۵۶
ﻪﺘﺷر رﺎﺸﺘﻧا و ﻪﻳﺎﭘ يﺎﺸﻏ تاﺮﻴﻴﻐﺗ شﻮﺧ يزﻼﭘﺮﭙﻴﻫ رد رﻻﻮﻜﻴﺗر يﺎﻫ
ﻢﻴﺧ
تﺎﺘﺳوﺮﭘ يﺎﻣﻮﻨﻴﺳرﺎﻛ و
ﻲﻧﺎﻣﺮﻛ ﻪﺒﻴﻃ ﺮﺘﻛد -1
ﺖﺳدرز دﻮﻤﺤﻣ ﺮﺘﻛد -2
يراﺰﺒﺳ ﺎﺿرﺪﻤﺣا -3
ﻪﺘﺳراو ﺎﺿﺮﻟاﺪﺒﻋ ﺮﺘﻛد
4
هﺪﻴﻜﭼ
فﺪﻫ و ﻪﻨﻴﻣز نﺎﻃﺮﺳ :
تﺎﺘﺳوﺮﭘ نﺎﻃﺮﺳ ﻦﻴﻣود ﻪﻛ ﺖﺳا ﺮﻛﺬﻣ ﺲﻨﺟ رد ﻊﻳﺎﺷ
ﮔﺪﻧز و دﺮﻓ ﺖﻣﻼﺳ ﻲﻋﺎﻤﺘﺟا ﻲ
-
راﺮﻗ ﺮﻴﺛﺎﺗ ﺖﺤﺗ ار يو يدﺎﺼﺘﻗا ﺪﻫد ﻲﻣ
. تﺎﺘﺳوﺮﭘ ﻦﺘﺷادﺮﺑ زا ﺲﭘ ناﻮﺗ ﻲﻣ يرﺎﻤﻴﺑ ﻲﻤﻴﺧﺪﺑ ناﺰﻴﻣ ﻦﻴﻴﻌﺗ و
ﺶﻴﭘ ﻲﻬﮔآ نآ ﻴﻴﻌﺗ ﻖﻴﻗد رﻮﻄﺑ ار ﻦ
دﻮﻤﻧ . ﻪﻳﺎﭘ ءﺎﺸﻏ دﻮﺟو مﺪﻋ ﺎﻳ دﻮﺟو ﻪﻜﻴﻳﺎﺠﻧآ زا رﻻﻮﻜﻴﺗر يﺎﻫ ﻪﺘﺷر و
ﺰﻴﻧ
ﻴﺨﺸﺗ رد ﻲﻟﻮﻠﺳ هدر ﺪﻨﻧﺎﻤﻫ ﻲﻤﻴﺧ ﺪﺑ و ﻲﻤﻴﺧ شﻮﺧ ﺺ
نﺎﻃﺮﺳ ﺎﻫ
،دراد ﺖﻴﻤﻫا ﻲﺑﺎﻳزرا فﺪﻫ ﺎﺑ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ
شﻮﺧ دراﻮﻣ رد دﺪﻏ ﻪﻳﺎﭘ يﺎﺸﻏ تاﺮﻴﻴﻐﺗ ﮓﻧر زا هدﺎﻔﺘﺳا ﺎﺑ ،ﻢﻴﺧﺪﺑ و ﻢﻴﺧ
ﺪﺷ مﺎﺠﻧا ﻲﺻﺎﺼﺘﺧا يﺰﻴﻣآ .
ﻲﺳرﺮﺑ شور كﻮﻠﺑ ،ﻲﺑﺮﺠﺗ ﻪﻌﻟﺎﻄﻣ ﻦﻳا رد:
شﻮﺧ تﺎﺘﺳوﺮﭘ ﻲﻨﻴﻓارﺎﭘ يﺎﻫ ﺐﻴﺳآ ﺶﺨﺑ زا ﻢﻴﺧﺪﺑ و ﻢﻴﺧ
ﻲﺳﺎﻨﺷ
ﺎﺿر مﺎﻣا نﺎﺘﺳرﺎﻤﻴﺑ )
ع ( ﻪﺑ ﻪﺘﺴﺑاو ﺪﺷ ﻪﻴﻬﺗ ،ﺪﻨﺟﺮﻴﺑ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد
. عﻮﻤﺠﻣ رد زا
8 يزﻼﭘﺮﭙﻴﻫ ﺎﺑ درﻮﻣ
شﻮﺧ و تﺎﺘﺳوﺮﭘ ﻢﻴﺧ 6
ﺪﺷ هدﺎﻔﺘﺳا ﺎﻣﻮﻨﻴﺳرﺎﻛﻮﻧدآ ﺎﺑ درﻮﻣ .
ﺮﻄﻗ ﻪﺑ ﺎﻬﺷﺮﺑ 5
ﺪﻧﺪﺷ ﻪﻴﻬﺗ نوﺮﻜﻴﻣ .
يﺮﺳ ﺮﻫ رد
ﺮﻫ زا شﺮﺑ 10
شور ﻪﺑ ﻲﻜﻳ ﻪﻧﻮﻤﻧ
H&E
) ﻦﻳزﻮﺋا و ﻦﻴﻠﻴﺴﻛﻮﺗﺎﻤﻫ (
لﺮﺘﻨﻛ و ﻪﻌﻳﺎﺿ ﻞﺤﻣ ﺺﻴﺨﺸﺗ رﻮﻈﻨﻣ ﻪﺑ
ﮓﻧر ،هﺪﻣآ ﺖﺳد ﻪﺑ ﺞﻳﺎﺘﻧ و ﺪﺷ ﻲﺳرﺮﺑ و يﺰﻴﻣآ
ﺎﻬﺷﺮﺑ ﺮﻳﺎﺳ ،دﺪﻏ ﺔﻳﺎﭘ يﺎﺸﻏ ﻲﺳرﺮﺑ ياﺮﺑ
شور ﻪﺑ هﺮﻘﻧ تاﺮﺘﻴﻧ
ﮓﻧر يﺰﻴﻣآ ﺪﺷ .
