ﺮﯿﺛﺎﺗ ﻪﺴﯾﺎﻘﻣ
ﻦﯿﻣﺎﺘﯾو فﺮﺼﻣ ﻪﺘﻔﻫ12 E بﺮﭼ ﺪﺒﮐ ﻪﺑ ﻼﺘﺒﻣ يﺪﺒﮐيﺎﻫ ﻢﯾﺰﻧآ حﻮﻄﺳ ﺮﺑ ﻢﻈﻨﻣ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ و ﯽﻠﮑﻟاﺮﯿﻏ
ﯽﻣﻼﺳا ﺎﯿﻌﻟ ﺎﯿﻧ ﯽﻧﺎﻤﺣر دﺎﻫﺮﻓ ،1
ﯽﺣور ﻦﯿﺘﺴﺨﻧ ﮏﺑﺎﺑ ،2 3
-1 سﺎﻨﺷرﺎﮐ ﺪﺷرا
هﺎﮕﺸﻧاد دازآ ﯽﻣﻼﺳا ﺪﺣاو ﺖﺷر
2 - دﺎﺘﺳا هﺎﮕﺸﻧاد نﻼﯿﮔ
3 - رﺎﯾدﺎﺘﺳا هﺎﮕﺸﻧاد دازآ ﯽﻣﻼﺳا ﺪﺣاو ﻞﯿﺑدرا
هﺪﯿﮑﭼ
رﺎﺛآ ﻪﺴﯾﺎﻘﻣ فﺪﻫ ﺎﺑ ﺮﺿﺎﺣ ﺶﻫوﮋﭘ ﻦﯿﻣﺎﺘﯾو فﺮﺼﻣ ﻪﺘﻔﻫ12
ﻢﯾﺰﻧآ حﻮﻄﺳﺮﺑ ﻢﻈﻨﻣ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ وE
يﺪﺒﮐ يﺎﻫ
.ﺪﻣآ ﻞﻤﻋ ﻪﺑ ﯽﻠﮑﻟا ﺮﯿﻏ بﺮﭼ ﺪﺒﮐ ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ ﺎﺑ ﯽﻠﮑﻟا ﺮﯿﻏ بﺮﭼ ﺪﺒﮐ يرﺎﻤﯿﺑ ﻪﺑ ﻼﺘﺒﻣ ﻎﻟﺎﺑ داﺮﻓا ﺮﻔﻧ ﺖﺴﯿﺑ
ﻦﯿﮕﻧﺎﯿﻣ ﻨﺳ 1 ﯽ 8/ 8± 41/ لﺎﺳ ﻦﯾا رد ﺶﻫوﮋﭘ ود ﻪﺑ ﯽﻓدﺎﺼﺗ رﻮﻃ ﻪﺑ نارﺎﻤﯿﺑ .ﺪﻧدﺮﮐ ﺖﮐﺮﺷ ﻪﻧﺎﺒﻠﻃواد رﻮﻃ ﻪﺑ
هﺮﻔﻧ هد هوﺮﮔ .ﺪﻧﺪﺷ ﻢﯿﺴﻘﺗ
هوﺮﮔ ﻦﯿﻣﺎﺘﯾو صﺮﻗ دﺪﻋ ود ﻪﻧازور ﻪﮐ ﯽﻧارﺎﻤﯿﺑ ﻞﻣﺎﺷA
،E
400 و ﺢﺒﺻ مﺮﮔ ﯽﻠﯿﻣ
تﺪﻣ ﻪﺑ ﺐﺷ 12
ﺖﻓﺎﯾرد ﻪﺘﻔﻫ ﯽﻣ
ﺪﻧدﺮﮐ هوﺮﮔ و ﻣﺎﻧﺮﺑ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ﻪﮐ ﯽﻧارﺎﻤﯿﺑ ﻞﻣﺎﺷB
ﻢﻈﻨﻣ و هﺪﺷ يﺰﯾر ﻪ
ﺪﻧدﺮﮐ ﯽﻣ ﺖﻓﺎﯾرد .
