲﺘﻧآ ﻲﻧﺪﻌﻣ داﻮﻣ و ﺎﻫ ﻴﺴﻛا
ﺐﻴﺳآ ﺶﻳاﺰﻓا و ﻲﻧاﺪ يﺎﻫ
ﺖﺳا هﺪﺷ هﺪﻫﺎﺸﻣ ﻲﻳﺎﻣﺮﮔ ﺶﻨﺗ ﺖﺤﺗ رﻮﻴﻃ رد ﻮﻴﺗاﺪﻴﺴﻛا )
4 .(
ﻪﺟﻮﺟ رد ﻲﻳﺎﻣﺮﮔ ﺶﻨﺗ ،ﻦﻳا ﺮﺑ هوﻼﻋ ﺪﻴﻟﻮﺗ ﻲﺘﺷﻮﮔ يﺎﻫ
لﺎﻜﻳدار و ﺪﻴﺴﻛاﺮﭘﻮﺳ لﺎﻜﻳدار Reactive oxygen
species ROS )
( رد ار ﻲﻣ ﺶﻳاﺰﻓا ﻪﻨﻴﺳ ﻪﭽﻴﻫﺎﻣ ﺪﻫد
) 5 .(
رد
ﻂﻴﺤﻣ ﺎﻜﻳدار ﺪﻴﻟﻮﺗ ،ﻮﻴﺗاﺪﻴﺴﻛا يﺎﻫ ﻲﻌﻴﺒﻃ ﺪﻨﻳاﺮﻓ ﻚﻳ دازآ ل
ﻲﻣ ﺪﺷﺎﺑ . لﻮﻠﺳ ﻪﻧﻮﮔ و دازآ لﺎﻜﻳدار ﻲﻤﻛ ﺮﻳدﺎﻘﻣ ﺎﻫ يﺎﻫ
ﺶﻨﻛاو نﮋﻴﺴﻛا ﺮﻳﺬﭘ
ROS) ( ﺪﻴﻟﻮﺗ ﻲﻌﻴﺒﻃ ﺖﻴﻟﺎﻌﻓ ﺖﻟﺎﺣ رد ار
ﻲﻣ ﺪﻨﻨﻛ . ﻢﻛ ﺮﻳدﺎﻘﻣ ﻪﭼﺮﮔا يﺎﻫﺪﻨﻳاﺮﻓ زا يرﺎﻴﺴﺑ رد ROS
نﺪﺷ ﻪﺘﺷﺎﺒﻧا ﺎﻣا ﺖﺳا يروﺮﺿ ﻲﻳﺎﻴﻤﻴﺷﻮﻴﺑ ﻪﺑ ﺪﻳﺎﺷ ROS
لﻮﻜﻟﻮﻣوﺮﻛﺎﻣ زا يرﺎﻴﺴﺑ يﺎﻫ
ﻦﻴﺌﺗوﺮﭘ ﺪﻨﻧﺎﻣ يژﻮﻟﻮﻴﺑ ،ﺎﻫ
تارﺪﻴﻫﻮﺑﺮﻛ ،ﺎﻫﺪﻴﭙﻴﻟ و ﺎﻫ
ﺪﻧﺎﺳﺮﺑ ﺐﻴﺳآDNA )
6 .(
ﻦﻴﺴﻛﻮﺗ ،ﺖﻧﻮﻔﻋ ،تراﺮﺣ ﺪﻨﻧﺎﻣ ﻲﺟرﺎﺧ يﺎﻫرﻮﺘﻛﺎﻓ ،ﺎﻫ
لﺎﻜﻳدار ﺶﻳاﺰﻓا ﺚﻋﺎﺑ ﺰﻴﻧ ﺪﻨﻠﺑ يﺎﻫاﺪﺻ و ﻢﺧز و دازآ يﺎﻫ
ﻲﻣROS ﺪﻧﻮﺷ ) 8 ، 7 .(
رد ﻪﺘﺳﻮﻴﭘ رﻮﻃ ﻪﺑ هﺪﻧز دﻮﺟﻮﻣ ﻪﭽﻧﺎﻨﭼ
زا ﻲﻨﻴﻳﺎﭘ حﻮﻄﺳ ضﺮﻌﻣ راﺮﻗ ROS
ﺪﺷر ﺮﻃﺎﺧ ﻪﺑ ،دﺮﻴﮔ
ﺐﻴﺳآ ﻲﺠﻳرﺪﺗ ﻲﻣ رﺎﭼد يﺮﻴﭘ يﺎﻫﺪﻨﻳاﺮﻓ ﻪﺑ ﻲﻟﻮﻠﺳ يﺎﻫ
دﻮﺷ .
ﻪﻧﺎﺸﻧ ،ﺪﺷﺎﺑ ﺪﻳﺪﺷ ﻮﻴﺗاﺪﻴﺴﻛا ﺶﻨﺗ ﻪﭽﻧﺎﻨﭼ ﻊﻳﺮﺳ ﻊﻤﺠﺗ زا ﻲﻳﺎﻫ
ﻲﻣ قﺎﻔﺗا ﻲﻟﻮﻠﺳ ﺐﻴﺳآ و ﻲﻳارﺎﻛ مﺪﻋ ،ROS ﺪﺘﻓا
. ﻪﻧﻮﮔ يﺎﻫ ﺶﻨﻛاو نﮋﻴﺴﻛا يرﺎﻤﻴﺑ رد ﺮﻳﺬﭘ
ﻲﺒﻠﻗ ﺪﻨﻧﺎﻣ يدﺎﻳز يﺎﻫ -
ﺎﻔﻣ ﻢﺴﻴﺗﺎﻣر ،ﺖﺑﺎﻳد ،ﻲﻗوﺮﻋ نﺎﻃﺮﺳ ،نﻮﺧ رﺎﺸﻓ ،ﻞﺻ
يﺎﻫ
ﺐﻴﺳآ ﺎﺑ ﻂﺒﺗﺮﻣ دراد ﺶﻘﻧ ﻲﻌﺿﻮﻣ ﻲﻧﻮﺧ ﻢﻛ و ﻲﺘﻓﺎﺑ يﺎﻫ
) 10 ، 9 .(
ﺎﺑ ﻪﻠﺑﺎﻘﻣ ياﺮﺑ هﺪﻧز تادﻮﺟﻮﻣ رد ﻲﻌﻴﺒﻃ رﻮﻃ ﻪﺑ
لﺎﻜﻳدار ﻢﺘﺴﻴﺳ ،دازآ يﺎﻫ ﻞﻣﺎﺷ يدﺪﻌﺘﻣ ﻲﺘﻇﺎﻔﺣ يﺎﻫ
،زﺎﺘﻛودر نﻮﻴﺗﺎﺗﻮﻠﮔ ،زاﺪﻴﺴﻛاﺮﭘ نﻮﻴﺗﺎﺗﻮﻠﮔ ،زﺎﺗﻮﻤﺳد ﺪﻴﺴﻛاﺮﭘﻮﺳ هوﺮﮔ و ﻦﻴﺴﻛودرﻮﻴﺗ ﻴﺗ يﺎﻫ
دراد دﻮﺟو ﻲﻟﻮﻠﺳ ﺮﻫ رد لﻮ )
11 .(
ﻲﺘﻧآ ﻢﺘﺴﻴﺳ ﻲﻳﺎﻧاﻮﺗ دﻮﺒﻬﺑ ياﺮﺑ ﺎﺑ ﻪﻠﺑﺎﻘﻣ رد ﻲﻧاﺪﻴﺴﻛا
ﺖﻴﻟﺎﻌﻓ تﺎﺒﻴﻛﺮﺗ ندوﺰﻓا ،ﺶﻨﺗ ﻂﻳاﺮﺷ ﺖﺤﺗ ﻮﻴﺗاﺪﻴﺴﻛا يﺎﻫ