ﻪﺘﻓﺎﻳ ﺎﻫ شﻮﺧ يﺎﻬﺘﻓﺎﺑ ﺶﻨﻛاو يﻮﮕﻟا: رﺎﻴﺴﺑ هﺮﻘﻧ تاﺮﺘﻴﻧ ﻪﺑ ﺖﺒﺴﻧ ﻢﻴﺧﺪﺑ و ﻢﻴﺧ
توﺎﻔﺘﻣ ؛دﻮﺑ ﻪﻧﻮﻤﻧ رد ﻢﻴﺧﺪﺑ يﺎﻫ
ﻲﻨﻴﺳآ فاﺮﻃا رد ﭘ يﺎﺸﻏ ،ﻲﻟﻮﻠﺳ يﺎﻬﺑﺎﻨﻃ و ﺎﻫ
يﺎﺸﻏ ،دﺪﻏ ﻞﺻﺎﻓ ﺪﺣ كﺪﻧا يﺎﻣوﺮﺘﺳا رد ﺎﻣا ﺪﺸﻧ هﺪﻫﺎﺸﻣ ﻪﻳﺎ
ﻪﻧﻮﻤﻧ رد ﻪﻳﺎﭘ يﺎﺸﻏ رﻻﻮﻜﻴﺗر فﺎﻴﻟا ﻪﻛ ﻲﻟﺎﺣ رد ؛ﺪﺷ ﻞﻴﻜﺸﺗ ﻲﻠﻴﻓﻮﻨﻳژرآ و ﺪﺘﻤﻣ ،ﻢﻴﺨﺿ شﻮﺧ يﺎﻫ
و كزﺎﻧ ﻢﻴﺧ
دﻮﺑ ﻪﺘﻓﺎﻳ شﺮﺘﺴﮔ ﺎﻣوﺮﺘﺳا ﻞﻴﻓﻮﻨﻳژرآ فﺎﻴﻟا ﺎﺑ و ﻊﻄﻘﻨﻣ .
ﻪﺠﻴﺘﻧ يﺮﻴﮔ ﻲﻨﻌﻣ فﻼﺘﺧا ﻲﻠﻛ رﻮﻃ ﻪﺑ ،ﻖﻴﻘﺤﺗ ﻦﻳا رد: راد
ﻪﻧﻮﻤﻧ ﻦﻴﺑ رد ﻪﻳﺎﭘ يﺎﺸﻏ رد ي شﻮﺧ يﺎﻫ
ﻢﻴﺧﺪﺑ و ﻢﻴﺧ
ﻲﻣ ﻪﻛ ﺪﺷ هﺪﻫﺎﺸﻣ دﺮﻴﮔ راﺮﻗ هدﺎﻔﺘﺳا درﻮﻣ كﻮﻜﺸﻣ دراﻮﻣ ﺺﻴﺨﺸﺗ رد ﺪﻧاﻮﺗ
. ﻲﻣ دﺎﻬﻨﺸﻴﭘ يﺎﻬﺷور يﺮﺑرﺎﻛ دﻮﺷ
سﺮﺘﺳد رد و ﻲﺻﺎﺼﺘﺧا ﻲﻳﺎﻴﻤﻴﺷﻮﺘﺴﻴﻫ ﺪﻨﻧﺎﻣ
ﮓﻧر ﻲﻗاﺮﺘﻓا ﺺﻴﺨﺸﺗ رد ﻪﻳﺎﭘ يﺎﺸﻏ يﺰﻴﻣآ ﺮﻳﺎﺳ
يﺎﻬﺘﻓﺎﺑ
شﻮﺧ عاﻮﻧا رد ﻢﻴﺧﺪﺑ و ﻢﻴﺧ لﻮﻠﺳ فاﺮﻃا ﺎﻳ ﻲﻨﻴﺳآ فاﺮﻃا ﻲﺣاﻮﻧ رد نآ دﻮﺟو و ﺎﻫرﻮﻣﻮﺗ
دﺮﻴﮔ راﺮﻗ ﻪﻌﻟﺎﻄﻣ درﻮﻣ ﺎﻫ .
هژاو ﺪﻴﻠﻛ ﺎﻫ شﻮﺧ يزﻼﭘﺮﭙﻴﻫ ؛تﺎﺘﺳوﺮﭘ: ﮓﻧر ؛ﻪﻳﺎﭘ يﺎﺸﻏ ؛ﺎﻣﻮﻨﻴﺳرﺎﻛﻮﻧدآ ؛ﻢﻴﺧ
ﻦﻴﻣﺎﻨﺘﻣرﻮﻠﻴﺳ يﺰﻴﻣآ
ﻣ ﺪﻨﺟﺮﻴﺑ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻲﻤﻠﻋ ﻪﻠﺠ )
هرود 11
، هرﺎﻤﺷ 4
، لﺎﺳ 1383
(
ﻲﺤﻳﺮﺸﺗ مﻮﻠﻋ ﻲﺷزﻮﻣآ هوﺮﮔ رﺎﻳدﺎﺘﺳا ؛لوﺆﺴﻣ هﺪﻨﺴﻳﻮﻧ1
) ﻲﻣﻮﺗﺎﻧآ ( ﺪﻨﺟﺮﻴﺑ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،ﻲﻜﺷﺰﭘ هﺪﻜﺸﻧاد ،
سردآ : ﺪﻨﺟﺮﻴﺑ - يرﺎﻔﻏ نﺎﺑﺎﻴﺧ -
ﺪﻨﺟﺮﻴﺑ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد -
ﻲﺤﻳﺮﺸﺗ مﻮﻠﻋ ﺶﺨﺑ
ﻦﻔﻠﺗ : 9 - 4443041 - 0561 رﺎﮕﻧرود : 4435168 - 0561 ﻲﻜﻴﻧوﺮﺘﻜﻟا ﺖﺴﭘ [email protected] :
ﺪﻨﺟﺮﻴﺑ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،ﻲﻜﺷﺰﭘ هﺪﻜﺸﻧاد ،ﻲﺳﺎﻨﺷ ﺐﻴﺳأ ﻲﺷزﻮﻣآ هوﺮﮔ رﺎﻳدﺎﺘﺳا2
هﺎﮕﺸﻧاد ،ﻲﻜﺷﺰﭘ يﻮﺠﺸﻧاد3
ﺪﻨﺟﺮﻴﺑ ﻲﻜﺷﺰﭘ مﻮﻠﻋ
رﺎﻴﺸﻧاد4
ﺶﺨﺑ ﺪﻬﺸﻣ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،ﻲﻠﻋﻮﺑ هﺪﻜﺸﻫوﮋﭘ يژﻮﻟﻮﻧﻮﻤﻳا
۵٧
ﻪﻣﺪﻘﻣ دﻮﺟو ﺎﺑ ﻌﻟﺎﻄﻣ و هدﺮﺘﺴﮔ تﺎﻘﻴﻘﺤﺗ و تﺎ ﺘﻓﺮﺸﻴﭘ
ﺔ ﻲﻟﻮﻠﺳ
و ﻦﻳﻮﻜﺗ سﺎﺳا ،ﻲﻟﻮﻜﻟﻮﻣ ﻞﻜﺷ
عاﻮﻧا يﺮﻴﮔ
يزﻼﭘﺮﭙﻴﻫ يﺎﻫ
شﻮﺧ رد ﻢﻴﺧﺪﺑ و ﻢﻴﺧ نﺪﺑ ﻒﻠﺘﺨﻣ يﺎﻀﻋا
ﻪﺘﺧﺎﻨﺷﺎﻧ نﺎﻨﭽﻤﻫ
ﺖﺳا ﻲﻧوﺰﻓ لﺎﺣ رد نآ ﻪﺑ ﻼﺘﺑا ناﺰﻴﻣ و هﺪﻧﺎﻣ ﻲﻗﺎﺑ )
1 (.