) زاﺮﻔﺴﻧاﺮﺗﻮﻨﯿﻣآ ﻦﯿﻧﻻآ يﺎﻫ ﻢﯾﺰﻧآ ) زاﺮﻔﺴﻧاﺮﺗﻮﻨﯿﻣآ تﺎﺗرﺎﭙﺳآ ،(ALT
ﻦﯿﻟﺎﮑﻟآ ،(AST
) زﺎﺗﺎﻔﺴﻓ ﺧاﺪﻣ زا ﺪﻌﺑ و ﻞﺒﻗ ،يﺪﺒﮐ ﯽﺑﺮﭼ ناﺰﯿﻣ ﯽﺑﺎﯾزرا ياﺮﺑ ﺪﺒﮐ ﯽﻓاﺮﮔﻮﻧﻮﺳ و ﯽﻧﻮﺧ مﺮﺳ (ALP
ﯽﻧﺎﻣرد ﻪﻠ
.ﺖﻓﺮﮔ راﺮﻗ يﺮﯿﮔ هزاﺪﻧا درﻮﻣ ﻧﺎﻣرد هوﺮﮔ ود ﺮﻫ رد
ﻞﺑﺎﻗ ﺶﻫﺎﮐ نﺎﻣرد زا ﺲﭘ يﺪﺒﮐ يﺎﻫ ﻢﯾﺰﻧآ ﺮﯾدﺎﻘﻣ ﯽ
) ﺪﻧداد نﺎﺸﻧ ﯽﻬﺟﻮﺗ
/05 0 P<
دﻮﺟو هوﺮﮔ ود يﺪﺒﮐ يﺎﻫ ﻢﯾﺰﻧآ ﺢﻄﺳ ﻦﯿﺑ يراد ﯽﻨﻌﻣ ﯽﻫوﺮﮔ ﻦﯿﺑ توﺎﻔﺗ ﺎﻣا ،(
) ﺖﺷاﺪﻧ
/05 0 P>
ﻣرد ﻪﻠﺧاﺪﻣ زا ﺲﭘ ،هﺪﺷ مﺎﺠﻧا ﯽﻓاﺮﮔﻮﻧﻮﺳ رد .(
ﺎ ﻦﯿﺑ يراد ﯽﻨﻌﻣ ﺶﻫﺎﮐ هوﺮﮔ ود ﺮﻫ رد ﯽﻧ
ﺮﮔ ﻪﻈﺣﻼﻣ يﺪﺒﮐ ﯽﺑﺮﭼ ﻪﺟرد ) ﺪﯾد
/05 0 P<
( ، ﯽﻨﻌﻣ يرﺎﻣآ توﺎﻔﺗ ﯽﺳرﺮﺑ درﻮﻣ يﺎﻫ هوﺮﮔ ﻦﯿﺑ رد ﻪﭼﺮﮔا
) ﺖﺷاﺪﻧ دﻮﺟو يراد
/05 0 P>
.(
و ﯽﯾاﺬﻏ ﻢﯾژر عﻮﻧ ﻦﺘﻓﺮﮔ ﺮﻈﻧ رد نوﺪﺑ ﻢﻈﻨﻣ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ مﺎﺠﻧا ﺪﺳر ﯽﻣ ﺮﻈﻧ ﻪﺑ
نزو ﺶﻫﺎﮐ ﺎﯾ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﻪﮐ دﻮﺷ بﺮﭼ ﺪﺒﮐ ﮏﯿﻓاﺮﮔﻮﻧﻮﺳ ﺪﻫاﻮﺷ و يﺪﺒﮐ يﺎﻫ ﻢﯾﺰﻧآ ﺶﻫﺎﮐ ﺚﻋﺎﺑ ﺪﻧاﻮﺗ ﯽﻣ
ﯽﺒﻧﺎﺟ تاﺮﺛا ﻦﯿﻣﺎﺘﯾو تﺪﻣ زارد فﺮﺼﻣ
ﺪﺷﺎﺑ وراد ﻦﯾا ياﺮﺑ ﯽﺒﺳﺎﻨﻣ ﻦﯾﺰﮕﯾﺎﺟ ﺪﻧاﻮﺗ ﯽﻣE
.