ﻲﺘﻧآ ﻦﻴﻣﺎﺘﻳو ﺪﻨﻧﺎﻣ ﻲﻧاﺪﻴﺴﻛا ﻲﻫﺎﻴﮔ يﺎﻫوراد و ﺎﻫﺪﻴﺋﻮﻨﺗرﺎﻛ ،E
ﺖﺳا ﺪﻴﻔﻣ ﻲﻳاﺬﻏ هﺮﻴﺟ ﻪﺑ )
12 .(
ﺒﻴﻛﺮﺗ ياراد ﻲﻳوراد نﺎﻫﺎﻴﮔ زا ﻲﻜﻳ ﻲﺘﻧآ تﺎ
و ﻲﻧاﺪﻴﺴﻛا
ﻲﻣ ﻪﺑﻮﭼدرز ،ﺪﻴﻔﻣ ﻲﺑﺎﻬﺘﻟا ﺪﺿ ﺪﺷﺎﺑ
. لﺎﻌﻓ ﺐﻴﻛﺮﺗ ﻦﻳﺮﺘﻤﻬﻣ
ﻲﻣ ﻦﻴﻣﻮﻛرﻮﻛ ،ﻪﺑﻮﭼدرز ﺪﺷﺎﺑ
) 13 .(
ﺖﻴﻟﺎﻌﻓ ﻦﻳﺮﺘﻤﻬﻣ زا يﺎﻫ
ﻲﻣ ﻦﻴﻣﻮﻛرﻮﻛ ﺶﻘﻧ ﻪﺑ ناﻮﺗ
ﻲﺘﻧآ ،ﻲﺑﺎﻬﺘﻟا ﺪﺿ يﺎﻫ ،ﻲﻧاﺪﻴﺴﻛا
ﺶﻬﺟ ﺪﺿ ،ﻲﻧﺎﻃﺮﺳ ﺪﺿ ،يرادرﺎﺑ ﺪﺿ ،نﻮﺧ دﺎﻘﻌﻧا ﺪﺿ ،ﻲﻳاز
،ﻲﻳﺎﻳﺮﺘﻛﺎﺑ ﺪﺿ ،ﺖﺑﺎﻳد ﺪﺿ ﺪﺿ ،ﻲﺳوﺮﻳو ﺪﺿ ،ﻲﭼرﺎﻗ ﺪﺿ
مﻮﻤﺳ ﺪﺿ ،ﻲﻳاوزﻮﺗوﺮﭘ )
تاﺮﺸﺣ ﺮﻫز (
و نﻮﺧ رﺎﺸﻓ هﺪﻨﻫﺎﻛ ،
دﻮﻤﻧ هرﺎﺷا نﻮﺧ لوﺮﺘﺴﻠﻛ هﺪﻨﻫﺎﻛ )
14 .(
رد ﻪﺑﻮﭼدرز ردﻮﭘ ﺮﻴﺛﺄﺗ ﻲﺑﺎﻳزرا ﺖﻬﺟ ،ﻪﻌﻟﺎﻄﻣ ﻦﻳا ﻦﻳاﺮﺑﺎﻨﺑ يور ﺮﺑ ﻲﻳﺎﻣﺮﮔ ﺶﻨﺗ زا ﻲﺷﺎﻧ ﻮﻴﺗاﺪﻴﺴﻛا ﺶﻨﺗ تاﺮﺛا ﺶﻫﺎﻛ
ﻪﺟﻮﺟ ﺑ ﻲﻄﻴﺤﻣ ﻂﻳاﺮﺷ ﺖﺤﺗ ﻪﺘﻓﺎﻳ شروﺮﭘ يﺎﻫ تراﺮﺣ ﻪﺟرد ﺎ
ﺪﺷ مﺎﺠﻧا ﻻﺎﺑ .
ﻖﻴﻘﺤﺗ شور
،ﻲﺑﺮﺠﺗ ﻖﻴﻘﺤﺗ ﻦﻳا رد 264
ﻦﻳرآ ﻲﺘﺷﻮﮔ ﻪﺟﻮﺟ ﻪﻌﻄﻗ
رد ﻲﻓدﺎﺼﺗ رﻮﻃ ﻪﺑ و هزور ﻚﻳ 12
ﻪﺳ ﺐﻟﺎﻗ رد ﻲﺸﻳﺎﻣزآ ﺪﺣاو
ﺪﻧﺪﺷ بﺎﺨﺘﻧا ﻲﻛارﻮﺧ رﺎﻤﻴﺗ .
يوﺎﺣ راﺮﻜﺗ ﺮﻫ 22
هﺪﻧﺮﭘ ﻪﻌﻄﻗ
دﻮﺑ . هﺮﻴﺟ ،ﺮﺒﻴﻓ ،ﻦﻴﺌﺗوﺮﭘ ،يژﺮﻧا ﺢﻄﺳ ياراد ﻲﺸﻳﺎﻣزآ يﺎﻫ
ﻣآ يﺎﻫﺪﻴﺳا دﻮﺑ ﻲﺘﺧاﻮﻨﻜﻳ ﻲﻧﺪﻌﻣ داﻮﻣ و ﻪﻨﻴ
. درﻮﻣ ﻪﻳﺎﭘ هﺮﻴﺟ
ﻲﺸﻳﺎﻣزآ ﻲﻛارﻮﺧ داﻮﻣ ﺮﻳﺎﺳ و دﻮﺑ ﺎﻳﻮﺳ و ترذ يوﺎﺣ ،هدﺎﻔﺘﺳا
ﺪﺷ ﻪﻓﺎﺿا هﺮﻴﺟ ﻦﻳا ﻪﺑ .
ﻞﻣﺎﺷ تﺎﻧاﻮﻴﺣ زﺎﻴﻧ درﻮﻣ ﻲﻛارﻮﺧ داﻮﻣ
ﻲﻧدوﺰﻓا ﺮﻳﺎﺳ و ﺎﻳﻮﺳ ،ترذ و ناد ﺖﻛﺮﺷ زا زﺎﻴﻧ درﻮﻣ يﺎﻫ
ﺪﺷ ﻪﻴﻬﺗ قﺮﺷ ﻪﻓﻮﻠﻋ .
هﺮﻴﺟ ﺳا درﻮﻣ ﻲﺸﻳﺎﻣزآ يﺎﻫ هﺮﻴﺟ ﻞﻣﺎﺷ ﻖﻴﻘﺤﺗ ﻦﻳا هدﺎﻔﺘ
ﻪﻳﺎﭘ ) ﻪﺑﻮﭼدرز ردﻮﭘ نوﺪﺑ (
ﻪﻳﺎﭘ هﺮﻴﺟ ، +
4 / 0 ردﻮﭘ ﺪﺻرد
ﻪﻳﺎﭘ هﺮﻴﺟ و ﻪﺑﻮﭼدرز +
8 / 0 دﻮﺑ ﻪﺑﻮﭼدرز ردﻮﭘ ﺪﺻرد .
ﻪﺟﻮﺟ تﺪﻣ ﻪﺑ ﻲﺘﺷﻮﮔ يﺎﻫ 42
هﺮﻴﺟ ﻦﻳا ﺎﺑ زور ﻪﻳﺬﻐﺗ ﺎﻫ
ﺪﻧﺪﺷ . ﻂﻴﺤﻣ يﺎﻣد ،ﺶﻳﺎﻣزآ هرود ﻢﺘﺸﻫ و ﺖﺴﻴﺑ زور زا
ﻪﺑ شروﺮﭘ 33
)
± 1 33 ( ﺘﻧﺎﺳ ﻪﺟرد ﻲ
ﺖﻓﺎﻳ ﺶﻳاﺰﻓا داﺮﮔ .