ﺪﻏ نﺎﻃﺮﺳ نﺎﻴﻣ ﻦﻳا رد ة
تﺎﺘﺳوﺮﭘ
، ﻞﻣﺎﻋ ﻦﻴﻣود
گﺮﻣ رد ﺮﻴﻣو ﻼﺘﺑا ﺮﺛا
يﺎﻴﻧد رد نادﺮﻣ نﺎﻴﻣ رد نﺎﻃﺮﺳ ﻪﺑ
ﺖﺳا بﺮﻏ )
2،1 ( ﺮﻴﺳ نآ عﻮﻴﺷ ﻦﺳ ﻦﻴﮕﻧﺎﻴﻣ ﺶﻳاﺰﻓا ﺎﺑ ﻪﻛ
دراد يدﻮﻌﺻ )
1 (.
نﺎﻃﺮﺳ ﺐﻠﻏا ﻞﻴﻜﺸﺗ رد لﻮﺒﻗ ﻞﺑﺎﻗ ﻪﺘﻜﻧ ﺎﻫ
، دﺎﺠﻳا
لﻮﻠﺳ رد نﻮﻴﺳﺎﺗﻮﻣ لﻮﻠﺳ ﺮﻴﻈﻧ ﻚﻴﺗﺎﻣﻮﺳ يﺎﻫ
ﻲﭘا يﺎﻫ ﻲﻟﺎﻴﻠﺗ
ﻚﭼﻮﻛ ﻂﻴﺤﻣ زا ﻪﻛ ﺖﺳا (Microenviroment)
فاﺮﻃا
لﻮﻠﺳ ﻣ ﺪﻨﻧﺎﻣ ﺎﻫ ،قوﺮﻋ ﻲﻧﺎﺳﺮﻧﻮﺧ ،ﻲﻟﻮﻠﺳ جرﺎﺧ ﺲﻜﻳﺮﺗﺎ
لﻮﻠﺳ ﺖﺳﻼﺑوﺮﺒﻴﻓ و ﻲﺑﺎﻬﺘﻟا يﺎﻫ ﻲﻣ راﺮﻗ ﺮﻴﺛﺄﺗ ﺖﺤﺗ ﺎﻫ
دﺮﻴﮔ
) 3 .(
ﻪﻫد ﻞﻳاوا رد 80
ﻪﻳﺮﻈﻧ يدﻼﻴﻣ Bissel's
ﻦﻳا ﺮﺑ ﻲﻨﺒﻣ
و ﻲﻌﻴﺒﻃ ﺖﻴﻟﺎﻌﻓ رد يﺪﻴﻠﻛ ﺶﻘﻧ ﻲﻟﻮﻠﺳ جرﺎﺧ ﺲﻜﻳﺮﺗﺎﻣ ﻪﻛ لﻮﻠﺳ ﻲﻌﻴﺒﻃ ﺮﻴﻏ ﻲﻣ ﺎﻔﻳا ﺎﻫ
رد ﺮﻴﻴﻐﺗ ﻪﻧﻮﮔﺮﻫ و ﺪﻨﻛ ﺲﻜﻳﺮﺗﺎﻣ
ﺎﭘ و لﻮﻠﺳ ﺦﺳ ﻲﻣ ﻲﻤﻴﺧﺪﺑ ﻪﺑ ﺮﺠﻨﻣ نآ ﻪﺑ ﺎﻫ
ﺪﺷ حﺮﻄﻣ ،ددﺮﮔ
) 4 .(
لﻮﻜﻟﻮﻣ نﻮﻨﻛﺎﺗ هﺪﺷ ﻲﻳﺎﺳﺎﻨﺷ يدﺪﻌﺘﻣ يﺎﻫ
ﺪﻧا هوﻼﻋ ﻪﻛ
ﺎﺸﻏ و ﺲﻜﻳﺮﺗﺎﻣ ﺶﻳارآ هﻮﺤﻧ ،رﺎﺘﺧﺎﺳ ﺮﺑ ي
ﺗ ﺖﺤﺗ ار ﻪﻳﺎﭘ ﺄ
ﺮﻴﺛ
ﻲﻣ راﺮﻗ ﻫد ﻨ ﺪ ) 5 - 7 .(
ﺖﺳا هﺪﺷ شراﺰﮔ ﻪﻛ
ﺶﻳارآ هﻮﺤﻧ
ﺎﺸﻏ ي ﻔﺣ ﺎﺑ و ﺖﺳا ﻂﺒﺗﺮﻣ نﺎﻃﺮﺳ ﻚﻳ ﺪﺷر يﻮﮕﻟا ﺎﺑ ﻪﻳﺎﭘ ﻆ
ﻢﻴﺨﺿ و ﻲﻣ نﺎﺸﻧ ﺶﻨﻛاو ﻦﺘﻓر ﻦﻴﺑ زا ﺎﻳ ﻲﮔﺪﺷ ﺪﻫد
) 5 .(
ﻲﻧژورﺪﻧآ ﺮﻴﻏ و ﻲﻧژورﺪﻧآ ﻞﻣاﻮﻋ ﻪﻛ تﺎﺘﺳوﺮﭘ رد
، ﻢﻴﻈﻨﺗ
لﻮﻠﺳ ﺪﺷر ﻲﻣ راﺮﻗ ﺮﻴﺛﺄﺗ ﺖﺤﺗ ار ﺎﻫ
و ﺪﻨﻫد ﺚﻋﺎﺑ
يﺎﻤﻧ
ﻲﻣ ﺚﻋﺎﺑ يدﺪﻌﺘﻣ ﻚﻳژﻮﻟﻮﻓرﻮﻣ ددﺮﮔ
) 1 ( ﺳ زا ﻲﻜﻳ ، ﺆ
تﻻا
صﻮﺼﺧ ﻦﻳا رد ﻢﻬﻣ
، رد ﻪﻳﺎﭘ يﺎﺸﻏ و ﺲﻜﻳﺮﺗﺎﻣ ﺶﻳارآ ﺮﻴﻴﻐﺗ
ا ﻲﻨﻴﺳآ فاﺮﻃ و ﺎﻫ
لﻮﻠﺳ ﻲﭘا يﺎﻫ رد تﺎﺘﺳوﺮﭘ هﺪﻏ لﺎﻴﻠﺗ
ﻒﻠﺘﺨﻣ ﻞﺣاﺮﻣ
شﻮﺧ يزﻼﭘﺮﭙﻴﻫ ﺖﺳا ﻢﻴﺧﺪﺑ و ﻢﻴﺧ
) 5 - 11 .(
ﻲﻗﺎﺑ ﺎﺸﻏ نﺪﻧﺎﻣ ي