:يﺪﯿﻠﮐ نﺎﮔژاو ﻦﯿﻣﺎﺘﯾو ،ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ،ﯽﻠﮑﻟاﺮﯿﻏ بﺮﭼ ﺪﺒﮐ
.زاﺮﻔﺴﻧاﺮﺗﻮﻨﯿﻣآ ،E
The effect of 12 week vitamin E supplementation and regular physical
activity on selected liver enzymes of non-alcoholic fatty liver patients
L. Eslami1, F. Rahmani-Nia2, B. Nakhostin-Roohi3 1. Master of Islamic Azad University, Guilan Branch
2. Professor at University of Guilan
3. Assistance professor at Islamic Azad University, Ardabil Branch Abstract
The purpose of this research was to evaluate the effects of 12 week vitamin E supplementation and regular physical activity on level of liver enzymes in non-alcoholic fatty liver patients. Thirty patients suffering from
ﯽﺷزرو ﻪﯾﺬﻐﺗ و يژﻮﻟﻮﯾﺰﯿﻓ
non-alcoholic fatty liver participated in this research voluntarily .They were randomly divided into two groups:
Group A (patients who use two 400 mg vitamin E tablet daily in the morning and at night for 12 weeks, n=10), and group B (patients who received programmed regular physical exercise, n=10). Aspartate amino transferase (AST), Alanine amino transferase (ALT), and alkalin phosphatase (ALP) Enzymes were measured. Sonography was used to measure fatty steatosis grade. In sonography, although there was no significant difference in fatty steatosis grade between groups (p>0.05), there was significant decrease after treatment in both groups compared with pre-treatment (p<0.05). All liver enzymes were decreased in both groups after treatment compared with pre-treatment (p<0.05). There was no significant differences between groups (p>0.05). It seems that regular physical activity without considering the kind of diet or weight loss results in decreasing liver enzymes and ultrasound evidences in non-alcoholic fatty liver patients. According to side-effects of long duration supplementation of vitamin E, regular physical activity can be more suitable method to treat non-alcoholic fatty liver.
Keywords: Non-alcoholic fatty liver, Vitamin E, Physical activity, Aminotransferase.
ﻪﻣﺪﻘﻣ
ﯽﻠﮑﻟا ﺮﯿﻏ بﺮﭼ ﺪﺒﮐ )1
NAFLD
يرﺎﻤﯿﺑ زا ﯽﻌﯿﺳو هدوﺪﺤﻣ ( ﺪﺒﮐ رد ﯽﺑﺮﭼ بﻮﺳر زا ﺎﻫ
2
) STEATOSIS
ﯽﺑﺮﭼ بﻮﺳر زا ﯽﺷﺎﻧ يﺪﺒﮐ بﺎﻬﺘﻟا ﺎﺗ ﻪﺘﻓﺮﮔ( )3
(NASH
يﺪﺒﮐ زوﺮﯿﺳ و )4
CIRRHOSIS
ار(
ﻞﻣﺎﺷ دﻮﺷ ﯽﻣ مﺪﻋ .
رﺎﻤﺷ ﻪﺑ يرﺎﻤﯿﺑ ﻦﯾا ﯽﻠﺻا ﻞﻠﻋ زا ﯽﯾاﺬﻏ ﻢﯾژر رد ﺎﻫ ناﺪﯿﺴﮐا ﯽﺘﻧآ دﻮﺒﻤﮐ و ﯽﻗﺎﭼ ،كﺮﺤﺗ
ﺪﻧور ﯽﻣ 1)
( عﻮﯿﺷ .
ﺪﺒﮐ بﺮﭼ ﯽﻠﮑﻟاﺮﯿﻏ 14دوﺪﺣ
34-
% ﺮﯿﺧا يﺎﻫ لﺎﺳ رد ار ﺎﮑﯾﺮﻣآو ﺎﯿﺳآ ،ﺎﭘورا ﺖﯿﻌﻤﺟ زا
دﻮﺷ ﯽﻣ ﻞﻣﺎﺷ 2)
3، ( نﺎﺸﻧ تﺎﻌﻟﺎﻄﻣ. ﺪﻨﻫد ﯽﻣ
ﻦﯿﻣﺎﺘﯾو ﺮﯿﻈﻧ ﯽﯾﺎﻫ ناﺪﯿﺴﮐا ﯽﺘﻧآ ﻪﮐ وE
، C
ار ﻮﯿﺗاﺪﯿﺴﮐا سﺮﺘﺳا
ﺖﺣاﺮﺘﺳا ﺖﻟﺎﺣ رد ﻢﻫ )
4 ( ﺖﯿﻟﺎﻌﻓ ﻪﺑ ﺦﺳﺎﭘ رد ﻢﻫ و )
5 ( ﺪﻧا هداد ﺶﻫﺎﮐ زا ﻞﺻﺎﺣ ﺞﯾﺎﺘﻧ .