ﻪﺟﻮﺟ نﺎﻳﺎﭘ ﺎﺗ ﺎﻫ 42
تﺪﻣ ﻪﺑ ﻪﻧازور ،ﻲﮔزور 5
ﺖﻋﺎﺳ
) ﺖﻋﺎﺳ 16 - 11 ( ﻲﺗراﺮﺣ ﺶﻨﺗ ﺖﺤﺗ )
يﻻﺎﺑ تراﺮﺣ ﻪﺟرد
شروﺮﭘ ﻂﻴﺤﻣ (
ﺪﻨﺘﻓﺮﮔ راﺮﻗ .
ﺮﻫ ﻪﺟﻮﺟ ود زا هرود نﺎﻳﺎﭘ رد
نﻮﺧ ﻲﺸﻳﺎﻣزآ ﺪﺣاو ،لوﺮﺘﺴﻠﻛ ﺖﻈﻠﻏ و ﺪﻣآ ﻞﻤﻋ ﻪﺑ يﺮﻴﮔ
،LDL ﺪﺷ ﻦﻴﻴﻌﺗ نﻮﺧ ﺪﻳﺮﺴﻴﻠﮔ يﺮﺗ و HDL
. ﻤﻫ ﻦﻴﻨﭽ
ﻢﻳﺰﻧآ ﺖﻴﻟﺎﻌﻓ ﻲﺘﻧآ يﺎﻫ
زاﺪﻴﺴﻛاﺮﭘ نﻮﻴﺗﺎﺗﻮﻠﮔ ﻞﻣﺎﺷ ﻲﻧاﺪﻴﺴﻛا
) GPx Glutathione peroxidase (
SOD ،
Superoxide dismutase) (
نﻮﻟﺎﻣ ناﺰﻴﻣ ﺺﺧﺎﺷ و
يد نﻮﺧ ﺪﻴﺋﺪﻟآ TBRAS
Tiobarbituric acid reaction )
score ( ﺪﻳدﺮﮔ ﻲﺑﺎﻳزرا نﻮﺧ .
ﻢﻳﺰﻧآ ﺖﻴﻟﺎﻌﻓ ﻦﻴﻴﻌﺗ ياﺮﺑ GPx يﺎﻫ
SOD و ﻛ زا ﺖﻴ يﺎﻫ
ﺖﻛﺮﺷ ﻲﻫﺎﮕﺸﻳﺎﻣزآ RANDOX
ﻪﺑ ﺐﻴﺗﺮﺗ ﻪﺑ نﺎﺘﺴﻠﮕﻧا
مﺎﻧ RANSEL يﺎﻫ RANSOD و
ﺪﺷ هدﺎﻔﺘﺳا .
ﻦﻳا ياﺮﺑ
ﺲﭙﺳ و ﺪﺷ ﻪﻴﻬﺗ تاﺰﻴﻟﻮﻤﻫ اﺪﺘﺑا ،ﺖﻴﻛ ﻞﻤﻌﻟارﻮﺘﺳد ﻖﺑﺎﻄﻣ ﺮﻣا ﺖﻨﺠﻳر زا هدﺎﻔﺘﺳا ﺎﺑ هدﺎﻣآ ﺖﻴﻛ يﺎﻫ
ﺪﺷ مﺎﺠﻧا يزﺎﺳ .
ﻪﻣادا رد
يﺮﺘﻣﻮﺘﻓوﺮﺘﻜﭙﺳا هﺎﮕﺘﺳد زا هدﺎﻔﺘﺳا ﺎﺑ CECIL
ﻮﻃ رد جﻮﻣ ل
340 و 505 ﻪﻧﻮﻤﻧ بﺬﺟ ﺐﻴﺗﺮﺗ ﻪﺑ ﺮﺘﻣﻮﻧﺎﻧ و ﺪﺷ هﺪﻧاﻮﺧ ﺎﻫ
ﺪﺷ ﻪﺒﺳﺎﺤﻣ ماﺪﻛ ﺮﻫ ﻲﻤﻳﺰﻧآ ﺖﻴﻟﺎﻌﻓ .
ناﺰﻴﻣ ﻦﻴﻴﻌﺗ ياﺮﺑ ﻞﺒﻗ ﻪﻠﺣﺮﻣ رد هﺪﺷ ﻪﻴﻬﺗ يﺎﻤﺳﻼﭘ زا ﺪﻴﺋﺪﻟآ يد نﻮﻟﺎﻣ Malondialdehyde)
MDA ﺎﻳ ( ﺎﻳ
ﺺﺧﺎﺷ TBARS هدﺎﻔﺘﺳا نارﺎﻜﻤﻫ و ﺎﻜﻴﺷﻮﻳ شور ﻚﻤﻛ ﻪﺑ
ﺪﺷ . اﺪﺘﺑا ﺮﻣا ﻦﻳا ياﺮﺑ 5
/ 0 ﻲﺳ ﻲﺳ ﺎﻤﺳﻼﭘ ﺎﺑ 5 / 2 ﻲﺳ ﻲﺳ
يﺮﺗ ﺪﻴﺳا ﻚﻴﺘﺳاوﺮﻠﻛ 20
و ﺪﺷ طﻮﻠﺨﻣ ﺪﺻرد 10
ﻪﻘﻴﻗد ﺪﻳدﺮﮔ ژﻮﻔﻳﺮﺘﻧﺎﺳ
. ﺲﭙﺳ 1 ﻲﺳ ﻚﻳرﻮﺘﻴﺑرﺎﺑﻮﻴﺗ ﻲﺳ 6
/ 0 ﺪﺻرد
و ﺪﺷ ﻪﻓﺎﺿا 30
و ﺪﺷ هداد راﺮﻗ مﺮﮔ بآ مﺎﻤﺣ رد ﻪﻘﻴﻗد
ﺪﺷ دﺮﺳ ﻪﻠﺻﺎﻓﻼﺑ .
4 ﻲﺳ n ﻲﺳ - ناﺰﻴﻣ و ﺪﺷ ﻪﻓﺎﺿا لﻮﻧﺎﺗﻮﺑ
لﻮﻃ رد ﻲﻳور ﻪﻳﻻ رد MDA جﻮﻣ
535 و 520 ﺮﺑ لﻮﻣﻮﻧﺎﻧ
ﺪﻳدﺮﮔ ﻦﻴﻴﻌﺗ لﻮﻧﺎﺗﻮﺑ ﺪﺿ .
نﺎﭘوﺮﭘ ﻲﺴﻛﻮﺗاﺮﺘﺗ زا 5
، 10 و 20
ﻲﻠﻴﻣ رد لﻮﻣﻮﻧﺎﻧ ﻲﻨﺤﻨﻣ ﻦﻴﻴﻌﺗ ﺖﻬﺟ دراﺪﻧﺎﺘﺳا ناﻮﻨﻋ ﻪﺑ ﺮﺘﻴﻟ
ﺪﺷ هدﺎﻔﺘﺳا دراﺪﻧﺎﺘﺳا )
15 .(
يرﺎﻣآ ﺰﻴﻟﺎﻧآ
هداد مﺮﻧ دراو اﺪﺘﺑا ﺎﻫ راﺰﻓا
Excel ﺪﺷ . ﺐﺗﺮﻣ زا ﺲﭘ يزﺎﺳ
مﺮﻧ ﺎﺑ راﺰﻓا 12 / SAS 6 و ﻲﻣﻮﻤﻋ ﻲﻄﺧ ﻪﻳور زا هدﺎﻔﺘﺳا ﺎﺑ
General linear model) GLM ﺎﻳ
( ًﻼﻣﺎﻛ حﺮﻃ ﺐﻟﺎﻗ رد
درﻮﻣ ﻲﻓدﺎﺼﺗ One Way ANOVA
ﺖﻓﺮﮔ راﺮﻗ .