ﻪﺘﻓﺮﺸﻴﭘ ﻞﺣاﺮﻣ رد ﻲﺘﺣ ،ﻪﻳﺎﭘ )
12 ( و ﻒﻠﺘﺨﻣ ﻞﺣاﺮﻣ رد نآ دﺪﺠﻣ ﻲﻫﺪﻧﺎﻣزﺎﺳ و ﻪﻳﺰﺠﺗ ﺎﻳ )
9 (
، رد
لﻮﻠﺳ رﺎﺸﺘﻧا دراد ﻲﺻﺎﺧ هﺎﮕﻳﺎﺟ و ﺖﻴﻤﻫا ﻲﻧﺎﻃﺮﺳ يﺎﻫ
) 5 - 11 ، 13 (
؛ ﺎﺠﻧآ زا اﺰﺟا ﻲﻟﻮﻠﺳ جرﺎﺧ تﺎﺒﻴﻛﺮﺗ ﻊﻳزﻮﺗ ﻪﻛ ي
ﺎﺸﻏ ي ﻳﺎﭘ ﺔ هﺪﺷ ﻞﻴﻜﺸﺗ هزﺎﺗ )
يزﻼﭘﻮﺌﻧ (
زا لﻮﻠﺳ ﺎﻣوﺮﺘﺳا و ﺎﻫ
ﺘﻣ ﺄ ﻲﻣ ﺮﺛ ددﺮﮔ ) 10 ( ﻖﻴﻘﺤﺗ ﻦﻳا رد ، ﮓﻧر زا هدﺎﻔﺘﺳا ﺎﺑ
يﺰﻴﻣآ
ﺎﺸﻏ تاﺮﻴﻴﻐﺗ ،ﻲﺻﺎﺼﺘﺧا ي
دﺪﻏ ﺪﺷر ﻒﻠﺘﺨﻣ ﻞﺣاﺮﻣ رد ﻪﻳﺎﭘ
راﺮﻗ ﻲﺳرﺮﺑ و ﻪﻌﻟﺎﻄﻣ درﻮﻣ ﺖﻓﺮﮔ
ﻲﻣﺎﮔ ﺪﻳﺎﺷ ﺎﺗ ﺖﻬﺟ رد
ﺪﺷﺎﺑ نآ ﻊﻗﻮﻤﺑ ﺺﻴﺨﺸﺗ
؛ نﺎﻃﺮﺳ ﻦﻳا ﻪﻛ نآ هﮋﻳﻮﺑ رد ﺎﻫ
ﻲﺗرﻮﺻ ﻮﺷ هداد ﺺﻴﺨﺸﺗ دوز ﻪﻛ
،ﺪﻧ ﺶﻴﭘ
ًﺎﺘﺒﺴﻧ ﻲﻬﮔآ ﻲﺒﺳﺎﻨﻣ
ﺖﺷاد ﺪﻨﻫاﻮﺧ .
ﻲﺳرﺮﺑ شور
،ﻲﺑﺮﺠﺗ ﻪﻌﻟﺎﻄﻣ ﻦﻳا رد 8
يزﻼﭘﺮﭙﻴﻫ ﺺﻴﺨﺸﺗ ﺎﺑ ﻪﻧﻮﻤﻧ
و تﺎﺘﺳوﺮﭘ 6
ﺐﻴﺳآ ﺶﺨﺑ زا ﺎﻣﻮﻨﻴﺳرﺎﻛﻮﻧدآ درﻮﻣ ﻲﺳﺎﻨﺷ
ﺎﺿر مﺎﻣا نﺎﺘﺳرﺎﻤﻴﺑ )
ع ( او ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻪﺑ ﻪﺘﺴﺑ
ﺪﺷ ﻪﻴﻬﺗ ﺪﻨﺟﺮﻴﺑ .
هدﺎﻣآ ﻪﻧﻮﻤﻧ ندﺮﻛ ﻦﻴﻟﺎﻣﺮﻓ رﻮﺗﺎﺴﻜﻴﻓ ﺎﺑ ﺎﻫ
,
ﺐﻟﺎﻗ و ﻲﺘﻓﺎﺑ شزادﺮﭘ لﻮﻤﻌﻣ شور ﻪﺑ ﻦﻴﻓارﺎﭘ رد يﺮﻴﮔ
ﺖﻓﺎﺑ ﻲﺳﺎﻨﺷ ﺪﺷ مﺎﺠﻧا )
17 .(
ﻪﻧﻮﻤﻧ ﺮﻫ زا ﻂﺳﻮﺘﻣ رﻮﻃ ﻪﺑ
4 ﺪﺷ ﻪﻴﻬﺗ ﻲﻨﻴﻓارﺎﭘ كﻮﻠﺑ .
يرﺎﺗور مﻮﺗوﺮﻜﻴﻣ ﻚﻤﻛ ﺎﺑ
(Leitz 1512) ﻊﻃﺎﻘﻣ
4 - 5 ﺎﻴﻬﻣ لﺎﻳﺮﺳ شور ﻪﺑ ﻲﻧوﺮﻜﻴﻣ
ﺪﻳدﺮﮔ . ﮓﻧر ﺎﺸﻏ ﺶﻨﻛاو ﺖﻬﺟ هﺮﻘﻧ تاﺮﺘﻴﻧ يﺰﻴﻣآ ي
و ﻪﻳﺎﭘ فﺎﻴﻟا
زا ﺪﻌﺑ شور ﻖﺑﺎﻄﻣ رﻻﻮﻜﻴﺗر Jone's
) 1957 ( ﺪﺷ مﺎﺠﻧا )
17 ( ؛
لﻮﻠﺳ ﺶﻨﻛاو نآ زا ﺲﭘ ﻲﭘا يﺎﻫ
دﺪﻏ لﺎﻴﻠﺗ
، ﻲﻨﻴﺳآ ﺎﻫ
، ﺎﻣوﺮﺘﺳا
ﻲﺳرﺮﺑ و ﻪﻌﻟﺎﻄﻣ يرﻮﻧ پﻮﻜﺳوﺮﻜﻴﻣ ﺎﺑ رﻻﻮﻜﺳﺎﻣوﺮﺒﻴﻓ ﺖﻓﺎﺑ و ﮔ راﺮﻗ ﺖﻓﺮ .