ﺰﯿﻟﺎﻧآﺎﺘﻣ ﻪﻌﻟﺎﻄﻣ ﮏﯾ
ﻦﯿﻣﺎﺘﯾو يﻻﺎﺑ زود ﺎﺑ و (لﺎﺳ ﮏﯾ زا ﺶﯿﺑ) تﺪﻣ ﯽﻧﻻﻮﻃ فﺮﺼﻣ ،ﻪﮐ ﺖﺳا نآ زا ﯽﮐﺎﺣ ﺚﻋﺎﺑ ﺪﻧاﻮﺗ ﯽﻣ E
ددﺮﮔ ﯽﻠﮐ ﺮﯿﻣ و گﺮﻣ رد ﺶﯾاﺰﻓا )
6 (.
ياﺮﺑ ﻞﻘﺘﺴﻣ زﺎﺳﺮﻄﺧ ﻞﻣاﻮﻋ ﻪﻠﻤﺟ زا ﯽﻧﺎﻤﺴﺟ ﺖﯿﻟﺎﻌﻓ مﺪﻋ و ﯽﻗﺎﭼ
ﯽﻠﮑﻟا ﺮﯿﻏ بﺮﭼ ﺪﺒﮐ يرﺎﻤﯿﺑ ﻪﻌﺳﻮﺗ ﺖﺳا
) 3 ( ﻢﻈﻨﻣ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ . ﺪﺳر ﯽﻣ ﺮﻈﻧ ﻪﺑ ﻪﮐ ﺖﺳا ﯽﯾﺎﻫ شور زا ﯽﮑﯾ
ﺪﻧاﻮﺗ ﯽﻣ ﺮﺘﻤﮐ ﯽﺒﻧﺎﺟ تاﺮﺛا ﺖﻠﻋ ﻪﺑ ﯽﻧﺎﻣرد ﺮﮕﯾد يﺎﻫ شور ﻦﯾﺰﮕﯾﺎﺟ
ﺎﻫ ناﺪﯿﺴﮐا ﯽﺘﻧآ ﻪﻠﻤﺟزا ﻪﻌﻟﺎﻄﻣ ﺎﺑ .دﻮﺷ
ﺐﺳﺎﻨﻣ تﺪﻣ و تﺪﺷ ﺎﺑ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ﻢﻈﻨﻣ يﺎﻫ شور ﺪﺳر ﯽﻣ ﺮﻈﻧ ﻪﺑ عﻮﺿﻮﻣ ﻦﯾا ﺎﺑ ﻂﺒﺗﺮﻣ تﺎﯿﺑدا
، رد ﺮﺘﻤﮐ
ﯽﻠﮑﻟاﺮﯿﻏ بﺮﭼ ﺪﺒﮐ نﺎﻣرد ﺖﻬﺟ ا ﻪﺘﻓﺮﮔ راﺮﻗ ﻪﺟﻮﺗ درﻮﻣ
ﺪﻧ . ﻖﯿﻘﺤﺗ زا فﺪﻫ ، هﺪﺷ ﺮﮐذ دراﻮﻣ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ
رﺎﺛآ ﻪﺴﯾﺎﻘﻣ ،ﺮﺿﺎﺣ 12
ﻦﯿﻣﺎﺘﯾو فﺮﺼﻣ ﻪﺘﻔﻫ ﻢﻈﻨﻣ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ وE
رد نارﺎﻤﯿﺑ ﻪﺑ ﻼﺘﺒﻣ ﯽﻠﮑﻟا ﺮﯿﻏ بﺮﭼ ﺪﺒﮐ
ﺪﺷﺎﺑ ﯽﻣ .