ﺖﻬﺟ
هوﺮﮔ ﻪﺴﻳﺎﻘﻣ ﻲﺒﻴﻘﻌﺗ نﻮﻣزآ زا ﺎﻫ
Dunken ﺢﻄﺳ رد
95
ﺪﺷ هدﺎﻔﺘﺳا ﺪﺻرد .
ﻪﺘﻓﺎﻳ ﺎﻫ
ﻪﺘﻓﺎﻳ يﺎﻫﺪﻴﭙﻴﻟ ﺖﻈﻠﻏ ﺮﺑ ﻪﺑﻮﭼدرز ردﻮﭘ ﺮﻴﺛﺄﺗ زا ﻞﺻﺎﺣ يﺎﻫ
ﺟﻮﺟ ﻲﻧﻮﺧ ﻪ
لوﺪﺟ رد ﻲﻳﺎﻣﺮﮔ ﺶﻨﺗ ﺖﺤﺗ ﻪﺘﻓﺎﻳ شروﺮﭘ يﺎﻫ 1
ﺖﺳا هﺪﺷ هداد نﺎﺸﻧ .
ﺪﻳﺮﺴﻴﻠﮔ يﺮﺗ و مﺎﺗ لوﺮﺘﺴﻠﻛ ﺖﻈﻠﻏ
ﻲﻨﻌﻣ ﺮﻴﻴﻐﺗ ﻪﺑﻮﭼدرز ردﻮﭘ ﺮﻴﺛﺄﺗ ﺖﺤﺗ نﻮﺧ مﺮﺳ دﻮﻤﻨﻧ يراد
.
ﺖﻈﻠﻏ ،ﻪﺑﻮﭼدرز ردﻮﭘ ﺢﻄﺳ ﺶﻳاﺰﻓا ﺎﺑ -HDL
لوﺮﺘﺴﻠﻛ
زا نﻮﺧ 98 /
± 2 7 / 63 ﻪﺑ ﻪﻳﺎﭘ هوﺮﮔ رد 87
/
± 3 0 / 74 رد
ﺷ ﻪﻳﺬﻐﺗ هوﺮﮔ ﺎﺑ هﺪ
8 / 0 ﺖﻓﺎﻳ ﺶﻳاﺰﻓا ﻪﺑﻮﭼدرز ﺪﺻرد .
ﺖﻈﻠﻏ
-LDL هوﺮﮔ رد لوﺮﺘﺴﻠﻛ ﻪﺑﻮﭼدرز ردﻮﭘ ﺎﺑ هﺪﺷ ﻪﻳﺬﻐﺗ يﺎﻫ
) 01 /
± 3 7 / 46 ( ﻪﻳﺎﭘ هﺮﻴﺟ ﺎﺑ ﻪﺴﻳﺎﻘﻣ رد )
17 /
± 2 0 / 52 (
ﻦﻴﻳﺎﭘ دﻮﺑ ﺮﺗ . ﻢﻳﺰﻧآ ﺖﻴﻟﺎﻌﻓ ناﺰﻴﻣ زاﺪﻴﺴﻛاﺮﭘ نﻮﻴﺗﺎﺗﻮﻠﮔ يﺎﻫ
GPx) ( زا 52 /
±8 1 / 183 ﻪﺑ 52 /
±10 7 / 220 ﻪﺟﻮﺟ رد يﺎﻫ
ﻪﻳﺬﻐﺗ ﺎﺑ هﺪﺷ 8 / 0 و ﻪﺑﻮﭼدرز ﺪﺻرد 52
/
±11 9 / 225 رد 4 / 0
ﺖﻓﺎﻳ دﻮﺒﻬﺑ ﻪﺑﻮﭼدرز ردﻮﭘ ﺪﺻرد )
لوﺪﺟ 2 ( ﺖﻴﻟﺎﻌﻓ ناﺰﻴﻣ ﻲﻟو ،
زﺎﺗﻮﻤﺳد ﺪﻴﺴﻛاﺮﭘﻮﺳ ﻢﻳﺰﻧآ SOD)
( ﺖﺷاﺪﻧ ﻲﻧاﺪﻨﭼ ﺮﻴﻴﻐﺗ
) 05 /
>0 .(P
هوﺮﮔ رد ﺺﺧﺎﺷ ،ﻪﺑﻮﭼدرز ردﻮﭘ حﻮﻄﺳ ﺎﺑ هﺪﺷ ﻪﻳﺬﻐﺗ يﺎﻫ
يد نﻮﻟﺎﻣ ناﺰﻴﻣ ﺎﻳ يﺪﻴﭙﻴﻟ يﺎﻫﺪﻴﺴﻛاﺮﭘ ناﺰﻴﻣ ﺎﻤﺳﻼﭘ ﺪﻴﺋﺪﻟآ
TBARS) (
ﻲﻨﻌﻣ رﻮﻃ ﻪﺑ ﺖﻓﺎﻳ ﺶﻫﺎﻛ يراد
. راﺪﻘﻣ TBARS
ﺮﺑاﺮﺑ ﻪﻳﺎﭘ هﺮﻴﺟ ﺎﺑ هﺪﺷ ﻪﻳﺬﻐﺗ هوﺮﮔ رد 0052
/
±0 76 / 0 رد و
هوﺮﮔ ﺎﺑ هﺪﺷ ﻪﻳﺬﻐﺗ يﺎﻫ 4
/ 0 و 8 / 0 ﻪﺑ ﻪﺑﻮﭼدرز ردﻮﭘ ﺪﺻرد
ﺐﻴﺗﺮﺗ 003 /
±0 538 / 0 و 003 /
±0 49 / 0 دﻮﺑ .