ﻪﺘﻓﺎﻳ ﺎﻫ
- ﻪﻧﻮﻤﻧ شﻮﺧ يزﻼﭘﺮﭙﻴﻫ يﺎﻫ ﻢﻴﺧ
: ﻲﻨﻴﺳآ ﺎﺑ دﺪﻏ يﺎﻫ
ﻲﭘا لﻮﻠﺳ ﻪﻳﻻ ود ﺎﺗ ﻚﻳ ﻢﻈﻨﻣ مﻮﻴﻠﺗ
، ﻊﻴﺳو يرﺎﺠﻣ
، ﻲﺧﺮﺑ
ﺎﻣوﺮﺘﺳا و ﻪﺳﻼﻴﻣآ مﺎﺴﺟا و تﺎﺤﺷﺮﺗ يﻮﺘﺤﻣ ﺖﻓﺎﺑ و
۵٨
ًﺎﺘﺒﺴﻧ رﻻﻮﻜﺳﺎﻣوﺮﺒﻴﻓ ﺪﺷ هﺪﻫﺎﺸﻣ ﻊﻴﺳو
) ﻞﻜﺷ 1 .(
ﮓﻧر رد لﻮﻠﺳ رد هﺮﻘﻧ تاﺮﺘﻴﻧ يﺰﻴﻣآ ﻲﭘا يﺎﻫ
ﻲﻟﺎﻴﻠﺗ
او ﻪﺘﺷر ﺎﻣا ﺪﺸﻧ هﺪﻫﺎﺸﻣ ﻲﺻﺎﺧ ﺶﻨﻛ رد ﻞﻴﻓﻮﻨﻳژرآ يﺎﻫ
ﺪﻋﺎﻗ و ﺎﻣوﺮﺘﺳا ة
ﺺﺨﺸﻣ و ﺰﻴﺗ زﺮﻣ نوﺪﺑ دﺪﻏ
، ناﺰﻴﻣ ﺎﺑ
ًﺎﺘﺒﺴﻧ ﺪﺷ هﺪﻫﺎﺸﻣ يدﺎﻳز )
ﻞﻜﺷ 2 .(
- ﻪﻧﻮﻤﻧ ﺎﻣﻮﻨﻴﺳرﺎﻛﻮﻧدآ يﺎﻫ :
ﻢﻛ يﺎﻣوﺮﺘﺳا
، ﻲﻨﻴﺳآ يﺎﻫ
ﻚﭼﻮﻛ و گرﺰﺑ
، لﻮﻠﺳ ﺎﺑ ﺎﺑ ﻲﻟﻮﻠﺳ تﺎﺠﺘﺳد ﺎﻳ دﺮﻔﻨﻣ يﺎﻫ
ﻪﺘﺴﻫ ﻚﻳزﻼﭙﺴﻳد يﺎﻫ )
گرﺰﺑ ﻪﺘﺴﻫ ﺎﺸﻏ ،ﻦﻴﺗﺎﻣوﺮﻛوﺮﺘﻫ ،
ي
ﻪﺘﺴﻫ ﻢﻈﻨﻣﺎﻧ و ﮓﻧرﺮﭘ يا (
زا ﻲﺧﺮﺑ نورد و هراﻮﻳد رد ﻲﻨﻴﺳآ
ﺪﺷ هﺪﻫﺎﺸﻣ ﺎﻫ .
ًﺎﺣﻼﻄﺻا و كﺪﻧا دﺪﻏ ﻦﻴﺑ يﺎﻣوﺮﺘﺳا
ﺑ دﺪﻏ ﻪ ﺖﺸﭘ ﻪﺑ ﺖﺸﭘ ترﻮﺻ (Back to Back)
ﺪﺷ هﺪﻫﺎﺸﻣ
) ﻞﻜﺷ 3 .(
ﮓﻧر رد هﺮﻘﻧ تاﺮﺘﻴﻧ يﺰﻴﻣآ
، ﺎﺸﻏ ي ﻳﺎﭘ ﺔ ﻲﻨﻴﺳآ يﺎﻫ
گرﺰﺑ و ﻚﭼﻮﻛ
، نﺎﺸﻧ ﺶﻨﻛاو ﻲﺑﻮﺨﺑ داد
. ﻪﺘﺷر يﺎﻫ
ﺖﻓﺮﮔ ﮓﻧر ﺰﻴﻧ ﺎﻣوﺮﺘﺳا ﻞﺧاد ﻞﻴﻓﻮﻨﻳژرآ .
ﺎﺑ ﻲﺣاﻮﻧ رد ﻢﻴﺧﺪﺑ يزﻼﭘﺎﻧآ تاﺮﻴﻴﻐﺗ
، ﺎﺸﻏ ي فاﺮﻃا ﻪﻳﺎﭘ
ﻲﻨﻴﺳآ نوﺪﺑ ﻲﻟﻮﻠﺳ تﺎﺠﺘﺳد و ﺖﻓر ﻦﻴﺑ زا ﻲﺣاﻮﻧ ﻲﺧﺮﺑ رد ﺎﻫ
ﺎﺸﻏ ي ﺪﺷ هﺪﻫﺎﺸﻣ ﻪﻳﺎﭘ )
ﻞﻜﺷ 4 .(
ﻞﻜﺷ 1 - شﻮﺧ يزﻼﭘﺮﭙﻴﻫ ﻲﭘا ﺎﺑ دﺪﻏ ﻢﻴﺧ
ﺎﺠﻣ و ﻢﻈﻨﻣ مﻮﻴﻠﺗ ير
ﻊﻴﺳو ( ) رﻻﻮﻜﺳﺎﻣوﺮﺒﻴﻓ ﺖﻓﺎﺑ و )
( ﻊﻴﺳو ًﺎﺘﺒﺴﻧ
ﻲﻳﺎﻤﻨﮔرﺰﺑ :
100
* ﮓﻧر ؛ يﺰﻴﻣآ H&E
ﻞﻜﺷ 2 - شﻮﺧ يزﻼﭘﺮﭙﻴﻫ دﺪﻏ ﻢﻴﺧ
:( ) ﻪﺘﺷر رﻻﻮﻜﺳﺎﻣوﺮﺒﻴﻓ ﺖﻓﺎﺑ رد رﻻﻮﻜﻴﺗر يﺎﻫ ؛
( ) : ﻲﻧﻮﺧ يﺎﻬﮔر
ﻲﻳﺎﻤﻨﮔرﺰﺑ :
100
* ﮓﻧر ؛ هﺮﻘﻧ تاﺮﺘﻴﻧ يﺰﻴﻣآ
ﻞﻜﺷ 3 - آ ﻲﻨﻴﺳآ ﻞﻴﻜﺸﺗ ،ﺎﻣﻮﻨﻴﺳرﺎﻛﻮﻧد ﻲﻟﻮﻠﺳ يﺎﻬﺑﺎﻨﻃ و ﺎﻫ
) ( ﺪﺷ هﺪﻫﺎﺸﻣ كﺪﻧا يﺎﻣوﺮﺘﺳا و .