:ﺎﻫ شور و داﻮﻣ
ﻪﻌﻟﺎﻄﻣ درﻮﻣ ﺖﯿﻌﻤﺟ
، داﺮﻓا ﯽﻨﺳ هدوﺪﺤﻣ رد) ﻎﻟﺎﺑ 22
- 55 ﻪﻌﺟاﺮﻣ (لﺎﺳ .دﻮﺑ سووﺎﮐﺪﺒﻨﮔ ﺮﻬﺷ رد هﺪﻨﻨﮐ
ﻦﯿﻣﺎﺘﯾو هوﺮﮔ ود رد نارﺎﻤﯿﺑ 400 E
مﺮﮔ ﯽﻠﯿﻣ ﺐﺷ و ﺢﺒﺻ
هوﺮﮔ و سﺎﯿﻘﻣ سﺎﺳا ﺮﺑ ﻢﻈﻨﻣ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓB
رﻮﺑ ،گ ﯽﺘﺨﺳ ﻪﺟرد ﺎﺑ شﻼﺗ كرد ناﺰﯿﻣ ﺎﺑ 8
9 و لدﺎﻌﻣ ، -40
ﯽﻓﺮﺼﻣ نﮋﯿﺴﮐا ﺮﺜﮐاﺪﺣ ﺪﺻرد60 ناﺰﯿﻣ ﻪﺑ ،
ﺎﺑ اﺪﺘﺑا رد ﻪﮐ ﻪﺘﻔﻫ رد ﻪﺴﻠﺟ ﻪﺳ عوﺮﺷ ﻪﻘﯿﻗد20
هﺪﺷ ﯽﻃ رد و ﻪﺑ ﻪﺘﻔﻫ12
ﺪﯿﺳر ﯽﻣ ﻪﻘﯿﻗد60
، .ﺪﻨﺘﻓﺮﮔ راﺮﻗ ﺎﺑ
ﻪﻣﺎﻧ ﺖﯾﺎﺿر مﺮﻓ ﻞﯿﻤﮑﺗ زا ﺲﭘ (قﻮﻓ يﺎﻫرﺎﯿﻌﻣ سﺎﺳا ﺮﺑ) ﺮﮕﯾد ﻞﻠﻋ ندﺮﮐ در و ﯽﻠﮑﻟا ﺮﯿﻏ بﺮﭼ ﺪﺒﮐ ﺺﯿﺨﺸﺗ
،
1. Non alcoholic fatty liver disease (NAFLD)
2. Steatosis
3. Non-alcoholicsteatohepatitis (NASH) 4. Liver cirrhosis
نزو و ﺪﻗ ،ﯽﺠﻨﺳ ﻦﺗ يﺎﻫ هداد يروآ ﻊﻤﺟ .ﺪﻧﺪﺷ ﯽﻣ ﻪﻌﻟﺎﻄﻣ دراو نارﺎﻤﯿﺑ (ﯽﻧﺪﺑ هدﻮﺗ ﺺﺧﺎﺷ)
درﻮﻣ داﺮﻓا
رﻮﯿﺑ ﯽﻟﺎﺘﯿﺠﯾد يوزاﺮﺗ ﺎﺑ ﯽﺳرﺮﺑ نﺎﻤﻟآ رﻮﺸﮐ ر
ﺖﻗد ﺎﺑ ﺎﮑﺳ ﺞﻨﺳﺪﻗ و مﺮﮔﻮﻠﯿﮐ ﻪﺑ 1
/ 0 ﺪﺷ يﺮﯿﮔ هزاﺪﻧا .
هزاﺪﻧا
،يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ يﺎﻫﺮﯿﻐﺘﻣ يﺮﯿﮔ ،ALT
وAST
، ALP
روﺰﯿﻟﺎﻧآﻮﺗا هﺎﮕﺘﺳد و نﻮﻣزآ سرﺎﭘ يﺎﻫ ﺖﯿﮐ زا 3000
BT- ﻦﭘاژ رﻮﺸﮐ -
و نﺎﻤﻟآ ﻮﻧﻮﺳ زا نﺪﺑ ﯽﺑﺮﭼ حﺎﺸﺗرا ﻪﺟرد
مﺮﻧ ﺎﺑ ،ﺎﻫ هداد يرﺎﻣآ ﻞﯿﻠﺤﺗ .ﺪﺷ هدﺎﻔﺘﺳا ﯽﻓاﺮﮔ
راﺰﻓا نژرو spss
18 و ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ ﯽﻔﯿﺻﻮﺗ رﺎﻣآ ﺎﺑ ﺎﻫ ﯽﻧدﻮﻣزآ يدﺮﻓ يﺎﻫ ﯽﮔﮋﯾو ﺪﺷ
نﻮﻣزآ ﺎﺑ .