ﺚﺤﺑ ﺶﻨﺗ ﻞﻣاﻮﻋ هزوﺮﻣا ﻤﻬﻣ ﻪﻠﻤﺟ زا ،ﻲﻄﻴﺤﻣ ياز
ﻦﻳﺮﺘ
يرﺎﻤﻴﺑ زا يرﺎﻴﺴﺑ زوﺮﺑ ﻞﻣاﻮﻋ ﻲﻣ ﻪﺘﺧﺎﻨﺷ ﻪﻌﻣﺎﺟ رد ﺎﻫ
ﺪﻧﻮﺷ . ﺶﻨﺗ ﻞﻣاﻮﻋ زا ﻲﻜﻳ ﻂﻴﺤﻣ يﻻﺎﺑ تراﺮﺣ ﻪﺟرد ،ﻲﻄﻴﺤﻣ ياز
ﻲﻣ ﺖﻴﻟﺎﻌﻓ ناﺰﻴﻣ ﻪﻛ ﺪﺷﺎﺑ ﺖﻴﻟﺎﻌﻓ رد ار ﻮﻴﺗاﺪﻴﺴﻛا يﺎﻫ
يﺎﻫ
ﻲﻣ ﺶﻳاﺰﻓا ﻲﻜﻳژﻮﻟﻮﻳﺰﻴﻓ ﺪﻫد
. زا يرﺎﻴﺴﺑ زوﺮﺑ ﺮﻄﺧ ﺖﻳﺎﻬﻧ رد
يرﺎﻤﻴﺑ ﻲﺒﻠﻗ ﺪﻨﻧﺎﻣ ﺎﻫ -
،ﺖﺑﺎﻳد ،ﻲﻗوﺮﻋ ،ﻞﺻﺎﻔﻣ ﻢﺴﻴﺗﺎﻣر
نﺎﻃﺮﺳ ،نﻮﺧرﺎﺸﻓ ﺐﻴﺳآ ﺎﺑ ﻂﺒﺗﺮﻣ يﺎﻫ
ﻲﻧﻮﺧ ﻢﻛ و ﻲﺘﻓﺎﺑ يﺎﻫ
ﻲﻣ ﺶﻳاﺰﻓا نﺎﺴﻧا رد ار ﻲﻌﺿﻮﻣ ﺪﻫد
) 10 ، 9 .(
يرﺎﻤﻴﺑ زوﺮﺑ ﻞﻣاﻮﻋ زا ﻲﻜﻳ ﻲﺒﻠﻗ يﺎﻫ
- ندﻮﺑ ﻻﺎﺑ ،ﻲﻗوﺮﻋ
و لوﺮﺘﺴﻠﻛ ﺢﻄﺳ ندﻮﺑ ﻦﻴﻳﺎﭘ و نﻮﺧ مﺮﺳLDL
مﺮﺳ HDL
ﻲﻣ نﻮﺧ ﺪﺷﺎﺑ
. ﻫﺎﻛ ﺖﻬﺟ رد يدﺎﻳز تﺎﻌﻟﺎﻄﻣ ﻦﻳاﺮﺑﺎﻨﺑ ﺶ
ﺶﻳاﺰﻓا و لوﺮﺘﺴﻠﻛ ﺖﺳا هﺪﺷ مﺎﺠﻧا لوﺮﺘﺴﻠﻛHDL
.
لوﺪﺟ 1 - ﻪﻌﻟﺎﻄﻣ درﻮﻣ هوﺮﮔ ﻪﺳ رد ﻪﺟﻮﺟ ﻲﻣﺮﺳ يﺎﻫﺪﻴﭙﻴﻟ ﻦﻴﮕﻧﺎﻴﻣ ﻪﺴﻳﺎﻘﻣ
هﺮﻴﺟ ﺎﻫ
مﺮﺳ ﺪﻴﭙﻴﻟ لوﺮﺘﺴﻠﻛ
ﺪﻳﺮﺴﻴﻠﮔ يﺮﺗ
LDL HDL
ﻪﻳﺎﭘ 88
/
±12 7 / 142 41
/
±9 0 / 89 17
/
±2 0*a
/ 52 98
/
±2 7**b
/ 63
ﻪﻳﺎﭘ + 4 / 0 ﻪﺑﻮﭼدرز ردﻮﭘ ﺪﺻرد 52
/
±11 7 / 140 76
/
±8 7 / 94 01
/
±3 7b
/ 46 09
/
±3 6b
/ 66
ﻪﻳﺎﭘ + 8 / 0 ﻪﺑﻮﭼدرز ردﻮﭘ ﺪﺻرد 14
/
±12 3 / 142 19
/
±6 0 / 95 66
/
±2 3b
/ 47 87
/
±3 0a
/ 74
ﻲﻨﻌﻣ ﺢﻄﺳ يراد 963
/ 0 652
/ 0 041
/ 0 008
/ 0
ﻲﻨﻌﻣ فﻼﺘﺧا مﺪﻋ ﺮﮕﻧﺎﻴﺑ نﻮﺘﺳ ﺮﻫ داﺪﻋا يور فوﺮﺣ دﻮﺟو مﺪﻋ هوﺮﮔ ﻦﻴﺑ راد
ﻲﻣ ﺎﻫ ﺪﺷﺎﺑ ) 05 /
>0 .(P
* ﻲﻨﻌﻣ فﻼﺘﺧا دﻮﺟو ﺮﮕﻧﺎﻴﺑ ﻦﻜﻧاد زا ﻞﺻﺎﺣ ﺞﻳﺎﺘﻧ ﺎﺑ ﻪﻳﺎﭘ هوﺮﮔ ﻦﻴﺑ راد
4 / 0 ﻪﺑﻮﭼدرز ﺪﺻرد )
044 / 0 P = ( ﺎﺑ ﻪﻳﺎﭘ و 8 / 0 ﻪﺑﻮﭼدرز ﺪﺻرد )
048 / 0 P= ( ﻲﻣ ﺪﺷﺎﺑ . ﻦﻴﺑ 4 / 0 و 8 / 0
ﻲﻨﻌﻣ فﻼﺘﺧا ﻪﺑﻮﭼدرز ﺪﺻرد دﻮﺒﻧ راد
.
**
ﻲﻨﻌﻣ فﻼﺘﺧا دﻮﺟو ﺮﮕﻧﺎﻴﺑ ﻦﻜﻧاد زا ﻞﺻﺎﺣ ﺞﻳﺎﺘﻧ هوﺮﮔ ﻦﻴﺑ راد
ﺎﺑ ﻪﻳﺎﭘ 8 / 0 ﻪﺑﻮﭼدرز ﺪﺻرد )
0109 / 0 P = ( دﻮﺑ . ﻲﻨﻌﻣ فﻼﺘﺧا ﻦﻳﺮﻳﺎﺳ نﺎﻴﻣ دﻮﺒﻧ راد
.
لوﺪﺟ 2 - ﻢﻳﺰﻧآ ﺖﻴﻟﺎﻌﻓ ﻪﺴﻳﺎﻘﻣ يﺎﻫ
،GPx ﺺﺧﺎﺷ وSOD
TBARS ﻪﻌﻟﺎﻄﻣ ﺖﺤﺗ هوﺮﮔ ﻪﺳ رد ﻪﺟﻮﺟ رد
هﺮﻴﺟ ﺎﻫ
ﻪﺠﻨﺳاﺮﻓ
GPx (U/l) SOD (U/l)
TBARS
لﻮﻣﻮﻧﺎﻧ / ﻲﻠﻴﻣ ﺮﺘﻴﻟ
ﻪﻳﺎﭘ 52
/
±8 1*b
/ 183 52
/
±13 7 / 188 0052
/
±0 760**a
/ 0
ﻪﻳﺎﭘ + 4 / 0 ﻪﺑﻮﭼدرز ردﻮﭘ ﺪﺻرد
52 /
±11 9a
/ 225 08
/
±14 2 / 176 0028
/
±0 538b
/ 0
ﻪﻳﺎﭘ + 8 / 0 ﻪﺑﻮﭼدرز ردﻮﭘ ﺪﺻرد
52 /
±10 7a
/ 220 31
/
±10 7 / 186 0032
/
±0 490b
/ 0
ﻲﻨﻌﻣ ﺢﻄﺳ يراد 002
/ 0 209
/ 0 0001
/ 0
ﻧﺎﻴﺑ نﻮﺘﺳ ﺮﻫ داﺪﻋا يور فوﺮﺣ دﻮﺟو مﺪﻋ ﻲﻨﻌﻣ فﻼﺘﺧا مﺪﻋ ﺮﮕ
هوﺮﮔ ﻦﻴﺑ راد ﻲﻣ ﺎﻫ
ﺪﺷﺎﺑ ) 05 /
>0 .(P
* ﻲﻨﻌﻣ فﻼﺘﺧا دﻮﺟو ﺮﮕﻧﺎﻴﺑ ﻦﻜﻧاد زا ﻞﺻﺎﺣ ﺞﻳﺎﺘﻧ ﺎﺑ ﻪﻳﺎﭘ هوﺮﮔ ﻦﻴﺑ راد
4 / 0 ﻪﺑﻮﭼدرز ﺪﺻرد )
004 / 0 P = ( ﺎﺑ ﻪﻳﺎﭘ و 8 / 0 ﻪﺑﻮﭼدرز ﺪﺻرد )
0101 / 0 P = ( ﻲﻣ ﺪﺷﺎﺑ . ﻦﻴﺑ 4 / 0 و
8 / 0 ﻲﻨﻌﻣ فﻼﺘﺧا ﻪﺑﻮﭼدرز ﺪﺻرد دﻮﺒﻧ راد
.