ﻲﻳﺎﻤﻨﮔرﺰﺑ :
100
* ﮓﻧر ؛ يﺰﻴﻣآ H&E
ﻞﻜﺷ 4 - ﻲﻨﻴﺳآ ﻞﻴﻜﺸﺗ ،ﺎﻣﻮﻨﻴﺳرﺎﻛﻮﻧدآ ﻲﻟﻮﻠﺳ يﺎﻬﺑﺎﻨﻃ و ﺎﻫ
ﺎﺸﻏ نوﺪﺑ ي
ﻪﻳﺎﭘ ) ( ﻞﻴﻓﻮﻨﻳژرآ كﺪﻧا يﺎﻣوﺮﺘﺳا و ﻪﻳﺎﭘ يﺎﺸﻏ و
) ( ﺪﺷ هﺪﻫﺎﺸﻣ .
ﻲﻳﺎﻤﻨﮔرﺰﺑ 100
*
؛ ﮓﻧر هﺮﻘﻧ تاﺮﺘﻴﻧ يﺰﻴﻣآ
۵٩
ﻪﺠﻴﺘﻧو ﺚﺤﺑ يﺮﻴﮔ
ﺎﺸﻏ ي زا ﻲﺸﺨﺑ ﻪﻳﺎﭘ ﺑ ﻪﻛ ﺖﺳاECM
ﻪ ﻲﻌﻴﺒﻃ رﻮﻃ
ﻪﺒﺷ و ﻲﺸﺷﻮﭘ يﺎﻬﺘﻓﺎﺑ فاﺮﻃا رد ﻲﻌﻴﺒﻃ ﺮﻴﻏ ﺎﻳ ﻲﺸﺷﻮﭘ
ﺶﻳارآ لﻮﻠﺳ يروﺮﺿ تﺎﻋﻼﻃا لﺎﻘﺘﻧا رد و ﻪﺘﻓﺎﻳ ﻪﺑ ﺎﻫ
ﻲﻣ ﺎﻔﻳا ﻲﺳﺎﺳا ﺶﻘﻧ ﺎﻣوﺮﺘﺳا ﺪﻨﻛ
. لﺎﻌﻓ ترﻮﺻ رد نﺪﺷ
نژ ﻃﺮﺳ يﺎﻫ لﻮﻠﺳ رد يرﻮﻣﻮﺗ تﺎﻌﻳﺎﺿ ﻞﻴﻜﺸﺗ و ﻲﻧﺎ
ﺎﺑ ،ﺎﻫ
ﺎﺸﻏ ﻦﺘﻓر ﻦﻴﺑ زا ﺎﻳ ﻆﻔﺣ
، نﺎﻴﻣ لﻮﻠﺳ ﺶﻨﻛ و ﻲﻧﺎﻃﺮﺳ يﺎﻫ
ﺗ ﺖﺤﺗ ﺎﻣوﺮﺘﺳا ﺄ
ﻲﻣ راﺮﻗ ﺮﻴﺛ دﺮﻴﮔ
ﺮﻓ رد ﻲﻤﻬﻣ ﺶﻘﻧ و ا
ﺪﻨﻳ
لﻮﻠﺳ ﻲﻤﺟﺎﻬﺗ ﻲﻣ ﺎﻔﻳا ﻲﻧﺎﻃﺮﺳ يﺎﻫ
ﺪﻨﻛ ) 19،18،1615 (
؛
ﻦﻳاﺮﺑﺎﻨﺑ ﺎﺸﻏ ﺶﻳارآ ﺮﻴﻴﻐﺗ ﻪﻌﻟﺎﻄﻣ ي
و ﺺﻴﺨﺸﺗ رد ﻪﻳﺎﭘ
نﺎﻃﺮﺳ نﺎﻣرد زا
هﮋﻳو ﺖﻴﻤﻫا يا
ﺖﺳا رادرﻮﺧﺮﺑ .
ﮓﻧر ﺎﺸﻏ يﺰﻴﻣآ ي
شور ﻪﺑ ﺮﻟﻮﻜﻴﺗر فﺎﻴﻟا و ﻪﻳﺎﭘ
هﺮﻘﻧ تاﺮﺘﻴﻧ
، عاﺪﺑا يﺎﻬﺷور زا ﻲﻜﻳ ﻂﺳﻮﺗ هﺪﺷ
Jone's
ﻲﻣ ﻲﺗاﺮﻴﻴﻐﺗ ﺎﺑ ﻪﻛ ﺪﺷﺎﺑ )
19 ( ﺶﻳارآ ﺮﻴﻴﻐﺗ ﺖﻬﺟ نﻮﻨﻛﺎﺗ
ﺎﺸﻏ ي ﻚﻳژﻮﻟﻮﺗﺎﭘ تاﺮﻴﻴﻐﺗ ﺎﻳ ﻚﻳژﻮﻟﻮﻴﺑ ﻞﻣﺎﻜﺗ ﺪﻧور رد ﻪﻳﺎﭘ
ﺖﺳا ﻪﺘﺷاد دﺮﺑرﺎﻛ )
20،19 ( ؛ آ زا ﺎﺠﻧ ﺎﺸﻏ داﻮﻣ ﻞﻴﻜﺸﺗ ﻪﻛ ي
ﺪﻳﺪﺟ ﻪﻳﺎﭘ )
يزﻼﭘﻮﺌﻧ (
ﻲﻤﺟﺎﻬﺗ ﻞﻣﺎﻜﺗ ﺪﻧور رد نﺎﻃﺮﺳ **
تﺎﺘﺳوﺮﭘ
، ﺖﺳا ﺚﺤﺑ درﻮﻣ و ﻲﻧاﺮﺤﺑ
، يﻮﮕﻟا ﻦﻴﻴﻌﺗ ﻦﻳاﺮﺑﺎﻨﺑ
ﻪﻧﻮﻤﻧ رد نآ ﺪﻨﻤﺷزرا ﻚﻳژﻮﻟﻮﺗﺎﭘ يﺎﻫ
ﻲﻣ ﺮﻈﻧ ﻪﺑ ﺪﺳر
.