فاﺮﮔﻮﻤﻠﮐ -
.ﺪﺷ ﻞﺻﺎﺣ نﺎﻨﯿﻤﻃا ﻪﻌﻣﺎﺟ ندﻮﺑ ﯽﻌﯿﺒﻃ زا ﻒﻧﺮﯿﻤﺳا ﺎﺑ ﯽﻤﮐ يﺎﻫﺮﯿﻐﺘﻣ زا ﻞﺻﺎﺣ تاﺮﯿﯿﻐﺗ ﯽﺑﺎﯾزرا
رﺎﻣآ يﺎﻫ نﻮﻣزآ ي
ﻪﺘﺴﺑاوt
ياﺮﺑ نﻮﺴﮐﺎﮑﻠﯾو و ﯽﻨﺘﯾو نﺎﻣ يﺎﻫ نﻮﻣزآ و ﮏﯾﺮﺘﻣارﺎﭘ يﺎﻫ هداد ياﺮﺑ ﻞﻘﺘﺴﻣ و
ﮏﯾﺮﺘﻣارﺎﭘﺮﯿﻏ يﺎﻫ هداد .ﺪﺷ هدﺎﻔﺘﺳا
يرﺎﻣآ يراد ﯽﻨﻌﻣ ﺢﻄﺳ
(P< 0.05)
.ﺪﺷ ﻪﺘﻓﺮﮔ ﺮﻈﻧ رد
ﺎﻫ ﻪﺘﻓﺎﯾ
لوﺪﺟ تاﺮﯿﯿﻐﺗ 1-
نورد ﯽﻫوﺮﮔ و
ﻦﯿﺑ ﯽﻫوﺮﮔ ﺺﺧﺎﺷ
هدﻮﺗ ﯽﻧﺪﺑ و ﻪﺟرد ﮏﯿﻓاﺮﮔﻮﻧﻮﺳ
ﯽﺑﺮﭼ يﺪﺒﮐ
هوﺮﮔ
A هوﺮﮔ
B
ﻞﺒﻗ
زا نﺎﻣرد ﺲﭘ
زا نﺎﻣرد ﻞﺒﻗ
زا نﺎﻣرد ﺲﭘ زا نﺎﻣرد
هدﻮﺗ ﺺﺧﺎﺷ ﯽﻧﺪﺑ
28/67 ± 3/44
28/56 ± 3/40
30/15 ± 3/38
*29/01 ± 3/45
Kg/m2 ) (
ﻪﺟرد ﮏﯿﻓاﺮﮔﻮﻧﻮﺳ ﯽﺑﺮﭼ
يﺪﺒﮐ
) 1 ﻪﺟرد 3ﺎﺗ ( 0/18
2/1 ±
*1/5 ± 0/22
1/2± 0/10 *1/2 ± 0/25
نﺎﺸﻧ٭ هﺪﻨﻫد ﺶﻫﺎﮐ رادﺎﻨﻌﻣ ﺖﺒﺴﻧ ﻪﺑ ﻞﺒﻗ زا ﻪﻠﺧاﺪﻣ ﯽﻧﺎﻣرد
داﺪﻋا• ﻪﺑ ترﻮﺻ ﻦﯿﮕﻧﺎﯿﻣ فاﺮﺤﻧا±
) دراﺪﻧﺎﺘﺳا
(X±SEM
شراﺰﮔ هﺪﺷ .ﺪﻧا
ﺚﺤﺑ و ﻪﺠﯿﺘﻧ يﺮﯿﮔ
ﻪﻌﻟﺎﻄﻣ رد ،ﺮﺿﺎﺣ
ﻂﻘﻓ 3 / 3 % نارﺎﻤﯿﺑ ﺮﯾز ﯽﻧﺪﺑ هدﻮﺗ ﺺﺧﺎﺷ 25
ﺪﻨﺘﺷاد ﻊﺑﺮﻣ ﺮﺘﻣ ﺮﺑ مﺮﮔﻮﻠﯿﮐ ﺺﺧﺎﺷ .