**
ﺞﻳﺎﺘﻧ ﻲﻨﻌﻣ فﻼﺘﺧا دﻮﺟو ﺮﮕﻧﺎﻴﺑ ﻦﻜﻧاد زا ﻞﺻﺎﺣ ﺎﺑ ﻪﻳﺎﭘ هوﺮﮔ ﻦﻴﺑ راد
4 / 0 ﺎﺑ ﻪﻳﺎﭘ و ﻪﺑﻮﭼدرز ﺪﺻرد 8
/ 0 ﻪﺑﻮﭼدرز ﺪﺻرد )
0001 / 0 P = ﻲﻣ ﺪﺷﺎﺑ . ﻦﻴﺑ 4 / 0 و 8 / 0 ﺪﺻرد
ﻲﻨﻌﻣ فﻼﺘﺧا ﻪﺑﻮﭼدرز دﻮﺒﻧ راد
.
ﺖﻈﻠﻏ ﻪﺑﻮﭼدرز ردﻮﭘ ندوﺰﻓا ،ﻪﻌﻟﺎﻄﻣ ﻦﻳا رد ﺶﻫﺎﻛ ار LDL
ﺖﻈﻠﻏ و داد ﺶﻳاﺰﻓا ار HDL
. ﺮﮕﻳد ﻦﻴﻘﻘﺤﻣ ﻪﺑﺎﺸﻣ رﻮﻃ ﻪﺑ
ﺶﻳاﺰﻓا ﺰﻴﻧ هوﺮﮔ رد ارHDL
ﻪﺑﻮﭼدرز ردﻮﭘ ﺎﺑ هﺪﺷ ﻪﻳﺬﻐﺗ يﺎﻫ
ﺪﻧدﻮﻤﻧ شراﺰﮔ )
17 ، 16 .(
ردﻮﭘ لﺎﻌﻓ هدﺎﻣ ﻦﻳﺮﺘﻤﻬﻣ ﻦﻴﻣﻮﻛرﻮﻛ
ﺘﺴﻠﻛ ﻲﮔﺪﻨﻫﺎﻛ ﺶﻘﻧ ،ﻪﺑﻮﭼدرز و لوﺮ
ﺎﻔﻟآ ﺶﻳاﺰﻓا و LDL
دراد هاﺮﻤﻫ ﻪﺑ ار لوﺮﻓﻮﻛﻮﺗ )
18 .(
دﻮﺧ ﻲﮔﺪﻨﻫﺎﻛ ﺮﺛا ﻦﻴﻣﻮﻛرﻮﻛ
لوﺮﺘﺴﻠﻛ يﺪﺒﻛ ﻢﻳﺰﻧآ ﺰﺘﻨﺳ ﻚﻳﺮﺤﺗ ﻖﻳﺮﻃ زا لوﺮﺘﺴﻠﻛ ﺮﺑ ار -
7 - ﻲﻣ ﺎﻔﻳا زﻼﻴﺴﻛورﺪﻴﻫ ﺪﻳﺎﻤﻧ
) 20 ، 19 .(
وKim شﻮﻣ ﻪﻳﺬﻐﺗ ﻪﻛ ﺪﻧداد نﺎﺸﻧ ﺰﻴﻧKim
هﺮﻴﺟ ﺎﺑ ﺎﻫ يﺎﻫ
ﻲﻣ ﺐﺒﺳ ﻪﺑﻮﭼدرز ردﻮﭘ يوﺎﺣ ﻪﻛ دﻮﺷ
،لوﺮﺘﺴﻠﻛ وLDL
HDL
ﺪﺑﺎﻳ ﺶﻫﺎﻛ .
يرﺎﻤﻴﺑ زوﺮﺑ لﺎﻤﺘﺣا نآ ﻲﭘ رد ﻲﺒﻠﻗ يﺎﻫ
- و ﻲﻗوﺮﻋ
ﺖﻓﺎﻳ ﺶﻫﺎﻛ ﺰﻴﻧ ﺰﻧژوﺮﺗآ ﺺﺧﺎﺷ )
21 .(
ندﻮﻤﻧ ﻞﻤﻜﻣ ﻦﻳاﺮﺑﺎﻨﺑ
ﻢﻳژر رﺎﻨﻛ رد ﻪﻳودا ناﻮﻨﻋ ﻪﺑ ﻪﺑﻮﭼدرز ردﻮﭘ ﻂﻳاﺮﺷ رد ﻲﻳاﺬﻏ يﺎﻫ
ﻲﻣ ﻚﺸﺧ و مﺮﮔ ﻖﻃﺎﻨﻣ ﻲﻳﺎﻣد و نﺪﺑ ﺮﺘﻬﺑ دﺮﻜﻠﻤﻋ ﻪﺑ ﺪﻧاﻮﺗ
يﺎﻫﺪﻴﭙﻴﻟ دﻮﺒﻬﺑ ﺪﻳﺎﻤﻧ ﻚﻤﻛ نﻮﺧ
.
ﺖﻴﻟﺎﻌﻓ ،ﺪﺷ هرﺎﺷا ﻪﻣﺪﻘﻣ رد ﻪﻛ رﻮﻃ نﺎﻤﻫ ﻮﻴﺗاﺪﻴﺴﻛا يﺎﻫ
ﻲﺗراﺮﺣ ﺶﻨﺗ ﻂﻳاﺮﺷ رد هﺪﻧز ﻢﺘﺴﻴﺳ رد دازآ لﺎﻜﻳدار ﺪﻴﻟﻮﺗ و ﻲﻣ ﺶﻳاﺰﻓا ﺪﺑﺎﻳ
. زا ﺖﻌﻧﺎﻤﻣ ﺖﻬﺟ ﻲﻔﻠﺘﺨﻣ يﺎﻫرﺎﻜﻫار ﻦﻳاﺮﺑﺎﻨﺑ
لﺎﻜﻳدار ﻪﻌﺳﻮﺗ ﺖﺳا هﺪﺷ دﺎﻬﻨﺸﻴﭘ دازآ يﺎﻫ
. ﺰﻴﻧ ﻪﻌﻟﺎﻄﻣ ﻦﻳا رد
درز ردﻮﭘ ندﻮﻤﻧ ﻞﻤﻜﻣ ناﺰﻴﻣ ﺶﻫﺎﻛ ﺚﻋﺎﺑ هﺮﻴﺟ ﻪﺑ ﻪﺑﻮﭼ
ﻪﺟﻮﺟ يﺎﻤﺳﻼﭘ يﺪﻴﭙﻴﻟ يﺎﻫﺪﻴﺴﻛاﺮﭘ ﺖﻴﻟﺎﻌﻓ و ﺪﻳدﺮﮔ ﺎﻫ
ﺖﻓﺎﻳ ﺶﻳاﺰﻓا زاﺪﻴﺴﻛاﺮﭘ نﻮﻴﺗﺎﺗﻮﻠﮔ Suvanated .