،ﺮﺿﺎﺣ ﻖﻴﻘﺤﺗ رد شﻮﺧ يﺎﻬﺘﻓﺎﺑ ﺶﻨﻛاو يﻮﮕﻟا
و ﻢﻴﺧ
تﺎﺘﺳوﺮﭘ ﻢﻴﺧﺪﺑ ﺖﺒﺴﻧ
ﻴﺴﺑ هﺮﻘﻧ تاﺮﺘﻴﻧ ﻪﺑ دﻮﺑ ﺰﻳﺎﻤﺘﻣ رﺎ
. رد
ﻪﻧﻮﻤﻧ شﻮﺧ يﺎﻫ ﻪﺘﺷر ﻢﻴﺧ
ﺪﺘﻤﻣ ﺮﻴﻏ يﺎﻤﻧ ﺎﺑ رﻻﻮﻜﻴﺗر يﺎﻫ
ﺪﻋﺎﻗ رد ة
ًﺎﺘﺒﺴﻧ ناﺰﻴﻣ ﻪﺑ و دﺪﻏ هﺪﻫﺎﺸﻣ ﺎﻣوﺮﺘﺳا رد ناواﺮﻓ
كزﺎﻧ ﺖﻠﻋ ﻪﺑ ﺪﻳﺎﺷ ﻪﻛ ﺪﺷ ﺎﺸﻏ ندﻮﺑ
ي ﻳﺎﭘ ﺔ تﺎﺘﺳوﺮﭘ دﺪﻏ
ﺖﺳا هﺪﺷ شراﺰﮔ ﺰﻴﻧ ﻲﻌﻴﺒﻃ ﻂﻳاﺮﺷ رد ﻪﻛ ﺪﺷﺎﺑ )
2 (
؛ رد ﺎﻣا
ﻨﻴﺳآ فاﺮﻃا رد ﻲﻤﻴﺧﺪﺑ دراﻮﻣ ﻲ
گرﺰﺑ و ﻚﭼﻮﻛ يﺎﻫ
)
ًﻻﺎﻤﺘﺣا ﻞﻴﻜﺸﺗ هزﺎﺗ هﺪﺷ
(
ًﺎﺘﺒﺴﻧ يﺎﺸﻏ ﻪﺘﺳﻮﻴﭘ و رﻮﻄﻗ
زا يا
ﻪﺘﺷر ﻴﺣﺎﻧ رد رﻻﻮﻜﻴﺗر يﺎﻫ ﺔ
ﺎﺸﻏ ي ﻳﺎﭘ ﺔ ﺪﺷ هﺪﻫﺎﺸﻣ دﺪﻏ
هدﺮﻛ اﺪﻴﭘ ﻲﻧﺎﺷﻮﭙﻤﻫ دﺪﻏ ﻞﺻﺎﻓ ﺪﺣ كﺪﻧا يﺎﻣوﺮﺘﺳا ﺎﺑ ﻪﻛ دﻮﺑ .
** Invasive Phenotype
دﺪﻏ ﺶﻳارآ ﺮﻴﻴﻐﺗ ﻲﺣاﻮﻧ رد
، هدﻮﺗ ﻢﻴﺧﺪﺑ ﻲﻟﻮﻠﺳ يﺎﻫ هﺪﻫﺎﺸﻣ
ﺪﺷ ﻲﻟو ﺎﺸﻏ ي د ﻪﻳﺎﭘ لﻮﻠﺳ فاﺮﻃا ر فﺎﻴﻟا و ﺪﺸﻧ هﺪﻫﺎﺸﻣ ﺎﻫ
رد ﻲﻟﻮﻠﺳ يﺎﻬﺑﺎﻨﻃ زا جرﺎﺧ رد ﻲﻟﻮﺴﭙﻛ ترﻮﺻ ﻪﺑ ﻞﻴﻓﻮﻨﻳژرآ ﺪﻧدﺮﻛ اﺪﻴﭘ ﺶﻳارآ ﻲﻨﻴﺳآ فاﺮﻃا ﻲﺣاﻮﻧ
؛
ًﻻﺎﻤﺘﺣا ﻦﻴﻤﻫ ﻞﻴﻟد ﻪﺑ
ﻊﻳزﻮﺗ يﻮﮕﻟا صﻮﺼﺧ رد ﻲﺗوﺎﻔﺘﻣ تﺎﺷراﺰﮔ ﻪﻛ ﺖﺳا فﻼﺘﺧا يﺎﻣﻮﻨﻴﺳرﺎﻛ عاﻮﻧا رد نآ دﺪﺠﻣ ﻲﻫﺪﻧﺎﻣزﺎﺳ ﺎﻳ ﻪﻳﺎﭘ يﺎﺸﻏ ﮔ تﺎﺘﺳوﺮﭘ ﺖﺳا هﺪﺷ شراﺰ
) 8 - 12 ، 18 .(
ﺎﺠﻧآ زا يزﻼﭘﺮﭙﻴﻫ ﻲﺘﻓﺎﺑ يﺎﻤﻧ ﻪﻛ
رد تﺎﺘﺳوﺮﭘ يﺎﻫ
ﺖﺳا عﻮﻨﺘﻣ هﺪﻏ ﻒﻠﺘﺨﻣ يﺎﻬﺸﺨﺑ
، ﺎﺸﻏ تاﺮﻴﻴﻐﺗ ي
ﻲﻣ ﻪﻳﺎﭘ ﺪﻧاﻮﺗ
شﻮﺧ عﻮﻧ ود قاﺮﺘﻓا رد ﻢﻴﺧﺪﺑ و ﻢﻴﺧ
يﺪﻴﻠﻛ ﺶﻘﻧ ﺪﻳﺎﻤﻧ ﺎﻔﻳا
؛
ﻦﻴﻨﭽﻤﻫ ﺎﻣﻮﻨﻴﺳرﺎﻛﻮﻧدآ رد
، فاﺮﻃا رد ﺎﺸﻏ ﻦﺘﻓر ﻦﻴﺑ زا
ﻲﻨﻴﺳآ ﻢﻴﺧﺪﺑ يﺎﻫ
، ﻲﻣ ﻧاﻮﺗ ﺮﮕﻧﺎﻴﺑ ﺪ لﺎﻤﺘﺣا و ﻲﻤﻴﺧﺪﺑ تﺪﺷ
زﺎﺘﺳﺎﺘﻣ
؛ﺪﺷﺎﺑ ﺎﻳ ﻪﺟرد رد يﺪﻨﺑ ﺖﻓﺎﺑ ﻲﺘﺧﺎﻨﺷ و
ﻪﻠﺣﺮﻣ ﺎﻳ يﺪﻨﺑ
ﻲﻨﻴﻟﺎﺑ (Stage) هدﺎﻔﺘﺳا درﻮﻣ
دﺮﻴﮔ راﺮﻗ .
،ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ رد ﻳﺎﭘ يﺎﺸﻏ
ﺔ ﻞﻴﻜﺸﺗ هزﺎﺗ قوﺮﻋ مﻮﻴﻠﺗوﺪﻧا
هﺪﺷ
، ﻲﻨﻴﺳآ ﻞﺻﺎﻓ ﺪﺣ رد ﮓﻧر ﺎﺑ ﺰﻴﻧ ﺎﻫ
نﺎﺸﻧ ﺶﻨﻛاو هﺮﻘﻧ يﺰﻴﻣآ
داد
؛ ﻧر عﻮﻧ ﻦﻳا ﮓ
ناﺰﻴﻣ ﻦﻴﻴﻌﺗ ﺖﻬﺟ ناﻮﺘﺑ ﺪﻳﺎﺷ ار يﺰﻴﻣآ
گر دﻮﻤﻧ هدﺎﻔﺘﺳا ﻲﻳاز .
ﺞﻳﺎﺘﻧ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ
،ﻞﺻﺎﺣ ﻲﻣ دﺎﻬﻨﺸﻴﭘ يﺎﻬﺷور يﺮﺑرﺎﻛ دﻮﺷ
سﺮﺘﺳد رد و ﻲﺻﺎﺼﺘﺧا ﻲﻳﺎﻴﻤﻴﺷﻮﺘﺴﻴﻫ
، ﮓﻧر هﮋﻳﻮﺑ يﺰﻴﻣآ
ﺎﺸﻏ ي شﻮﺧ يﺎﻬﺘﻓﺎﺑ ﻲﻗاﺮﺘﻓا ﺺﻴﺨﺸﺗ رد ﻪﻳﺎﭘ رد ﻢﻴﺧﺪﺑ و ﻢﻴﺧ
ﺎﻫرﻮﻣﻮﺗ عاﻮﻧا و
ﺳآ فاﺮﻃا ﻲﺣاﻮﻧ رد نآ دﻮﺟو فاﺮﻃا ﺎﻳ ﻲﻨﻴ
لﻮﻠﺳ دﺮﻴﮔ راﺮﻗ ﻪﻌﻟﺎﻄﻣ درﻮﻣ ﺎﻫ .
ﺮﻜﺸﺗ و ﺮﻳﺪﻘﺗ
ﺖﻳﺎﻤﺣ ﻪﻛ ﺪﻨﺟﺮﻴﺑ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻲﺸﻫوﮋﭘ رﻮﻣا زا
؛ددﺮﮔ ﻲﻣ ﻲﻧادرﺪﻗ و ﺮﻜﺸﺗ ،ﺪﻨﺘﺷاد هﺪﻬﻋ ﺮﺑ ار ﻖﻴﻘﺤﺗ ﻦﻳا ﻲﻟﺎﻣ ﻲﺑ يرﺎﻜﻤﻫ زا ﻦﻴﻨﭽﻤﻫ يﺪﻬﻣ يﺎﻗآ بﺎﻨﺟ ﻎﻳرد
ﻴﻬﺗ رد ﻪﻛ داﮋﻧ ﺔ
ﻪﻧﻮﻤﻧ ﻨﺟ و ﺪﻧدﻮﻤﻧ تﺪﻋﺎﺴﻣ ﺐﺳﺎﻨﻣ يﺎﻫ رد هداﺰﻳدﺎﺷاﺮﺧ يﺎﻗآ بﺎ
ﻴﻬﺗ رد ﻪﻛ ﺪﻨﺟﺮﻴﺑ ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد تﺎﻘﻴﻘﺤﺗ هﺎﮕﺸﻳﺎﻣزآ ﺔ
ﺲﻜﻋ ﻲﻣ يراﺰﮕﺳﺎﭙﺳ ،ﺪﻧدﻮﻤﻧ يرﺎﻜﻤﻫ ﺎﻫ ﺪﻳﺎﻤﻧ
.
۶٠ ﻊﺑﺎﻨﻣ :
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J Histotechnol 1996; 19(3):211-218.
۶١
The changes in basement membrane and
distribution of reticular fibers in benign hyperplasia and adenocarcinoma of prostate
T. Kermani *, M. Zardast**, AR. Sabzari***, AR. Varasteh****
* Assistant Professor, Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
** Assistant Professor, Department of Pathology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
*** Student of Medicine, Birjand University of Medical Sciences, Birjand, Iran
**** Associate Professor, Department of Immunology, BU-Ali Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background and Aim: Prostate cancer is the second most prevalent malignancy in men, which affects health, economy, and social life. The ability to predict accurately, after prostatectomy, would increase optimization of disease management, because the presence or absence of basement membrane (BM) and reticular fibers are as important as cell lines in detecting of benignancy and malignancy of cancers. This study was designed to assess the condition of the BM and reticular fibers in stroma in benign prostatic hyperplasia (BPH) and adenocarcinomaof prostate.
Materials and Methods: In this experimental study, prostate tissue samples were obtained from pathology department of Emam Reza Hospital of Birjand University of Medical Sciences. On the whole, 8 cases with BPH and 6 cases with Adenocarcinoma of prostate were used in the research.
The samples were sectioned to 5μ thickness. One out of 10 per sections was stained with H-E in order to obtain histologic diagnosis, and the others stained with silver-methenamine to detect BM.
Results: The bengin and malignant tissues showed different reaction patterns against Ag nitrate. In the malignant samples, BM and reticular fibers were not observed at newly formed periacinar and cell cords. In a few stroma between the acinars, continuous, arginophil, and thick membrane was formed. BM reticular fibers, in benign samples were thin and discontinuous expanding to stroma arginophil fibers.
Conclusion: The study showed that BM pattern is different in bengin and malignant samples, a point that is important in detecting of doubtful cases. And probably newly formed periacinar BM would restrict the malignancy distribution. We suggest these available and special BM staining methods to detect benignancy and malignancy in various tumors and the presence of BM in periacinar and pericellular areas would also be used.
۶٢ Key Words: Prostate; BPH; Adenocarcinoma; Basement membrane; Silver-methenamine stain