ﯽﻧﺪﺑ هدﻮﺗ
رد 3 / 83
% ﻦﯿﺑ ،نارﺎﻤﯿﺑ 25
- 35 رد و 3 / 13
% يﻻﺎﺑ نارﺎﻤﯿﺑ 35
ﻊﺑﺮﻣ ﺮﺘﻣ ﺮﺑ مﺮﮔﻮﻠﯿﮐ درﻮﻣ هوﺮﮔ ود ﺮﻫ رد .دﻮﺑ
هدﻮﺗ ﺺﺧﺎﺷ ،ﻪﻌﻟﺎﻄﻣ زا ﺲﭘ .دﻮﺑ هﺪﺷ ﯽﻠﮐ ﻪﯿﺻﻮﺗ ﯽﯾاﺬﻏ ﻪﻣﺎﻧﺮﺑ ﻪﺋارا نوﺪﺑ نزو ﺶﻫﺎﮐ ﺎﺑ طﺎﺒﺗرا رد ،ﻪﻌﻟﺎﻄﻣ ﯽﻧﺪﺑ هوﺮﮔ رد يراد ﯽﻨﻌﻣ ﺶﻫﺎﮐ نارﺎﻤﯿﺑ داد نﺎﺸﻧ B
) /05 0 P<
رد ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ﺮﯿﺛﺎﺗ ﺮﮕﻧﺎﺸﻧ ﺪﻧاﻮﺗ ﯽﻣ ﻪﮐ (،
.ﺪﺷﺎﺑ ﯽﻓﺮﺼﻣ يﺮﻟﺎﮐ ﺶﯾاﺰﻓا ﻖﯾﺮﻃ زا نزو ﺶﻫﺎﮐ هوﺮﮔ رد
راﺮﻗ ﻢﻈﻨﻣ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ﺎﺑ نﺎﻣرد ﺖﺤﺗ ﻪﮐ B
ﺪﻨﺘﺷاد ﺪﺷ هﺪﻫﺎﺸﻣ ﯽﻓاﺮﮔﻮﻧﻮﺳ سﺎﺳا ﺮﺑ ﺪﺒﮐ ﯽﺑﺮﭼ ناﺰﯿﻣ رد ﺢﺿاو ﺶﻫﺎﮐ ، )
/05 0 (P<
) .(لوﺪﺟ ﻪﻌﻟﺎﻄﻣ رد
ﺢﻄﺳ رد راد ﯽﻨﻌﻣ ﺶﻫﺎﮐ ،ﺮﺿﺎﺣ هﺪﯾد نﺎﻣرد هﺎﻣ ﻪﺳ زا ﺲﭘ ﺰﯿﻧ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ هوﺮﮔ رد يﺪﺒﮐ يﺎﻫ ﻢﯾﺰﻧآ
ﺪﺷ ) /05 0 (P<
و يﺪﺒﮐ يﺎﻫ ﻢﯾﺰﻧآ ﺢﻄﺳ يور ﺮﺑ هدﺎﻔﺘﺳا درﻮﻣ ﯽﻧﺎﻣرد يﺎﻫ شور ﺮﺛا ﻪﻧﺎﮔاﺪﺟ ﯽﺑﺎﯾزرا ﺮﺑ هوﻼﻋ.