نارﺎﻜﻤﻫ و
ﻪﺟﻮﺟ هﺮﻴﺟ ﻪﺑ ﻪﺑﻮﭼدرز ردﻮﭘ ندﻮﻤﻧ ﻞﻤﻜﻣ ﺎﺑ ﺰﻴﻧ ،ﻲﺘﺷﻮﮔ يﺎﻫ
ﻢﻳﺰﻧآ ﺖﻴﻟﺎﻌﻓ دﻮﺒﻬﺑ ﻲﺘﻧآ يﺎﻫ
ﺺﺧﺎﺷ ﺶﻫﺎﻛ و ﻲﻧاﺪﻴﺴﻛا
TBARS ﺪﻧدﻮﻤﻧ شراﺰﮔ ار
) 22 .(
ﻪﺑﻮﭼدرز ﻲﺘﺴﻳز لﺎﻌﻓ ﺐﻴﻛﺮﺗ ﻦﻳﺮﺘﻤﻬﻣ ﻦﻴﻣﻮﻛرﻮﻛ ﻲﻣ ﻲﺘﻧآ ﻢﺘﺴﻴﺳ ﺮﺑ ﻪﻛ ﺪﺷﺎﺑ ﺖﻴﻟﺎﻌﻓ و ﻲﻧاﺪﻴﺴﻛا
ﻮﻴﺗاﺪﻴﺴﻛا يﺎﻫ
ﻲﻣ ﺮﻴﺛﺄﺗ دراﺬﮔ . هوﺮﮔ ﻦﻴﻣﻮﻛرﻮﻛ نﺎﻤﺘﺧﺎﺳ رد دﻮﺟﻮﻣ ﻲﻠﻨﻓ يﺎﻫ
ﻦﺘﺴﻜﺷ و ﺎﻫﺪﻴﭙﻴﻟ نﻮﻴﺳاﺪﻴﺴﻛاﺮﭘ زا ﺖﻌﻧﺎﻤﻣ رد ﻲﻤﻬﻣ ﺶﻘﻧ رﺎﺘﺧﺎﺳ ﻲﻣ ﺎﻔﻳا DNA
ﺪﻳﺎﻤﻧ . هوﺮﮔ ﻦﻳا ندﺮﺑ ﻦﻴﺑ زا ﻲﻳﺎﻧاﻮﺗ ﺎﻫ
نﻮﻳ و ﻚﻳﺮﺘﻴﻧ ﺪﻴﺴﻛا ،ﻞﻴﺴﻛورﺪﻴﻫ لﺎﻜﻳدار ،ﺪﻴﺴﻛاﺮﭘﻮﺳ يﺎﻫ
يد دراد ار نژوﺮﺘﻴﻧ ﺪﻴﺴﻛا )
23 .(
ﻢﻳﺰﻧآ ﺖﻴﻟﺎﻌﻓ ﺶﻳاﺰﻓا ﺎﺑ ﻪﺑﻮﭼدرز ﻦﻴﻨﭽﻤﻫ
ﺪﺿ يﺎﻫ
زﺎﺗﻮﻤﺳد ﺪﻴﺴﻛاﺮﭘﻮﺳ ،زاﺪﻴﺴﻛاﺮﭘ نﻮﻴﺗﺎﺗﻮﻠﮔ ﺪﻨﻧﺎﻣ ﻲﻧﻮﻴﺳاﺪﻴﺴﻛا ﻴﭙﻴﻟ نﻮﻴﺳاﺪﻴﺴﻛاﺮﭘ ﺶﻫﺎﻛ ﺚﻋﺎﺑ زﻻﺎﺗﺎﻛ و ﻲﻣ ﺎﻫﺪ
دﻮﺷ ) 24 .(
ناﺪﻴﺴﻛا ﺪﺿ دﻮﺒﻤﻛ زا ﺖﻌﻧﺎﻤﻣ ﺎﺑ ﻲﻳوراد هﺎﻴﮔ ﻦﻳا ﻦﻴﻨﭽﻤﻫ ﺎﻫ
يرﺪﻨﻛﻮﺘﻴﻣ زا ﺖﻈﻓﺎﺤﻣ ،نﺪﺑ رد ﻮﻴﺗاﺪﻴﺴﻛا ﺐﻴﺳآ ﻞﺑﺎﻘﻣ رد ﺎﻫ
نداد ﺖﺳد زا ﻖﻳﺮﻃ زا سردوز ندﻮﻤﻧ ﻲﺻﺎﺼﺘﺧا و ATP
ﻲﻣ يﺮﻴﮔﻮﻠﺟ ﻲﻟﻮﻠﺳ گﺮﻣ زا لﻮﻠﺳ ﺖﻴﻟﺎﻌﻓ ﺪﻳﺎﻤﻧ
) 27 - 25 .(
ﺖﻴﻟﺎﻌﻓ ﺶﻫﺎﻛ ﺎﺑ ﻦﻳاﺮﺑﺎﻨﺑ ﻛا يﺎﻫ
،هﺪﻧز ﻢﺘﺴﻴﺳ رد ﻮﻴﺗاﺪﻴﺴ
يرﺎﻤﻴﺑ زوﺮﺑ ﺶﻨﻛاو ﻦﻳا ﺎﺑ ﻂﺒﺗﺮﻣ يﺎﻫ
ﺪﻫاﻮﺧ ﺶﻫﺎﻛ ﺰﻴﻧ ﺎﻫ
ﺖﻓﺎﻳ . ﻲﺘﺴﻳز لﺎﻌﻓ تﺎﺒﻴﻛﺮﺗ ندﻮﺑ اراد ﻞﻴﻟد ﻪﺑ ﻪﺑﻮﭼدرز ردﻮﭘ
ﻲﻣ ﺖﻴﻟﺎﻌﻓ ندﻮﻤﻧ ﻞﻗاﺪﺣ ﺖﻬﺟ ﻲﺒﺳﺎﻨﻣ ﻲﻳوراد هﺎﻴﮔ ﺪﻧاﻮﺗ يﺎﻫ
ﺪﺷﺎﺑ نﺪﺑ رد ﻮﻴﺗاﺪﻴﺴﻛا .
ﻪﺑ ﻪﺑﻮﭼدرز ردﻮﭘ ندوﺰﻓا ﻦﻳا ﺮﺑ هوﻼﻋ
ﻪﺟﻮﺟ هﺮﻴﺟ ار ﺖﺷﻮﮔ يرﺎﮔﺪﻧﺎﻣ و ﺖﻴﻔﻴﻛ ،ﻲﺘﺷﻮﮔ يﺎﻫ
داد ﺪﻫاﻮﺧ ﺶﻳاﺰﻓا )
28 ( لﺎﻜﻳدار ناﺰﻴﻣ ﻪﻛ اﺮﭼ ؛ دازآ يﺎﻫ
ﺖﺷﻮﮔ عﻮﻧ ﻦﻳا رد هﺪﺷ ﻪﺘﺷﺎﺒﻧا و ﻪﻌﺳﻮﺗ ،دﻮﺑ ﺪﻫاﻮﺧ ﺮﺘﻤﻛ ﺎﻫ
لﺎﻜﻳدار ﺶﻳاﺰﻓا ﺪﻫاﻮﺧ ﺮﺘﻤﻛ ﺰﻴﻧ يراﺪﻬﮕﻧ نﺎﻣز رد دازآ يﺎﻫ
داﺮﻓا ﻢﺴﻴﻟﻮﺑﺎﺘﻣ و يژﻮﻟﻮﻳﺰﻴﻓ ﺮﺑ يﺮﺘﻤﻛ ﻲﻔﻨﻣ ﺮﺛا و دﻮﺑ فﺮﺼﻣ ﺖﺷاد ﺪﻫاﻮﺧ هﺪﻨﻨﻛ )
23 .(
ﺖﻴﻟﺎﻌﻓ زا ﻲﺸﺨﺑ يرﺎﺠﻨﻫﺎﻧ و ﻮﻴﺗاﺪﻴﺴﻛا يﺎﻫ
رد ﻪﻛ ﻲﻳﺎﻫ
ﻲﻣ زوﺮﺑ نﺎﺴﻧا ﻲﻣ ﻲﺗﺎﺒﻴﻛﺮﺗ زا ﻲﺷﺎﻧ ،ﺪﻨﻛ
ﻖﻳﺮﻃ زا ﻪﻛ ﺪﺷﺎﺑ
ﻲﻣ نﺎﺴﻧا ﻲﻤﺴﻴﻟﻮﺑﺎﺘﻣ ﻢﺘﺴﻴﺳ دراو ﻪﻳﺬﻐﺗ دﻮﺷ
. غﺮﻣ ﺖﺷﻮﮔ
نﺎﺴﻧا ﻪﻳﺬﻐﺗ رد ﻲﻧاﻮﻴﺣ ﻦﻴﺌﺗوﺮﭘ ﻦﻴﻣﺄﺗ ﻊﺑﺎﻨﻣ ﻦﻳﺮﺘﻤﻬﻣ زا ﻲﻜﻳ ﻲﻣ دﻮﺒﻬﺑ ﺎﺑ و ﺪﺷﺎﺑ ﻲﻣ نآ ﺖﻴﻔﻴﻛ
ﻲﺘﻣﻼﺳ ﺶﻳاﺰﻓا ﻪﺑ ناﻮﺗ
دﻮﻤﻧ ﻚﻤﻛ نﺎﺴﻧا .