ﺺﺨﺸﻣ ﻪﮐ ﺪﻧﺪﺷ ﻪﺴﯾﺎﻘﻣ ﻢﻫ ﺎﺑ ﺰﯿﻧ ﺎﻫ هوﺮﮔ ﻦﯿﺑ رد ﯽﻧﺎﻣرد ﺮﺛا ،بﺮﭼ ﺪﺒﮐ ﮏﯿﻓاﺮﮔﻮﻧﻮﺳ ﺪﻫاﻮﺷ ﺰﯿﻧ ﮔ
ﺪﯾدﺮ
ﺼﺨﺸﻣ هوﺮﮔ ﻦﯿﺑ ﻪﻌﻟﺎﻄﻣ ياﺪﺘﺑا رد ﯽﻓاﺮﮔﻮﻧﻮﺳ رد بﺮﭼ ﺪﺒﮐ ﻪﺟرد و يﺪﺒﮐ يﺎﻫ ﻢﯾﺰﻧآ ﺮﯾدﺎﻘﻣ ،ﮏﯿﻓاﺮﮔﻮﻣد تﺎ
ﺘﺷاﺪﻧ يراد ﯽﻨﻌﻣ توﺎﻔﺗ ﯽﻧﺎﻣرد يﺎﻫ ﺖﺳا ﻪ
) /05 0 (P>
ﺎﺑ . ،ﻪﻠﺻﺎﺣ ﺞﯾﺎﺘﻧ ﻪﺑ ﻪﺟﻮﺗ ﻪﺑ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ﺪﺳر ﯽﻣ ﺮﻈﻧ ﻪﺑ
ﯽﯾﺎﻬﻨﺗ ﺖﺳا ﻪﺘﺴﻧاﻮﺗ ﻦﯿﻣﺎﺘﯾو هزاﺪﻧا ﻪﺑ
ﻧ و يﺪﺒﮐ يﺎﻫ ﻢﯾﺰﻧآ ﺶﻫﺎﮐ ردE
.ﺪﺷﺎﺑ ﺮﺛﻮﻣ ﺪﺒﮐ ﯽﺑﺮﭼ ﺶﻫﺎﮐ ﺰﯿ
تادﺎﻬﻨﺸﯿﭘ ﯽﺋاﺮﺟا
- ﯽﺸﻫوﮋﭘ و ﯽﻤﻠﻋ
ﺮﺘﺸﯿﺑ تﺎﻨﯾﺮﻤﺗ ﯽﺷزرو
ﯽﺘﻣﺎﻘﺘﺳا ﺎﯾ
ﯽﺘﻣوﺎﻘﻣ ﺎﺑ
تﺎﻧﺎﮑﻣا ﯽﻫﺎﮕﺷﺎﺑ
مﺎﺠﻧا
ﯽﻣ
،دﺮﯿﮔ ﺮﺘﺸﯿﺑ نارﺎﻤﯿﺑ تﺎﻧﺎﮑﻣا ﯽﻫﺎﮕﺷﺎﺑ
ار ﺪﻧراﺪﻧ و ﺎﯾ ﻪﺑ يرﺎﻤﯿﺑ ﻞﯿﻟد يﺎﻫ
ﺮﮕﯾد ردﺎﻗ ﻪﺑ مﺎﺠﻧا نآ ﯽﻤﻧ
سﺎﺳاﺮﺑ ،ﺪﻨﺷﺎﺑ سﺎﯿﻘﻣ
گرﻮﺑ ﯽﻣ ﺪﻧاﻮﺗ ﺖﻟﺎﺣ ﯽﻣﻮﻤﻋ ﻪﺘﺷاد و داﺮﻓا رد ﺮﻫ و ﯽﻄﯾاﺮﺷ ردﺎﻗ ﯽﺗﺎﻧﺎﮑﻣا
ﻪﺑ مﺎﺠﻧا
ﺖﯿﻟﺎﻌﻓ ﯽﻧﺪﺑ ﻢﻈﻨﻣ .ﺪﻨﺷﺎﺑ
ﻊﺑﺎﻨﻣ 1) Chalasani N, Younossi Z, Lavine E J, Diehel M A, Brunt M E, Cusi K, et al. The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology 2012 by the AGA Institute.
Am J Gastroenterol. 2012. (142):1592–609.
2) Armsrong M J, Houlihan D D, Bentham L, Shaw J C, Cramb R, Olliff S, et al. Presence and severity of non- alcoholic fatty liver disease in a large prospective primary care cohort. J Hepatol. 2012. 56 (1): 234-40.
3) Caballeria L, Auladell M A, Torán P, Miranda D, Aznar J Pera G, et al. Prevalence and factors associated with the presence of non-alcoholic fatty liver disease in an apparently healthy adult population in primary care units. BMC Gastroenterol. 2007. 7(41):1-6.
4) Hung H, Apple L, Croft K, Miller E, Mori T, Puddy I. Effect of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trail. Am J Clin Nutr. 2002. 76(3): 549-55.
5) Vincent H K, Bourguignon C M, Vincent K R, Weltman A L, Bryant M, Taylor A,G. Antioxidant supplementation lowers exercise-induced oxidative stress in young overweight adults. Obesity. 2006. 14(12):
2224 -35.
6) Miller E R, Pastor-Barriuso R, Dalal D, Riemersma R A, Apple L J, Guallar E. Metaanalysis:
high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005. 142(1):37-46.