ﻪﺠﻴﺘﻧ يﺮﻴﮔ
ﻲﻣ لﺎﻤﺘﺣا ﻚﺸﺧ و مﺮﮔ ﻖﻃﺎﻨﻣ رد ندﻮﻤﻧ ﻞﻤﻜﻣ ﻪﻛ دور
ﺶﻫﺎﻛ ﺚﻋﺎﺑ ،ﻲﻳاﺬﻏ ﻢﻳژر ﻪﺑ ﻪﺑﻮﭼدرز ردﻮﭘ و لوﺮﺘﺴﻠﻛLDL
ﺶﻳاﺰﻓا دﻮﺷ لوﺮﺘﺴﻠﻛHDL
. ﻲﺘﻧآ ﻢﺘﺴﻴﺳ ﻦﻴﻨﭽﻤﻫ ﻲﻧاﺪﻴﺴﻛا
ﻲﻣ دﻮﺒﻬﺑ ار يرﺎﻤﻴﺑ زوﺮﺑ ﺖﻳﺎﻬﻧ رد ﻪﻛ ﺪﺸﺨﺑ
ﺎﻫ ﻲﺒﻠﻗ ي -
داد ﺪﻫاﻮﺧ ﺶﻫﺎﻛ ار زوﺮﻠﻜﺳاوﺮﺗآ و ﻲﻗوﺮﻋ .
ﻲﻣ دﺎﻬﻨﺸﻴﭘ دﻮﺷ
ﺮﺑ ﻲﻨﻏور ﻊﺑﺎﻨﻣ هاﺮﻤﻫ ﻪﺑ ﻪﺑﻮﭼدرز ردﻮﭘ ﺮﺗﻻﺎﺑ حﻮﻄﺳ ﺮﻴﺛﺄﺗ ﻪﻛ
ﻪﺠﻨﺳاﺮﻓ ﻲﺘﻧآ ،يﺪﻴﭙﻴﻟ يﺎﻫ ﺖﻓﺎﺑ و ﻲﻧاﺪﻴﺴﻛا
هﮋﻳو ﻪﺑ ﻲﺳﺎﻨﺷ
درﻮﻣ هﺪﻨﻳآ تﺎﻌﻟﺎﻄﻣ رد ﻲﻳﺎﻣﺮﮔ ﺶﻨﺗ ﻂﻳاﺮﺷ ﺖﺤﺗ ﺪﺒﻛ ﺖﻓﺎﺑ دﺮﻴﮔ راﺮﻗ ﻲﺳرﺮﺑ .
ﺗ و ﺮﻳﺪﻘﺗ
ﺮﻜﺸ
نﺎﮔﺪﻨﺴﻳﻮﻧ زا
يزروﺎﺸﻛ هﺪﻜﺸﻧاد ﻲﻣاد مﻮﻠﻋ هوﺮﮔ
ﻪﺑ ﻲﻣاد مﻮﻠﻋ تﺎﻘﻴﻘﺤﺗ ﻪﺴﺳﺆﻣ و ﺪﻬﺸﻣ ﻲﺳودﺮﻓ هﺎﮕﺸﻧاد
،حﺮﻃ ياﺮﺟا رد يرﺎﻜﻤﻫ ظﺎﺤﻟ ﺮﻜﺸﺗ
و ﻲﻧادرﺪﻗ
ﻲﻣ ﺪﻨﻳﺎﻤﻧ .
ﻊﺑﺎﻨﻣ :
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Abstract Original Article
Influence of Turmeric Rhizome Powder diets on decreasing oxidative stress caused by heat stress inbroiler model
Seyyed Javad Hosseini-Vashan1, Akbar Yaghobfar2, Abolghasem Golian3, Ahmad Reza Raji4, Mohammad Reza Nassiri5, Peyman Esmaeilinasab6
Background and Aim: Production of reactive oxygen species (ROS) increases during oxidative stress conditions, which stimulates diabetes, inflammatory reactions, rheumatism and anemia. Some antioxidant properties of turmeric rhizome powder (TRP) were revealed by previous researchers. The present study was conducted to evaluate the influence of TRP on decreasing effects of oxidative stress resulted from heat stress in broiler chickens.
Materials and Methods: In this experimental study, two-hundred-sixty-four 1-day-old broilers were divided into 3 dietary treatments. The dietary treatments involved 0(control), 0.4 and 0.8% turmeric rhizome powder (cases). In order to create oxidative stress, the ambient temperature was daily raised from 21 to 33oc for 5 hours (11a.m-4p.m) throughout the 28th-42nd days. Blood lipids, Glutathione peroxidase (GPx) ,superoxide dismutase (SOD), and Tiobarbituric acid reaction score (TBARS) were determined at the end of the experiment.
Results: The results revealed that total cholesterol and triglyceride were not affected. The 0.4 TRP diet decreased blood LDL (46.7±3.01) compared to basal group (52.0±2.17). HDL increased in broilers fed 0.8%
TRP (74.0 ± 3.87) compared to chickens with basal diet (63.7± 2.98). Enzyme activity of GPx improved in broilers fed TRP diets (225.9± 11.52) as compared to chickens with basal diet (183.1± 8.52); however, the TRP diet did not affect enzyme activity of SOD (P > 0.05). The TBARS index decreased in broilers fed TRP (0.76 ± 0.0052 in basal vs.0.49 ± 0.0032 in 0.8% TRP).
Conclusion: The major bioactive component of TRP is Curcumin that can improve the antioxidant properties under oxidative stress and high ambient temperature.
Key Words: Turmeric Rhizome Powder, Heat stress, Antioxidant parameters, Broiler, Oxidative stress Journal of Birjand University of Medical Sciences. 2012; 19(2): 157-164
Received: April 16, 2012 Accepted: May 29, 2012
1 Ph.D. student of poultry nutrition, Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
2 Corresponding Author, Professor of poultry nutrition, Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran g [email protected]
3 Associate professor, Department of Animal Nutrition, Animal Science Research Institute, Karaj, Iran
4 Assistant professor of Pathology, Veterinary Faculty, Ferdowsi University of Mashhad, Mashhad, Iran.
5 Associate professor of Animal Breeding, Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
